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复旦大学生命科学学院王洪海老师介绍

研究生院 免费考研网/2006-09-27

姓名: 王洪海
出生年月: 1945年12月
职称: 教授, 博士生导师
联系电话:(021)65643777
传真:(021)65648376
E-mail:hhwang@fudan.edu.cn

简历:1969年毕业于复旦大学生物学系,现任遗传所常务副所长,兼任遗传学科“211工程” 设备管理组组长。上海市免疫学会理事,国外医学微生物学分册副主编。2000年享受国务院颁发的政府特殊津贴。

科研方向:分子免疫学。发表学术论文50多篇,SCI论文18篇。目前正从事结核杆菌分子生物学和蛋白质组学研究。现主持有国家“863”、“973”、“十五”攻关、自然科学基金等8个关于结核病防治的科研项目。

教学方面:指导硕士生、博士生和博士后共12名。主讲硕士研究生的专业课-免疫分子遗传学。合作编著“基因工程实验技术”(湖南科技出版社,1997)和“免疫学导论”(高等教育出版社,1999)。
获奖情况:参与的军事医学科研“xxx 装置的研制”获国家科技进步奖壹等奖(奖励证号:后-1-001,1990)。“蛋白质抗原决定簇的筛选及其化学合成多肽疫苗的研究”获军队科技进步奖叁等奖(1990-3-65-1)。“基因工程实验技术”获上海市优秀教材壹等奖(1999)。参与的酵母表达人a 干扰素的研究和开发获 上海市科技进步贰等奖(2001)。“免疫学导论”获教育部优秀教材贰等奖(2002)。

代表性论文目录:
1. Bernhard Dietzschold, Honghai Wang, Charles E.Rupprecht, et al. Induction of protective immunity against rabies by immunization with rabies virus ribonucleoprotein. Proc. Natl. Acad. Sci. USA 1987; 84:9165
2、Wang Honghai, Bernhard Dietzschold and Hilary Koprowski. Selection and identification of antigenic determinant of Mycobacterium Tuberculosis H37Ra strain. Chinese Medical Journal 1992; 105(5):420
3、 Wang HH., Liu W., Chen PL., Hu W., Zhuang YH. Selection and determination of the Specific and protective antigens of Mycobacterium tuberculosis. Chinese Medical Journal 1999; 112(8):750-753
4. Xie JP, Li Y, Yue J, Xu YZ, Huang DQ, Liang L & Wang HH. Exploring Mycobacterium tuberculosis infection-induced alterations in gene expression in macrophage by microarray hybridization. Science in China ( Series C),2003; 46(4):337-347
5. Xu YZ, Xie JP, Li Y, Yue J, Chen JP, Chunyu LJ & Wang HH. Using cDNA microarray to study cellular gene expression altered by Mycobacterium tuberculosis. Chinese Medical Journal 2003; 116(7):1070-1073
6. Jun Yue, Wei Shi, Jianping Xie, Yao Li, Erliang Zeng and Honghai Wang.. Mutations of rpoB gene of multidrug-resistant Mycobacterium tuberculosis isolates from China. Journal of Clinical Microbiology 2003, 41(5):2209-2212
7. J.P.Xie, J.Yue, Y.L.Xiong, W.Y.Wang, S.Q.Yu and H.H.Wang. In Vitro activities of small peptides from Snake Venom against clinical isolated drug-resistant Mycobacterium tuberculosis.Inter. J. of Antimicrobial Agents 2003; 22:172-174
8. J.Yue, J.P.Xie, L.R.Liu and H.H.Wang. Detection of Rifampin-resistant Mycobacterium tuberculosis strains by using a specializated oligonucleotide microarray. Diagnostic microbiology and infectious disease.2004, 48(1):47-54
9. Bao-Lin Wang,Ying Xu, Chao-Qun Wu, Yun-Min Xu, Hong-Hai Wang. Cloning,Expression and Refolding of a Secretory Protein ESAT-6 of Mycobacterium tuberculosis. Protein Expression and Purification 2005, 39(2):184-188 (SCI论文)
10. Jianqiang Lei, Hongmei Zhang, Chunlan Wu, Xiaolei Wang, Yanping Yang, Xuelian Zhang, Honghai Wang. p38 MAPK-dependent YY1-mediated the chemokine receptors CCR5 and CXCR4 up-regulation in U937 cell line infected by Mycobacterium tuberculosis. B.B.R.C. 2005; 329:610-615
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