姓名：梅岩艾
职称：教授，博士生导师
联系地址：复旦大学生命科学学院
联系电话:86-21-55664711
E-mail:yanaimei@yahoo.com, yamei@fudan.edu.cn



简历：1986年上海第二医科大学生理专业硕士研究生毕业.
1991至1995年在法国鲁昂大学的国家医学研究院所属细胞和分子神经内分泌实验室攻读生物学博士研究生，作“膜片箝方法研究腺苷对促黑素细胞生物电影响的机制"和“用分子生物学、膜片箝方法鉴定大鼠小脑颗粒细胞上的多巴胺受体新亚D4及其对钙通道的调节机制”课题的研究。
1995年获博士学位后回国,同年晋升为副教授
1996年调入复旦大学生理和生物物理学系后于1999年晋升为教授.2000年评为博士生导师。


目前主要从事的研究内容为:神经递质和生物活性肽受体激活后对细胞膜离子通道的调控及其有关的跨膜信号转导机制；细胞膜离子通道在神经元和心血管等细胞的发育、增殖、迁移和凋亡中的变化规律及其作用；中枢神经元突触传递机制研究.


近年来发表的SCI论文：
1. Lin-Yun Liu, Xiao-Wei Fei, Zhao-Min Li, Yan-Ai Mei. The nonsteroidal anti-inflammatory drug, diclofenac, activates the transient outward K+ current in rat cereballer granule cells. Neuropharmacology 2005 (in press)
2. Bo-Xun Lu, Lin-Yun Liu, Zhao-Ming Li, Zhi-Hong Zhang, Yan-Ai Mei. Inhibition of Na+ channel currents in rat myoblasts by 4-aminopyridine. Toxicology and Applied Pharmacology. 2005 (in press)
3. Hu Chang-Long, Gao Zhen-Yu, Liu Zheng, Zhang Zhi-Hong, Mei Yan-Ai 2-iodomelatonin prevents apoptosis of cerebellar granule neurons via inhibition of A-type transient outward K+ currents. J. Pineal Res. 2005, 38:53-61
4. Yan-ai Mei, D. Vaudry et al, PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway. Evidence for the involvement of Ik in the anti-apoptosis action of PACAP. Eur. J. Neuronsci. 2004 14:225-230.
5．MiOu Zhou, Zheng Liu, ChangLong Hu, ZhiHong Zhang and Yan-Ai Mei Developmental Regulation of a Na+-activated Fast Outward K+ Current in Rat Myoblasts. Cell Physiol Biochem 2004;14 ：225-230.
6．Lin-Yun Liu , Chang-Long Hu, Lai-ji Ma, Zhi-hong Zhang, and Yan-Ai Mei. ET-1 inhibits B-16 murine melanoma cell migration by decreasing K+ currents. Cell Motility Cytoskel . 2004: 58:127-136.
7．Song Jiao, Ming-Ming Wu, Chang-Long Hu, Zhi-Hong Zhang and Yan-Ai Mei. Melatonin receptor agonist 2-iodomelatonin prevents apoptosis of cerebellar granule neurons via K+ currents inhibition. J. Pineal Res. 2004; 36:109-116
. 8. Lai-Ji Ma , Lin-Yun Liu, Song Jiao, Shao-Ming Wei, Yan-Ai Mei Ca2+- inactivated K+ current modulated by endothelin-I in B-16 murine melanoma cells. Pigment Cell Res. 2003,16:463-469
9．ZHOU Mi-ou, JIAO Song, LIU Zheng, ZHANG Zhi-hong, Mei Yan-ai. Luzindole, a melatonin receptor antagonist, inhibits the transient outward K+ current in rat cerebellar granule cells. Brain Res.2003,970: 169-177
10．Hua Wei, Yan Ai Mei, Jia Ting Sun, Han Ging Zhou, Zhi Fong Zhang. Regulation of sewlling-activated chloride channels in embryonic chick heart cells. Cell Res. 2003, 1: 21-28.
11. Wei DS, Mei YA, Bagal A, Kao JP, Thompson SM, Tang CM. Compartmentalized and binary behavior of terminal dendrites in hippocampal pyramidal neurons. Science. 2001 Sep 21;293(5538):2272-5.
12. Mei YA, Lee PP, Wei H, Zhang ZH, Pang SF. Melatonin and its analogs potentiate the nifedipine-sensitive high-voltage-activated calcium current in the chick embryonic heart cells. J Pineal Res. 2001 Jan;30(1):13-21.
13. Huan CL, Zhou MO, Wu MM, Zhang ZH, Mei YA. Melatonin receptor Activate the rectify inward K+ current by a MT2 melatonin receptor in cerebellar granule cells. Brain Res, 2001,917:182-190.
14. Wei H, Mei YA, Wu MM, Sun JT, Zhou HQ, Zhang ZH. Swelling-activated chloride currents in embryonic chick heart cells. Acta Pharmacol Sinica. 2000 Nov;21(11):986-90.
15. Mei YA, Wu MM, Huan CL, Sun JT, Zhou HQ, Zhang ZH. 4-aminopyridine, a specific blocker of K(+) channels, inhibited inward Na(+) current in rat cerebellar granule cells. Brain Res. 2000 Aug 4;873(1):46-53.
16. Mei YA, Huang LX, Wei H, Sun JT, Zhou HQ, Zhang ZH. Characterization of outward potassium current in embryonic chick heart cells. Acta Pharmacol Sinica. 1999 Apr;20(4):303-7.
17. Mei YA. High-voltage-activated calcium current and its modulation by dopamine D4 and pituitary adenylate cyclase activating polypeptide receptors in cerebellar granule cells. Acta Pharmacol Sinica. 1999 Jan;20(1):3-9.
18. Mei YA, Vaudry H, Cazin L. Patch clamp study on mechanism of adenosine-induced inhibitory effects in frog pituitary melanotrophs. Acta Pharmacol Sinica. 1996 Sep;17(5):385-9.
19. Soriani O, Vaudry H, Mei YA, Roman F, Cazin L. Sigma ligands stimulate the electrical activity of frog pituitary melanotrope cells through a G-protein-dependent inhibition of potassium conductances. J Pharmacol Exp Ther. 1998 286(1):163-71.
20. Mei YA, Soriani O, Castel H, Vaudry H, Cazin L. Adenosine potentiates the delayed-rectifier potassium conductance but has no effect on the hyperpolarization-activated Ih current in frog melanotrophs. Brain Res. 1998 793(1-2):271-8.
21. Mei YA, Vaudry H, Cazin L. Patch clamp study on mechanism of adenosine-induced inhibitory effects in frog pituitary melanotrophs. Acta Pharmacol Sinica. 1996 Sep;17(5):385-9.
22. Gonzalez BJ, Basille M, Mei YA, Vaudry D, Fournier A, Cazin L, Vaudry H. Ontogeny of PACAP and PACAP receptors in the rat brain: role of PACAP in the cerebellum during development. Ann N Y Acad Sci. 1996 26;805:302-13;
23. Mei YA, Le Foll F, Vaudry H, Cazin L. Adenosine inhibits L- and N-type calcium channels in pituitary melanotrophs. Evidence for the involvement of a G protein in calcium channel gating. J Neuroendocrinol. 1996 Feb;8(2):85-91.
24. Mei YA, Louiset E, Vaudry H, Cazin L. A-type potassium current modulated by A1 adenosine receptor in frog melanotrophs.J Physiol. 1995 Dec 1;489 ( Pt 2):431-42.
25. Mei YA, Griffon N, Buquet C, Martres MP, Vaudry H, Schwartz JC, Sokoloff P,Cazin L. Activation of dopamine D4 receptor inhibits an L-type calcium current in cerebellar granule cells. Neuroscience. 1995 Sep;68(1):107-16.
26. Mei YA, Vaudry H, Cazin L. Inhibitory effect of adenosine on electrical activity of frog melanotrophs mediated through A1 purinergic receptors. J Physiol. 1994 481 ( Pt 2):349-55.
27. Louiset E, Mei YA, Valentijn JA, Vaudry H, Cazin L. Characterization of the GABA-induced current in frog pituitary melanotrophs. J Neuroendocrinol. 1994 Feb;6(1):39-46.