李大金



李大金 /教授

专业名称：妇产科学 导师类别：博导

研究方向：母－胎免疫调节、生育免疫调节、神经－生殖内分泌－免疫调节 E-mail:djli#shmu.edu.cn





研究成果 近五年代表性论文(第一或通讯作者)

1. Wu HX, Jin LP, Xu B, Liang SS, Li DJ*. Decidual stromal cells recruit Th17 cells into decidua that promote proliferation and invasion of human trophoblast cells through secreting IL-17. Cell Mol Immunol 2014(IF: 3.419); 10 (in press)
2. Fu Q, Tao Y, Piao HL, Du MR, Li DJ*. Trophoblasts and decidual stromal cells regulate decidual NK cell functions via interaction between collagen and LAIR-1. Am J Reprod Immunol 2014 (IF: 3.317); 71: 368–378
3. Du MR, Guo PF, Piao HL, Wang SC, Sun C, Jin LP, Tao Y, Li YH, Zhang D, Zhu R, Fu Q, Li DJ*. Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells. J Immunol 2014 (IF: 5.52);192:1502-1511
4. Duan J, Jiang XP, Li MQ, Fan DX, Wang Y, Li DJ*, Jin LP*. Thymic stromal lymphopoietin suppresses the apoptosis of decidual gamma-delta T cells via regulation of the signal transduction and activation of transcription 3/caspase-3 signaling pathway. Am J Reprod Immunol 2013 (IF: 3.317); 70: 461–471
5. Li MQ, Shao J, Meng YH, Mei J, Wang Y, Li H, Zhang L, Chang KK, Wang XQ, Zhu XY, Li DJ*. NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathway in the endometriotic milieu. Hum Reprod 2013 (IF: 4.670); 28:2822-2831
6. Zhu R, Wang SC, Sun C, Tao Y, Piao HL, Wang XQ, Du MR*, Li DJ*. Hyaluronan-CD44 interaction promotes growth of decidual stromal cells in human first-trimester pregnancy. PLoS One 2013(IF: 3.730); 8: e74812.
7. Chang KK, Liu LB, Jin LP, Meng YH, Shao J, Wang Y, Mei J, Li MQ*, Li DJ*. NME1 suppression of endometrial stromal cells promotes angiogenesis in the endometriotic milieu via stimulating the secretion of IL-8 and VEGF. Int J Clin Exp Pathol 2013 (IF: 2.242); 6:2030-2038
8. Wang Y, Xu B, Li MQ, Li DJ*, Jin LP*. IL-22 secreted by decidual stromal cells and NK cells promotes the survival of human trophoblasts. Int J Clin Exp Pathol 2013 (IF: 2.242); 6:1781-1790
9. Li H, Huang YH, Li MQ, Meng YH, Chen X, Shao J, Tang CL, Du MR, Jin LP, Li DJ*. Trophoblasts-derived chemokine CCL24 promotes the proliferation, growth and apoptosis of decidual stromal cells in human early pregnancy. Int J Clin Exp Pathol 2013 (IF: 2.242); 6: 1028-1037
10. Shao J, Li MQ, Meng YH, Chang KK, Wang Y, Zhang L, Li DJ*. Estrogen promotes the growth of decidual stromal cells in human early pregnancy. Mol Hum Reprod 2013 (IF: 4.542); 19:655-664
11. Sun Ch, Zhang YY, Tang CL, Wang SC, Piao HL, Tao Y, Zhu R, Du MR*, Li DJ*. Chemokine CCL28 induces apoptosis of decidual stromal cells via binding CCR3/CCR10 in human spontaneous abortion. Mol Hum Reprod 2013 (IF: 4.542); 19:676-686
12. Zhu R, Huang YH, Tao Y, Wang SC, Sun Ch, Piao HL, Wang XQ, Du MR*, Li DJ*. Hyaluronan up-regulates growth and invasion of trophoblasts in an autocrine manner via PI3K/AKT and MAPK/ERK1/2 pathways in early human pregnancy. Placenta 2013 (IF: 3.117); 34:784-791
13. Meng YH, Li H, Chen X, Liu LB, Shao J, Chang KK, Du MR, Jin LP, Li MQ, Li DJ*. RANKL promotes the growth of decidual stromal cells in an autocrine manner via CCL2/CCR2 interaction in human early pregnancy. Placenta 2013 (IF: 3.117); 34:663-671
14. Tang CL, Li F, Sun L, Li DJ*. Therapeutic effect of Bushen Huoxue Recipe on autoimmune premature ovarian failure mice established by immunization with recombinant porcine zona pellucida 4 antigen. Chi J Integr Med 2013 (IF: 1.059); 19: 439–445
15. Xie F, Meng YH, Liu LB, Chang KK, Li H, Li MQ, Li DJ*. Cervical carcinoma cells stimulate the angiogenesis through TSLP promoting growth and activation of vascular endothelial cells. Am J Reprod Immunol 2013 (IF: 3.317); 70: 69–79
16. Wang SC, Tang CL, Piao HL, Zhu R, Sun C, Fu Q, Li DJ*, Du MR*. Cyclosporine A promotes in vitro migration of human first-trimester trophoblasts via MAPK/ERK1/2-mediated NF-kB and Ca2+/calcineurin/NFAT signaling. Placenta 2013 (IF: 3.117); 34:374-380
17. Wang L, Qiu XM, Hao Q, Li DJ*. Anti-inflammatory effects of a Chinese herbal medicine in atherosclerosis via estrogen receptor b mediating nitric oxide production and NF-?B suppression in endothelial cells. Cell Death Dis 2013 (IF: 6.044); 4:e551
18. Du MR, Qiu Q, Gruslin A, Gordon J, He M, Chan CC, Li DJ*, Tsang BK*. SB225002 promotes mitotic catastrophe in chemo-sensitive and -resistant ovarian cancer cells independent of p53 status in vitro. Plos One 2013 (IF: 3.730); 8:e54572
19. He YY, He XJ, Guo PF, Du MR, Shao J, Li MQ, Li DJ*. The decidual stromal cells-secreted CCL2 induces and maintains decidual leukocytes into Th2 bias in human early pregnancy. Clin Immunol 2012 (IF: 3.771); 145:161-173
20. Piao HL, Wang SC, Tao Y, Zhu R, Sun C, Fu Q, Du MR*, Li DJ*. Cyclosporine A enhances Th2 bias at the maternal-fetal interface in early human pregnancy with aid of the interaction between maternal and fetal cells. Plos One 2012 (IF: 3.730); 7:e45275
21. Tang CL, Zhao HB, Li MQ, Du MR, Meng YH, Li DJ*. Focal adhesion kinase signaling is necessary for the Cyclosporin A-enhanced migration and invasion of human trophoblast cells. Placenta 2012 (IF: 3.117); 33:704-711
22. Piao HL, Tao Y, Zhu R, Wang SC, Tang CL, Fu Q, Du MR*, Li DJ*. The CXCL12/CXCR4 axis is involved in the maintenance of Th2 bias at the maternal/fetal interface in early human pregnancy. Cell Mol Immunol 2012 (IF: 3.419); 9:423-430
23. Zhao HB, Tang CL, Hou YL, Xue LR, Li MQ, Du MR, Li DJ*. CXCL12/CXCR4 axis triggers the activation of EGF receptor and ERK signaling pathway in CsA-induced proliferation of human trophoblast cells. Plos One 2012 (IF: 3.730); 7:e38375
24. Meng YH, Shao J, Li H, Hou YL, Tang CL, Du MR, Li MQ*, Li DJ*. CsA improves the trophoblasts invasiveness through strengthening the cross-talk of trophoblasts and decidual stromal cells mediated by CXCL12 and CD82 in early pregnancy. Int J Clin Exp Pathol 2012 (IF: 2.242); 5:299-307
25. Li MQ, Luo XZ, Meng YH, Mei J, Zhu XY, Jin LP, Li DJ*. CXCL8 enhances proliferation and growth and reduces apoptosis in endometrial stromal cells in an autocrine manner via a CXCR1-triggered PTEN/AKT signal pathway. Hum Reprod 2012 (IF: 4.670); 27:2107-2116
26. Du MR, Zhou WH, Piao HL, Li MQ, Tang CL, Li DJ*. Cyclosporin A promotes cross-talk between human cytotrophoblast and decidual stromal cell through upregulating CXCL12/CXCR4 interaction. Hum Reprod 2012 (IF: 4.670); 27:1955-1965
27. Li MQ, Li HP, Meng YH, Wang XQ, Zhu XY, Mei J, Li DJ*. Chemokine CCL2 enhances survival and invasiveness of endometrial stromal cells in an autocrine manner via activating Akt and MAPK/Erk1/2 signal pathway. Fertil Steril 2012 (IF: 4.174); 97:919-929
28. Pu HH, Duan J, Wang Y, Fan DX, Li DJ*, Jin LP*. Thymic stromal lymphopoietin promotes the proliferation of human trophoblasts via phosphorylated STAT3-mediated c-Myc upregulation. Placenta 2012 (IF: 3.117); 33:387-391
29. Ji YQ, Zhang YQ*, Li MQ, Du MR, Wei WW, Li DJ*. EPO improves the proliferation and inhibits apoptosis of trophoblast and decidual stromal cells through activating STAT-5 and inactivating p38 signal in human early pregnancy. Int J Clin Exp Pathol 2011 (IF: 1.893); 4:765-774
30. Fan DX, Duan J, Li MQ, Xu B, Li DJ*, Jin LP*. The decidual gamma-delta T cells up-regulate the biological functions of trophoblasts via secreting IL-10 in human early pregnancy. Clin Immunol 2011 (IF: 4.046); 141:284-292
31. Sun Y, Wang W, Shan B, Di J, Chen L, Ren L, Li W, Li DJ*, Lin Y*. FTY720-induced conversion of conventional Foxp3-CD4+ T cells to Foxp3+ regulatory T cells in NOD mice. Am J Reprod Immunol 2011 (IF: 3.050); 66:349-362
32. Jin LP, Fan DX, Zhang T, Guo PF, Li DJ*. The costimulatory signal upregulation is associated with Th1 bias at the maternal-fetal interface in human miscarriage. Am J Reprod Immunol 2011 (IF: 3.050); 66:270-278
33. Li MQ, Hou XF, Lv SJ, Meng YH, Wang XQ, Tang CL, Li DJ*. CD82 gene suppression in endometrial stromal cells leads to increase of the cell invasiveness in the endometriotic milieu. J Mol Endocrinol 2011 (IF: 3.485); 47:195–208
34. Jin LP, Fan DX, Li DJ*. Regulation of costimulatory signal in maternal-fetal immune tolerance. Am J Reprod Immunol 2011 (IF: 3.050); 66:76-83
35. Li MQ, Tang CL, Du MR, Fan DX, Zhao HB, Xu B, Li DJ*. CXCL12 controls over-invasion of trophoblasts via upregulating CD82 expression in DSCs at maternal-fetal interface of human early pregnancy in a paracrine manner. Int J Clin Exp Pathol 2011 (IF: 1.893); 4(3):276-286
36. Lin Y*, Li C, Shan B, Wang WJ, Saito S, Xu JH, Di JF, Zhong YM, Li DJ*. Reduced stathmin-1 expression in natural killer cells associated with spontaneous abortion. Am J Pathol 2011 (IF: 4.890); 178(2):506-514
37. Wang L, Hao Q, Wang YD, Wang WJ, & Li DJ*. Protective effects of dehydroepiandrosterone on atherosclerosis in ovariectomized rabbits via alleviating inflammatory injury in endothelial cells. Atherosclerosis 2011 (IF: 3.794); 214:47-57
38. Luo CY, Wang L, Sun C & Li DJ*. Estrogen enhances the functions of CD4+CD25+Foxp3+ regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro. Cell Mol Immunol 2011 (IF: 2.992); 8:50-58
39. Wang XQ, Yu J, Luo XZ, Shi YL, Wang Y, Wang L & Li DJ*. The high level of RANTES in the ectopic milieu recruits macrophages and induces their tolerance in progression of endometriosis. J Mol Endocrinol 2010 (IF: 3.628); 45: 291–299
40. Guo PF, Du MR, Wu HX, Lin Y, Jin LP, & Li DJ*. Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans. Blood 2010 (IF:10.558); 116:2061-2069
41. Zhao HB, Wang C, Li RX, Tang CL, Li MQ, Du MR, Hou XF, & Li DJ*. E-cadherin, as a negative regulator of invasive behavior of human trophoblast cells, is down-regulated by Cyclosporin A via epidermal growth factor/extracellular signal-regulated protein kinase signaling pathway. Biol Reprod 2010 (IF:3.870); 83(3):370-376
42. Wu HX, Guo PF, Jin L-P, Liang SS, & Li DJ*. Functional regulation of thymic stromal lymphopoietin on proliferation and invasion of trophoblasts in human first-trimester pregnancy. Hum Reprod 2010 (IF: 4.357); 25(5):1146-1152
43. Li MQ, Hou XF, Shao J, Tang CL, & Li DJ*. The DSC-expressed KAI1/CD82 controls the invasiveness of trophoblast cells via integrinβ1/MAPK/Erk1/2 signaling pathway in human first-trimester pregnancy. Biol Reprod 2010 (IF: 3.870); 82:968-979
44. Xie KM, Hou XF, Li MQ, & Li DJ*. NME1 at the human maternal-fetal interface downregulates titin expression and invasiveness of trophoblast cells via MAPK pathway in early pregnancy. Reproduction 2010 (IF: 3.049); 139:799-808
45. Wang Y, Yu J, Luo XZ, Wang XQ, Li MQ, & Li DJ*. Abnormal regulation of chemokine TECK and its receptor CCR9 in the endometriotic milieu is involved in pathogenesis of endometriosis by way of enhancing invasiveness of endometrial stromal cells. Cell Mol Immunol 2010 (IF: 2.026); 7:51-60
46. Li DJ*, Guo PF. Regulating roles of thymic stromal lymphopoietin (TSLP) in maternal-fetal immune tolerance during early human pregnancy. J Reprod Immunol 2009 (IF: 2.52); 83:106-109
47. Jin LP, Chen QY, Zhang T, Guo PF, & Li DJ*. The CD4+CD25bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage. Clin Immunol 2009 (IF: 3.86); 133(3):402-410
48. Lin Y*, Wang HQ, Wang WJ, Zeng S, Zhong YM, & Li DJ*. Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2(+)ISG20(+) natural killer-cell transfer. Reproduction 2009 (IF: 2.58); 137(6):943-955
49. Wang YD, Cui KM, Zhao H, Li DJ*, Wang W-J, Zhu Y. Bushen Ningxin Decoction pharmacological serum promotes the proliferation and suppresses the apoptosis of murine osteoblasts through MAPK pathway. J Ethnopharmacol 2009 (IF: 2.32); 122 (1):221-226
50. Wang WJ, Lin Y*, Zeng S, & Li DJ*. Involvement of fertility with adoptive CD25+ natural kiler cell transfer in subfertile non-obese diabetic mice. Reprod Biomed Online 2009 (IF: 2.38); 18 (1):95-103
51. Wang L, Wang YD, Wang WJ, & Li DJ*. Differential regulation of dehydroepiandrosterone and estrogen on bone and uterus in ovariectomized mice. Osteoporosis Int 2009 (IF: 5.00); 20(1):79-92
52. 唐传玲，孙婵，杜美蓉，李大金*：环孢素A通过活化Src信号通路促进人绒毛癌细胞株JEG-3侵袭。生殖与避孕 2013；33（6）：361-366
53. 杜美蓉，徐冰，朴海兰，李大金*：人早孕期蜕膜基质细胞下调蜕膜NK细胞杀伤活性。现代免疫学 2012；32（4）：303-307
54. 赵洪波，薛丽蓉，李大金*：E-钙黏蛋白(E- cadheri)对人滋养细胞侵袭能力及妊娠结局的影响。生殖与避孕 2012；32（1）：10-16
55. 邵君，李明清，沈宗姬，李大金*：早孕期母-胎界面蜕膜基质细胞过表达肿瘤转移抑制基因KAI1/CD82导致妊娠失败。复旦学报（医学版）2011；38（5）：382-388
56. 李明清，杜美蓉，周雯慧，李大金*：环孢素A对人母-胎界面IL-10和IFN-?细胞因子格局的调节作用。现代免疫学 2011；31（2）：121-125
57. 徐冰，吴海霞，李大金*：人早孕期蜕膜基质细胞对蜕膜NK细胞分泌IL-22的调节作用。中国免疫学杂志 2011；27（1）：37-40
58. 陈巧英，李大金*，陈安儿，卢文波，陈慧琴，陈顺美，李宁宁，吕美雅，范惠英：外周血CD4+CD25+Foxp3+调节性T细胞影响先兆流产的妊娠预后。现代免疫学 2010；30（2）：124-126
59. 罗雪珍，李大金*，史颖莉，王凌：趋化因子受体CCR6在子宫内膜异位症在位内膜及异位灶中的表达。中国妇产科临床杂志 2010；11：34-36
60. 马方，杜美蓉，李大金*：早孕期人绒毛趋化因子CCL2及其受体CCR2的表达。生殖与避孕 2009；29（11）：755-758
61. 郭培奋，贺银燕，李大金*：人胸胁淋巴细胞生成素（hTSLP）在早孕绒毛组织的表达及意义。中国免疫学杂志 2009；25（11）：1019-1022
62. 罗成燕，王凌，孙婵，李大金*：调节性T细胞源性IL-10与TGF-β1对破骨细胞分化与骨吸收的抑制作用。中华内分泌代谢杂志 2009；25（4）：434-437
63. 侯晓帆，谢可鸣，李明清，李大金*：环孢素A对人滋养细胞内膜nm23-H1表达的调控作用。中国病理生理杂志2009；25（3）：493-496
64. 谢锋，李明清，李大金*：嗜酸粒细胞对恶性肿瘤病灶的清润及调节作用。现代免疫学 2012；32（2）：172-175
65. Jin L-P, Fan D-X, Li D-J*. Regulation of costimulatory signal in maternal-fetal immune tolerance. Am J Reprod Immunol 2011(IF:2.45):76-83
66. 王晓秋，李大金*：内分泌干扰物促进子宫内膜异位症发生发展的研究进展。中国妇产科临床杂志 2010；11（2）：158-160
67. 李大金*：重视协同刺激分子在母胎免疫耐受中的调控作用（应邀述评）。国际妇产科学杂志 2009；36（1）：1-3
68. 侯晓帆，赵洪波，金莉萍，唐传玲，李大金*：转移抑制基因nm23-H1及在母胎界面的表达。国际生殖健康计划生育杂志 2009；28（1）：41-43
69. 王凌，李大金*：绝经后骨质疏松症发病的骨免疫学机制。中华内分泌代谢杂志 2009；25（1）：124-126
70. 李大金*：趋化因子在人母-胎界面的整合性调节作用。现代免疫学 2009；29（1）：1-5





任职学会 职务 任期起始时间 任期结束时间

上海市免疫学会生殖免疫分会
中国免疫学会生殖免疫分会
中国生理学会消化内分泌生殖代谢理专业委员会
上海市免疫学会
中国中西医结合学会妇产科专业委员会
中国免疫学会生殖免疫分会
中国免疫学会
中华医学会生殖医学分会
中国免疫学会生殖免疫分会
中国中西医结合学会
中国中西医结合学会妇产科专业委员会
上海市计划生育与生殖健康学会
上海市免疫学会
中国中西医结合学会妇产科专业委员会
任职期刊
American Journal of Reproductive Immunology (in USA)
Cellular & Molecular Immunology (in China)
International Journal of Clinical and Experimental Pathology (in U.S.A.)
《中华微生物与免疫学杂志》
《细胞与分子免疫学杂志》
《生殖与避孕》
《中国免疫学杂志》
《生殖医学杂志》
《复旦大学学报医学版》
《现代免疫学》
《国际生殖健康/计划生育杂志》
《中国中西医结合杂志》

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承担项目 1.2014.1-2016.1212巨噬细胞主导的免疫耐受微环境参与子宫内膜异位症发病的分子机制教育部高等学校博士学科点专项科研基金（博导类）：20**1
2. 2013.1-2016.12 80调节性T细胞与Th17细胞动态平衡参与母-胎免疫调节的分子机制,国家自然科学基金面上项目：**
3. 2013.1-2015.12 40CXCL12/CXCR4信号介导滋养细胞调节蜕膜NK细胞功能的分子机制上海市科委基础重点项目12JC**
4. 2012.1-2015.12 100新型免疫避孕制剂的研究国家科技支撑计划 2012BAI31B07（分课题负责人）
5. 2010.9-2013.860反复自然流产的诊断流程、免疫病因分类及治疗新策略研究上海市申康新兴前沿技术联合攻关项目SHDC **
6. 2010.1-2012.1280TSLP在免疫耐受形成中的调节作用国家自然科学基金重大国际合作项目
7. 2009.1-2011.1232环孢素A调控人滋养细胞生物学功能的信号转导机制国家自然科学基金面上项目**
8. 2008.1-2011.12150妊娠期调节性T细胞来源及在母-胎免疫耐受中的作用国家自然科学基金重点项目**
9. 2007.1-2011.12231生殖细胞健康与母胎识别及免疫豁免的分子基础：蜕膜化相关基因的筛选、调节及功能国家重大科学研究计划项目2006CB944009
10. 2007.1-2009.1227α型趋化因子CXCL12及CXCL16对人滋养细胞的自分泌调节作用国家自然科学基金项目**
11. 2005.1-2007.1222过继转输胚胎抗原耐受性T细胞对妊娠预后影响的分子机制国家自然科学基金项目**
12. 2004.1-2006.1230环孢素A对移植物－宿主双向调节作用机制的研究上海市基础研究重点项目03JC14016
13. 2003.1-2005.1218携新型分子佐剂C3d 增强hCG?避孕疫苗Th2型免疫效应国家自然科学基金项目**
14. 2001.1-2003.125“更年青”胶囊治疗更年期综合征上海市科技攻关项目
15. 2001.1-2003.124携分子佐剂的hCG－β避孕疫苗的Th2型免疫效应上海市自然科学金00ZB14058
16. 2000.1-2002.124分子佐剂C3d转变DNA避孕疫苗免疫应答模式教育部博士学科点专项科研基金9941
17. 1998.1-2000.1210生育免疫调节上海医科大学临床重点建设项目
18. 1998.1-2000.122分子佐剂C3d3应用于免疫避孕疫苗的研究卫生部优秀青年人才基金97031
19. 1998.1-2000.129协同刺激分子在母-胎免疫调节中作用机理研究国家自然科学基金**
20. 1995.6-1998.1210.2中药在RU486终止早孕中止血作用的研究上海市现代生物及新药发展基金
21. 1995.1-1997.126卵透明带独特型抗体内影像及其免疫抗生育作用的研究国家自然科学基金**