李明清



李明清 /研究员

专业名称：妇产科学 导师类别：硕导

研究方向：子宫内膜异位症的免疫机制、母-胎免疫和妇科肿瘤免疫 E-mail:mqli#fudan.edu.cn



个人经历 起止年月 工作单位 职称/职务

2018.12-至今
2015.01-2018.11
2013.12-2014.12
2011.07-2013.11
2010.11-2011.06
2005.09-2010.07
2003.07-2005.07
1998.09-2003.07

复旦大学附属妇产科医院
复旦大学附属妇产科医院
复旦大学附属妇产科医院
复旦大学附属妇产科医院
复旦大学附属妇产科医院
复旦大学附属妇产科医院
九江市妇幼保健院
安徽医科大学

研究员/硕导
副研究员/硕导
副研究员
助理研究员
住院医师
博士
住院医师
学士



研究成果 近五年代表性论文(第一或通讯作者)

"1.Rui-Qi Chang, Jun Shao, Yu-Han Meng, Jian Wang, Da-Jin Li*, Ming-Qing Li*. Decidual RANKL/RANK interaction promotes the residence and polarization of TGF-B1-producing regulatory yq T cells. Cell Death Dis (accepted) (IF:5.638)"
"2.Jie Mei, Yuan Yan, Shi-Yuan Li, Wen-Jie Zhou, Ming-Qing Li*, Hai-Xiang Sun*. CXCL16/CXCR6 interaction promotes endometrial decidualization via the PI3K/AKT pathway. Reproduction 2019 Jan 1. pii: REP-18-0417.R2. (IF:3.086)"
"3.Jiao Cheng, Hui-Li Yang, Chun-Jie Gu, Yu-Kai Liu, Jun Shao, Rui Zhu, Yin-Yan He, Xiao-Yong Zhu, Ming-Qing Li*. Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1a/ROS/VEGF. Int J Mol Med 2019; 43(2):945-955. (IF:2.784)"
"4.Xuan-Tong Liu, Hui-Ting Sun, Zhong-Fang Zhang, Ru-Xia Shi*, Li-Bing Liu, Jia-Jun Yu, Wen-Jie Zhou, Chun-Jie Gu, Shao-Liang Yang, Yu-Kai Liu, Hui-Li Yang, Feng-Yuan Xu, Ming-Qing Li*. Indoleamine 2, 3-dioxygenase suppresses the cytotoxicity of NK cells in response to ectopic endometrial stromal cells in endometriosis. Reproduction 2018; 156(5):397-404. (IF:3.086)"
"5.Jie Mei#, Wen-Jie Zhou#, Xiao-Yong Zhu, Han Lu, Ke Wu, Hui-Li Yang, Qiang Fu, Chun-Yan Wei, Kai-Kai Chang, Li-Ping Jin, Jian Wang, Yong-Ming Wang, Da-Jin Li*, Ming-Qing Li*. Suppression of autophagy and Hck signaling promotes PTGS2high FCGR3- NK cell differentiation triggered by ectopic endometrial stromal cells. Autophagy 2018; 14(8)1376-1397. (IF:11.100)"
"6.Hui-Li Yang, Wen-Jie Zhou, Chun-Jie Gu, Yu-Han Meng, Jun Shao, Da-Jin Li, Ming-Qing Li*. Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion and polycystic ovary syndrome. Am J Reprod Immunol 2018; 80(1):e12839. (IF:2.745)"
"7.Bing Zhang#, Wen-Jie Zhou#, Chun-Jie Gu, Ke Wu, Hui-Li Yang, Jie Mei, Jia-Jun Yu, Xiao-Fan Hou, Jian-Song Sun, Feng-Yuan Xu, Da-Jin Li, Li-Ping Jin*, Ming-Qing Li*. The ginsenoside PPD exerts anti-endometriosis effects by suppressing estrogen receptor-mediated inhibition of endometrial stromal cell autophagy and NK cell cytotoxicity. Cell Death Dis 2018; 9:574 (IF:5.638)"
"8.Rui-Qi Chang, Da-Jin Li*, Ming-Qing Li*. The role of indoleamine-2,3-dioxygenase in normal and pathological pregnancies. Am J Reprod Immunol 2018; 79(4):e12786 (IF:2.745)"
"9.Wen-Jie Zhou#, Kai-Kai Chang#, Ke Wu#, Hui-Li Yang, Jie Mei, Feng Xie*, Da-Jin Li, Ming-Qing Li*. Rapamycin synergizes with cisplatin in antiendometrial cancer activation by improving IL-27-stimulated cytotoxicity of NK cells. Neoplasia 2018; 20(1):69-79. (IF:4.994)"
"10.Hui-Li Yang#, Wen-Jie Zhou#, Kai-Kai Chang, Jie Mei, Li-Qing Huang, Ming-Yan Wang, Yi Meng, Si-Yao Ha, Da-Jin Li, Ming-Qing Li*. The crosstalk between endometrial stromal cells and macrophages impairs cytotoxicity of NK cells in endometriosis by secreting IL-10 and TGF-β. eproduction 2017; 154(6):815-825. (IF:3.086)"
"11.Hui-Li Yang, Jie Mei, Kai-Kai Chang, Wen-Jie Zhou, Li-Qing Huang, Ming-Qing Li*. Autophagy in endometriosis. Am J Transl Res 2017; 9(11):4707-4725. (IF:3.061)"
"12.Yu-Han Meng#, Wen-Jie Zhou#, Li-Ping Jin, Li-Bing Liu, Kai-Kai Chang, Jie Mei, Hui Li, Jian Wang, Da-Jin Li*, Ming-Qing Li*. RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization. Cell Death Dis 2017; 8(10): e3105. (IF:5.638)"
"13.Bing Zhang#, Feng Xie#, Chun-Lin Dong, Chun-Jie Gu, Jiao Cheng, Yuan Wang, Xi-Zhong Xu, Hong Pu, Yi-Bo Wu, Xiao-Wei Qi, Da-Jin Li, Jin-Jin Yu*, Ming-Qing Li*. The cross talk between cervical carcinoma cells and vascular endothelial cells mediated by IL-27 restrains angiogenesis. Am J Reprod Immunol 2017; 78(4): e12706. (IF:2.745)"
"14.Chun-Jie Gu, Jiao Cheng, Bing Zhang, Shao-Liang Yang, Feng Xie, Jian-Song Sun, Li-Qing Huang, Jin-Jin Yu*, Ming-Qing Li*. Protopanaxadiol and metformin synergistically inhibit estrogen-mediated proliferation and anti-autophagy effects in endometrial cancer cells. Am J Transl Res 2017;9(9):4071-4082. (IF:3.061) "
"15.Kai-Kai Chang, Li-Bing Liu, Li-Ping Jin, Bing Zhang, Jie Mei, Hui Li, Chun-Yan Wei, Wen-Jie Zhou, Xiao-Yong Zhu, Jun Shao, Da-Jin Li*, Ming-Qing Li*. IL-27 triggers IL-10 production in Th17 cells via a c-Maf/RORγt/Blimp-1 signal to promote the progression of endometriosis. Cell Death Dis 2017; 8(3):e2666 (IF:5.638) "
"16.Chun-Yan Wei, Jie Mei, Ling-Li Tang, Yu-Kai Liu, Da-Jin Li, Ming-Qing Li*, Xiao-Yong Zhu*. 1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis. Cell Death Dis 2016; 7: e2489 (IF:5.965)"
"17.Jun Shao#, Bing Zhang#, Jia-Jun Yu, Chun-Yan Wei, Wen-Jie Zhou, Kai-Kai Chang, Hui-Li Yang, Li-Ping Jin, Xiao-Yong Zhu*, Ming-Qing Li*. Macrophages promote the growth and invasion of endometrial stromal cells by downregulating IL-24 in endometriosis. Reproduction 2016; 152(6):672-682. (IF:3.100)"
"18.Jia-Jun Yu, Hui-Ting Sun, Zhong-Fang Zhang, Ru-Xia Shi*, Li-Bing Liu, Wen-Qing Shang, Chun-Yan Wei, Kai-Kai Chang, Jun Shao, Ming-Yan Wang, Ming-Qing Li*. IL15 promotes growth and invasion of endometrial stromal cells and inhibits killing activity of NK cells in endometriosis. Reproduction 2016; 152(2): 139-150. (IF:3.100)"
"19.Wen-Qing Shang#, Jia-Jun Yu#, Lei Zhu#, Wen-Jie Zhou, Kai-Kai Chang, Qing Wang*, Ming-Qing Li*. Blocking IL-22, a potential treatment strategy for adenomyosis by inhibiting crosstalk between vascular endothelial and endometrial stromal cells. Am J Transl Res 2015; 7(10): 1782-1797. (IF:3.146) "
"20.Li-Bing Liu#, Feng Xie#, Kai-Kai Chang, Wen-Qing Shang, Yu-Han Meng, Jia-Jun Yu, Hui Li, Qian Sun, Min-Min Yuan, Li-Ping Jin*, Da-Jin Li, Ming-Qing Li*. Chemokine CCL17 induced by hypoxia promotes the proliferation of cervical cancer cell. Am J Cancer Res 2015; 5(10): 3072-3084. (IF:3.425)"
"21.Hui Li, Yu-Han Meng, Wen-Qing Shang, Li-Bing Liu, Xuan Chen, Min-Min Yuan, Li-Ping Jin, Ming-Qing Li*, Da-Jin Li*. Chemokine CCL24 promotes the growth and invasiveness of trophoblasts through ERK1/2 and PI3K signaling pathways in human early pregnancy. Reproduction 2015; 150(5):417-427. (IF:3.184) "
"22.Wen-Qing Shang, Hui Li, Li-Bing Liu, Kai-Kai Chang, Jia-Jun Yu, Feng Xie, Ming-Qing Li*, Jin-Jin Yu*. RANKL/RANK interaction promotes the growth of cervical cancer cells by strengthening the dialogue between cervical cancer cells and regulation of IL-8 secretion. Oncol Rep 2015; 34(6):3007-3016. (IF:2.486)"
"23.Jie Mei#, Xiao-Yong Zhu#, Li-Pin Jin, Zhong-Liang Duan, Da-Jin Li*, Ming-Qing Li*. Estrogen promotes the survival of human secretory phase endometrial stromal cells via CXCL12/CXCR4 up-regulation-mediated autophagy inhibition. Hum Reprod 2015; 30(7):1677-1689. (IF:4.621)"
"24.Feng Xie#, Li-Bing Liu#, Wen-Qing Shang, Kai-Kai Chang, Yu-Han Meng, Jie Mei, Jia-Jun Yu, Da-Jin Li*, Ming-Qing Li*. The infiltration and function regulation of eosinophils induced by TSLP promote the proliferation of cervical cancer cell. Cancer Lett 2015; 364(2):106-117. (IF:5.992) "
25.Ming-Qing Li#, Yun Wang#, Kai-Kai Chang#, Yu-Han Meng, Li-Bing Liu, Jie Mei, Ying Wang, Xiao-Qiu Wang, Li-Ping Jin, Da-Jin Li*. CD4+Foxp3+ regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesion. Cell Death Dis 2014; 5:e1436 (IF:5.014)

近五年获奖情况
第30届上海市优秀发明奖 银奖 RANK+巨噬细胞用于制备治疗自然流产保胎药物中的用途 (主要完成人)李明清
复旦大学 复旦大学上海医学院优秀教师奖 (主要完成人)李明清
上海市女医师协会 二等奖 第二届“医树奖”基础医学科技创新奖 (主要完成人)李明清
复旦大学2015-2016年度“三八红旗手” (主要完成人)李明清
上海市 2015年度青年科技启明星计划 (主要完成人)李明清
上海市卫生系统 第十五届“银蛇奖”提名奖 (主要完成人)李明清
复旦大学 第七届复旦大学“十大医务青年”提名奖 (主要完成人)李明清
复旦大学 第一三共制药奖教金 (主要完成人)李明清
上海市 上海市卫生系统优秀青年人才培养计划 (主要完成人)李明清
复旦大学 复旦大学“卓学”人才计划 (主要完成人)李明清
中国免疫学会 第三届中国免疫学会青年****奖 (主要完成人)李明清

近五年获得专利情况
1,6-二磷酸果糖在制备自然流产保胎药物中的应用 0.8 " 李明清，周文洁，金莉萍"
原人参二醇PPD在制备子宫内膜异位症药物中的应用 6.1 李明清，周文洁，张冰，金莉萍，孙建松，杨慧丽
RANK+巨噬细胞用于制备治疗自然流产保胎药物中的用途 9.8 李明清，李大金，孟玉菡，周文洁，金莉萍，杜美蓉
白细胞介素抗体在制备子宫内膜异位症药物组合物中的用途 0.4 李明清，常凯凯，李大金，金莉萍，邵珺，刘立兵



任职学会
职务
任期起始时间
任期结束时间


中国免疫学会生殖免疫分会
中国免疫学会青年委员会
American Society for Reproductive Immunology
American Society for Reproductive Medicine
European Academy for Tumor Immunology


秘书
委员
会员
会员
会员

2018
2016.12
2014.2
2015.6
2016.5
2022
至今
至今
至今
至今

任职期刊 职务 任期起始时间 任期结束时间

中华生殖与避孕杂志

第一届通讯编委

2018.02

2020.12




承担项目 2017.01-2020.12 61万元 RANKL通过调节蜕膜巨噬细胞分化诱导母-胎免疫耐受的分子机制 国家自然基金面上项目
2016.04-2019.03 40万元 Hck诱导异位灶微环境CD16-NK细胞分化发育的分子机制 上海市青年科技启明星计划项目
2016.01-2018.12 84万元 雌激素通过抑制ESC自噬调节异位灶微环境NK细胞分化的分子机制 国家自然基金重大研究计划培育项目
2015.10-2018.09 10万元 人参皂甙治疗子宫内膜异位症的基础实验研究 上海市人才发展基金
2015.01-2018.12 74万元 IL-27通过诱导异位灶微环境IL-10+Th17细胞分化促进内异症进展的分子机制 国家自然基金面上项目
2013.11-2016.10 60万元 人早孕期母-胎界面RANKL调节蜕膜巨噬细胞功能表型的分子机制 上海市卫生系统优秀青年人才培养计划
2013.1-2015.12 15万元 /复旦大学“卓学”人才计划
2013.1-2014.12 10万元 人早孕期母-胎界面RANKL调节蜕膜巨噬细胞功能表型的分子机制 复旦大学青年教师科研能力提升项目
2012.1-2014.12 26万元 CXCL12通过促进蜕膜基质细胞CD82的表达控制滋养细胞侵袭能力的分子机制研究 国家自然基金青年基金项目
2012.1-2014.12 4万元 CXCL12通过促进蜕膜基质细胞CD82的表达控制滋养细胞侵袭能力的分子机制 教育部博士点新教师基金
2012.01-2014.12 2万元 CXCL12通过促进蜕膜基质细胞CD82表达控制滋养细胞过度侵袭的分子机制 上海市卫生局青年科研面上项目







其他（已办或参与重要学术会议情况等） "1.Ming-Qing Li, Mei Jie, Wen-Jie Zhou. “Estrogen-autophagy” regulatory axis contributes the immune escape of ectopic lesions by triggering COX-2highCD16- NK cells differentiation. The 7th Asian Conference on Endometriosis Sep 14-16 2018 Taipei, Taiwan（oral presentation）"
"2.Ming-Qing Li*. Estrogen-autophagy-NK cells” regulatory axis in endometrium immune homeostasis and endometriosis.中美联合生殖免疫大会暨第38届美洲生殖免疫大会暨第六届中国生殖免疫大会 2018.6.28-7.1 中国上海（oral presentation）"
"3.Bing Zhang, Li-Ping Jin, Dong Zhao, Xiao-Yong Zhu, Jian-Song Sun, Ming-Qing Li*. Ginsenoside protopanaxadiol induces the autophagy and restricts the growth of endometrial stromal cells in endometriosis by down-regulation of estrogen receptor α. 5th Asian Conference on Endometriosis (ACE V 2016) Sep 22-24, 2016, Osaka, Japan (Oral presentation)"
"4.Ming-Qing Li, Jun Shao, Li-Ping Jin. IL-22 promotes angiogenesis of adenomyosis by strengthening crosstalk between vascular endothelial and endometrial stromal cells. 2nd Congress of the Society of Endometriosis and Uterine Disorders (SEUD 2016) May12-14, 2016, Barcelona, Spain (Oral presentation)"
"5.Ming-Qing Li. IL-27 promotes the development of endometriosis by inducing IL-10-producing Th17 cell differentiation. 6nd Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2016) Apr8-1
"6.Kai-Kai Chang, Da-Jin Li*, Li-Ping Jin*, Ming-Qing Li*. IL-27 promotes the progress of endometriosis through driving IL-10+Th17 cell production. 4rd Asian Conference on Endometriosis (ACE IV 2015) Nov 19-21, 2015, Amman, Jordan (Oral presentation)"
"7.Ming-Qing Li, Yun Wang, Kai-Kai Chang, Yu-Han Meng, Li-Bing Liu, Jie Mei, Ying Wang, Xiao-Qiu Wang, Lin-Ping Jin, Da-Jin Li*. CD4+Foxp3+ regulatory T cells differentiation mediated by endometrial stromal cells-derived TECK promotes growth and invasion of endometriotic lesion. 第九届全国免疫学学术大会，2014.10.19-10.21 中国济南（分会场发言）"
"8.Ming-Qing Li, Yun Wang, Kai-Kai Chang, Yu-Han Meng, Li-Bing Liu, Lin-Ping Jin*, Da-Jin Li*. The TECK-drived CD4+Foxp3+ regulatory T cells enhancing proliferation and invasiveness of endometrial stromal cells via cross regulation in the endometriotic milieu. American Journal of Reproductive Immnunology, 2013; 70 (Suppl. 1): 6-6 Third International Conference on Reproductive Immunology 2013 Aug28-29, 2013, Shanghai, China "
"9.Ming-Qing Li, Chuan-Ling Tang, B Xu, Hong-Bo Zhao, Deng-Xuan Fan, Da-Jin Li*. The trophoblast cells-derived chemokine CXCL12 controls the over-invasion of themselves via up-regulating CD82 expression in DSCs at maternal-fetal interface in human early pregnancy. American Journal of Reproductive Immnunology, 2010; 64 (Suppl. 1): 18-18 Second International Conference on Reproductive Immunology 2010 November 28-December 2, 2010, Shanghai, China "
"10.Ming-Qing Li, Xiao-Fan Hou, Shi-Jian Lv, Xiao-Qiu Wang, Chuan-Ling Tang, Da-Jin Li *. Downregulation of KAI1 expression in endometrial stromal cells enhances the cell invasiveness in the endometriotic milieu. American Journal of Reproductive Immnunology, 2010; 64 (Suppl. 1): 18-19
Second International Conference on Reproductive Immunology 2010 November 28-December 2, 2010, Shanghai, China"