柳素玲
博士，研究员，博士生导师
地址：东安路 270号，复旦大学附属肿瘤医院2号楼1317B室，上海 200032
电话：（办公室）， （实验室）
邮箱：suling@fudan.edu.cn


工作经历
研究员，复旦大学，生物医学研究院/附属肿瘤医院（2016.12-今）
教授，中国科学技术大学，生命科学学院（2012.11-2016.11）
研究助理教授，美国密西根大学（2010.10-2012.10）
助理研究员，美国密西根大学（2006.10-2010.09）
博士后，美国密西根大学（2003.12-2006.09）

教育经历
博士，美国俄亥俄州立大学，生物学系（1997-2003）
学士，中国科学技术大学，生物系（1992-1997）
所获人才项目
科技部中青年科技创新领军人才, 科技部, 2020
复旦大学“卓越2025”: 卓识杰出人才, 复旦大学，2020
上海市医学领军人才,上海市卫健委,2019
国家优秀青年科学基金，国家自然科学基金，2014
所获奖项
中国肿瘤青年科学家奖，中国抗癌协会，2018
中美抗癌协会-美国国家癌症基金学术奖，中美抗癌协会，2014
Susan G. Komen Scholar in Training Award，美国癌症协会，2010
Merck Scholar in Training Award，美国癌症协会，2006
研究方向
1）乳腺肿瘤干细胞的异质性及其调控和耐药研究；
2）乳腺肿瘤干细胞的起源研究；
3）肿瘤微环境与肿瘤干细胞的互作研究；
4）肿瘤干细胞的免疫调控研究；
5）靶向肿瘤干细胞的新型治疗策略研究及药物开发。
代表论文

Huang, Y.^#, Wang, H., Hao, Y., Lin, H., Dong, M., Ye, J., Song, L., Wang, Y., Li, Q., Shan, B., Jiang, Y., Li, H., Shao, Z.M., Kroemer, G., Zhang, H., Bai, L., Jin, T., Wang, C., Ma, Y., Cai, Y., Ding, C., Liu, S.*,Pan, Y.*, Jiang, W.*, Zhou R.*. Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Nature Cell Biology(online), 2020.（*为通讯作者或共同通讯作者）
Qin, Y.^#, Chen, W.^#, Jiang, G., Zhou, L., Yang, X., Li, H., He, X., Wang, H., Zhou, Y., Huang, S.,Liu,S.*. Interfering MSN-NONO complex activated CREB signaling serves a novel therapeutic strategy for triple-negative breast cancer, Science Advances6(8), 2020.PMID: **.
Zhang, L.^#, Qiang, J.^#, Yang, L.^#, Wang, D., Adeel, R., He, X., Chen, W., Sheng , D., Zhou, L., Jiang, Y. Z., Li, T., Du, Y., Feng, J., Hu, X., Zhang, J., Hu, X. C., Shao, Z. M., Liu, S.*. IL1R2 blockade suppresses breast tumorigenesis and progression by impairing USP15-dependent BMI1 stability. Advanced Science 7(1):**, 2020. PMID: **
Zhou，L.^#, Wang, D.^#, Sheng, D.^#, Xu, J., Chen, W., Qin, Y., Du, R., Yang, X., He, X., Xie, N.*, Liu, S.*, Zhang, L.*. NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer. Theranostics 10(5): 2405-2421, 2020.PMID:**
Zhang, J., Yang, Y., Zhou, S., He, X., Cao, X., Wu, C., Hu, H., Qin, J., Wei, G., Wang, H., Liu, S.*, Sun, L.*. Membrane-bound TNFmediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling.Cell Death and Differentiation485, 2019. PMID: **
Jiang, G.^#, Wang, X.^#, Sheng, D., Zhou, L., Liu, Y., Xu, C., Liu, S.*and Zhang, J.*. Cooperativity of co-factor NR2F2 with Pioneer Factors GATA3, FOXA1 in promoting ERα function. Theranostics9(22): 6501-6516, 2019. PMID: **
Jin, X.^#, Xu, X-E. ^# *, Jiang, Y-Z.^#, Liu, Y-R., Sun, W., Guo, Y-J., Ren, Y-X., Zuo, W-J., Hu, X., Huang, S-L., Shen, H-J., Lan, F., He, Y-F., Hu, G-H., Di, G-H., He, X-H., Li, D-Q., Liu, S.*, Yu, K-D.*,, Shao, Z-M.*. The endogenous retrovirus-derived long noncodingRNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation. Science Advances5(3): eaat9820, 2019. PMID: **
Liu, J., Duan, Z., Guo, W., Zeng, L., Wu, Y., Chen, Y., Tai, F., Wang, Y., Lin, Y., Zhang, Q., He, Y., Deng J., Stewart, R., Wang, C., Lin, P., Ghaffari, S., Evers, B.M., Liu, S.*, Zhou, M-M.*, Zhou, B.*, and Shi, J.*. Targeting the BRD4/FOXO3a/CDK6 axis Sensitizes AKT Inhibition in Luminal Breast Cancer. Nature Communications 9(1): 5200, 2018. PMID: **
Liu, B., Du, R., Zhou L.,Xu, J., Chen, S., Chen, J., Yang, X., Liu, D-X., Shao, Z-M., Zhang, L., Yu, Z., Xie, N.^*, Guan, J-L.^*, and Liu, S.^*. miR-200c/141 regulates breast cancer stem cell heterogeneity via targeting HIPK1/β-catenin axis. Theranostics8(21):5801-5813, 2018. PMID: **
Deng, L., Gao, X., Liu, B., He, X., Xu, J., Qiang, J., Wu, Q., Liu, S.^*. NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway. Cell Death and Disease9(12):1143, 2018. PMID: **
Chen, W., Qin, Y., Wang, D., Zhou, L., Liu, Y., Chen, S., Yin, L., Xiao, Y., Yao, X-H., Yang, X., Ma, W., Chen, W., He, X., Zhang, L., Yang, Q., Bian, X., Shao, Z-M., Liu, S.^*CCL20 triggered by chemotherapy hinders the therapeutic efficacy of breast cancer.Plos Biology16(7): e**, 2018. PMID: **
Liu, M., Liu, Y., Deng, L., Wang, D., He, X., Zhou, L., Wicha, M.S., Bai, F.*, Liu, S.*.Transcriptionalprofilesof differentstatesof cancerstemcells in triple-negative breast cancer.Mol Cancer17(1): 65, 2018. PMID: **
Du, R., Liu, B., Zhou, L., Wang, D., He, X., Xu, X., Zhang, L., Niu, C.*, Liu, S.*. Downregulation of annexin A3 inhibits tumor metastasis and decreases drug resistance in breast cancer.Cell Death and Disease9(2):126, 2018. PMID: **
Wang, D., Xu, J., Liu, B., He, X., Zhou, L., Hu, X., Qiao, F., Zhang, A., Xu, X., Zhang, H., Wicha, MS., Zhang, L., Shao, Z., Liu, S.*. IL6 blockade potentiates the anti-tumor effects of γ-secretase inhibitors in Notch3-expressing breast cancer.Cell Death and Differentiation25(2):330-339, 2018. PMID: **
Qin, Y., Chen, W., Liu, B., Zhou, L., Deng, L., Niu, W., Bao, D., Cheng, C., Li, D., Liu, S.*, Niu, C.*. MiR-200c Inhibits the Tumor Progression of Glioma via Targeting Moesin.Theranostics7(6):1663-1673, 2017.
Liu, Y., Burness, M.L.*, Martin-Trevino, R., Guy, J., Bai, S., Harouaka, R., Brooks, M.D., Shang, L., Fox, A., Luther, T.K., Davis, A., Baker, T.L., Colacino, J., Clouthier, S.G., Shao, Z-M., Wicha, M.S., and Liu, S*.RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer. Clinical Cancer Research 23(2): 514-522, 2017.
Liu, S.*, Cong, Y., Wang, D., Sun, Y., Deng, L., Liu, Y., Martin-Trevino, R., Shang, L., McDermott, S. P., Landis, M. D., Hong, S., Adams, A., D'Angelo, R., Ginestier, C., Charafe-Jauffret, E., Clouthier, S. G., Birnbaum, D., Wong, S. T., Zhan, M., Chang, J.C.*, and Wicha, M.S.* Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts. Stem Cell Reports2, 78-91,2014. PMID:**.
Deng, L., Shang, L., Bai, S., Chen, J., He, X., Martin-Trevino, R., Chen, S., Li, X.-Y., Meng, X., Yu, B., Wang, X., Liu, Y., McDermott, S. P., Ariazi, A. E., Ginestier, C., Ibarra, I., Ke, J., Luther, T., Clouthier, S. G., Xu, L., Shan, G., Song, E., Yao, H., Hannon, G. J., Weiss, S. J., Wicha, M. S., and Liu, S*. MicroRNA100 Inhibits Self-Renewal of Breast Cancer Stem-like Cells and Breast Tumor Development. Cancer research74, 6648-6660, 2014. PMID:**.