段树民，中国科学院院士，第11,12,13届全国政协委员，中国神经科学学会理事长（2011-2019）、监事长（2019-现在），国际脑研究组织常务理事。1991年获日本九州大学医学博士。2000-2009年在中国科学院神经科学研究所先后任研究员、神经科学国家重点实验室主任、副所长。2010年任浙江大学医学院院长兼医学部主任。2019年任复旦大学脑科学转化研究院院长。主持过科技部973项目、国家基金委重大项目、重点项目等多项，国家基金委创新团队负责人，以及为期8年的国家基金委重大研究计划“情感和记忆的神经环路基础”项目专家组组长，对我国脑科学环路水平的研究起到了重要推动作用，在全国脑科学研究领域产生重要影响。先后担任J Neurophysiol、Neurobiol Disease、 Hippocampus、 Glia、 Cell Calcium 等国际杂志编委， Neuron 顾问委员会委员，Neuroscience Bulletin主编。主要研究突触功能、神经元-胶质细胞相互作用及脑功能的神经环路解析，相关研究成果分别发表在 Science、Cell、Neuron、Nature Neuroscience、Nature Cell Biology等国际著名杂志，在该领域产生了重要的国际影响。研究成果入选为2003年中国医药科技十大新闻，2006年中国基础研究十大新闻。指导的学生多次获全国百篇优秀博士论文。研究成果两次获得国家自然科学二等奖（2010年第一获奖人，2017年第二获奖人）。2008年获何梁何利科学与技术进步奖。



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长期从事神经生物学研究，在神经元-胶质细胞相互作用、突触发育和功能、脑功能精准调控的神经环路解析等方面作出了系统的创新工作。
研究方向包括：1、胶质细胞释放ATP对突触可塑性的调节机制；2、神经元突触囊泡转运释放机制；3、小胶质细胞囊泡转运释放机制；4、神经元早期网络形成；5、情绪和情绪相关疾病的神经环路基础。
研究手段主要包括：1、在培养神经元和离体脑片进行单个和双膜片钳记录；2、共聚焦显微镜和电镜的形态学研究；3、活细胞实时成像，结合转染连接有GFP的蛋白研究一些重要蛋白分子的动态分布、细胞器运动及囊泡分泌；4、利用胶质细胞特异分子作驱动子及Cre-LoxP系统产生的转基因动物和条件性基因敲除小鼠，特异干扰胶质细胞的一些重要分子，研究胶质细胞在各种神经功能中的重要作用；5.利用光遗传学、动物行为学和病毒逆向追踪等技术研究特定类型神经元在情绪或疾病相关的神经环路中的作用。


李莎莎 实验室管家邮箱：lss@fudan.edu.cn研究方向：小鼠脑的透明化及成像
潘高杰 博士生邮箱：**@fudan.edu.cn研究方向：脑相关的神经环路和突触可塑性
吕佳慧 博士生邮箱：**@fudan.edu.cn研究方向：小胶质细胞的发育
查看更多查看更多查看更多 Fan Meng, Zhige Guo, Yaling Hu, Weihao Mai, Zhenjie Zhang, Bin Zhang, Qianqian Ge, Huifang Lou, Fang Guo, Jiangfan Chen, Shumin Duan*, Zhihua Gao*. CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling. Brain 142, 700-718, (2019).

Xia Li#, Liming Qin#, Yefei Li#, Hao Yu#, Zhijun Zhang, Changlu Tao, Yijun Liu, Yanhong Xue, Xiaoxing Zhang, Zhenghao Xu, Yi Wang, Huifang Lou, Zhibin Tan, Paul Saftig, Zhong Chen, Tao Xu, Guoqiang Bi, Shumin Duan*, Zhihua Gao*. Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles. Cell reports 28, 1015-1028. (2019).

Yaling Hu, Weihao Mai, Lunhao Chen, Kelei Cao, Bin Zhang, Zhenjie Zhang, Yijun Liu, Huifang Lou, Shumin Duan*, Zhihua Gao*. mTOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP. Glia, (2019).

Zhibing Tan#, Yu Liu#, Wang Xi, Hui-Fang Lou, Liya Zhu, Zhifei Guo, Lin Mei, Shumin Duan*. Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons. Nature communications 8, 13772-13772, (2017).

Junhua Yang#, Hongbin Yang#, Yali Liu, Xia Li, Liming Qin, Huifang Lou, Shumin Duan*, Hao Wang*. Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP. eLife 5, (2016).

Hongbin Yang#, Junhua Yang#, Wang Xi, Sijia Hao, Benyan Luo, Xiaobin He, Liya Zhu, Huifang Lou, Yan-qin Yu, Fuqiang Xu, Shumin Duan*, Hao Wang*. Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear. Nature neuroscience 19, 283-289, (2016).

Cong Chen#, Hui-Quan Li#, Yi-Jun Liu, Zhi-Fei Guo, Hang-Jun Wu, Xia Li, Hui-Fang Lou, Liya Zhu, Di Wang, Xiao-Ming Li, Li Yu, Xuetao Cao, Linrong Lu, Zhihua Gao*, Shu-Min Duan*. A novel size-based sorting mechanism of pinocytic luminal cargoes in microglia. The Journal of neuroscience 35, 2674-2688, (2015).

Yong Han, Yu-feng Shi, Wang Xi, Rui Zhou, Zhi-bing Tan, Hao Wang, Xiao-ming Li, Zhong Chen, Guoping Feng, Minmin Luo, Zhi-li Huang, Shumin Duan*, Yan-qin Yu*. Selective activation of cholinergic basal forebrain neurons induces immediate sleep-wake transitions. Current biology 24, 693-698, (2014).

Hui-quan Li#, Cong Chen#, Ying Dou, Hang-jun Wu, Yi-jun Liu, Hui-Fang Lou, Jian-min Zhang, Xiao-ming Li, Hao Wang, Shumin Duan*. P2Y4 receptor-mediated pinocytosis contributes to amyloid beta-induced self-uptake by microglia. Molecular and cellular biology 33, 4282-4293, (2013).

Jiadong Chen#, Zhibing Tan#, Li Zeng, Xiaoxing Zhang, You He, Wei Gao, Xiumei Wu, Yuju Li, Bitao Bu, Wei Wang, Shumin Duan*. Heterosynaptic long-term depression mediated by ATP released from astrocytes. Glia 61, 178-191, (2013).

Bing Zhu, Dongsheng Xu, Xiaobei Deng, Qiang Chen, Yunlong Huang, Hui Peng, Yuju Li, Beibei Jia, Wallace B. Thoreson, Wenjun Ding, Jianqing Ding, Lixia Zhao, Yi Wang, Kristin Leland Wavrin, Shumin Duan*, Jialin Zheng*. CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway. Stem cells 30, 2571-2583, (2012).

Ying Dou#, Hang-jun Wu#, Hui-quan Li, Song Qin, Yin-er Wang, Jing Li, Hui-fang Lou, Zhong Chen, Xiao-ming Li, Qing-ming Luo, Shumin Duan*. Microglial migration mediated by ATP-induced ATP release from lysosomes. Cell research 22, 1022-1033, (2012).

ShuMin Duan*. Progress in glial cell studies in some laboratories in China. Science China Life sciences 53, 330-337, (2010).
Xiao-ping Tong, Xiang-yao Li, Bing Zhou, Wanhua Shen, Zhi-jun Zhang, Tian-le Xu, Shumin Duan*. Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration. The Journal of cell biology 186, 113-128, (2009).

Ai-Hong Song, Dong Wang, Gang Chen, Yuju Li, Jianhong Luo, Shumin Duan*, Mu-Ming Poo*. A selective filter for cytoplasmic transport at the axon initial segment. Cell 136, 1148-1160, (2009).

Haimin Li, Gang Chen, Bing Zhou, Shumin Duan*. Actin filament assembly by myristoylated alanine-rich C kinase substrate-phosphatidylinositol-4,5-diphosphate signaling is critical for dendrite branching. Molecular biology of the cell 19, 4804-4813, (2008).

Zhijun Zhang#, Gang Chen#, Wei Zhou#, Aihong Song, Tao Xu, Qingming Luo, Wei Wang, Xiao-song Gu, Shumin Duan*. Regulated ATP release from astrocytes through lysosome exocytosis. Nature cell biology 9, 945-953, (2007).

Gang Chen, Hai-Min Li, Yi-Ren Chen, Xiao-Song Gu*, Shumin Duan*. Decreased estradiol release from astrocytes contributes to the neurodegeneration in a mouse model of Niemann-Pick disease type C. Glia 55, 1509-1518, (2007).

Wanhua Shen#, Bei Wu#, Zhijun Zhang, Ying Dou, Zhi-Ren Rao, Yi-Ren Chen, Shumin Duan*. Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling. Neuron 50, 401-414, (2006). (Cover article)
Comment in Presynaptic Unsilencing: Searching for a Mechanism. Neuron 50, 345-346 (2006).

Woo-Ping Ge#, Xiu-Juan Yang#, Zhijun Zhang, Hui-Kun Wang, Wanhua Shen, Qiu-Dong Deng, Shumin Duan*. Long-term potentiation of neuron-glia synapses mediated by Ca2+-permeable AMPA receptors. Science 312, 1533-1537, (2006).

Shumin Duan*, Joseph T. Neary. P2X7/P2Z receptors: properties and relevance to CNS function (Invited review). Glia 54, 738-746, (2006).

Cheng-yu Li#, Jiang-teng Lu#, Chien-ping Wu, Shu-min Duan*, Mu-ming Poo*. Bidirectional modification of presynaptic neuronal excitability accompanying spike timing-dependent synaptic plasticity. Neuron 41, 257-268, (2004).

Jing-ming Zhang, Hui-kun Wang, Chang-quan Ye, Wooping Ge, Yiren Chen, Zheng-lin Jiang, Chien-ping Wu, Mu-ming Poo, Shumin Duan*. ATP released by astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression. Neuron 40, 971-982, (2003).
Comment in: Synaptic Inhibition Mediated by Glia. Neuron 40, 873-875, (2003).

Xiao-bing Yuan#*, Ming Jin#, Xiaohua Xu#, Yuan-quan Song, Chien-ping Wu, Mu-ming Poo, Shumin Duan*. Signalling and crosstalk of Rho GTPases in mediating axon guidance. Nature cell biology 5, 38-45, (2003).

Yunlei Yang#, Wooping Ge#, Yiren Chen, Zhijun Zhang, Wanhua Shen, Chienping Wu, Muming Poo, Shumin Duan*. Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine. Proceedings of the National Academy of Sciences of the United States of America 100, 15194-15199, (2003).

Zhiru Wang, Ning-long Xu, Chien-ping Wu, Shumin Duan*, Mu-ming Poo*. Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications. Neuron 37, 463-472, (2003).

Shumin Duan, Christopher M. Anderson, Edmund C. Keung, Yongmei Chen, Yiren Chen, Raymond A. Swanson*. P2X7 receptor-mediated release of excitatory amino acids from astrocytes. The Journal of neuroscience 23, 1320-1328, (2003).

Yang Xiang, Yan Li, Zhe Zhang, Kai Cui, Sheng Wang, Xiao-bing Yuan, Chien-ping Wu, Mu-ming Poo, Shumin Duan*. Nerve growth cone guidance mediated by G protein-coupled receptors. Nature neuroscience 5, 843-848, (2002).

S. Duan, I. M. Cooke. Glutamate and GABA activate different receptors and Cl- conductances in crab peptide-secretory neurons. Journal of neurophysiology 83, 31-37, (2000).

S. Duan, I. M. Cooke. Selective inhibition of transient K+ current by La3+ in crab peptide-secretory neurons. Journal of neurophysiology 81, 1848-1855, (1999).

S. Duan, C. M. Anderson, B. A. Stein, R. A. Swanson*. Glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of GLAST. The Journal of neuroscience 19, 10193-10200, (1999).

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星型胶质细胞释放...
先天性恐惧的神经...
小胶质细胞胞饮后...
GABA通过钠-钙交换...
星型胶质细胞溶酶...
神经元对NG2胶质细...
神经元突触发育新机制
查看更多查看更多查看更多查看更多查看更多查看更多查看更多查看更多 招聘博士后2名2020-04-06
查看更多 地址：上海市徐汇区东安路131号二号医学科研楼B座二楼201室
邮编：200032
电话/传真：
邮箱：shumin@fudan.edu.cn