陈钧

药剂学, 教授, 博士生导师


姓名
陈钧
性别
男

职称
教授
学历
理学博士

电话

传真


电子邮件
chenjun@fudan.edu.cn
个人主页


通讯地址
上海市浦东新区张衡路826号复旦大学张江校区科研楼609室

教育经历 1993.09 – 1997.06上海医科大学药学院药学专业本科生，获理学学士学位
1999.09 – 2005.12复旦大学药学院药剂学专业博士研究生，获理学博士学位
工作经历
1997.07 – 2001.12复旦大学药学院药物分析教研室，助教
2002.01 – 2008.11复旦大学药学院药剂学教研室，讲师
2008.12 – 2014.11复旦大学药学院药剂学教研室，副教授，硕导
2014.12 – 至今复旦大学药学院药剂学教研室，教授，博导
专家类别 教授，教育部新世纪优秀人才支持计划入选者
专家类别 职务 博士生导师
承担科研项目情况
1. 集光动力治疗、化疗于一体的卟啉－聚己内酯纳米粒的设计及其多模式肿瘤靶向治疗策略研究（国家自然科学基金面上项目， No：**）
2. 基于微流控芯片的脑靶向脂质体递药系统的构建及其靶向性的研究（国家自然科学基金面上项目， No：**）
3. 寡核苷酸配体介导的脂质立方晶纳米递释系统的构建及其肿瘤靶向特性研究（国家自然科学基金青年基金， No：**）
4. 教育部新世纪优秀人才支持计划（No：NCET-12-0130）
5. 集荧光诊断、光动力治疗、化疗于一体的多功能纳米递释系统的设计（上海市纳米专项， No：13NM**）
6. 寡核苷酸配体介导的PLGA纳米递释系统的构建（上海市纳米专项， No：0852nm04500）
获奖及荣誉
2011 教育部“新世纪优秀人才支持计划”
2012中国药学会-石药青年药剂学奖
2014上海市优秀硕士学位论文导师
2015上海市优秀硕士学位论文导师
2010 中国药学会科学技术二等奖（排名第五）
2011默克-复旦奖教金


研究方向
1. 靶向递药系统
2. 药物制剂体内药动学及成药性评价
3. 药物新剂型与新制剂的研究开发

科研成果
在基于纳米技术的新型药物递释系统研究取得了一些成果,主要包括:
1. 主动靶向和肿瘤渗透多肽共递释的策略，提高纳米制剂在肿瘤部位的穿透。化疗是肿瘤诸多治疗环节中至关重要的一环，其成败直接影响病人的生活质量和预后，但是化疗药物难以渗透入肿瘤组织内部。为了提高药物递送系统对肿瘤组织的选择靶向性，从血管中溢出和肿瘤组织穿透的能力，本课题组提出了主动靶向和肿瘤渗透多肽共递释的策略，提高纳米制剂在肿瘤部位的穿透，围绕该策略发表系列SCI论文4篇(Biomaterials. 2014, 35:4319-4332. Mol. Pharmaceutics. 2014, 11:90?101. Biomaterials. 2013, 34:5138-5148. Biomaterials. 2013, 34: 1135-1145.)。
2. 提高细胞穿膜肽的特异性，用于脑靶向和肿瘤靶向研究。细胞穿膜肽是近年来发现的一类具有高效细胞膜穿透能力的短肽，但其缺乏细胞特异性，临床上的应用受到限制。为了解决这个问题，本课题组通过优化给药途径、优选带适合电荷的穿膜肽及采用肿瘤微环境响应的触发式穿膜肽的策略构建了三种细胞穿膜肽修饰的纳米递释系统，提高了穿膜肽的靶向性，分别用于脑靶向和肿瘤靶向研究，提高递释系统的靶向治疗效果。围绕该主题发表SCI论文4篇(Biomaterials. 2013, 34: 196-208. Bioconjug Chem. 2013, 24:419?430. Int J Pharm. 2012,436: 840-850. Biomaterials. 2011, 32: 9888-9898.)。
3. 双重靶向肿瘤新生血管和肿瘤细胞的多靶点纳米递释系统，提高肿瘤靶向治疗效果。抗新生血管疗法是化疗的主要方法，但是该方法对边缘的肿瘤细胞没有杀伤作用，甚至增加了这些细胞的侵袭和转移，所以临床疗效较为短暂，长期治疗效果更为有限。我们筛选了一系列能同时靶向肿瘤血管和肿瘤细胞的寡核苷酸和多肽，并构建了寡核苷酸和多肽介导的纳米递释系统，能起到双重靶向作用，提高治疗效果。围绕该主题发表了4篇论文(Biomaterials. 2014, 35:8215-8226. Biomaterials. 2013, 34: 5640-5650. Biomaterials, 2013, 34: 9496-9508. Biomaterials. 2011, 32: 8010-8020.)。
4. 受体介导的纳米递释系统提高治疗性多肽的入脑效率，提高阿尔兹海默症的治疗效果。本课题组设计了两种受体介导的纳米递释系统：①乳铁蛋白修饰的纳米递释系统，通过鼻腔给药的方式减少递释系统在非靶组织的摄取，并进一步通过呼吸部高表达的乳铁蛋白受体增加纳米递释系统的经鼻入脑效率。②转铁蛋白模拟肽B6修饰的纳米递释系统，静脉注射给药后通过与脑毛细血管内皮细胞上高表达的转铁蛋白受体特异性结合提高治疗性多肽的入脑效率。研究结果表明：两种纳米递释系统能高效介导中枢活性类蛋白入脑，在治疗神经退行性疾病方面具有较高应用价值。相关研究发表于药剂学的权威期刊（Biomaterials. 2013, 34: 3870-3881，Bioconjug Chem. 2013;24:997-1007）。
5. 在国际上率先开展以大豆磷脂/二油酸甘油酯为基本处方的脂质液晶纳米制剂，并系统进行了药动学和细胞转运研究，为难溶性药物的递送提供了新方法，在此基础上发表SCI论文2篇（Int J Nanomedicine. 2012, 7: 3703-3718，Int J Pharm. 2012, 424: 58-66.）。
6. 目前培养博士生2人，硕士生9人，其中已毕业4人，2人获得上海市优秀硕士学位论文。


代表性论著
近五年来以来以通讯作者或第一作者共发表SCI科研论文26篇，总影响因子158.66，平均影响因子为6.1；其中14篇发表在本学科一区杂志。并得到广泛引用和认可，现已被他引300余次；3篇文章被Web of Science 评为高引用文章（Highly Cited Paper，即某个领域的所有文章中当年被引用次数为前百分之一的文章）。
1. Kang Ting, Gao Xiaoling, Hu Quanyin, Jiang Di, Feng Xingye, Zhang Xue, Song Qingxiang, Yao Lei, Huang Meng, Jiang Xinguo, Pang Zhiqing, Chen Hongzhuan, Chen Jun*(通讯作者), iNGR-modified PEG-PLGA nanoparticles that recognize tumor vasculature and penetrate gliomas[J]. Biomaterials. 2014, 35:4319-4332 (IF:8.312)
2. Miao Deyu, Jiang Mengyin, Liu Zhongyang, Gu Guangzhi, Hu Quanyin, Kang Ting, Song Qingxiang, Yao Lei, Li Wei, Gao Xiaoling,* Sun Mingjiang, Chen Jun*(第一单位通讯作者), Co-administration of Dual-Targeting Nanoparticles with Penetration Enhancement Peptide for Antiglioblastoma Therapy[J]. Mol. Pharmaceutics. 2014, 11:90?101. (IF: 4.787)
3. Gu Guangzhi, Hu Quanyin, Feng Xingye, Gao Xiaoling, Jiang Menglin, Kang Ting, Jiang Di, Song Qingxiang, Chen Hongzhuan, Chen Jun*(通讯作者), PEG-PLA nanoparticles modified with APTEDB peptide for enhanced anti-angiogenic and anti-glioma therapy[J]. Biomaterials. 2014, 35:8215-8226. (IF:8.312)
4. Lei Yao, Qingxiang Song, Wenkun Bai, Jizhen Zhang, Deyu Miao, Mengyin Jiang, Yu Wang, Zhiyong Shen, Quanyin Hu, Xiao Gu, Meng Huang, Gang Zheng, Xiaoling Gao*, Bing Hu*, Chen Jun *(第二单位通讯作者), Hongzhuan Chen* , Facilitated brain delivery of poly (ethylene glycol)-poly (lactic acid) nanoparticles by microbubble-enhanced unfocused ultrasound. Biomaterials. 2014; 35:3384-95. (IF:8.312)
5. Ting Kang, Xiaoling Gao, Chen Jun*(通讯作者), Harnessing the Capacity of Cell-Penetrating Peptides for Drug Delivery to the Central Nervous System. Current Pharmaceutical Biotechnology, 2014, 15, 220-230. (IF:2.511)
6. Gu Guangzhi, Gao Xiaoling, Hu Quanyin, Kang Ting, Liu Zhongyang, Jiang Mengyin, Miao Deyu, Song Qingxiang, Yao Lei, Tu Yifan, Pang Zhiqing, Chen Hongzhuan, Jiang Xinguo, Chen Jun *(通讯作者), The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells[J]. Biomaterials. 2013, 34:5138-5148. (IF:8.312)
7. Hu Quanyin, Gao Xiaoling, Gu Guangzhi, Kang Ting, Tu Yifan, Liu Zhongyang, Song Qingxiang, Yao Lei, Pang Zhiqing, Jiang Xinguo, Chen Hongzhuan , Chen Jun* (通讯作者), Glioma therapy using tumor homing and penetrating peptide functionalized PEG-PLA nanoparticles loaded with paclitaxel[J]. Biomaterials. 2013, 34(22): 5640-5650. (IF:8.312)
8. Hu Quanyin, Gao Xiaoling, Kang Ting, Feng Xingye, Jiang Di, Tu Yifan, Song Qingxiang, Yao Lei, Jiang Xinguo, Chen Hongzhuan, Chen Jun *(通讯作者), CGKRK-modified nanoparticles for dual-targeting drug delivery to tumor cells and angiogenic blood vessels. Biomaterials, 2013, 34: 9496-9508. (IF:8.312)
9. Gu Guangzhi, Xia Huimin, Hu Quanyin, Liu Zhongyang, Jiang Mengyin, Kang Ting, Miao Deyu, Tu Yifan, Pang Zhiqing, Song Qingxiang, Yao Lei, Chen Hongzhuan, Gao Xiaoling*, Chen Jun*(第一单位通讯作者), PEG-co-PCL nanoparticles modified with MMP-2/9 activatable low molecular weight protamine for enhanced targeted glioblastoma therapy[J]. Biomaterials. 2013, 34(1): 196-208. (IF:8.312)
10. Hu Quanyin, Gu Guangzhi, Liu Zhongyang, Jiang Mengyin, Kang Ting, Miao Deyu, Tu Yifan, Pang Zhiqing, Song Qingxiang, Yao Lei, Xia Huimin, Chen Hongzhuan, Jiang Xinguo, Gao Xiaoling*, Chen Jun*(第一单位通讯作者), F3 peptide-functionalized PEG-PLA nanoparticles co-administrated with tLyp-1 peptide for anti-glioma drug delivery[J]. Biomaterials. 2013, 34(4): 1135-1145. (IF:8.312)
11. Liu Zhongyang, Jiang Mengyin, Kang Ting, Miao Deyu, Gu Guangzhi, Song Qingxiang, Yao Lei, Hu Quanyin, Tu Yifan, Pang Zhiqing, Chen Hongzhuan, Jiang Xinguo, Gao Xiaoling*, Chen Jun*(第一单位通讯作者), Lactoferrin-modified PEG-co-PCL nanoparticles for enhanced brain delivery of NAP peptide following intranasal administration[J]. Biomaterials. 2013, 34(15): 3870-3881. (IF:8.312)
12. Liu Zhongyang, Gao Xiaoling, Kang Ting, Jiang Mengyin, Miao Deyu, Gu Guangzhi, Hu Quanyin, Song Qingxiang, Yao Lei, Tu Yifan, Chen Hongzhuan, Jiang Xinguo, , Chen Jun*(通讯作者), B6 peptide-modified PEG-PLA nanoparticles for enhanced brain delivery of neuroprotective peptide[J]. Bioconjug Chem. 2013;24(6):997-1007. (IF:4.821)
13. Xia Huimin, Gu Guangzhi, Hu Quanyin, Liu Zhongyang, Jiang Mengyin, Kang Ting, Miao Deyu, Song Qingxiang, Yao Lei, Tu Yifan, Chen Hongzhuan, Gao Xiaoling*, Chen Jun*(第一单位通讯作者), Activatable cell penetrating peptide-conjugated nanoparticles with enhanced permeability for site-specific targeting delivery of anticancer drug[J]. Bioconjug Chem. 2013, 24:419?430. (IF: 4.821)
14. Song Qingxiang, Wang Xiaoling, Hu Quanyin, Huang Meng, Yao Lei, Qi Hong, Qiu Yu, Jiang Xinguo, Chen Jun*(第二单位通讯作者), Chen Hongzhuan*, Gao Xiaoling*, Cellular internalization pathway and transcellular transport of pegylated polyester nanoparticles in Caco-2 cells[J]. Int J Pharm. 2013,445(1-2): 58-68. (IF: 3.785)
15. Song Qingxiang, Yao Lei, Huang Meng, Hu Quanyin, Lu Qing, Wu Bingxian, Qi Hong, Rong Zhengxing, Jiang Xinguo, Gao Xiaoling*, Chen Jun*(第二单位通讯作者), Chen Hongzhuan*, Mechanisms of transcellular transport of wheat germ agglutinin-functionalized polymeric nanoparticles in Caco-2 cells[J]. Biomaterials. 2012,33(28): 6769-6782. (IF:8.312)
16. Xia Huimin, Gao Xiaoling, Gu Guangzhi, Liu Zhongyang, Hu Quanyin, Tu Yifan, Song Qingxiang, Yao Lei, Pang Zhiqing, Jiang Xinguo, Chen Jun*(第一单位通讯作者), Chen Hongzhuan*, Penetratin-functionalized PEG-PLA nanoparticles for brain drug delivery[J]. Int J Pharm. 2012,436(1-2): 840-850. (IF: 3.785)
17. Zeng Ni, Gao Xiaoling, Hu Quanyin, Song Qingxiang, Xia Huimin, Liu Zhongyang, Gu Guangzhi, Jiang Mengying, Pang Zhiqing, Chen Hongzhuan, Chen Jun*(通讯作者), Fang L, Lipid-based liquid crystalline nanoparticles as oral drug delivery vehicles for poorly water-soluble drugs: cellular interaction and in vivo absorption[J]. Int J Nanomedicine. 2012,7: 3703-3718. (IF: 4.195)
18. Zeng Ni, Hu Quanyin, Liu Zhongyang, Gao Xiaoling, Hu Rongkuan, Song Qingxiang, Gu Guangzhi, Xia Huimin, Yao Lei, Pang Zhiqing, Jiang Xinguo, Chen Jun*(第一单位通讯作者), Fang Liang*, Preparation and characterization of paclitaxel-loaded DSPE-PEG-liquid crystalline nanoparticles (LCNPs) for improved bioavailability[J]. Int J Pharm. 2012,424(1-2): 58-66. (IF: 3.785)
19. Guo Jianwei, Gao Xiaoling, Su Lina, Xia Huimin, Gu Guangzhi, Pang Zhiqing, Jiang Xinguo, Yao Lei, Chen Jun*(第一单位通讯作者), Chen Hongzhuan*. Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery[J].Biomaterials. 2011, 32(31): 8010-8020. (IF:8.312)
20. Xia Huimin, Gao Xiaoling, Gu Guangzhi, Liu Zhongyang, Zeng Ni, Hu Quanyin, Song Qingxiang, Yao Lei, Pang Zhiqing, Jiang Xinguo, Chen Jun*(第一单位通讯作者), Chen Hongzhuan*. Low molecular weight protamine functionalized nanoparticles for drug delivery to the brain after intranasal administration[J].Biomaterials. 2011, 32(36): 9888-9898. (IF:8.312)
21. Gao Xiaoling, Yao Lei, Song Qingxiang, Zhu Liang, Xia Zheng, Xia Huimin, Jiang Xinguo, Chen Jun*(第二单位通讯作者) , Chen Hongzhuan*. The association of autophagy with polyethylenimine-induced cytotoxicity in nephritic and hepatic cell lines[J]. Biomaterials. 2011, 32(33): 8613-8625. (IF:8.312)
22. Gu Guangzhi, Xia Huimin, Pang Zhiqing, Liu Zhongyang, Jiang Xinguo, Chen Jun*(通讯作者), Determination of sulphasalazine and its main metabolite sulphapyridine and 5-aminosalicylic acid in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study[J]. J Chromatogr B. 2011, 879(6): 449-456. (IF: 2.977)
23. Liu Zhongyang, Gu Guangzhi, Xia Huimin, Liu Qiang, Pang Zhiqing, Jiang Xinguo, Chen Jun*(通讯作者), Determination of Fulvestrant in Rat Plasma by LC–MS–MS: Application to a Pharmacokinetic Study[J]. Chromatographia. 2011,74(3-4): 227-234. (IF: 1.437)
24. Xia Huimin, Su Lina, Guo Jianwei, Liu Guangming, Pang Zhiqing, Jiang Xinguo, Chen Jun*(通讯作者), Determination of vinpocetine and its primary metabolite, apovincaminic acid, in rat plasma by liquid chromatography-tandem mass spectrometry[J]. J Chromatogr B Analyt Technol Biomed Life Sci. 2010, 878(22):1959-1966. (IF: 2.977)
25. Su Lina, Guo Jianwei, Liu Guangming, Xia Huimin, Chen Jun*(通讯作者), Jiang X, LC determination and pharmacokinetic study of gemfibrozil in human plasma[J]. Chromatographia，2010, 71: 833-838. (IF: 1. 437)
26. Zhang Xiaoyan, Chen Jun(共同第一作者), Gao Xiaoling, Kang Yu, Xu Congjian. Follicle-stimulating hormone peptide can facilitate paclitaxel nanoparticles to target ovarian carcinoma in vivo[J].Cancer Res. 2009, 69(16): 6506-6514. (IF:9.284)