姓名：蔡启良 博士

职称：研究员
E-MAIL: qiliang@fudan.edu.cn
课题组网址：http://www.viralcancer.fudan.edu.cn




研究方向
1. 微环境应激与病毒共诱发细胞增殖、抗凋亡和免疫逃避的促癌机理
2. 抗疱疹病毒潜伏感染及其致病分子机制和相关疾病诊治
3. 疱疹病毒感染与中枢神经系统疾病的相关性

重要学术贡献
长期从事“微环境与疱疹病毒互作共诱癌分子机制及其相关皮肤血液神经肿瘤等疾病诊治基础与应用研究。率先提出了“病毒与微环境互作致病”新理论，为阐明致瘤性病毒的诱癌机制提供了重要线索，目前正进行以针对肿瘤微环境应激因子为靶标的新型抗疱疹病毒相关肿瘤治疗手段的前期动物试验。在国际权威杂志PLoS Pathog、J Virol等发表SCI系列文章50余篇、申请专利8项授权4项，主/参编中英文专著5部。部分研究成果受到了了Science Daily，Faculty of 1000，PennMedicine等国际学术期刊媒体多次推荐评述。获国家自然科学基金、国家重点研发计划、国家重大基础研究（973）、教育部新世纪优秀人才计划、和上海市教委创新计划重点项目等项目资助。

荣誉与获奖
2013 教育部新世纪优秀人才

国内外学术团体任职
2013- 中国微生物学会病毒分会青年副主任委员
2013- 中华医学会医学病毒分会委员;

受邀审稿学术刊物
2017- Frontier Cell Infection Micorbiology副主编
2016- Oncol Commun副主编
2016- Cancer Cell& Microenvirnment编委
2013- PLoS On编委

受邀学术报告
•2017 Title: LANA-mediated cleavage of Aurora kinase B is essential for KSHV- infected cell segregation, 5th National Herpesvirus Conference, Shenyang
•2017 Topic: Malignant lymphoma and EBV infection, 4th international forum on Clinical Microbiology, Shanghai
•2017 Topic: Nuclear translocation and cleavage of STAT6 is induced by KSHV for viral latency, 20th International workshop on KSHV and related agents. Berlin, Germany
•2016 Topic: The role of microenvironmental stress on viral B-lymphoma malignancy. 2nd National Young Scholar on Virology Conference, Shenzhen
•2016 Topic: The role of microenvironmental stress on viral B-lymphoma malignancy.The 4th International Symposium for herpesvirus, associated diseases and antiviral development. Wuhan,
•2016 Topic: Herpesvirus infection and host immune response. International Forum of Behcet's disease. Shanghai
•2016 Topic: Microenvironmental stress signaling is essential for KSHV pathogenesis and oncogenesis, 19th International workshop on KSHV and related agents. Los Angeles, USA,
•2015 Topic: The role of IL-4/IL-13 dependent and independent STAT6 signaling in KSHV pathogenesis, 3rd Chinese Annual Conference on Herpesvirus. Nanjing, Jiangsu, China
•2015 Topic: Hypoxia-related SUMO2 modification is essential for KSHV pathogenesis, High Forum of Microbe Infection and Cancers, Tsingdao, Shangdong, China
•2014, Topic: Hypoxia-related SUMO2 modification is essential for KSHV pathogenesis. International forum for herpesvirus, associated diseases and antiviral development, Guangzhou, China
•2013, Topic: Inhibition of KAP1 on the regulation KSHV-associated primary effusion lymphoma cell proliferation The 10th national conference on virology in China. Haerbing, China
•2013, Topic: Role of SUMOylation on hypoxia and viral cancers. The symposia of university of Nevada at Reno School of Medicine. Reno, Nevada, USA
•The national conference on human herpesvirus in China. Shanghai, China, Jan 10, 2013.
Topic: Impact of the hypoxia on viral oncogenesis.
•2012 Topic: Impact of the hypoxic microenvironment on KSHV-mediated oncogenesis. The national conference on clinical microbiology and infectious immunology in China. Chongqing, China
•2012 Topic: KSHV upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylation. The 2012 International Congress on Oncogenic Herpesvirus and Associated Diseases. Philadelphia, U.S.A


发表论文
1.Mo X, Wei F, Tong Y, Ding L, Zhu Q, Du S, Tan F, Zhu C, Wang Y, Yu Q, Liu Y, Robertson ES, Yuan Z, Cai Q*. Lactic acid downregulates viral microRNA to promote Epstein-Barr Virus-immortalized B lymphoblastic cell adhesion and growth. Journal of Virology, 2018, Feb 14. doi: 10.1128/JVI.00033-18.
2.Wang C, Zhu C, Wei F, Gao S, Zhang L, Li Y, Feng Y, Tong Y, Xu J, Wang B, Yuan Z, Cai Q*. Nuclear translocation and cleavage of STAT6 is induced by Kaposi’s sarcoma-associated herpesvirus for viral latency. PLoS Pathogens, 2017, 13(1):e**.
3.Liang Q, Wang K, Wang B*, Cai Q*. HCMV-encoded miR-UL112-3p promotes glioblastoma progression via tumour suppressor candidate 3. Scientific Reports, 2017, 7:44705
4.Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q*. The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers. Virologica Sinica, 2017, 32(5):357-368
5.Zhu Q, Gu F, Zhu C, Wang Y, Wei F*, Cai Q*. Interplay between microenvironmental abnormalities and infectious agents in tumorigenousis. Adv Exp Med Biol, 2017, 1018:253-271
6.Zhu C, Wang Y, Cai C, Cai Q*. Bacterial infection and associated Cancers. Adv Exp Med Biol, 2017, 1018:181-191
7.Cai Q*, Yuan Z. Overview of infectious causes of human cancers. Adv Exp Med Biol, 2017, 1018:1-9
8.Liu YQ, Zhang GL, Mo XH, Wang B, Wu F, Chen J, Luo H, Zhu LD, Xu MY, Zhou Q, Cai Q*, Wang XL*. A novel homozygous DOCK8 mutation associated with unusual coexistence of gross molluscum contagiosum and epidermodysplasia verruciformis in a DOCK8 deficiency patient. J Eur Acad Dermatol Venereol. 2017, May 18. doi: 10.1111/jdv.14344.
9.Wei F, Gan J, Wang C, Zhu C, Cai Q*. Cell-cycle regulatory functions of the KSHV oncoproteins LANA. Frontier in Microbiology, 2016, 7(334): doi 103389
10.Wang C, Wei F, Cai Q*. Deregulation of IL-4/IL-13-induced STAT6 signaling in viral oncogenesis. Oncology Communication, 2015, 1:e1131
11.Wang C, Zhu C, Wei F, Zhang L, Mo X, Feng Y, Xu J, Yuan Z, Robertson E, Cai Q *. Constitutive activation of IL-13/STAT6 contributes to KSHV-associated PEL cell proliferation and survival. Journal of Virology, 2015, 89(20):10416-10426.
12.Gan J, Wang C, Jin Y, Guo Y, Xu F, Zhu Q, Ding L, Shang H, Wang J, Wei F*, Cai Q*, Robertson E*. Proteomic profiling identifies the SIM-associated complex of KSHV-encoded LANA. Proteomics, 2015,15(12):2023-37.
13.Zhang L, Zhu C, Guo Y, Wei F, Lu J, Qin J, Wang J, Verma SC, Shan H, Yuan ZH, Robertson ES*, Cai Q*. Inhibition of KAP1 enhances hypoxia-induced KSHV reactivation through RBP-J?. Journal of Virology, 2014, 88(12):6873-84.
14.Cai Q*, Cai S, Zhu C, Verma SC, Choi JY, Robertson ES*. A SUMO2-interacting motif within LANA is essential for KSHV latency. PLoS Pathogens, 2013, 9(10):e**.
15.Cai Q*, Shuovomoy A, Cervini A, Lu J, Hislop AD, Dzeng R, Robertson ES*. IRF4-mediated CIITA transcription is blocked by KSHV encoded LANA to inhibit MHC II presentation. PLoS Pathogens, 2013, 9(10):e**.
16.Cai Q, Xiao B, Si H, Cervini A, Gao J, Lu J, Robertson ES. Kaposi’s sarcoma herpesvirus upregulates Aurora A kinase to promote phosphorylation-dependent ubiquitylation of p53. PLoS Pathogens, 2012, 8(3): e**.
17.Cai Q, Guo Y, Xiao B, Banerjee S, Saha A, Lu J, Glisovic T, Robertson ES. Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis. PLoS Pathogens, 2011, 7(12):e**.
18.Cai Q, Verma SC, Choi JY, Ma M, Robertson ES. Kaposi’s sarcoma associated herpesvirus inhibites IL-4-mediated STAT6 phosphorylation to regulate apoptosis and maintain latency. Journal of Virology, 2010, 84(21):11134-11144.
19.Cai Q, Verma SC, Lu J, Robertson ES (2010). Molecular biology of Kaposi’s sarcoma-associated herpesvirus and related oncogenesis. Advances in Virus Research, 2010, 78:87-142.
20.Cai Q, Murakami M, Si H, Robetson ES. A potential alpha-helix motif in theamino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxia. Journal of Virology, 2007, 81(19):10413-23.
21.Cai Q, Peng G, Bu L, Lin Y, Zhang L, Lustigmen S, Wang H. Immunogenicity and in vitro protective efficacy of a polyepitope Plasmodium falciparum candidate vaccine constructed by epitope shuffling. Vaccine. 2007, 25(28):5155-65.
22.Cai Q, Knight JS, Verma SC, Zald P, Robertson ES. EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of VHL and p53 tumor suppressors. PLoS Pathogens, 2006, 2(10): e116.
23.Cai Q, Lan K, Verma SC, Si H, Lin D, Robertson ES. Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditions. Journal of Virology, 2006, 80(16):7965-75.
24.Cai Q, Wei F, Lin Y, Shao D, Wang H. Immunogenicity of polytope library assembled by epitope shuffling: an approach to design chimeric DNA vaccine against malaria. Vaccine, 2004, 23(2):267-77.

学术专著
1.Infectious Agents Associated Cancers: Epidemiology and Molecular Biology. Qiliang Cai, Zhenghong Yuan, Ke Lan, eds. Springer press, eBook: DOI 10.1007/978-981-10-5765-6. p1-277, 2017.

申请或授权专利
授权专利
1.Cai Q, Zhu C, Cai S. The SIM-based vaccine and drug against Kapposi’s sarcoma herpesvirus. China Patent, 2013, A#:.0.
2.Wang H, Cai Q. A novel epitope against Plasmodium falciparum parasite and its relative vaccine. China Patent, 2005, Jan 21st, A#:26
3.Cai Q, Wang H. A method for preparing epitope chimeric gene vaccine. International Patent, 2003, PCT/CN03/00620 (WO, AU A1, US2007/**A1)

申请专利
1.Cai Q, Gan J, Zhu C (2017). A kit for rapidly SUMO modification in vitro. 2017.01.09, China Patent, A#:9.6.
2.Cai Q, Gan J, Zhu C (2017). A kit for rapidly ubiquitin modification in vitro. 2017.01.09, China Patent, A#:3.3
3.Cai Q, Ding L, Zhu Q, Zhu C (2017). A kit for rapidly detection of human herpesvirus subtype. 2017. 03.01, China Patent, A#:6.9.
4.Cai Q, Robertson ES (2007). HIF-1 as a therapeutic target for KSHV-associated cancers. United States Patent, US**.
5.Cai Q, Robertson ES (2006). Proteasome inhibitors: a novel therapy for KSHV-Associated Human Malignancies. United States Patent, US**