姓名：沈霖霖 博士
职称：教授
E-MAIL: llshen@shmu.edu.cn
WWW: http://www.-----


研究方向
1.呼吸活动的神经调控
2.心血管系统的中枢神经调控
重要学术贡献
中枢化学感受性调节在呼吸活动的稳态中起了重要的作用。脑内多个区域存在化学敏感性，且其感受机制仍不清楚。本课题组主要探讨了中枢化学感受器的定位及其感受机制。确认了下丘脑、延髓头端腹外侧区、孤束核、舌下神经核等脑内多个区域可以检测到化学感受性反应，发现pH敏感的离子通道（ASICs 和TASKs）相互协调感知脑内局部pH的波动，共同介导中枢化学敏感神经元对呼吸活动的调控。本研究的科学意义不仅能促进对中枢化学敏感神经元的感受机制的认识，也对研究呼吸中枢调控障碍导致的相关疾病提供了新的思路。
荣誉与获奖
国内外学术团体任职
1994-今 中国自动化学会生物控制论与医学工程专业委员会委员
2002-今 上海市生物医学工程学会生物力学专业委员会委员
2011-今 中国生理学会呼吸生理专业委员会委员
2012-2016 上海市神经科学学会理事
2013-今 上海市抗癌协会肿瘤微创治疗专业委员会委员
2014-2018 上海生理学会副理事长
受邀审稿学术刊物
2003-今 生理学报
2010-今 The American Journal of Physiology, Neuroscience Bulletin, Brain Research Bulletin, Acta Pharmacologica Sinica, PLoS ONE, Scientific Reports
校内学术机构任职
2015-今 复旦大学本科教学督导组委员
受邀学术报告
2014 Effect of vagus nerve on development of pulmonary fibrosis, International Symposium on Aging and medicine, Shanghai, China
2014 Extracellular pH regulation of respiratory activities by ASICs in the brain of SD rats，全国呼吸医学研究生论坛暨呼吸系统重大疾病转化医学学术论坛，广州
2013 下丘脑化学敏感神经元的研究进展，全国呼吸系统重大疾病转化医学学术交流会，长沙
2012 The Mechanism of central chemosentitive neurons on respiratory regulation, International Conference of Physiological Sciences, Suzhou, China
发表论文
1.Xia Wang, Long Li, Ruijuan Guan, Danian Zhu, Nana Song*, Linlin Shen*. Emodin Inhibits ATP-Induced Proliferation and Migration by Suppressing P2Y Receptors in Human Lung Adenocarcinoma Cells, Cellular Physiology and Biochemistry, 44:1337-1351, 2017
2.Nana Song, Ruijuan Guan, Qian Jiang, Comron J. Hassanzadeh, Yuyang Chu, Xiaomei Zhao, Xia Wang, Dawei Yang, Qijun Du, Xiang-Ping Chu*, Linlin Shen*. Acid-sensing ion channels are expressed in the ventrolateral medulla and contribute to central chemoreception, Scientific Reports, DOI: 10.1038/srep38777, 2016
3.Ruijuan Guan, Xia Wang, Xiaomei Zhao, Nana Song, Jimin Zhu, Jijiang Wang, Jin Wang, Chunmei Xia, Yonghua Chen, Danian Zhu, Linlin Shen*. Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation, Scientific Reports, DIO: 10.1038/srep35696, 2016
4.Ruijuan Guan, Xiaomei Zhao, Xia Wang, Nana Song, Yuhong Guo, Xianxia Yan, Liping Jiang, Wenjing Cheng, Linlin Shen*. Emodin alleviates bleomycin-induced pulmonary fibrosis in rats, TOXICOLOGY LETTERS, 262:161–172, 2016
5.GH Zhang, ZL Liu, BJ Zhang, WY Geng, NN Song, W Zhou, YX Cao, SQ Li, ZL Huang*, LL Shen*. Orexin A activates hypoglossal motoneurons and enhances genioglossus muscle activity in rats. British Journal of Pharmacology, 171(18):4233-4246, 2014
6.Wen-ye Geng, Zi-bing Liu, Na-na Song, Gui-hong Zhang, Wei-zhong Jin, Wang Zhou, Li Li, Yin-xiang Cao, Da-nian Zhu, Lin-lin Shen*. Effects of electroacupuncture at Zusanli (ST36) on inflammatory cytokines in a rat model of smoke-induced chronic obstructive pulmonary disease. J Integr Med, 11(3):213-219, 2013
7.Nana Song, Guihong Zhang, Wenye Geng, Zibing Liu, Weizhong Jin, Li Li, Yinxiang Cao, Danian Zhu, Jerry Yu, Linlin Shen*. Acid sensing ion channel 1 in lateral hypothalamus contributes to breathing control. PLoS ONE, 7(7):e39982:1-10, 2012
8.G-H ZHANG, W-Y GENG, W ZHOU, Y-X CAO, Y QIAN, L LI, D-N ZHU, Z-L HUANG, L-L SHEN*. REGULATION OF GENIOGLOSSUS MUSCLE BY OREXINS ON FREELY MOVING RATS. Respirology, 16(Suppl2): 240, 2011
9.W ZHOU, G ZHANG, W GENG, N SONG, Y QIAN, L LI, Y CAO, D ZHU, L SHEN*. LESION OF OREXIN NEURONS IN LATERAL HYPOTHALAMUS ATTENUATES RESPIRATORY ACTIVITY IN ADULT RATS. Respirology, 16(Suppl2): 240-241, 2011
10.Zibing Liu, Nana Song, Wenye Geng, Weizhong Jin, Li Li, Yinxiang Cao, Yuan Qian, Danian Zhu, Linlin Shen*. Orexin-A and Respiration in a rat model of smoke-induced chronic obstructive pulmonary disease. Clinical and Experimental Pharmacology and Physiology, 37(10):963-968, 2010
学术专著
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