个人简历
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1975：复旦大学光学系获学士学位
1991：复旦大学物理系获博士学位
学术活动：
1992：德国Kaiserslautern大学物理系 访问学者
1995, 1997：香港浸会大学物理系 访问研究学者
1999/07/12：香港浸会大学生物系 访问研究员
2001/10/12：德国Kaiserslautern大学物理系 访问教授
2002/07/09：香港理工大学生物组 访问教授
2003/05/08：南非Rhodes大学化学系 访问教授
2005/07/09：香港理工大学生物组 访问教授
研究方向
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Photobiology and lasers in medicine and biology
● Biological activities of quantum dots
● Photodynamic therapy and detection of tumors
● The stimulation effects and related mechanism of laser irradiation on living cells especially on red blood cells
● The detection of image and spectrum in living cells with confocal microscope by one photon and two photon excitation
主要发表文章
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(1) J.Ma, J.Y.Chen*, J.Guo, C.C.Wang, W.L.Yang, N.H.Cheung, P.N.Wang, Improvement of the photostability of thiol-capped CdTe quantum dots in aqueous solutions and living cells. Nanotechnology. 17: 5875-5881 (2006)
(2) J.Guo, W.L.Yang, C.C.Wang, J.He, J.Y.Chen, Poly(N-isopropylacrylamide)-coated luminescent/magnetic silica microspheres: preparation, characterization, and biomedical applications. Chem.Mater. 18, 5554-5562 (2006)
(3) Y.L.Jin, J.Y.Chen*, L.Xu, P.N.Wang, Refractive index measurement for biomaterial samples by total internal reflection. Phys.Med.Biol. 51, N371-N379 (2006)
(4) Y. Zhang, J. He, P.N.Wang, J.Y.Chen*, Z.J.Lu, D.R.Lu, J.Guo, C.C.Wang, W.L.Yang, Time-dependent photoluminescence blue shift of the quantum dots in living cells: effect of oxidation by singlet oxygen. JACS. 128, 13396-13401 (2006)
(5) R.W.K. Wu, E.S.M. Chu, C.M.N. Yow, J.Y. Chen*., A comparative study of photodynamic activities of 5-aminolevulinic acid and its hexyl ester on nasopharyngeal carcinoma (NPC) cells. Cancer Letters.242, 112-119(2006)
(6) E.S.M. Chu, R.W.K. Wu, C.M.N. Yow, T.K.S. Wong, J.Y. Chen*, The cytotoxic and genotoxic potential of 5-aminolevulinic acid on lymphocytes: a comet assay study, Cancer Chemother Pharmacol. 58: 408-414 (2006)
(7) Ma J, Chen Ji-Yao*, Guo J, Wang C.C, Yang W.L, Xu L, Wang P.N ,. Photostability of thiol-capped CdTe quantum dots in living cells: the effect of photooxidation, Nanotechnology, 17: 2083-2089 (2006).
(8) X.Q.Mi, J.Y.Chen*, L.W.Zhou, Effect of low power laser irradiation on disconnecting the membrane-attached hemoglobin from erythrocyte membrane, J.Photochem.Photobiol.B:boil, 83, 146-150 (2006)
(9) Lu X.Y, Yi H.H, Chen J.Y, Fang H.P, Lattice BGK simulations of the blood flow in elastic vessels. Chin.Phys.Lett. 23:738-741 (2006)
(10) Jiyao Chen*, Naiki Mak, Wongneng Leung, Naihou Cheung, Qian Peng., Comparison of Merocyanine 540-Mediated Photodynamic Action on Leukemia Cells between Pulsed and Continuous Wave Light Sources. Journal of Environmental Pathology, Toxicology, and Oncology. 25: 217-222 (2006)
(11) Ji-Tong Yu, Ji-Yao Chen*, Zhi-Fang Lin, Lei Xu, Pei-Nan Wang, Min Gu., Surface stress on the erythrocyte under laser irradiation with finite-difference time-domain calculation. J. Biomedical Optics. 10: 064013-1 – 6 (2005).
(12) Itumeleng Swotsanyana-Mokhosi, Ji-Yao Chen, Tebello Nyokong., Synthesis, Photophysicochemical studies of adjacently tetrasubstituteed bioaphthalo-phthalocyanines. J. Porphyrins and Phthalocyanines. 9: 316-525 (2005).
(13) Q.G.Ren, J.Y.Chen*, J.Guo, W.L.Yang, L.Xu, P.N.Wang, L.W.Zhou., Uptake of water-soluble CdTe quantum dots in living cells of euglena gracilis. Chinese Optics letters. 3: S216-217 (2005).
(14) J. Ma, Y. Cen, J.Y.Chen*., An in vitro study on transition from NO-Hemoglobin to Methemoglobin: Oxygen effect. Chinese Journal of Chemistry. 23: 637-639 (2005).
(15) X.Q.Mi, J.Y.Chen*, R.Chen, S.Zheng, L.W.Zhou., Mechanism of low power laser irradiation on red blood cell deformability. Chinese Optics Letters. 3: S182-184 (2005).
(16) Y.Cen, R.Zhang, W.H.Yao, J.Ma, J.Y.Chen*., Raman spectral study of nitrosyhemoglobin and several other hemoglobins. Spectroscopy and Spectral Analysis. 25: 405-408 (2005).
(17) J.Ma, J.Y.Chen*, J.Guo, C.C.Wang, L.Xu, P.N.Wang., Photo-stability of water-soluble quantum dots in living cells. Chinese Optics Letters. 3: S208-209 (2005).
(18) Y. Cen, J.Y.Chen*, “Photohemolysis of erythrocytes by He-Ne laser irradiation: the effect of power density”, Lasers in Medical Science, 19, 161-164 (2004).
(19) X.Q.Mi, J.Y.Chen*, Z.J.Liang, L.W.Zhou, In vitro effects of helium-neon laser irradiation on human blood: blood viscosity and deformability of erythrocytes, Photomedicine and laser surgery, 22, 477-482 (2004).
(20) A. Ogunsipe, J.Y.Chen, T.Nyokong, Photophysical and photochemical studies of Zine(II) phthalocyanine derivatives – effects of substituents and solvents. New.J.Chem. 28, 822-827 (2004).
(21) Y. Cen, J.Ma, R.Y.Zhu, J.J.Lu, S.X.Qian, J.Y.Chen*, Femtosecond time – resolved absorption of oxyhaemoglobin photolysis in living erythrocytes, Chin.Phys.Lett. 21, 1636-1639 (2004).
(22) Mi X.Q, J.Y.Chen*, Y.Cen, Z.J.Liang, L.W.Zhou. A comparative study of 632.8 and 532 nm laser irradiation on some rheological factors in human blood in vitro. J.Photochem.Photobiol.B:Biol, 74, 7-12 (2004).
(23) Wu S.M, Q.G.Ren, M.O.Zhou, Q.Peng, J.Y.Chen*, Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester. Cancer Letters, 200, 123-131 (2003).
(24) Chen J.Y*, Q.Peng, H-J.Jodl, Infrared spectral comparison of 5-aminolevulinic acid and its hexyl ester. Spectrochimica Acta Part A. 59, 2571-2576 (2003).
(25) Wu S.M, Q.G.Ren, M.O.Zhou, Y.Wei and J.Y.Chen*, Photodynamic effects of 5-aminolevulinic acid and its hexylester on several cell lines. Acta Biochemica et Biophysica Sinica. 35 (7), 655-660 (2003).
(26) Chen J.Y*, Ren Q.G, Wu S.M, Wang P.N., The effects of ALA-PDT on leukemia cells and hepatoma cells. Journal of Photoscience. 9(2), 512-514 (2002).
(27) Chen J.Y*, Peng Q, Jodl H-J, A spectral comparison of PDT drugs – ALA and ALA-Hexyl ester. Journal of Photoscience. 9(2), 521-523 (2002).
(28) Ren Q.G, Wu S.M, Peng Q, Chen J.Y*., Compar ison of 5-aminolevulinic acid and its hexyl ester mediated photodynamic action on human hepatoma cells. Acta Biochemica et Biophysica Sinica, 34, 650-654 (2002).
(29) Chen J.Y*, N.K.Mak, N.H.Cheung, R.N.Leung and Q.Peng., Endogenous production of protoporphyrin IX induced by 5-aminolevulinic acid in leukemia cells. Acta Pharmacon Sin. 22 (2), 163-168 (2001).
(30) Chen J.Y, N.K.Mak, C.M.N.Yow, M.C.Fung, W.N.Leung and N.H.Cheung., The binding characteristics? and intracellular localization of mTHPC in myeloid leukemia cells: phototoxicity and mitochondrial damage. Photochem.Photobiol. 72, 541-547 (2000).
(31) Yow C.M.N, J.Y.Chen, N.K.Mak, N.H.Cheung, A.W.N.Leung., Cellular uptake, subcellular localization and photodamaging effect of temoporfin (mTHPC) in nasopharyngeal carcinoma cells: comparson with hematoporphyrin derivative. Cancer Letters. 157, 123-131 (2000).
(32) Chen J.Y, N.H.Cheung, M.C.Fung, W.N.Leung and N.K.Mak., A study on uptake and localization of merocyanine 540 (MC540) in murine myeloid leukemia cells by confocal laser scanning microscopy (CLSM). Chinese Journal of Laser (B-English version), B9(3), 1-7 (2000).
(33) Chen J.Y, N.H.Cheung, M.C.Fung, J.M.Wen, W.N.Leung and N.K.Mak., Subcellular localization of merocyanine 540 (MC540) and induction of apoptosis in murine myeloid leukemia cells. Photochem.Photobiol. 72, 114-120 (2000).
(34) Yow C.M.N, N.K.Mak, S.Szeto, J.Y.Chen, Y.L.Lee, N.H.Cheung, D.P.Huang, A.W.N.Leung., Photocytotoxic and DNA damaging effect of Temoporfin (mTHPC) and merocyanine 540 (MC540) on nasopharyngeal carcinoma cell. Toxicology letters. 115 (1), 53-61 (2000).
(35) Chen J.Y, N.K.Mak, J.M.Wen, W.N.Leung, S.C.Chen, M.C.Fung and N.H.Cheung., Acomparison of the photodynamic effectrs of Temoporfin (mTHPC) and MC540 on leukemia cells: efficacy and apoptosis. Photochem.Photobiol, 68(4), 545-554 (1998).
(36) Chen Ji-Yao, N.K.Mak, W.N.Leung, S.C.Chen, K.N.Leung and N.H.Cheung., A study of the binding of merocyanine 540 to myeloid leukemia M1 cells using an intensified charge-coupled device for fluorescence imaging microscopy. Journal of Photochemistry and Photobiology B:Biology. 39, 49-54 (1997).
(37) Guo Hui-Min, Chen Ji-Yao, Yu Shan-Qian, Cai Huai-Xin., Preliminary studies on photodynamic inactivation of newcastle disease virus by aluminum phthalocyanine sulfonate. Chinese Science Bulletin (English version), 39, 1495-1496 (1994).
(38) Chen Ji-Yao, Chen Wen, Cai Huaixin, Dong Rongchun., Studies on pharmacokinetics of sulfonated aluminum phthalocyanine in a transplantable mouse tumor by in vivo fluorescence. J.Photochem.Photobiol.B:biol, 18,233-239 (1993).
(39) Zheng Siding, Wang Jianping, Chen Ji-Yao.,? Surface-Enhanced Raman Scattering (SERS) study of the interaction between hematoporphyrin derivative and guanine. Applied Spectroscope, 46, 1579-1582 (1992).
(40) Yao Huiying, Zeng Xianzhou, Chen Ji-Yao, Chen Wen, Cai Huaixin., Application of PIXE to cancer research. International Journal of PIXE, 2,529-532 (1992).
(41) Chen Ji-Yao, Yao Huiyin, Chen Wen, Dong Rongchun, Cai Huaixin., PIXE determination of photosensitizer tissue distribution in mice bearing S180 tumor sensitized with GaCl-tetrasulphthalocyanine. Int.J.Radiat.Biol, 61, 773-777 (1992).
(42) Chen Ji-Yao, Xie Rong, Chen Shiming, Lu Fadu, Chen Kaitai, Cai Huaixin., Studies on the photochemical and photocytotoxic properties of new PDT photosensitizer aluminum sulfonated phthalocyanine.? Cancer Biochemistry Biophysics, 12, 103-112(1991).
(43) Chen Ji-Yao, Xie Rong, Cai Huaixin, Lu Fadu, Ming Hongbo., A new photosensitizer sulfonated aluminum phthalocyanine : in vitro study on its photodynamic action.? Chinese Journal of Cancer Research (English version), 3, 5-9 (1991).
(44) Yu Hong-Yu, Dong Rong-Chun, Chen Ji-Yao, Cai Huai-Xin., Mechanism of photodynamic inactivation of hepatocarcinoma cells with sulfonated alumunum phthalocyanine.? SPIE, 1616,259-262(1991).
(45) Chen Ji-Yao, Chen Wen, Dong Rong-Chun, Cai Huai-Xin., A study on biological effects of sulfonated chloroaluminum phthalocyanine in a transplantable mouse tumor (S180). SPIE, 1616-1621, 319 (1991).
(46) Chen Ji-Yao, Lu Yaming, Chen Shiming, Cai Huaixin, Xu Deyu., A study on singlet oxygen photoproduction of? meso-tetrakis-(substituted phenyl) porphine derivatives. Chem.J.Chinese University (series B, English version), 6,313-316 (1990).
通讯地址：
复旦大学物理系
中国上海市邯郸路220号（200433）
办公室：物理楼107室
电话：86-21-65643084
传真：86-21-65104949
电子信箱：jychen@fudan.edu.cn
