黄瑾 博士、教授、博士生导师

电话：
地址：梅陇路130号实验18楼627室
Email：huangjin@ecust.edu.cn
个人简介：
上海市浦江人才计划获得者。先后荣获华东理工大学优秀青年女教师（2012）；华东理工大学研究生优秀指导教师（2013、2014、2015）；上海市研究生优秀成果（学位论文）（指导教师：2013）。作为项目负责人，已完成和正在承担共计10余项国家和省部课题，包括来自国家自然科学委、教育部、上海市科委和上海市教委等研究计划。迄今已在Angew. Chem. Int. Ed.、Haematologica、Oncogene、J. Med. Chem.等国内外重要期刊发表学术论文90余篇，现为Med.Res.Rev.、J. Med. Chem.、ACS Med. Chem. Lett.等药学知名期刊的审稿人。

主要研究方向：
1）肿瘤治疗新药物发现及体内外活性评价
2）免疫性疾病治疗新药物筛选及药理活性评价
3）药物作用新机制挖掘
4）药物筛选新方法开发
5）关键药物靶标的结构生物学研究




课题组发表论文列表（*为通讯作者）：
2020年
1. Zehui Liu, Qian Hu, Wanyan Wang, Sisi Lu, Dang Wu, Shuyin Ze, Jiacheng He, Ying Huang, Wuyan Chen, Yechun Xu, Weiqiang Lu*, Jin Huang*. Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase. Biochem Pharmacol (Biochemical Pharmacology), 2020 Jul;177:114000
2. Jiajun Wang, Mengyin Li, Jie Yang, Yaqian Wang, Xueyuan Wu, Jin Huang, Yi-Lun Ying, Yi-Tao Long. Direct Quantification of Damaged Nucleotides in Oligonucleotides Using an Aerolysin Single Molecule Interface.ACS Cent Sci (ACS central science). 2020 Jan 22; 6(1): 76–82
3. Guixiang Yang, Yan Huang, Lulu Zheng, Li Zhang, Lin Su, Yuhang Wu, Jie Li, Licheng Zhou, Jin Huang, Yun Tang*, Rui Wang*, Lei Ma*. Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents.Eur J Med Chem (European Journal of Medicinal Chemistry), 2020 Feb 1, 187: 111913
2019年
1. Zehui Liu, Wanyan Wang, Tingyu Huang, Cunfang Wang, Ying Huang*, Yong Tang*, Jin Huang*. CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer's disease. PLoS One, 2019 Sep 23, 14(9): e**.
2. Feixiong Cheng, Weiqiang Lu, Chuang Liu, Jiansong Fang, Yuan Hou, Diane E. Handy, Ruisheng Wang, Yuzheng Zhao, Yi Yang,Jin Huang, David E. Hill, Marc Vidal, Charis Eng, Joseph Loscalzo*. A genome-wide positioning systems network algorithm for in silico drug repurposing. Nat Commun (Nature Communications), 2019 Aug 2, 10(1): 3476.
3. Xueyuan Wu, Mingbo Wang, Yaqian Wang, Mengyin Li, Yilun Ying, Jin Huang*, Yitao Long*. Precise Construction and Tuning of an Aerolysin Single-Biomolecule Interface for Single-Molecule Sensing. CCS Chemistry. 2019 Aug; 1(3): 81-89.
4. Zhonghong Zhu, Qian Hu, Huiling Pan, Yuexing Zhang, Haibing Xu, Mohamedally Kurmoo, Jin Huang*, Ming-Hua Zeng*. Tracking the multiple-step formation of an iron(III) complex and its application in photodynamic therapy for breast cancer. Science China-chemistry. 2019 Jun, 62(6): 719-726.
5. Wenhua Chen, Xue Yao, Zhenghui Huang, Fei Mao, Longfei Guan, Yun Tang, Hualiang Jiang, Jian Li, Jin Huang*, Lubin Jiang*, Jin Zhu*. Novel dual inhibitors against FP-2 and PfDHFR as potential antimalarial agents: Design, synthesis and biological evaluation. Chinese Chemical Letters. 2019 Jan, 30(1): 250-254.
2018年1. Dang Wu, Wanyan Wang, Wuyan Chen, Fulin Lian, Li Lang, Ying Huang, Yechun Xu, Naixia Zhang, Yinbin Chen, Mingyao Liu, Ruth Nussinov, Feixiong Cheng*, Weiqiang Lu*, Jin Huang*. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Haematologica. 2018 Sep, 103(9): 1472-1483.
2. Li Lang, Qian Hu, Jingyuan Wang, Zehui Liu, Jin Huang*, Weiqiang Lu*, Ying Huang*. Coptisine, a natural alkaloid from Coptidis Rhizoma, inhibits plasmodium falciparum dihydroorotate dehydrogenase. Chem Biol Drug Des (Chemical Biology & Drug Design). 2018 Jul, 92(1):1324-1332
3. Li Liu, Wanqi Wang, Jin Huang, Zhenjiang Zhao, Honglin Li*, Yufang Xu*. Novel benzoyl thioureido benzene sulfonamides as highly potent and selective inhibitors of carbonic anhydrase IX: optimization and bioactive studies. Medchemcomm. 2018 Nov 9, 9(12): 2100-2105.
4. Yaqian Wang, Mengyin Li, Hu Qiu, Chan Cao, Mingbo Wang, Xueyuan Wu, Jin Huang, Yilun Ying*, Yitao Long*. Identification of Essential Sensitive Regions of the Aerolysin Nanopore for Single Oligonucleotide Analysis. Anal Chem. 2018 Jul 3, 90(13): 7790-7794.
5. Dang Wu, Lepeng Wang, Yanhong Yang,Jin Huang, Yuhua Hu, Yongwei Shu, Jingyu Zhang, Jing Zheng*. MAD2-p31comet axis deficiency reduces cell proliferation, migration and sensitivity of microtubule-interfering agents in glioma.Biochem Biophys Res Commun (Biochemical and Biophysical Research Communications). 2018 Mar 25, 498(1): 157-163.
6. Yaqian Wang, Chan Cao, Yilun Ying , Shuang Li, Mingbo Wang, Jin Huang, Yitao Long*. Rationally Designed Sensing Selectivity and Sensitivity of an Aerolysin Nanopore via Site-Directed Mutagenesis.ACS Sens (ACS Sensors). 2018 Apr 27, 3(4): 779-783.
7. Zengrui Wu, Weiqiang Lu, Weiwei Yu, Tianduanyi Wang, Weihua Li, Guixia Liu, Hankun Zhang, Xiufeng Pang, Jin Huang, Mingyao Liu*, Feixiong Cheng*, Yun Tang*. Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches. Pharmacol Res (Pharmacological Research). 2018 Mar, 129: 400-413.
8. GuixiangYang, Songlan Ge, Yan Wu,Jin Huang, Shiliang Li*, Rui Wang*, Lei Ma*. Design, synthesis and biological evaluation of 3-piperazinecarboxylate sarsasapogenin derivatives as potential multifunctional anti-Alzheimer agents. Eur J Med Chem (European Journal of Medicinal Chemistry). 2018 Aug 5, 156: 206-215.
2017年
1. Weiqiang Lu, Feixiong Cheng, Wenzhong Yan, Xi Li, Xue Yao, Wenqiang Song, Mingyao Liu, Xu Shen, Hualiang Jiang, Jing Chen, Jian Li*, Jin Huang*.Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA. Oncogene. 2017, Aug 17, 36(33): 4719-4731
2. Weiqiang Lu, Xue Yao, Ping Ouyang, Ningning Dong, Dang Wu, Xingwu Jiang, Zengrui Wu, Chen Zhang, Zhongyu Xu, Yun Tang, Shien Zou, Mingyao Liu, Jian Li, Minghua Zeng, Ping Lin, Feixiong Cheng*,Jin Huang*. Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. J Med Chem (Journal of Medicinal Chemistry). 2017 Mar 9; 60(5): 1817-1828.
3. Jingyuan Wang, Xue Yao, Jin Huang*. New Tricks for Human Farnesyltransferase Inhibitor: Cancer and Beyond. MedChemComm, 2017, 8, 841-852.
2016年
1. Zengrui Wu, Weiqiang Lu, Dang Wu, Anqi Luo, Hanping Bian, Jie Li, Weihua Li, Guixia Liu, Jin Huang*, Feixiong Cheng*, Yun Tang*. In silico prediction of chemical mechanism-of-action via an improved network-based inference method. Br J Pharmacol (British Journal of Pharmacology). 2016 Sep 20;173:3372-3385.
2. Li Lang, Ningning Dong, Deyan Wu, Xue Yao, Weiqiang Lu*, Chen Zhang, Ping Ouyang, Jin Zhu, Yun Tang, Wei Wang, Jian Li*, Jin Huang*.2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors. J Enzyme Inhib Med Chem (Journal of Enzyme Inhibition and Medicinal Chemistry). 2016 Sep 2; 31(sup4): 98-105.
3. Minghua Zeng*, Zheng Yin, Zehui Liu, Haibing Xu, Yingchun Feng, Yueqiao Hu, Lixian Chang, Yuexing Zhang, Jin Huang*, Mohamedally Kurmoo. Assembly of a Highly Stable Luminescent Zn5 Cluster and Application to Bio-Imaging. Angew Chem Int Ed Engl (Angewandte Chemie International Edition). 2016 Sep 12; 55(38): 11407-11411.
4. Xue Yao, Dang Wu, Ningning Dong, Ping Ouyang, Jiaqian Pu, Qian Hu, Jingyuan Wang, Weiqiang Lu*, Jin Huang*. Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Int J Mol Sci (International Journal of Molecular Sciences). 2016 Jul 25; 17(8). pii: E1199.
5. Huiling Pan, Qian Hu, Jingyuan Wang, Zehui Liu, Dang Wu, Weiqiang Lu*, Jin Huang*. Myricetin is a novel inhibitor of human inosine 5'-monophosphate dehydrogenase with anti-leukemia activity. Biochem Biophys Res Commun (Biochemical and Biophysical Research Communications). 2016 Sep 2; 477(4): 915-922.
6. Jiling Li, Dang Wu, Xiaoyong Xu, Jin Huang, Xusheng Shao*, Zhong Li*. Design, synthesis and inhibitory activity against human dihydroorotate dehydrogenase (hDHODH) of 1,3-benzoazole derivatives bearing amide units. Bioorg Med Chem Lett (Bioorganic & Medicinal Chemistry Letters). 2016 Jul 1; 26(13): 3064-3066.
7. Tianshu Zhang, Wei Wang, Jin Huang, Xia Liu*, Haiyan Zhang*, Naixia Zhang*. Metabolomic investigation of regional brain tissue dysfunctions induced by global cerebral ischemia. BMC Neurosci (BMC Neuroscience). 2016 May 20; 17(1): 25.
8. Qiang Xiao, Ningning Dong, Xue Yao, Dang Wu, Yanli Lu, Fei Mao, Jin Zhu, Jian Li,Jin Huang, Aifang Chen, Lu Huang, Xuehai Wang, Guangxiao Yang, Guangyuan He*, Yong Xu*, Weiqiang Lu*. Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H. Sci Rep (Scientific Reports). 2016 Apr 29; 6: 25298.
9. Wei Zhou, Shiliang Li, Weiqiang Lu, Jun Yuan, Yufang Xu, Honglin Li*, Jin Huang*, Zhenjiang Zhao*. Isoindole-1,3-dione derivatives as RSK2 inhibitors: synthesis, molecular docking simulation and SAR analysis. MedChemComm. 2016, 7: 292-296.
2015年
1. Wenzhong Yan, Jie Qing, Hanbing Mei, Junxiu Nong,Jin Huang, Jin Zhu, Hualiang Jiang, Lei Liu*, Linqi Zhang*, Jian Li*. Identification, synthesis and pharmacological evaluation of novel anti-EV71 agents via cyclophilin A inhibition. Bioorg Med Chem Lett (Bioorganic & Medicinal Chemistry Letters). 2015 Dec 15; 25(24): 5682-5686.
2. Xiaodong Hao, Jun Chang, Bo-Yin Qin, Chen Zhong, Zhibo Chu,Jin Huang, Wenjiang Zhou*, Xun Sun*. Synthesis, estrogenic activity, and anti-osteoporosis effects in ovariectomized rats of resveratrol oligomer derivatives.Eur J Med Chem (European Journal of Medicinal Chemistry). 2015 Sep 18; 102: 26-38.
3. Wenzhong Yan, Jie Qing, Hanbing Mei, Fei Mao, Jin Huang, Jin Zhu, Hualiang Jiang, Lei Liu*, Linqi Zhang*, Jian Li*. Discovery of Novel Small Molecule Anti-HCV Agents via the CypA Inhibitory Mechanism Using O-Acylation-Directed Lead Optimization. Molecules. 2015 Jun 4; 20(6): 10342-10359.
4. Weiqiang Lu, Feixiong Cheng, Jing Jiang, Chen Zhang, Xiaokang Deng, Zhongyu Xu, Shien Zou*, Xu Shen, Yun Tang*, Jin Huang*. FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach. Sci Rep (Scientific Reports). 2015 Jan 29; 5: 8114.
5. Yiming Chen, Zhongyu Xu, Dang Wu, Jian Li, Cheng Song*, Weiqiang Lu*, Jin Huang*. Luciferase reporter gene assay on human 5-HT receptor: which response element should be chosen? Sci Rep (Scientific Reports). 2015 Jan 27; 5: 8060.
6. Liuqing Yang, Wei Liu, Hanbing Mei, Yuan Zhang, Xiaojuan Yu, Yufang Xu, Honglin Li*, Jin Huang*, Zhenjiang Zhao. Synthesis and biological evaluation of pentanedioic acid derivatives as farnesyltransferase inhibitors. MedChemComm. 2015, 6: 671-676.
7. Junsheng Zhu, Le Han, Yanyan Diao, Xiaoli Ren, Minghao Xu, Liuxin Xu, Shiliang Li, Qiang Li, Dong Dong, Jin Huang, Xiaofeng Liu, Zhenjiang Zhao, Rui Wang, Lili Zhu*, Yufang Xu, Xuhong Qian*, Honglin Li*. Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase. J Med Chem (Journal of Medicinal Chemistry). 2015 Feb 12;58(3):1123-1139.
8. Deyan Wu, Hanbing Mei, Ping Tan, Weiqiang Lu, Jin Zhu, Wei Wang,Jin Huang, Jian Li*. Total synthesis of the 2-arylbenzo[b]furan-containing natural products from Artocarpus. Tetrahedron Lett (Tetrahedron Letters). 2015 Jul 15; 56(29): 4383-4387.
2014年
1. Lei Chen, Dang Wu, Han-ping Bian, Guang-lin Kuang, Jing Jiang, Weihua Li, Guixia Liu, Shien Zou*, Jin Huang, Yun Tang*. Selective ligands of estrogen receptor β discovered using pharmacophore mapping and structure-based virtual screening. Acta Pharmacol Sin (Acta Pharmacologica Sinica). 2014 Oct; 35(10): 1333-1141.
2. Huangtao Jin, Zhongyu Xu, Dongfeng Li*, Jin Huang*. Antiproliferative activity and therapeutic implications of potassium tris (4-methyl-1-pyrazolyl) borohydride in hepatocellular carcinoma. Chem-Biol Interact (Chemico-Biological Interactions). 2014 Apr 25; 213: 69-76.
3. Huangtao Jin, Zhongyu Xu, Kunqiang Cui, Tianshu Zhang, Weiqiang Lu*, Jin Huang*. Dietary ?avonoids ?setin and myricetin: Dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II. Fitoterapia. 2014 Apr; 94:55-61.
4. Liyan Wang, Shoude Zhang, Junsheng Zhu, Lili Zhu, Xiaofeng Liu, Lei Shan, Jin Huang*, Weidong Zhang*, Honglin Li*. Identification of diverse natural products as falcipain-2 inhibitors through structure-based virtual screening. Bioorg Med Chem Lett (Bioorganic & Medicinal Chemistry Letters) 2014 Mar; 24(5): 1261-1264.
5. Xue Zhao, Weiqiang Lu, Cheng Song*,Jin Huang*. Detection of mammalian 5-lipoxygenase activity using the fluorescent probe dihydrorhodamine. Eur J Lipid Sci Tech (European Journal of Lipid Science and Technology) 2014 Feb; 116(2): 119-125.
2013年
1. Jun Yuan, Ye Zhong, Shiliang Li, Xue Zhao, Guoqin Luan, Zhenjiang Zhao,Jin Huang*, Honglin Li*, Yufang Xu*.Triazole and Benzotriazole Derivatives as Novel Inhibitors for p90 Ribosomal S6 Protein Kinase 2: Synthesis, Molecular Docking and SAR Analysis. Chin J Chem (Chinese Journal of Chemistry). 2013 Sep; 31(9): 1192-1198.
2. Weiqiang Lu,Xue Zhao,Zhongyu Xu,Ningning Dong,Shien Zou,Xu Shen,Jin Huang*. Development of a new colorimetric assay for lipoxygenase activity. Anal Biochem (Analytical Biochemistry). 2013 Oct 15; 441(2): 162-168.
3. Liyan Wang, Chunmei Yang, Weiqiang Lu, Li Liu, Rui Gao, Sha Liao, Zhenjiang Zhao, Lili Zhu, Yufang Xu, Honglin Li*,Jin Huang*, Weiping Zhu*. Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening. Bioorg Med Chem Lett (Bioorganic & Medicinal Chemistry Letters). 2013 June 15; 23(12): 3496-3499.
4. Kunqiang Cui, Weiqiang Lu, Lili Zhu, Xu Shen,Jin Huang*. Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pylori peptide deformylase activity. Biochem Biophys Res Commun (Biochemical and Biophysical Research Communications). 2013 May 31; 435(2): 289-294.
5. Xianwen Cao, Jing Jiang, Shoude Zhang, Lili Zhu, Juan Zou, Yanyan Diao, Weilie Xiao, Lei Shan, Handong Sun, Weidong Zhang*, Jin Huang*, Honglin Li*. Discovery of natural estrogen receptor modulators with structure-based virtual screening. Bioorg Med Chem Lett (Bioorganic & Medicinal Chemistry Letters). 2013 Jun 1; 23(11): 3329-3333.
6. Xiaojuan Yu, Xue Zhao, Lili Zhu, Chuanxin Zou, Xiaofeng Liu, Zhenjiang Zhao, Jin Huang*, Honglin Li*. Discovery of novel Inhibitors for human farnesyl transferase (hFTase) via structure-based virtual Screening. MedChemComm. 2013 Apr 10; 4(6): 962-971.
7. Hu Yuan, Weiqiang Lu, Liyan Wang, Lei Shan, Honglin Li, Jin Huang*, Qingyan Sun*, Weidong Zhang*. Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1). Eur J Med Chem (European Journal of Medicinal Chemistry). 2013 Apr; 62: 148-157.
8. Rui Gao, Sha Liao, Weilong Zhu, Liyan Wang, Jin Huang, Zhenjiang Zhao*, Honglin Li, Xuhong Qian, Yufang Xu*. Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship. Eur J Med Chem (European Journal of Medicinal Chemistry). 2013 Apr; 62: 597-604.
9. Yuwei Song, Huangtao Jin, Xiaofeng Liu, Lili Zhu*,Jin Huang*, Honglin Li*. Discovery of non-peptide inhibitors of Plasmepsin II by structure-based virtual screening. Bioorg Med Chem Lett (Bioorganic & Medicinal Chemistry Letters). 2013 Apr 1; 23(7): 2078-2082.
10. Ye Zhong, Mengzhu Xue, Xue Zhao, Jun Yuan, Xiaofeng Liu, Jin Huang, Zhenjiang Zhao*, Honglin Li*, Yufang Xu*. Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2(RSK2) inhibitors: Molecular docking simulation and structure-activity relationship analysis. Bioorg Med Chem Lett (Bioorganic & Medicinal Chemistry Letters). 2013 Apr 1; 21(7): 1724-1734.
11. Shanzhai Shang, Lingmei Kong, Liping Yang, Jing Jiang, Jin Huang, Haibo Zhang, Yiming Shi, Wei Zhao, Honglin Li, Huairong Luo, Yan Li, Weilie Xiao*, Handong Sun*. Bioactive phenolics and terpenoids from Manglietia insignis. Fitoterapia. 2013 Jan; 84: 58-63.
12. Weijing Chen, Danrong Ye, Hongfei Wang*, Dechang Lin,Jin Huang, Hongzhe Sun and Weiqing Zhong*. Binding of oxo-Cu₂clusters to ferric ion-binding protein A from Neisseria gonorrhoeae: a structural insight. Metallomics. 2013 May, 1430-1439.
13. Minghao Xu, Junsheng Zhu, Yanyan Diao, Hongchang Zhou, Xiaoli Ren, Deheng Sun, Jin Huang, Dongmei Han, Zhenjiang Zhao, Lili Zhu*, Yufang Xu*, and Honglin Li*. Novel Selective and Potent Inhibitors of Malaria Parasite Dihydroorotate Dehydrogenase: Discovery and Optimization of Dihydrothiophenone Derivatives. J Med Chem (Journal of Medicinal Chemistry). 2013 Sep 27; 56(20): 7911-7924.
14. Mengzhu Xue, Minghao Xu, Weiqiang Lu, Jin Huang, Honglin Li, Yufang Xu, Xiaofeng Liu*, Zhenjiang Zhao*. Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors. J Enzyme Inhib Med Chem (Journal of Enzyme Inhibition and Medicinal Chemistry). 2013 Aug, 28(4): 747-752.
15. Weiqiang Lu, Junsheng Zhu, Shien Zou, Xi Li, Jin Huang*. The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors. J Enzyme Inhib Med Chem (Journal of Enzyme Inhibition and Medicinal Chemistry). 2013 Aug, 28(4): 741-746.
2012年
1. Guoping Hu, Xi Li,Yaozong Li,Xianqiang Sun,Guixia Liu,Weihua Li,JinHuang*, Xu Shen,Yun Tang*. Inhibitors of HIV-1 integrase-human LEDGF/p75 interaction identified from natural products via virtual screening. Chin J Chem (Chinese Journal of Chemistry). 2012 Dec, 30(12): 2752-2758.
2. Guoping Hu,Xi Li,Xuan Zhang,Yaozong Li, Lei Ma,Liumeng Yang,Guixia Liu,Weihua Li,Jin Huang*,Xu Shen,Lihong Hu*,Yongtang Zheng*, Yun Tang*. Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays. J Med Chem (Journal of Medicinal Chemistry). 2012 Oct, 55(22): 10108-10117.
3. Yanyan Diao, Weiqiang Lu, Huangtao Jin, Junsheng Zhu, Le Han, Minghao Xu, Rui Gao, Xu Shen, Zhenjiang Zhao, Xiaofeng Liu, Yufang Xu, Jin Huang*, Honglin Li*. Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening. J Med Chem (Journal of Medicinal Chemistry). 2012 Sep, 55(19): 8341-8349.
4. Maosheng Lv,Ting Shi,Xiaona Mao,Xi Li,Yingyi Chen,Jin Zhu*,Shuaishuai Ni, Xu Shen,Hualiang Jiang,Jian Li,Jian Zhang*,Jin Huang*. 1-(2,6-Dibenzyloxybenzoyl)-3- (9H-fluoren-9-yl)-urea: a novel cyclophilin A allosteric activator. Biochem Biophys Res Commun (Biochemical and Biophysical Research Communications). 2012 Sep, 425(4): 938-943.
5. Liyan Wang,Xi Li,Shoude Zhang,Weiqiang Lu,Sha Liao,Xiaofeng Liu,Lei Shan,Xu Shen,Hualiang Jiang,Weidong Zhang*,Jin Huang*,Honglin Li*. Natural products as a gold mine for selective matrix metalloproteinases inhibitors. Bioorg Med Chem (Bioorganic & Medicinal Chemistry). 2012 Jul, 20(13): 4164-4171.
6. Jie Shen,Jing Jiang,Guanglin Kuang,Chengfang Tan,Guixia Liu,Jin Huang*,Yun Tang*. Discovery and structure-activity analysis of selective estrogen receptor modulators via similarity-based virtual screening. Eur J Med Chem (European Journal of Medicinal Chemistry). 2012 Aug, 54: 188-196.
7. Feixiong Cheng, Chuang Liu, Jing Jiang, Weiqiang Lu, Weihua Li, Guixia Liu, Weixing Zhoumail, Jin Huang*, Yun Tang*. Prediction of drug-target interactions and drug repositioning via network-based inference. PLoS Comput Biol (PLoS Computational Biology). 2012 May, 8(5): e**.
8. Weiqiang Lu,Xue Zhao,Shien Zou,Jin Huang*. A fluorimetric assay for human reticulocyte 15-lipoxygenase-1 activity. Anal Biochem (Analytical Biochemistry). 2012 Jul, 426(1): 66-68.
9. Guoping Hu,Xi Li,Xianqiang Sun,Weiqiang Lu,Guixia Liu,Jin Huang*,Xu Shen,Yun Tang*, Identification of old drugs as potential inhibitors of HIV-1 integrase -human LEDGF/p75 interaction via molecular docking. J Mol Model (Journal of Molecular Modeling). 2012 Dec, 18(12): 4995-5003.
10. Deyan Wu, Fangfang Jin, Weiqiang Lu, Jin Zhu, Cui Li, Wei Wang, Yun Tang, Hualiang Jiang, Jin Huang*, Guixia Liu,* Jian Li*. Synthesis, structure-activity relationship and pharmacophore modeling studies of pyrazole-3-carbohydrazone derivatives as dipeptidyl peptidase IV inhibitors. Chem Biol Drug Des (Chemical Biology & Drug Design). 2012 Mar, 79(6): 897-906.
11. Cui Li, Weiqiang Lu, Chunhua Lu, Wen Xiao, Xu Shen, Jin Huang*, Guixia Liu*, Yun Tang. Identification of diverse dipeptidyl peptidase IV inhibitors via structure-based virtual screening. J Mol Model (Journal of Molecular Modeling). 2012 Sep, 18(9): 4033-4042.
12. Juan Zou, Libin Yang, Jing Jiang, Yanyan Diao, Xiaonian Li,Jin Huang, Jianhong Yang, Honglin Li, Weilie Xiao*, Xue Du, Shanzhai Shang, Jianxin Pu, Handong Sun*. Lanostane Triterpenoids from the Stems of Schisandra glaucescens. Planta Med (Planta Medica). 2012 Mar, 78(5):472-479.
13. Juan Zou，Jing Jiang，Yanyan Diao，Libin Yang，Jin Huang，Honglin Li，Xue Du，Weilie Xiao*，Jianxin Pu，Handong Sun*. Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity. Fitoterapia. 2012 Jul, 83(5): 926-931.
14. Huang Huang, Weiqiang Lu, Xi Li, Xiaoli Cong, Hongmei Ma, Xiaofeng Liu*, Yu Zhang, Peng Che, Ruoqun Ma, Honglin Li, Xu Shen, Hualiang Jiang, Jin Huang*, Jin Zhu*. Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent. Bioorg Med Chem Lett (Bioorganic & Medicinal Chemistry Letters). 2012 Jan, 22(2): 958-962.
15. U.R. Mane, H. Li,Jin Huang, R.C. Gupta, S.S. Nadkarni, R. Giridhar, P.P. Naika, M.R. Yadava*. Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors. Bioorg Med Chem (Bioorganic & Medicinal Chemistry). 2012 Nov, 20(21): 6296-6304.
2011年
1. Shoude Zhang, Weiqiang Lu, Xiaofeng Liu, Yanyan Diao, Fang Bai, Lei Shan*, Jin Huang*, Honglin Li*, Weidong Zhang*. Fast and effective identification of the bioactive compounds and their targets form the medicinal plants via computational chemical biology approach. MedChemComm. 2011 May, 2(6): 471-477.
2. Veronika Ehmke,Falco Kilchmann,Cornelia Heind,Kunqiang Cui,Jin Huang,Tanja Schirmeister, Fran?ois Diederich*, Peptidomimetic nitriles as selective inhibitors for the malarial cysteine protease falcipain-2. MedChemComm. 2011 Jul, 2(8): 800-804.
3. Shenyi Zhang, Chunmei Yang, Weiqiang Lu, Jin Huang, Weiping Zhu, Honglin Li, Yufang Xu* and Xuhong Qian* A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging. Chem Commun (Chemical Communications). 2011 Jun, 47(29): 8301-8303.
4. Weiqiang Lu, Xiaofeng Liu, Xianwen Cao, Mengzhu Xue, Kangdong Liu*, Zhenjiang Zhao, Xu Shen, Hualiang Jiang, Yufang Xu, Jin Huang*, Honglin Li*. SHAFTS: a hybrid approach for 3D molecular similarity calculation. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration. J Med Chem (Journal of Medicinal Chemistry). 2011 Apr, 54(10): 3564-3574.
5. Weiqiang Lu, Peng Che, Yanyan Zhang, Honglin Li, Shien Zou, Jin Zhu, Jing Deng, Xu Shen, Hualiang Jiang, Jian Li*,Jin Huang*. HL005-a new selective PPARgamma antagonist specifically inhibits the proliferation of MCF-7. J. Steroid Biochem Mol Biol (The Journal of Steroid Biochemistry and Molecular Biology). 2011 Apr, 124(3): 112-120.
6. Yang Liu, Kunqiang Cui, Weiqiang Lu, Wei Luo, Jian Wang, Jin Huang, Chun Guo*. Synthesis and antimalarial activity of novel dihydro-artemisinin derivatives. Molecules. 2011 May, 16(6): 4527-4538.
7. Shiliang Li, Yi Zhou, Weiqiang Lu, Ye Zhong, Wenlong Song, Kangdong Liu, Jin Huang*, Zhenjiang Zhao, Yufang Xu, Xiaofeng Liu*, Honglin Li. Identification of inhibitors against p90 ribosomal S6 kinase 2 (RSK2) through structure-based virtual screening with the inhibitor-constrained refined homology model. J Chem Inf Model (Journal of Chemical Information and Modeling). 2011 Oct, 51(11): 2939-2947.
2010年
1. Jie Shen, Chengfang Tan, Yanyan Zhang, Xi Li, Weihua Li,Jin Huang*, Xu Shen, Yun Tang*. Discovery of potent ligands for estrogen receptor beta by structure-based virtual screening. J Med Chem (Journal of Medicinal Chemistry). 2010 Jun, 53(14): 5361-5365.
2009年
1. Jin Zhu, Tong Chen, Jie Liu, Ruoqun Ma, Weiqiang Lu,Jin Huang*, Honglin Li*, Jian Li*, Hualiang Jiang. 2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors design, synthesis and biological evaluation. Molecules. 2009 Feb, 14(2): 785-797.
2. Jin Zhu, Tong Chen, Lili Chen, Weiqiang Lu, Peng Che,Jin Huang*, Honglin Li*, Jian Li*, Hualiang Jiang. 2-amido-3-(1H-indol-3-yl)-N-substituted-propanamides as a new class of falcipain-2 inhibitors. Design, synthesis, biological evaluation and binding model studies. Molecules. 2009 Jan, 14(1): 494-508.
3. Shuaishuai Ni, Yaxia Yuan,Jin Huang, Xiaona Mao, Maosheng Lv, Jin Zhu, Xu Shen, Jianfeng Pei*, Luhua Lai, Hualiang Jiang, Jian Li*. Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. J Med Chem (Journal of Medicinal Chemistry). 2009 Aug, 52(17): 5295-5298.
4. Yongtao Li, Li Li, Jing Chen*, Tiancen Hu, Jin Huang, Yuewei Guo*, Hualiang Jiang, Xu Shen. 7-Chloroarctinone-b as a new selective PPARgamma antagonist potently blocks adipocyte differentiation. Acta Pharmacol Sin (Acta Pharmacologica Sinica). 2009 Aug, 30(9): 1351-1358.
5. Honglin Li, Jin Huang, Lili Chen, Xiaofeng Liu, Tong Chen, Jin Zhu, Weiqiang Lu, Xu Shen, Jian Li*, Rolf Hilgenfeld*, Hualiang Jiang*. Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening. J Med Chem (Journal of Medicinal Chemistry). 2009 Jul, 52(15): 4936-4940.
2008年
1. Gang Zou, Zhenting Gao, Jidong Wang, Yu Zhang, Hong Ding, Jin Huang, Lili Chen, Yuewei Guo*, Hualiang Jiang, Xu Shen*. Deoxyelephantopin inhibits cancer cell proliferation and functions as a selective partial agonist against PPARγ. Biochem Pharmacol (Biochemical Pharmacology). 2008 Mar, 75(6): 1381-1392.
2. Zhaohu Lin, Hong Shen, Jin Huang*, Shuai Chen, Lili Chen, Jing Chen, Guixia liu, Hualiang Jiang, Xu Shen*. Butyl 4-(butyryloxy)benzoate functions as a new selective estrogen receptor b agonist and induces GLUT4 expression in CHO-K1 cells. J Steroid Biochem Mol Biol (The Journal of Steroid Biochemistry and Molecular Biology). 2008 May, 110(1): 150-156.
3. Lijun Chen, Ke Wang, Youming Shao, Jin Huang, Xiaofeng Li, Jufang Shan, Dianqing Wu*, Jie Zheng*. Structural insight into the mechanisms of wnt signaling antagonism by Dkk. J Biol Chem (The Journal of biological chemistry). 2008 Aug, 283(34): 23364-23370.