赵玉政 教授 博士生导师

电话/传真：

E-mail: yuzhengzhao@ecust.edu.cn
通讯地址：上海市徐汇区梅陇路130号实验18楼733室；邮编：200237

【个人简介】：
赵玉政，教授，博士生导师，国家重点研发计划项目首席科学家，中国医学科学院医学与健康科技创新工程首席专家，中国医学科学院院外创新单元主任，国家自然科学基金重点项目负责人，国家优秀青年科学基金获得者，国家自然科学基金重大研究计划集成项目成员，中国科协首批“青年人才托举工程”优秀人才，上海青年科技英才，上海市青年拔尖人才, 上海市青少年科技创新“市长”奖获得者等，中国细胞生物学学会细胞代谢专业委员会委员，中国细胞生物学学会衰老细胞生物学专业委员会委员，中国老年学和老年医学学会老年病学分会衰老基础医学专家委员会委员，中国抗癌协会肿瘤代谢专业委员会委员，中国医药生物技术协会神经修复与再生专业委员会委员，中国研究型医院学会过敏医学专业委员会青年委员等。2007年7月获山东大学理学学士学位，2012年6月获华东理工大学工学博士学位并留校任教，历任讲师、副教授、研究员，现为华东理工大学教授。迄今已在Nature Methods、Nature Protocols(2篇)、Cell Metabolism(2篇)、Developmental Cell、ScienceAdvances、Blood等国际权威期刊发表SCI论文40多篇，编写英文著作Methods in Enzymology1个章节。已申请22项中国发明专利（授权7项）和5项国际PCT专利（授权2项美国发明专利）。研究成果在国际上产生重要影响，相关技术已被全球来自哈佛大学、斯坦福大学、麻省理工学院、牛津大学、剑桥大学及中科院等500多个实验室跟踪应用，典型技术应用发表于Science、Cell。主持国家重点研发计划、中国医学科学院医学与健康科技创新工程、国家自然科学基金重点项目、优秀青年科学基金、重大研究计划、面上项目等科研项目。
【研究方向】：
1、细胞代谢监测与成像新技术开发
2、细胞代谢调控机制研究
3、衰老及相关疾病（肿瘤、糖尿病、肥胖、心脑血管疾病等）即时诊断与创新药物开发

【研究生招生】：

本实验室研究对象涉及基因、蛋白质、细菌、哺乳动物细胞、线虫、斑马鱼、果蝇和小鼠，研究领域涉及药学、药理学、细胞生物学、生物化学与分子生物学、合成生物学、光遗传学、化学遗传学、化学生物学等。我们热忱欢迎有志于从事细胞代谢及代谢性疾病候选药物开发方面研究的同学加盟本实验室。

【代表性论文】（*通讯作者）：

1. Chen, C.^#, Hao X.^#, Lai X.^#, Liu L.^#, Zhu J.^#, Shao H., Huang D., Gu H., Zhang T., Yu Z., Xie L., Zhang X., Yang Y., Xu J.*, Zhao Y.*, Lu Z.*, Zheng J.*. Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B-cell acute lymphoblastic leukemia. Science Advances, 2021, inpress.2. Zou, Y.^#, Wang, A.^#, Huang, L.^#, Zhu, X.^#, Hu, Q.^#, Zhang, Y., Chen, X., Li, F., Wang, Q., Wang, H., Liu, R., Zuo, F., Li, T., Yao, J., Qian, Y., Shi, M., Yue, X., Chen, W., Zhang, Z., Wang, C., Zhou, Y., Zhu, L., Ju, Z., Loscalzo, J., Yang, Y.*, Zhao, Y.*. Illuminating NAD⁺metabolism in live cells and in vivo using a genetically encoded fluorescent sensor. Developmental Cell, 2020, 53(2), 240-252.3. Gu, H.^#, Chen, C.^#, Hao, X.^#, Su, N.^#, Huang, Dan., Zou, Y., Lin, S., Chen, X., Zheng, D., Liu, L., Yu, Z., Xie, L., Zhang, Y., He, X., Lai, X., Zhang, X., Chen, G., Zhao, Y.*, Yang, Y.*, Loscalzo, J., Zheng, J.*. MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells. Blood, 2020,136 (5), 553-571.4. Zhang, Z., Cheng, X., Zhao, Y.*, Yang, Y.*. Lighting up live-cell and in vivo central carbon metabolism with genetically encoded fluorescent sensors. Annual Review of Analytical Chemistry, 2020, 13, 293-314.5. Li, L.^#, Cheng, Y.^#, Shen S.^#, Zhou, J., Wang, A., Chen, G., Xu, J., Yang, Y., Zhao, Y.*, Zhang, S.*, Tian, Y. Sensitive detection via the time-resolved ?uorescence of circularly permuted yellow ?uorescent protein biosensors.Sensors & Actuators: B. Chemical,2020, 321, 128614.
6. Li, L.^#, Zhang, C.^#, Wang, P., Wang, A., Zhou, J., Chen, G., Xu, J., Yang, Y.,Zhao, Y.*, Zhang, S.*, Tian, Y. Imaging the redox states of live cells with the time-resolved fluorescence of genetically encoded biosensors. Analytical Chemistry, 2019, 91(6), 3869-3876.7. Zou, Y.^#, Wang, A.^#, Shi, M., Chen, X.,Liu, R., Li, T., Zhang, C., Zhang, Z., Zhu, L., Ju, Z., Loscalzo, J., Yang, Y.*, Zhao, Y.*.Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded ?uorescent sensors. ?Nature Protocols, 2018, 13(10), 2362-2386.8. Tao, R.^#, Shi, M.^#, Zou, Y.^#, Cheng, D., Wang, Q., Liu, R.,Wang, A., Zhu, J., Deng, L., Hu, H.,Chen, X.,Du,J., Zhu, W., Zhao, Y.*,Yang, Y.*.Multicolouredfluorescent indicators for live-cell and in vivo imaging of inorganic mercury dynamics.FreeRadicalBiology&Medicine, 2018, 121, 26-37.
9. Hu, H.^#, Wang, A.^#, Huang, L., Zou, Y., Gu, Y., Chen, X.,Zhao, Y.*, Yang, Y.*. Monitoring cellular redox state underhypoxia using a fluorescent sensor based on eel fluorescent protein.FreeRadicalBiology&Medicine, 2018, 120, 255-265.
10. Zhao, Y.*,Zhang, Z., Zou, Y., Yang, Y.*. Visualization of nicotine adenine dinucleotide redox homeostasis with genetically encoded fluorescent sensors. Antioxidants & Redox Signaling, 2018, 28(3), 213-229.
11. Tao, R.^#, Zhao, Y.^#, Chu, H.^#, Wang, A., Zhu, J., Chen, X., Zou, Y., Shi, M., Liu, R., Su, N., Du, J., Zhou, H., Zhu, L., Qian, X., Liu, H., Loscalzo, J., and Yang, Y. Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism.Nature Methods, 2017, 14(7), 720-728.
12. Zhao, Y., Wang, A., Zou, Y., Su, N., Loscalzo, J., and Yang, Y. In vivo monitoring of cellular energy metabolism using SoNar, a highly responsive sensor for NAD⁺/NADH redox state. Nature Protocols, 2016, 11(8), 1345-1359. (Cover Story)
13. Zhao, Y.*, Yang, Y.*. Real-time and high-throughput analysis of mitochondrial metabolic states in living cells using genetically encoded NAD⁺/NADH sensors. FreeRadicalBiology&Medicine, 2016, 100, 43-52.
14. Zhao, Y., Hu, Q., Cheng, F., Su, N., Wang, A., Zou, Y., Hu, H., Chen, X., Zhou, H., Huang, X.,Yang, K., Zhu, Q., Wang, X., Yi, J., Zhu, L., Qian, X., Chen, L., Tang, Y., Loscalzo, J., and Yang, Y. SoNar, a highly responsive NAD⁺/NADH sensor, allows high-throughput metabolic screening of anti-tumor agents. Cell Metabolism, 2015, 21(5), 777-789.
15. Zhao, Y., and Yang, Y. Profiling metabolic states with genetically encoded fluorescent biosensors for NADH. Current Opinion in Biotechnology, 2015, 31, 86-92.
16. Zhao, Y., Jin, J., Hu, Q., Zhou, H.M., Yi, J., Yu, Z., Xu, L., Wang, X., Yang, Y., and Loscalzo, J. Genetically encoded fluorescent sensors for intracellular NADH detection. Cell Metabolism, 2011, 14(4), 555-566.

【参与合作论文】：

1. He X., Wan J., Yang X., Zhang X., Huang D., Li X., Zou Y., Chen C., Yu Z., Xie L., Zhang Y., Liu L., Li S.,Zhao Y., Shao H., Yu Y., Zheng J. Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models. Journal of Clinical Investigation, 2021, online.
2. Li T., Chen X., Qian Y., Shao J., Li X., Liu S, Zhu L., Zhao Y., Ye H., Yang. Y.A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice.Nature Communications, 2021, in press.
3. Liu, K., Guo, C., Lao, Y., Yang, J., Chen, F., Zhao, Y., Yang, Y., Yang, J., Yi, J. A fine-tuning mechanism underlyingself- control for autophagy: deSUMOylation of BECN1 by SENP3. Autophagy, 2020, 16(6), 975-990.
4.Li, X., Zhang, C., Xu, X., Miao, J., Yao, J., Liu, R., Zhao, Y., Chen, X., Yang Y.A single-component light sensor system allows highly tunable and direct activation of gene expression in bacterial cells. Nucleic Acids Research, 2020, 48(6), e33.
5. Chen, X., Zhang, D., Su, N., Bao, B., Xie, X.?, Zuo, F., Yang, L., Wang, H., Jiang, L., Lin, Q., Fang, M., Li, N., Hua, X., Chen, Z., Bao, C., Xu, J., Du, W., Zhang, L., Zhao, Y., Zhu, L., Loscalzo, J., Yang, Y. Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs. Nature Biotechnology, 2019, 37(11), 1287-1293.
6. Hao, X., Gu, H., Chen, C., Huang, D., Zhao, Y., Xie, L., Zou, Y., Shu, H., Zhang, Y., He, X., Lai, X., Zhang, X., Zhou, B., Zhang, C., Chen, G., Yu, Z., Yang, Y., Zheng, J. Metabolic imaging reveals a unique preference of symmetric cell division and homing of leukemia-Initiating cells in an endosteal niche. Cell Metabolism, 2019, 29(4), 950-965.
7. Cheng, F., Lu, W., Liu, C., Fang, J., Hou, Y., Handy, D., Wang, R., Zhao, Y., Yang, Y., Huang, J., Hill, D., Vidal, M., Eng, C., Loscalzo, J. A genome-wide positioning systems network algorithm for in silico drug repurposing. Nature Communications, 2019, 10, 3476.
8. Zhu, X., Shen, W., Yao, K., Wang, H., Liu B., Li, T., Song, L., Diao, D., Mao, G., Huang, P., Li, C., Zhang, H., Zou, Y., Qiu, Y., Zhao, Y., Wang, W., Yang, Y., Hu, Z., Auwerx, J., Loscalzo, J., Zhou, Y., Ju, Z. Fine-tuning of PGC1α expression regulates cardiac function and longevity. Circulation Research, 2019, 125(7), 707-719.
9. Liu, X., Zhang, F., Zhang, Y., Li, X., Chen, C., Zhou, M., Yu. Z., Liu, Y., Zhao, Y., Hao, X., Tang, Y., Zhu, L., Liu, L., Xie, L., Gu, H., Shao, H., Xia, F., Yin, C., Tao, M., Xie, J., Zhang, C., Yang, Y., Sun, H., Chen, G., Zheng, J. PPM1K regulates hematopoiesis and leukemogenesis through CDC20-mediated ubiquitination of MEIS1 and p21. Cell Reports, 2018, 23, 1461-1475.
10. Chen, X., Tian, M., Sun, R., Zhang, M., Zhou, L., Jin, L., Chen, L., Zhou, W., Duan, K., Chen, Y., Gao, C., Cheng, Z., Wang, F., Zhang, J., Sun, Y., Yu, H.,Zhao, Y., Yang, Y., Liu, W., Shi, Y., Xiong, Y., Guan, K., and Ye, D. SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer, EMBO Reports, 2018, e45124.
11. Fang, Y., Liu, Z., Chen, Z., Xu, X., Xiao, M., Yu, Y., Zhang, Y., Zhang, X., Du, Y., Jiang, C., Zhao, Y., Wang, Y., Fan, B., Terheyden-Keighley, D., Liu, Y., Shi, L., Hui, Y., Zhang, X., Zhang, B., Feng, H., Ma, L., Zhang, Q., Jin, G., Yang, Y., Xiang, B., Liu, L., Zhang, X. Smad5 acts as an intracellular pH messenger and maintains bioenergetic homoeostasis. Cell Research, 2017, 27, 1083-1099.
12. Yang, K., Wang, M., Zhao, Y., Sun, X., Yang, Y., Li, X., Zhou, A., Chu, H., Zhou, H., Xu, J., Wu, M., Yang, J., and Yi, J. A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nature Communications, 2016, 7, 13599.
13. Yang, H., Zhou, L., Shi, Q., Zhao, Y.,Lin, H., Zhang, M., Zhao, S., Yang, Y., Ling, Z., Guan, K., Xiong, Y., and Ye, D. SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth. EMBO Journal, 2015, 34, 1110-1125.
14. Wang, Y., Zhou, L., Zhao, Y., Wang, S., Chen, L., Liu, L., Ling, Z., Hu, F., Sun, Y., Zhang, J., Yang, C., Yang, Y., Xiong, Y., Guan, K., and Ye, D. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO Journal, 2014, 33, 1304–1320.

【著作】：

1. Zhao, Y., Yang, Y., and Loscalzo, J.Real-Time Assessment of the Metabolic Profile of Living Cells with Genetically Encoded NADH Sensors.Methods in Enzymology,2014, 542, 349-367. (ISBN：978-0-12-416618-9)