吴海珍

生物化学与分子生物学专业：博士生导师/硕士生导师
生物工程专业：硕士生导师
生物工程领域：工程硕士生导师


博士，教授，博士生导师。1975年3月出生，2000年获华东理工大学生物化学与分子生物学硕士学位并留任华东理工大学生物工程学院，2005年获华东理工大学生物化工博士学位，2016年升教授。现任生物科学与工程学位评定分委员会主任助理，应用生物学系系主任。研究方向为微生物分子生物学，目前研究工作主要包括水产病原微生物致病机制的研究与疫苗开发、天然产物生物合成调控分子机制的解析等。主持并参与多项863计划项目、自然科学基金项目等，近年来已在国内外学术期刊中发表论文50余篇，参编专著2本。
主持科研项目：
1. 国家自然科学基金面上项目“持家酶GAPDH和FBA分泌机制的解析与关键表位多肽的筛选”，**，2014.1-2017.12，主持
2. 国家自然科学基金重点项目“胰岛素降解酶在隐孢子虫入侵中的作用机制”，**，2017.1-2021.12，参与
3. 国家自然科学基金青年科学基金项目“评价鳗弧菌减毒活疫苗体内免疫效力的新方法”，**，2011.1-2013.12，主持
4. 国家863计划主题项目“迟钝爱德华氏菌活疫苗的应用研究和产业化开发”，2013AA093101，2013.1-2016.12，主持
5. 国家863计划重点项目“迟钝爱德华氏菌毒力相关功能基因研究及疫苗开发”，2008AA092501，2009.8-2012.12，主持
6. 国家863计划主题项目“壳聚糖及其衍生物作为疫苗佐剂的深度开发”，2014AA093604，2014.1-2016.12，子课题负责
近年来发表的论文(责任作者)
（1）Hui Xia, Xichen Yang, Qiongwei Tang, Jiang Ye, Haizhen Wu*, Huizhan Zhang*. EsrE?a yigPlocus-encoded transcript?is a 3’ UTR sRNA involved inthe respiratory chain of E. coli.Frontiers in Microbiology. 2017. 8:1658.
（2）Hui Xia, Qiongwei Tang, Jie Song, Jiang Ye, Haizhen Wu*, Huizhan Zhang*. A yigPmutant strain is a small colony variant of E. coli, and shows pleiotropic antibiotic resistance. Canadian Journal of Microbiology. 2017. 63(12): 961-969.
（3）Xiaohong Liu, Jiamin Sun, Haizhen Wu*. Glycolysis-related proteins are broad spectrum vaccine candidates against aquacultural pathogens. Vaccine. 2017, 35(31): 3813-3816.
（4）Zhongyang Sun, Jia Deng, Haizhen Wu*, Qiyao Wang, and Yuanxing Zhang. Selection of Stable Reference Genes for Real-Time Quantitative PCR Analysis in Edwardsiella tarda. Journal of Microbiology and Biotechnology. 2017. 27(1): 112-121.
（5）ShanShan Song, Yuanyuan Xue, Enfu Liu, Keping Wang, Yuanxing Zhang, Haizhen Wu*, and Huizhan Zhang*. Comparative analysis of sigma factors RpoS, FliA, and RpoN in Edwardsiella tarda. Canadian Journal of Microbiology. 2016. 62: 861-869.
（6）Ni Ye, Haizhen Wu*, Yuanxing Zhang. Maternal transfer and protection role in zebrafish offspring following vaccination of the brood stock with a live attenuated Vibrio anguillarum vaccine. Aquaculture Research. 2015. DOI: 10.1111/are.12821.
（7）Xiaohong Liu, Hua Zhang, Yuan Gao, Yang Zhang, Haizhen Wu*, Yuanxing Zhang. Efficacy of chitosan oligosaccharide as aquatic adjuvant administrated with a formalin-inactivated Vibrio anguillarumvaccine. Fish and Shellfish Immmunolgoy. 2015. 47(2): 855-860.
（8）Zhongyang Sun, Binbing Shen, Haizhen Wu*, Xiangyu Zhou, Qiyao Wang, Jingfan Xiao, Yuanxing Zhang.The secreted fructose 1,6-bisphosphate aldolase as a broad spectrum vaccine candidate against pathogenic bacteria in aquaculture. Fish and Shellfish Immmunolgoy. 2015. 46(2): 638-647.
（9）Xiaohong Liu, Haizhen Wu*, Qin Liu, Qiyao Wang, Jinfan Xiao, Xinyue Chang, Yuanxing Zhang. Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish and Shellfish Immunology. 2015. 45(2): 342-345.
（10）Hua Zhang,Haizhen Wu*, Liang Gao, Ying Qiu, Jingfan Xiao, Yuanxing Zhang. Identification, expression and immunological responses to bacterial challenge following vaccination of BLT1 gene from turbot, Scophthalmus maximus. Gene. 2015. 557(2): 229-235.
（11）Xiaohong Liu, Haizhen Wu*, Qin Liu, Qiyao Wang, Jinfan Xiao, Yuanxing Zhang. Skin-injured Zebrafish (Danio rerio) are more susceptible to Vibrio anguillarumInfection. Journal of the World Aquaculture Society. 2015. 46(3): 301-310.
（12）Xiaohong Liu,Xinyue Chang, Haizhen Wu*, Jingfan Xiao, Yuan Gao, Yuanxing Zhang. Role of intestinal inflammation in predisposition of Edwardsiella tardainfection in zebrafish (Danio rerio). Fish and Shellfish Immunology. 2014. 41(2): 271-278.
（13）Yuan Gao, Haizhen Wu*, Qiyao Wang, Jiangbo Qu, Qin Liu, Jingfan Xiao, Yuanxing Zhang. A live attenuated combination vaccine evokes effective immune-mediated protection against Edwardsiella tardaand Vibrio anguillarum. Vaccine. 2014. 32(45): 5937-5944.
（14）Yuan Gao, Yangyang Yi, Haizhen Wu*, Qiyao Wang, Jiangbo Qu, Yuanxing Zhang. Molecular cloning and characterization of secretory and membrane-bound IgMof turbot. Fish and Shellfish Immunology. 2014. 40(2): 354-361.
（15）Xiaohong Liu, Haizhen Wu*, Xinyue Chang, Yufei Tang, Qin Liu, Yuanxing Zhang. Notable mucosal immune responses induced in the intestine of zebrafish (Danio rerio) bath-vaccinated with a live attenuated Vibrio anguillarumvaccine. Fish and Shellfish Immunology. 2014. 40(2): 99-108.
（16）Hua Zhang, Binbing Shen, Haizhen Wu*, Liang Gao, Qin Liu, Qiyao Wang, Jingfan Xiao, Yuanxing Zhang. Th17-like immune response in fish mucosal tissues after administration of live attenuated Vibrio anguillarumvia different vaccination routes. Fish and Shellfish Immunology. 2014, 37: 229-238.
（17）Zhihui Zhang, Haizhen Wu*, Jingfan Xiao, Qiyao Wang, Qin Liu, Yuanxing Zhang. Booster vaccination with live attenuated Vibrio anguillarumelicits strong protection despite weak specific antibody response in zebrafish.Journal of applied ichthyology.2014. 30: 117-120
（18）Hua Zhang, Chao Fei, Haizhen Wu*, Minjun Yang, Qin Liu, Qiyao Wang and Yuanxin Zhang. Transcriptome profiling reveals Th17-like immune responses induced in zebrafish bath-vaccinated with a live attenuated Vibrio anguillarum. PLOS ONE.2013. 8(9): e73871
（19）Zhihui Zhang, Haizhen Wu*, Jingfan Xiao, Qiyao Wang, Qin Liu, Yuanxing Zhang. Immune responses evoked by infection with Vibrio anguillarumin zebrafish bath-vaccinated with a live attenuated strain. Veterinary Immunology and Immunopathology. 2013, 154(3-4): 138-144.


专著
（1）张惠展, 吴海珍, 叶江. DNA重组操作技术. 上海交通大学出版社, 28万字, 2006,
（2）张惠展. 途径工程——第三代基因工程（第二章细胞代谢途径的解析与控制撰写）. 中国轻工业出版社, 38万字, 2002,
专利：
（1）吴海珍, 沈斌兵, 孙忠洋, 王启要, 肖婧凡, 张元兴. 一种迟钝爱德华氏菌亚单位疫苗及其制备方法和应用.2016.06.29, ZL6.9
（2）王启要, 刘琴, 张元兴, 肖婧凡, 吴海珍. 迟钝爱德华氏菌天然弱毒株及其应用, 2015.04.08, 中国, ZL3.5
（3）王启要, 王亚敏, 刘琴, 吴海珍, 肖婧凡, 张元兴. 鱼用多效价活疫苗及其应用. 2014.09.03, 中国, ZL3.4
（4）唐敏峰, 费静, 杨娟, 董正廉, 王卫华, 张小明, 吴海珍, 叶江. 牦牛源性纤维成分荧光定量PCR定性检测方法. 2014.03.12, 中国, ZL0.7
（5）吴海珍, 张萌, 李小勇, 沈斌兵, 王启要, 张元兴. 迟钝爱德华氏菌免疫保护性抗原、相关表达载体、疫苗和应用. 2013.06., 中国, ZL6.7
联系方式
wuhzh@ecust.edu.cn