(1) 生物催化工程：包括酶的获得、定向进化及酶新功能的开发，固定化技术及生物催化过程工程研究。(2) 生物反应工程：包括蛋白/多肽药物、酶等基因的克隆与高效表达及工程菌的稳定性、培养与发酵过程工程研究。

代表性论文：
1.Chen S, Mao XZ, Shen YL, Deng ZX, Wei DZ* et al. Tailoring P450 monooxygenase gene for FR-008/candicidin biosynthesis. AEM(IF3.9) 2009, 75 (6): 1778-1781, MAR 2009
2.Ren YH, Wang Y, Zhang YF, Wei DZ* Overcoming multidrug resistance in human carcinoma cells by an antisense oligodeoxynucleotide-doxorubicin conjugate in vitro and in vivo, MOLECULAR PHARMACEUTICS 5(4): 579-587, JUL-AUG 2008
3.Yang XP, Wei LJ, Lin JP, Yin B, Wei DZ* Membrane-bound pyrroloquinoline quinone-dependent dehydrogenase in Gluconobacter oxydans M5, responsible for production of 6-(2-hydroxyethyl) amino-6-deoxy-L-sorbose, AEM(IF3.9) 74(16): 5250-5253 AUG 2008
4.Wang FQ, Li B, Wang W, Wei DZ*, et al., Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14, AEM(IF3.9)77 (4): 771-777 DEC 2007.