(1)利用系统生物学方法开展红霉糖孢菌功能基因组及红霉素合成调控机理研究;(2)小分子代谢产物的信号转导及转录调控作用研究,以B. subtilis作为格兰氏阳性菌模型，研究小分子代谢产物的基因转录调控模式及分子调控机理;(3)新型高灵敏多元分析方法研究,如：新的基于微阵列方法高通量分析技术平台及仪器开发；小分子微阵列(SMM)技术开发及应用研究；纳米生物分析技术；生物传感器等，生物分子和纳米粒子界面基础研究及功能器件设计等

2007年获明治乳业生命科学奖,上海市2008年技术发明二等奖,2006年获浙江省科技进步三等奖。申请发明专利14项,其中授权中国专利4项,申请美国专利1项。代表性论文:
1.Peptide-Functionalized Spherical Polyelectrolyte Nanobrushes for Real-Time Sensing of Protease Activity. ChemBioChem 11:494-497,2010.
2.Time-resolved Transcriptome Analysis of Bacillus subtilis Responding to Valine, Glutamate, and Glutamine PLoS ONE 4:e7073,2009.
3.A Multiplexed Bead-based Mesofluidic System for Foodborne Pathogen Bacteria Detection Applied and Environmental Microbiology 75:6647-6654,2009.
4.An Allosteric Dual-DNAzyme Unimolecular Probe for Colorimetric Detection of Copper(II) J Am Chem Soc 131:14624-14625,2009.
5.DNAzyme-Based Microarray for Highly Sensitive Detection of Metal Ions. Biosensor and Bioelectronics 25:935-939,2009.
6.Highly Sensitive Detection of Mercury (II) ion by Fluorescence Polarization via Gold Nanoparticle Enhancement Angew Chem Int Ed 47:8386-8389,2008.
7.SNP allele-frequency estimation in DNA pool by microarrays using Langmuir adsorption isotherm function BMC Genomics 9:605,2008.