1． 酶、DNA等耐热性的研究
2． 古生菌中多种代谢途径研究
3． 其他多种环境微生物的基因、蛋白、代谢途径等综合研究

Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for coenzyme A biosynthesis in the Archaea. J. Biol. Chem. , in press (2009)

Expression profiles and physiological roles of two types of prefoldins from the hyperthermophilic archaeon Thermococcus kodakaraensis. J. Mol. Biol., 382, 298-311 (2008)

A global transcriptional regulator in Thermococcus kodakaraensis controls the expression level of both glycolytic and gluconeogenic enzyme-encoding genes. J. Biol. Chem., 282(46), 33659-33670 (2007)

A novel ADP-forming succinyl-CoA synthetase in Thermococcus kodakaraensis structurally related to the archaeal NDP-forming acetyl-CoA synthetases. J. Biol. Chem., 282(37), 26963-26970 (2007)

Archaeal Type III Rubiscos function in a pathway for AMP metabolism. Science, 315(5814), 1003-1006 (2007)

Phosphoenolpyruvate synthase plays an essential role for glycolysis in the modified Embden-Meyerhof pathway in Thermococcus kodakarensis. Mol. Microbiol.,61,898-909 (2006)