制药工程与技术；合成药物化学:

1 绿色高效合成方法研究

2 重点药物品种的合成工艺研究

3 基于临床及绿色高效合成方法的新药（包括抗肿瘤药物、抗抑郁症药物、抗艾滋病药物和抗菌药物等）设计与合成

1) Organocatalysis: asymmetric cascade reactions catalysed by chiral secondary amines. Org. Biomol. Chem., 2008, 6, 2037
2) Hydrogen-bond-mediated asymmetric catalysis. Chem. Asian J., 2008, 3，516
3）Chiral amine catalysed enantioselective cascade aza-ene-type cyclization reactions. Chem. Eur. J., 2008, 14,6333
4) Microwave-assisted three-component Knoevenagel-nucleophilic aromatic substitution reactions. Tetrahedron Lett., 2008, 49，4687
5) Chiral Pyrrolidine Sulfonamide Catalyzed Enantioselective Michael Addition of Cyclohexanones to Maleimides. Synlett, 2011, (4): 473-476.
6）Total synthesis of polyene natural product dihydroxerulin by mild organocatalyzed dehydrogenation of alcohols. Chem. Eur. J, 2012, 18(8),2230-2234.
7） A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-L-proline with aldehydes. Sci. China–Chem, 2012, 55(1), 43-49.
8) Efficient Synthesis of Polysubstituted Quinolines and Chiral1,4-Dihydroquinolines by an Organocatalytic Cascade Approach. An Unanticipated Effect of “N” Protecting Groups on Formed Products. Angew. Chem. Int. Ed., 2012, 51(29),7282-7286.