余金生 青年研究员，博士生导师
化学与分子工程学院??????


导航
个人资料
研究方向
开授课程
科研项目
学术成果
荣誉及奖励







个人资料
部门： 化学与分子工程学院
毕业院校： 华东师范大学
学位：
学历： 博士
邮编： 200062
联系电话：
传真：
电子邮箱： jsyu@chem.ecnu.edu.cn
办公地址： 化学馆C305
通讯地址： 上海市中山北路3663号华东师范大学化学馆C305

教育经历
2011.09 - 2016.06华东师范大学 化学与分子工程学院 博士 (导师：周剑教授)
2007.09 - 2011.07江西师范大学 化学化工学院 学士 (导师：丁秋平教授)


工作经历

2019.02 - 至今：华东师范大学化学与分子工程学院 青年研究员 （紫江青年****）
2017.01 - 2019.01日本微生物化学研究所 (JSPS博士后，导师：Masakatsu Shibasaki教授)
2016.07 - 2017.01上海药明康德新药开发有限公司 (高级研究员)


个人简介

社会兼职
Editorial Board Memberof Current Organocatalysis. (2020.11- )


研究方向
手性含氟化合物的不对称催化合成及其在药物研究中的应用




开授课程
高等有机化学—结构与机理


科研项目


学术成果
代表性论文：

24. X.-X. Zhang, Y. Gao, X.-S. Hu, C.-B. Ji,* Y.-L. Liu, J.-S. Yu*, Recent Advances in Catalytic Enantioselective Synthesis of Fluorinated alpha- and beta-Amino Acids. Adv. Synth. Catal. 2020, DOI: 10.1002/adsc. (VIP, Cover picture).
23. X.-S. Hu, J.-X. He, S.-Z. Dong, Q.-H. Zhao, J.-S. Yu*, J. Zhou*, Regioselective Markovnikov hydrodifluoroalkylation of mono-, di-, tri-, and tetrasubstituted alkenes using difluoroenoxysilanes. Nature Commun. 2020, 11, 5500.
22. P.-G. Ding, X.-S. Hu, J.-S. Yu*, J. Zhou*, Diastereodivergent Synthesis of α-Chiral Tertiary Azides through Catalytic Asymmetric Michael Addition. Org. Lett. 2020, DOI: 10.1021/acs.orglett.0c03123.
21. B.-W. Pan, Y. Shi, Y.-P. Tian, J.-S. Yu*, Y. Zhou*, J. Zhou*, Synthesis of Multifunctional α,α-Difluoroketones through Allylic Alkylation of Difluoroenoxysilanes with MBH Carbonates. Chem. Asian J. 2020, DOI: 10.1002/asia..
20. Y. Shi, B.-W. Pan, J.-S. Yu*, Y. Zhou,* J. Zhou*, Recent Advances in Applying Carbonyl-stabilized Phosphorus Ylides for Catalysis. ChemCatChem 2020, DOI: 10.1002/cctc..
19. Y.-J. Hao, Y. Gong, Y. Zhou,* J. Zhou, J.-S. Yu*, Construction of beta-Quaternary α,α-Difluoroketones via Catalytic Nucleophilic Substitution of Tertiary Alcohols with Difluoroenoxysilanes. Org. Lett. 2020, DOI: 10.1021/acs.orglett.0c03123.
18. W.-B. Wu, J.-S. Yu*, J. Zhou* Catalytic Enantioselective Cyanation: Recent Advances and Perspectives. ACS Catal. 2020, 10, 7668.

17. Y.-J. Hao, X.-S. Hu, Y. Zhou*, J. Zhou, J.-S. Yu*, Catalytic Enantioselective α-Arylation of Carbonyl Enolates and Related Compounds. ACS Catal. 2020, 10, 955-993.
16. X.-S. Hu, J.-S. Yu*, J. Zhou*, Catalytic selective mono- and difluoroalkylation using fluorinated silyl enol ethers. Chem. Commun. 2019, 55, 13638-13648.
15. X.-S. Hu, P.-G. Ding, J.-S. Yu*, J. Zhou*, A Sc(OTf)3 catalyzed Mukaiyama-Mannich reaction of difluoroenoxysilanes with unactivated ketimines. Org. Chem. Front. 2019, 6, 2500-2505.
14. Y.-P. Tian, Y. Gong, Hu, X.-S. Hu, J.-S. Yu*, Y. Zhou*, J. Zhou*, HClO4 catalysed aldol-type reaction of fluorinated silyl enol ethers with acetals or ketals toward fluoroalkyl ethers. Org. Biomol. Chem. 2019, 17, 9430-9434.
13. K. Liao, X.-S. Hu, R.-Y. Zhu, R.‐H. Rao, J.-S. Yu*, F. Zhou, J. Zhou*, Catalytic Enantioselective Protonation of Monofluorinated Silyl Enol Ethers towards Chiral α-Fluoroketones. Chin. J. Chem. 2019, 37, 799-806. (封面文章)
12. P.-W. Xu, J.-S. Yu*, C. Chen, Z.-Y. Cao, F. Zhou, J. Zhou*, Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters. ACS Catal. 2019, 9, 1820-1882.
11. Y. Gong, J.-S. Yu*, Y.-J. Hao, Y. Zhou*, J. Zhou*, Catalytic Enantioselective Aldol-Type Reaction Using alpha-Fluorinated Enolates. Asian J. Org. Chem. 2019, 8, 610-626.
10. J.-S. Yu,M. Espinosa, H. Noda*, M. Shibasaki*, Traceless Electrophilic Amination for the Synthesis of Unprotected Cyclic β?Amino Acids. J. Am. Chem. Soc.2019, 141, 10530-10537. (Highlighted by Synfacts 2019, 1072)
9. J.-S. Yu,H. Noda, N. Kumagai*, M. Shibasaki*, Direct Catalytic Asymmetric Mannich-Type Reaction of an α-CF3 Amide to Isatin Imines. Synlett, 2019, 30, 488-492. (Invited paper as part of the 30 Years SYNLETT-Pearl Anniversary Issue)
8. J.-S. Yu, H. Noda*, M. Shibasaki*, Quaternary β2,2-Amino Acids: Catalytic Asymmetric Synthesis and Incorporation into Peptides by Fmoc-Based Solid-Phase Peptide Synthesis. Angew. Chem. Int. Ed. 2018, 57, 818-822.
7. J.-S. Yu, H. Noda*, M. Shibasaki*, Exploiting β-Amino Acid Enolates in Direct Catalytic Diastereo- and Enantioselective C-C Bond-Forming Reactions. Chem. Eur. J. 2018, 24, 15796-15800.
6. J.-S. Yu, H.-M. Huang, P.-G. Ding, X.-S. Hu, F. Zhou, J. Zhou*, Catalytic Enantioselective Construction of Sulfur-containing Tetrasubstituted Carbon Stereocenters. ACS Catal. 2016, 6, 5139-5344.
5. J.-S. Yu, J. Zhou*, Organocatalytic Enantioselective Mukaiyama–Mannich Reaction of Fluorinated Enol Silyl Ethers and Cyclic N-Sulfonyl Ketimines. Org. Chem. Front. 2016, 3, 298-303.
4. J.-S. Yu, W.-B. Wu, F. Zhou*, The First Catalytic Asymmetric Thioacetalization by Chiral Phosphoric Acid Catalysis. Org. Biomol. Chem. 2016, 14, 2205-2209.
3. J.-S. Yu, F.-M. Liao, W.-M. Gao, K. Liao, J. Zhou*, Michael Addition Catalyzed by Chiral Secondary Amine Phosphoramide Using Fluorinated Silyl Enol Ethers: Formation of Quaternary Carbon Stereocenters. Angew. Chem. Int. Ed. 2015, 54, 7381-7385. (Highlighted by Synfacts 2015, 876)
2.J.-S. Yu, J. Zhou*, A Highly Efficient Mukaiyama–Mannich Reaction of N-Boc Isatin Ketimines and Other Active Cyclic Ketimines Using Difluoro Enol Silyl Ethers Catalyzed by Ph3PAuOTf. Org. Biomol. Chem. 2015, 13, 10968-10972. (封面文章)
1. J.-S. Yu, Y.-L. Liu, J. Tang, X. Wang*, J. Zhou*, Highly Efficient“On Water” Catalyst-free Nucleophilic Addition Reactions Using Difluoroenoxysilanes: Dramatic Fluorine Effects. Angew. Chem. Int. Ed. 2014?53, 9512-9516. (被《有机化学》（2014, 34, 2184）作为亮点工作介绍)







荣誉及奖励
2016年 上海市优秀毕业生
2015年 华东师范大学研究生校长奖学金（全校共6人）
2015年 博士研究生国家奖学金
2014年 华东师范大学优秀学生称号
2012年 硕士研究生国家奖学金
2012年 华东师范大学校长奖学金二等奖



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