杨帆
化学与分子工程学院??????


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开授课程
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个人资料
部门： 化学与分子工程学院
毕业院校：
学位：
学历：
邮编：
联系电话： **
传真： **
电子邮箱： fyang@chem.ecnu.edu.cn
办公地址： 理科大楼B1403
通讯地址： 上海市中山北路3663号华东师范大学科学与技术跨学科高等研究院

教育经历

工作经历

个人简介

社会兼职
上海化学试剂产业技术创新战略联盟技术标准委员会委员（2017-）


研究方向

小分子药物发现


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教育与工作经历
1986年9月-1990年7月,西北大学化学系学士学位
1990年9月-1996年7月，中国科学院兰州化学物理研究所硕士学位、博士学位
1996年11月-1999年5月,中国药科大学药学院博士后
2000年8月-2006年11月，华东师范大学化学系副教授
2006年12月-今，华东师范大学化学与分子工程学院，上海分子治疗与新药创制工程技术研究中心教授
2008年11月-12月，法国加香高师邀请教授


科研工作简介
多年来从事功能有机分子合成与应用领域的研究工作：生物活性天然甾体和萜类化合物为母核的结构改造及其在代谢性疾病治疗、抗菌、抗肿瘤等小分子药物发现中的应用；甾体药物绿色制造工艺研究。2001年入选“上海市科技启明星”计划，2015年获江苏省“淮上英才计划”创新创业领军人才称号，2016年获近年来主持或参与国家自然科学基金、“十二五”重大新药创制国家科技重大专项、国家科技支撑项目、上海市科委基础研究重点、国际合作等项目十余项；同时，与多家企业开展科技合作，完成、承担企业项目十余项。发表研究论文80余篇；申请专利57项，其中31项已授权；8项成果通过省级鉴定。
目前研究兴趣：小分子药物发现；甾体药物绿色制造。
学术兼职：英国皇家化学会“Green Chemistry”，以及“Journal of Heterocyclic Chemistry”、“Organic & Biomolecular Chemistry”等期刊特约审稿人。
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开授课程


科研项目


学术成果
1.Sheng Wang, Lei Xu, Yu-Ting Lu, Yu-Fei Liu, Bing Han, Ting Liu, Jie Tang, Jia Li, Jiangping Wu, Jing-Ya Li, Li-Fang Yu, Fan Yang, Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet B-cells from apoptosis, Eur. J. Med. Chem., 2017, 130, 195-208
2.Jing Wang, Teng Yang, Huang Chen, Yun-Nan Xu, Li-Fang Yu, Ting Liu, Jie Tang, Zhengfang Yi, Cai-Guang Yang, Wei Xue, Fan Yang, The synthesis and antistaphylococcal activity of 9,13-disubstituted berberine derivatives, Eur. J. Med. Chem., 2017, 127, 424-433
3.Sun, Hao; Shi, Min; Zhang, Wei; Zheng, Yue-Ming; Xu, Yazhou; Shi, Jun-Jie; Liu, Ting; Gunosewoyo, Hendra; Pang, Tao; Gao, Zhao-Bing; Yang, Fan; Tang, Jie; Yu, Li-Fang, Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Anti-Nociceptive Efficacy, J. Med. Chem., 2016, 59, 6329-6343
4.Shi-Wei Mao, Huang Chen, Li-Fang Yu, Fang Lv, Ya-Jing Xing, Ting Liu, JiaXie, Jie Tang, Zhengfang Yi, Fan Yang，Novel 3,4-seco bile acid diamides as selective anticancer proliferation and migration agents, Eur. J. Med. Chem., 2016, 122， 574-583
5.Jiefeng Zhang, JiakunQiu, Chunmei Xiao, Lifang Yu, Fan Yang, Jie Tang, Tandem demethylation/annulation/oxidation of 2,3-Bis(2-methoxyphenyl)-3- oxopropanals for One-Pot Construction of Coumestans, Eur. J. Org. Chem., 2016, 3380-3385
6.Sheng Wang, Chao Zhao, Ting Liu, Lifang Yu, Fan Yang, Jie Tang, Efficient construction of 3-arylquinolin-4(1H)-ones via in situ Meinwald rearrangement/intramolecular reductive cyclization of 2’-nitrochalcone epoxides, Tetrahedron, 2016, 72(44),7025-7031
7.Shi-Wei Mao, Lin Shuai, Hai-Bing He, Na Pan, Li-Xin Gao, Li-Fang Yu, Jia Li, Jing-Ya Li, Fan Yang, Synthesis and biological evaluation of novel 2,3-pyrazole ring-substituted-4,4-dimethyl lithocholic acid derivatives as selective protein tyrosine phosphatase 1B (PTP1B) inhibitors with cellular efficacy, RSC Adv., 2015, 5, 106551-106560
8.Ben-ren Liao, Hai-bing He, Ling-ling Yang, Li-Xin Gao, Liang Chang, Jie Tang, Jing-Ya Li, Jia Li, Fan Yang, Synthesis and structure-activity relationship of non-phosphorus-based fructose-1,6-bisphosphatase inhibitors: 2,5-diphenyl-1,3,4-oxadiazoles, Eur. J. Med. Chem. 2014, 83, 15-25
9.Libo Ruan,Min Shi,Nian Li, Xu Ding,FanYang,Jie Tang, Practical Approach for Preparation of Unsymmetric Benzils from ?-Ketoaldehydes, Org. Lett., 2014, 16, 733-735
10.Libo Ruan, Min Shi, Shiwei Mao, Lifang Yu, Fan Yang, Jie Tang, An efficient approach to construct 2-arylbenzo[b]furans from 2-methoxychalcone epoxides, Tetrahedron, 2014, 70, 1065-107011.Yantao Qi, XiuhuaWang, Hong Chen, Jie Tang,Fan Yang, Pingang He,Luminescent Multiruthenium Metallocyclodextrins: Synthesis, Fluorescence and Electrochemiluminescence Properties Based on Host-Guest Recognition, Inorganic Chemistry Communications, 2014, 40, 11-1412. JiaJin,YifanShan,FanYang,HuaLai,HongweiTan,XiaofengLiu,JieTang,QiangFang,OrganicphotosensitizerswithN-carboxymethylpyridiniumacceptor/anchoringgroupfordye-sensitizedsolarcells,SyntheticMetals,2012,162,2222-222713.Hai-BingHe,Li-XinGao,Qi-FengDeng,Wei-PingMa,Chun-LanTang,Wen-WeiQiu,JieTang,Jing-YaLi,JiaLi,FanYang,Synthesisandbiologicalevaluationof4,4-dimethyllithocholicacidderivativesasnovelinhibitorsofproteintyrosinephosphatase1B,Bioorg.Med.Chem.Lett.,2012,22,7237-7242,DOI:10.1016/j.bmcl.2012.09.04014.YifanShan,JieTang,HuaLai,HongweiTan,XiaofengLiu,FanYangandQiangFang,Ethoxy-substituted Oligo-phenylenevinylene-Bridged Organic Dyes for Efficient Dye-Sensitized Solar Cells,Chin.J.Chem.2012,30,1497-1503,DOI:10.1002/cjoc.(MostAccessedin7/2012,No1)4.Hai-BingHe,Li-XinGao,Yue-YangZhou,TingLiu,JieTang,Xue-PingGong,Wen-WeiQiu,Jing-YaLi,JiaLi,andFanYang,Design,SynthesisandBiologicalActivityEvaluationof2,5-Diphenyl-1,3,4-oxadiazoleDerivativesasNovelInhibitorsofFructose-1,6-bisphosphatase,Heterocycles,2012,85(11),2693-2712,DOI:10.3987/COM-12-1256515.HuiLi,Jin-PingWang,FanYang,TingLiu,Wen-WeiQiu,Jing-YaLi,JiaLi,andJieTang,Design,synthesisandbiologicalactivityevaluationof2-mercapto-4(3H)-quinazolinonederivativesasnovelinhibitorsofproteintyrosinephosphatase1B,Hetrocycles,2012,85(8),1897-191116.HuiLi,HuiZou,LixinGao,TingLiu,FanYang,JingyaLi,JiaLi,Wen-WeiQiu,andJieTang, Synthesisand biologicalevaluationofoleanolicacidderivativesasnovelinhibitorsofproteintyrosinephosphatase1B,Heterocycles,2012,85(5),1117-113917.XianWu,ZhenxiLi,ZhengfengYang,ChunbingZheng,JiJing,YihuaChen,XiyunYe,XiaoyuanLian,WeiweiQiu,FanYang,JieTang,JianruXiao,MingyaoLiu,JianLuo,CADPEsuppressesRANKL-inducedosteoclastogenesisandpreventsovariectomy-inducedbonelossthroughinhibitionofMAPK/AP-1andCa2+-NFATsignalingpathways,J.BoneMiner.Res.(IF7.1,thebestjournalinBonefield),2012, 27(6), 1298-2308 DOI:10.1002/jbmr.157618.JunXu,ZhenxiLi,JianLuo,FanYang,TingLiu,MingyaoLiu,Wen-WeiQiu,JieTang, SynthesisandBiological EvaluationofHeterocyclicRingsubstitutedBetulinicAcidDerivativesasNovelInhibitorsofOsteoclastDifferentiationandBoneResorption,J.Med.Chem.,2012,55(7),3122-3134,19.HuiLi,QingZhou,PierreAudebert,FabienMiomandre,ClémenceAllain,FanYang,JieTang,Newconductingpolymersfunctionalizedwithredoxactivetetrazines,J.Electroanal.Chem.,2012,668,26-29.20.YifanShan,JieTang,HuaLai,HongweiTan,FanYang,QiangFang,PierreAudebert,AdamPron,Pyridiniumhemicyaninedyeswithcarboxylateanionanchoringgroup：Anovelacceptorinapplicationofdye-sensitizedsolarcells,TetrahedronLett.,2012,53,1341-134421.WanrongLuo,QiuchaoMu,WenweiQiu,TingLiu,FanYang,XiaofengLiu,JieTang,ANovelFriedlander-TypeSynthesisOf3-ArylQuinolinesFrom3-Oxo-2,3-Diaryl-Propionaldehydes,Tetrahedron,2011,67,7090-709523.WanrongLuo,ZhichaoYu,WenweiQiu,FanYang,XiaofengLiu,andJieTang,One-potproductionofchiralα,β-epoxyketonesfrombenzaldehydesandacetophenonesbyrecyclablepoly(aminoacid)catalysis,Tetrahedron,2011,67,5289-529224.Wanghaiming,WangJinping,QiuWenwei,YangFan,LiuXiaofeng,TangJie,Highlyefficientpalladacycle/DihydroimidazoliumchloridesystemfortheSuzuki-Miyauracross-couplingofarylhalides(I,Br,Cl)witharylboronicacids,Chin.J.Chem.,2010,28,2416-242025.XiuhuaWang,HaoFan,FanZhang,YantaoQi,WenweiQiu,FanYang,JieTang,andPingangHe,SynthesisOfAbCyclodextrinDerivateAndItsMolecularRecognitionBehaviorOnModifiedGlassyCarbonElectrodeByDiazotization,Tetrahedron,2010,66,7815-782026.ChunLi,WenweiQiu,ZhengfengYang,JianLuo,FanYang,MingyaoLiu,JuanXie,JieTang,StereoselectivesynthesisofsomemethylsubstitutedsteroidhormonesandtheirinvitrocytotoxicactivityagainsthumangastriccancercelllineMGC-803,Steroids,2010,75(12),859-6927.Wen-WeiQiu,QiangShen,FanYang,BoWang,HuiZou,Jing-YaLi,JiaLi,JieTang,Synthesisandbiologicalevaluationofheterocyclicring-substitutedmaslinicacidderivativesasnovelinhibitorsofproteintyrosinephosphatase1,Bioorganic&MedicinalChemistryLetters2009,19,6618–662228.WenweiQiu,LinmeiHe,QiChen,WanrongLuo,ZhichaoYu,FanYang,JieTang,Imidazolium-ModifiedPoly(L-Leucine)Catalyst:AnEfficientandRecoverableCatalystforJuliá-ColonnaReactions,TetrahedronLett.2009,50(37),5225-522729.BoWang,FanYang,Yi-FanShan,Wen-WeiQiu,JieTang, Highlyefficientsynthesis ofcapsaicinanalogues bycondensationofvanillylamineandacylchloridesinabiphaseH2O/CHCl3system,Tetrahedron,2009,65(27),5409-541230.GONG,Yong-Hua,QIU, WenWei,YANG,Fan,AUDEBERT,Pierre, CLAVIER,Gilles,MIOMANDRE, Fabien, TANG,Jie,PyridiniumConjugatedFerroceneswithThienandBithienBridges: Synthesisand Electrochemical Properties,Chin.J.Chem.2009,27,1515-152231.XiulingXu,WenweiQiu,QingZhou,PierreAudebert,JieTang,FanYang,ZhenrongSun,NonlinearOpticalAbsorptionPropertiesofTwoultisubstitutedp-Dimethylaminophenyl-ethenylPyridiniums,J.Phy.Chem.B,2008,112(16),4913-491732.Yong-HuaGong,PierreAudebert,FanYang,FabienMiomandre,Xiao-ChunLian,JieTang,Newpyridiniumconjugatedferrocenes:Synthesisandelectrochemicalproperties,J.Electroanal.Chem.,2007,606(1),8-1633. FanYang,Lin-MeiHe,HuaYi,GangZou,JieTang,Ming-YuanHe,Anefficientsilica-graftedpoly-(L)-leucinecatalystforasymmetricepoxidationofa,b-unsaturatedketone,J.Mol.Catal.A:Chemical,2007,273(1-2),1-434. FanYang,Xiu-LingXu,Yong-HuaGong,Wen-WeiQiu,Zhen-RongSun,Jin-WeiZhou,PierreAudebert,JieTang,SynthesisandNonlinearOpticalAbsorptionofTwoNewConjugatedFerrocene-Bridge-PyridiniumCompounds,Tetrahedron,2007,63(37),9188-919435.Hai-MingWang,PengCui,GangZou,FanYang,JieTang,Temperature-controlledhighlyselectivedimerizationofa-methylstyrenecatalyzedbyBronstedacidicionicliquidundersolvent-freeconditions,Tetrahedron,2006,62(17),3985-3988

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