李纪文
生命科学学院??????


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个人资料
研究方向
开授课程
科研项目
学术成果
荣誉及奖励







个人资料
部门： 生命科学学院
毕业院校：
学位：
学历：
邮编：
联系电话： **
传真： **
电子邮箱： jiwenster@gmail.com
办公地址： 闵行校区实验B楼513室
通讯地址： 东川路500号实验B楼513室

教育经历

工作经历

个人简介

社会兼职


研究方向
a．研究DNA甲基化、组蛋白修饰和核小体改造对染色质结构和功能的调控；
b．研究组蛋白修饰的独特形式在干细胞更新、细胞分化和肿瘤发生等生理和病理过程中的重要作用。
c．以核激素受体作为模型‚研究基因表达的基本机制；
d．研究MLL诱导急性淋巴细胞白血病的机理。


开授课程


科研项目


学术成果
1. Li‚ J.‚ O’Malley B.W and Wong J. 2000. p300 requires its HAT activity and SRC-1 interaction motif to facilitate TR activation in chromatin. Mol. Cell. Biol. 20: 2031-2042.
2. Li‚ J‚. Wang‚ J; Wang‚ J; Nawaz‚ Z; Liu‚ J.‚ Jun‚ Q.‚ and Wong J. 2000. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. EMBO J. 19(16): 4342-4350.
3. Huang‚ Z.‚ Li‚ J. and Wong J. 2002. Androgen receptor possesses an intrinsic-hormone-independent trans-activation activity. Molecular Endocrinology. 16: 924-937.
4. Li‚ J; Lin‚ Q; Wade‚ P.‚ Wang‚ W and Wong J. 2002. Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression. Genes & Development 16: 687-692.
5. Li‚ J.‚ Lin‚ Q.‚ Yoon‚ H-G.‚ Huang‚ Z.‚ Strahl‚ B.D.‚ Allis‚ C.D.‚ and Wong J. 2002. Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. Mol Cell Biol 22 (16): 5688-5697.
6. Yoon HG‚ Chan DW‚ Huang ZQ‚ Li‚ J‚ Fondell JD‚ Qin J and Wong J. 2003. Purification and Functional Characterization of the Human N-CoR Complex: the Roles of HDAC3 and two WD-40 Repeat Subunits TBL1 and TBLR1. EMBO J 22(6):1336-1346.
7. Lee KC^#‚ Li‚ J^#‚ Cole PA‚ Wong J* and Kraus L*. 2003. Transcriptional activation by thyroid hormone receptor involves chromatin remodeling‚ histone acetylation‚ and cooperative stimulation by p300 and SRC coactivators. Molecular Endocrinology‚ 17(5):908-22. (#equal contribution and co-corresponding authors.)
8. Huang ZQ‚ Li‚ J‚ Sachs LM‚ Cole PA and Wong J. 2003. A Role for Cofactor-Cofactor and Cofactor-Histone Interaction in Targeting of CBP/p300‚ SWI/SNF and Mediator for transcription. EMBO J 22(9):2146-2155.
9. Stewart MD‚ Li J and Wong J. 2005 Relationship between H3 lysine 9 methylation‚ transcription repression and heterochromatin protein 1 recruitment. Mol Cell Biol;25(7):2525-38.
10. Burd CJ‚ Petre CE‚ Morey LM‚ Wang Y‚ Revelo MP‚ Haiman CA‚ Lu S‚ Fenoglio-Preiser CM‚ Li J‚ Knudsen ES‚ Wong J and Knudsen KE. 2006 Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation. Proc Natl Acad Sci U S A; 103:2190-5.
11. Li‚ J.‚ Fu J‚ Toumazou C‚ Yoon HG‚ and Wong J. 2006. A role of the amino-terminal (N) and carboxyl-terminal (C) interaction in binding of androgen receptor to chromatin. Mol Endocrinol 20:776-85.


荣誉及奖励


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