李晓涛
生命科学学院??????


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个人资料
研究方向
开授课程
科研项目
学术成果
荣誉及奖励







个人资料
部门： 生命科学学院
毕业院校：
学位：
学历：
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联系电话：
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电子邮箱： xiaotaol@gmail.com
办公地址： 闵行校区生科大楼435室
通讯地址： 上海市闵行区东川路500号生科大楼435室

教育经历

工作经历

个人简介

社会兼职
ORGANIZATION MEMBERSHIPS
American Society for Endocrinology
American Association for the Advancement of Science


研究方向
主要从事蛋白质代谢与肿瘤发生发展的机制，蛋白质降解的药物的研究。
蛋白质研究是我国中长期科学和技术发展规划（2006-2020）中重大科学研究计划之一。蛋白质降解有关的许多关键问题尚未解决。目前正与美国‚加拿大等国的科学家合作‚展开多层次的研究。我们今后的研究重点包括：REGγ与蛋白质降解原理及调整的基础理论研究：REGγ与恶性肿瘤发生发展机制的研究；REGγ的病理生理学；REGγ相关的抗癌药物探索；脊椎动物中REGγ的生物学作用。


开授课程


科研项目


学术成果
近年来对蛋白质研究领域的贡献：
在REGγ（一种蛋白酶体激活因子）介导的非泛素依赖的蛋白酶体（proteasome）降解通路的研究中首次发现并证实了REGγ蛋白复合体的第一个生物学靶位点‚该发现突破了REGγ仅具有降解短肽链模型底物的禁区‚并提出了REGγ可以直接降解细胞内完整生物蛋白的新理论（Cell JAN.‚2006）。我们的最新研究（Mol.Cell June‚2007）进一步发现了REGγ-蛋白酶体的多种靶蛋白‚而这些蛋白质对细胞周期/肿瘤发生发展的调控起着重要的作用。这些研究结果都进一步揭示了REGγ介导的降解通路的生物学意义。
科研成果:

1. Dong H, Xu J, Li W,Gan J,Lin W,Ke J,Jiang J,Du L,Chen Y,Zhong X,Zhang D,Yeung SJ,Li X,Zhang H, Reciprocal androgen receptor/interleukin-6 crosstalk drives oesophageal carcinoma progression and contributes to patient prognosis,JPathol,2017(影响因子：7.382）
2.Sun J, Luan Y, Xiang D, Tan X, Chen H, Deng Q, Zhang J, Chen M, Huang H, Wang W, Niu T, LiW, Peng H, Li S, Li L, Tang W, Li X, Wu D, Wang P. The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense against Bacterial Pathogens. Cell Rep. 2016 Feb 2;14(4):737-49.（影响因子：7.87）
3.Sun L, Fan G, Shan P, QiuX ,Dong S, Liao L, Yu C, Wang T, Gu X, Li Q, Cao L, Li X, Cui Y, Zhang S, Wang C. Regulation of energy homeostasis by the ubiquitin-independent REGgamma protein. Nature Communications,2016（影响因子：10.015）
4. Wan Z, Jiang D, Chen S, Jiao J, Ji L, Shah AS, Wei H, Yang X, Li X, Wang Y, Xiao J. T-box transcription factor brachyury promotes tumor cell invasion and metastasis in non-small cell lung cancer via upregulation of matrix metalloproteinase 12. Oncol Rep.2016May 9.（影响因子：2.48）
5. Xu J et al The REGγ-proteasome forms a regulatory circuit withI?Bε and NFκB to control progression of inflammatory bowel disorders and associated cancer. Nature Communications 2016 Feb 22;7:10761. （影响因子：10.015）
6. Klionsky DJ et al (over 1000 authors). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy. 2016 Jan 2;12(1):1-222. （影响因子：12.042）
7. Sun J, Luan Y, Xiang D, Tan X, Chen H, Deng Q, Zhang J, Chen M, Huang H, Wang W, Niu T, Li W, Peng H, Li S, Li L, Tang W, Li X, Wu D, Wang P. The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense against Bacterial Pathogens. Cell Rep. 2016 Feb 2;14(4):737-49. （影响因子：8.0）
8. Shi J, Fung G, Deng H, Zhang J, Fiesel FC, Springer W, Li X, Luo H. NBR1is dispensable for PARK2-mediatedmitophagyregardlessof thepresenceorabsenceof SQSTM1. Cell Death Dis. 2015 Oct 29;6:e1943（影响因子：5.37）
9. Fan G, Sun L, Shan P, Zhang X, Huan J, Zhang X, Li D, Wang T, Wei T, Zhang X, Gu X, Yao L, Xuan Y, Hou Z, Cui Y, Cao L, Li X, Zhang S, Wang C. Loss of KLF14 triggers centrosome amplification and tumorigenesis. Nature Communications 2015 Oct 6;6:8450. （影响因子：10.015）
10.Lv Y, Meng B, Dong H, Jing T, Wu N, Yang Y, Huang L, Moses RE, O'Malley BW, Mei B, Li X. Up-regulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice. Neuropsychopharmacology. 2015 Sept 15. （影响因子：7.8）
11.Shuangxi Li, Cong Jiang, Jingjing Pan, Xinbo Wang, Jiali Jin, Linlin Zhao, Weijuan Pan, Guanghong Liao, Xiaopan Cai, Li X, Jianru Xiao, and Ping WangRegulation of c-Myc protein stability by proteasome activator REGγ. Cell Death and Differentiation. 2015 Jun;22(6):1000-11. （影响因子：4.651）
12.Ji L, Xu J, Liu J, Amjad A, Zhang K, Liu Q, Zhou L, Xiao J, Li X. Mutant p53 Promotes Tumor Cell Malignancy by both Positive and Negative Regulation of TGF-beta Pathway. J Biol Chem 2015 May 1;290(18):11729-40. （影响因子：4.651）
13. Yuanyuan Zhang,Shuang Liu, Qiuhong Zuo,Lin Wu,Lei Ji,Wanli Zhai,Jianru Xiao,Jiwu Chen,and Li X.Oxidative challenge enhances REGgamma proteasome dependent protein degradation. Free Radical Biology & Medicine.（影响因子：5.3）
14.Li L, Dang Y, Xiao J, Moses RE, & Li X. (2015). REGgamma is critical for skin carcinogenesis by modulating Wnt/beta-catenin pathway. Nature Communication（影响因子：10.015）
15.Amjad Ali, Pei Zhang, Yao Liangfang, Sun Wenshe, Hao Wang, Xia Lin, Yan Dai, Xin-hua Feng, Robb Moses, Daxin Wang, Li X*, Jianru Xiao. KLF17 empowers TGF-β/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression Cell Death & Disease2015 Mar 12; 6. （影响因子：6.0）
16.Jianping Jin, Weiguo Cao, Carlos Caulin, Robb E. Moses, and Xiaotao Li*Stresses, Aging, and Age-Related Disorders. Oxidative Medicine and Cellular Longevity 2014 Special edition, Vol. 2014 (Article ID 320564). （影响因子：3.2）
17.Liu S, Lai L, Zuo Q, Dai F, Wu L, Wang Y, Liu M, Yi Z, Xiao J, Li X*. PKA turnover by the REGγ-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis. J Mol Cell Cardiol. 2014 Feb 20; 72C: 28-38. （影响因子：5.166）
18.Shi J, Wong J, Piesik P, Fung G, Zhang J, Jagdeo J, Li X, Jan E, Luo H. Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling. Autophagy. 2013 Aug 13;9 (10).（影响因子：12.042）
19.Ali A,Wang Z,Ji L, Liu J, Li L, Yang Y, Wang Y, Zhou L,Guo L, Wang H, Chen J, Caulin C, Myers JN, Fu J, Xiao J, Zhang B, Li X*. WT-p53/TGF-β signaling and mutant-p53 differentially regulates REGγ to target ubiquitin/ATP-independent REGγ-proteasome pathway during cancer progression. Nature Communication 2013 4:2667 （影响因子：10.015）
20.Dong S, Jia C, Zhang S, Fan G, Xiao W, Shan P, Sun L, Li L, Zheng Y, Liu J, Li Y, Wei H, Hu C, Zhang W, Li Q, Liu J, Jia F, Mo Q, Edwards DP, Huang S, Chan L, O'Malley BW, Li X* and Wang C* The REGγ Proteasome Regulates Hepatic Lipid Metabolism through Inhibition of Autophagy. Cell Metabolism 2013 Sep 3;18(3):380-91.（影响因子：17.3）
21.Li L, Zhao D, Wei H, Yao L, Dang Y, Amjad A, Xu J, Liu J, Guo L, Li D, Li Z, Zuo D, Zhang Y, Liu J, Huang S, Jia C, Wang L, Wang Y, Xie Y, Luo J, Zhang B, Luo H, Donehower LA, Moses RE, Xiao J, O'Malley BW, Li X*. REGγ deficiency promotes premature aging via the casein kinase 1 pathway. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11005-10. （影响因子：9.737）
22.Liu J, Wang Y, Li L, Zhou L, Wei H, Zhou Q, Liu J, Wang W, Ji L, Shan P, Wang Y, Yang Y, Jung SY, Zhang P, Wang C, Long W, Zhang B, Li X*. Site-specific acetylation of the proteasome activator REGγ directs its heptameric structure and functions. J Biol Chem. 2013 Jun 7;288(23):16567-78 （影响因子：4.651）
23.Redfern AD, Colley SM, Beveridge DJ, Ikeda N, Epis MR, Li X, Foulds CE, Stuart LM, Barker A, Russell VJ, Ramsay K, Kobelke SJ, Li X, Hatchell EC, Payne C, Giles KM, Messineo A, Gatignol A, Lanz RB, O'Malley BW, Leedman PJ. RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6536-41.（影响因子：9.737）
24.Jing He, Long Cui, Yu Zeng, Guangqiang Wang, Li X*. (2012).REGgamma is associated with multiple oncogenic pathways in human cancers. BMC Cancer. Feb 23; 12(1):75. （影响因子：3.333）
25.Qiao S, Murakami K, Zhao Q, Wang B, Seo H, Yamashita H, Li X, Iwamoto T, Ichihara M, Yoshino M. (2012). Mimosine-Induced Apoptosis in C6 Glioma Cells Requires the Release of Mitochondria-Derived Reactive Oxygen Species and p38, JNK Activation. Neurochem Res. Feb;37(2):417-27. （影响因子：2.125)
26.Shen J, Zhang S, Li Y, Zhang W, Chen J, Zhang M, Wang T, Jiang L, Zou X, Wong J, Li X, Cui Y, Wang C. (2011). p14(ARF) inhibits the functions of adenovirus E1A oncoprotein. Biochem J. Mar 1;434(2):275-85. （影响因子：4.654）
27.Wu Y, Wang L, Zhou P, Wang G, Li X*. (2011). Regulation of REGGAMMA cellular distribution and function by SUMO modification , Cell Research,2011（影响因子：10.526）
28.Gao G, Wong J, Zhang J, Mao I, Shravah J, Wu Y, Xiao A, Li X*, Luo H. (2010). Proteasome Activator REGgamma enhances Coxsackieviral infection via facilitating p53 degradation. J.Virol（影响因子：5.076）
29.Liu J, Yu G., Zhao P., Wang C., Luo H., Long W., Wang Y., Zhao Y., Tsai M., O'Malley B.W. and Li X*. (2010).REGγ modulates p53 activity by regulating its cellular localization. J. Cell Science. 123 (pt23): 4076-84.（影响因子：5.877）
30.Tian M, Xiaoyi W, Li X, Guosheng R. (2009). Proteasomes reactivator REGgamma enchances oncogenicity of MDA-MB-231 cell line via promoting cell proliferation and inhibiting apoptosis. Cell Mol Biol (Noisy-le-grand). 55 Suppl:OL1121-31.（影响因子：0.812）
31.Yu G, Zhao Y, He J, Mukherjee A, Mao CA, Li M, and Li X*. (2008). Comparative analysis of REGγ expression augurs functional implication. J. Mol. Cell. Biol. Aug; 2(4):192-8.（影响因子：7.308）
32.Ivy Mao, Jian Liu, Li X*, Honglin Luo. (2008). REGgamma，a proteasome activiator and beyond? cell and Mol. life SCI,（影响因子：5.615）
33.Li X, Larbi Amazit, Weiweng Long, David M. Lonard, John J. Monaco and O’Malley B.W. (2007). Proteolytic turnover of p21 by the REGgamma-proteasome pathway. Mol. Cell, 26,831-842.（影响因子：15.28）
34.Li X., Lonard D., Jung S.Y., Malovannaya A., Feng Q., Qin J., Tsai S. Y., Tsai M-J., and O’Malley B.W. (2006).The SRC-3/AIB1 coactivator is degraded in an ubiquitin- and ATP-independent manner by the REGgamm-proteasomeCell. 124, 381-392.（影响因子：31.957）
35.Verma S., Ismail A., Gao X., Fu G., Li X., O’Malley B. W., Nawaz Z. (2004).Ubiquitin-conjugating enzyme, UBCH7 act as a coactivator for steroid hormone receptors. Mol. Cell. Biol. 24, 8716-26.（影响因子：5.372）
36.Li X. Lonard D. M. and O’Malley B. W. (2004).A Contemporary Understanding of Progesterone Receptor Function (Review). Mechanisms of Aging and Development. 125, 669-78. （影响因子：3.264）
37.Auboeuf D., Dowhan D.H., Li X., Larkin K., Ko L., Berget S.M., O'Malley B.W. (2004). CoAA, a Nuclear Receptor Coactivator Protein at the Interface of Transcriptional Coactivation and RNA Splicing. Mol. Cell. Biol. 24, 442-53.（影响因子：5.372）
38.Li X. and O'Malley B.W. Unfolding the action of progesterone receptors (minireview). (2003). J. Biol. Chem. 10, 39261-4.（影响因子：4.651）
39.Li X., Wong J., Tsai S.Y., Tsai M.J., and O'Malley B.W. (2003). Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Mol. Cell. Biol. 23, 3763-73. （影响因子：5.372）
40.Li X., Bhattacharya C., Maity S., Dayal S, and Klein W.H. (2002). Ectoderm Gene Activation in Sea Urchin Embryos Mediated by CCAAT Binding Factor CBF. Differentiation. 70, 109-19.（影响因子：2.855）
41.Angerer L.M., Oleksyn D. W., Levine A.M., Li X., Klein W.H. and Angerer R. (2001). Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral embryonic axes. Development. 128, 4393-404.（影响因子：6.208）
42.Yuh C., Li X., Davidson E.H., and Klein W.H. (2001). Correct Expression of Spec2a in the Sea Urchin Embryo Requires Both Otx and Other cis-Regulatory Elements. Dev. Biol. 232, 424-438.（影响因子：3.868）
43.Huang L., Li X., El-Hodiri H.M., Dayal S., Athula H.W., and Klein W.H. (2000). Involvement of Tcf/Lef in Establishing Cell Types along the Animal-Vegetal Axis of Sea Urchins. Dev. Genes Evol. 210, 73-81. （影响因子：1.695）
44.Li X., Athula HW and Klein WH. (1999). Requirement of SpOtx in Cell Fate Decisions in the Sea Urchin Embryo and Possible Roles as a Mediator of beta-Catenin Signaling. Dev. Biol. 212, 425-439.（影响因子：3.868）
45.Klein W.H. and Li X. (1998). Function and Evolution of Otx Proteins. Biochem. Biophys. Res. Commun.258, 22-34.（影响因子：2.406）
46.Li X., Chuang C.K., Mao C.A., Angerer L.M., and Klein WH. (1997). Two Otx proteins generated from alternative splicing of multiple transcripts of a single gene in Strongylocentrotus purppuratus.Dev. Biol. 187, 253-266.（影响因子：3.868）
47.Chuang C.K., Athula H.W., Mao C.A., Li X. and Klein W.H. (1996). Transient Appearance of S. purpuratus Otx in Micromere Nuclei: Cytoplasmic Retention of SpOtx Mediated Through an alpha-Actinin SH3 Domain.Dev. Genetics 19, 231-239
48.Li X., Weinstock G.M. and Murray B.E. (1995).Generation of Auxotrophic mutants of Enterococcus faecalis. J. Bacteriol. 177, 6866-6873.（影响因子：3.194）




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