马欣然 研究员
生命科学学院??????


导航
个人资料
研究方向
开授课程
科研项目
学术成果
荣誉及奖励







个人资料
部门： 生命科学学院
毕业院校：
学位：
学历：
邮编：
联系电话：
传真：
电子邮箱： xrma@bio.ecnu.edu.cn
办公地址： 生命科学学院143室
通讯地址： 上海市闵行区东川路500号华东师范大学闵行校区生命科学学院143室

教育经历
2002-2006 南京大学生命科学学院 生物化学与分子生物学专业 理学学士
2006-2011中国科学院上海生命科学研究院健康科学研究所生物化学与分子生物学硕博连读 理学博士
2011-2016美国国立卫生研究院(NIH)糖尿病，消化病及肾病研究所(NIDDK)博士后


工作经历
2016.11-至今 华东师范大学生命科学学院，上海市调控生物学重点实验室，研究员，生物化学与分子生物学学科副主任

个人简介
2006年本科毕业于南京大学，2011年博士毕业于中科院上海生命科学研究院，并赴美国NIH, NIDDK进行博士后研究。2016年起任华东师范大学生命科学学院研究员，入选国家自然科学基金委“优青”、上海市高校****“****”、上海市“浦江人才计划”、上海市“青年拔尖人才”、华东师范大学“紫江优秀青年****”。在Cell Metabolism, PNAS，Hepatology, Journal of Hepatology等国际著名学术期刊发表文章二十余篇，获得科技部、基金委、上海市科委和教委等多项基金资助。


社会兼职
中国生物物理学会代谢生物学分会秘书
中国中药协会微循环用药专业委员会委员
上海市生物化学与分子生物学学会理事



研究方向
长期围绕脂肪和肝脏中脂质代谢调控分子，深入研究代谢组织脂质合成和消耗的平衡机制。
(1) 研究应激感应分子在肥胖和衰老过程中调控脂肪组织产热和能量代谢的作用和机制；
(2) 鉴定并系统解析关键脂质调控分子在转录/表观遗传调控层面对脂质代谢稳态的维持机制，以及对肥胖和脂肪肝发生发展的影响。



开授课程


科研项目
国家自然科学基金优秀青年基金项目
国家自然科学基金面上项目
科技部国家重点研发计划-重大慢性非传染性疾病防控研究重点专项-糖尿病及代谢疾病防控技术研究子课题
上海市高校****“****”
上海市“浦江人才”
上海市“青年拔尖人才”
华东师范大学“紫江优秀青年****”
华东师范大学科研创新基金青年教师科研能力提升项目
上海市调控生物学重点实验室开放研究课题基金



学术成果
1. Qiu J*, Zhang Z*, Wang S*, Chen Y*, Liu C, Xu S, Wang D, Su J, Ni M, Yu J, Cui X, Ma L, Hu T, Hu Y, Gu X#, Ma X#, Wang J#, Xu L#. Transferrin Receptor Functionally Marks Thermogenic Adipocytes. Front Cell Dev Biol. 2020 Nov 5;8:572459.
2. Xu L*, Ma X*, Verma N, Perie L, Pendse J, Shamloo S, Marie Josephson A, Wang D, Qiu J, Guo M, Ping X, Allen M, Noguchi A, Springer D, Shen F, Liu C, Zhang S, Li L, Li J, Xiao J, Lu J, Du Z, Luo J, Aleman JO, Leucht P, Mueller E. PPARγ agonists delay age-associated metabolic disease and extend longevity. Aging Cell. 2020 Nov;19(11):e13267.
3. Guo M*, Qiu J*, Shen F*, Wang S, Yu J, Zuo H, Yao J, Xu S, Hu T, Wang D, Zhao Y, Hu Y, Shen F, Ma X#, Lu J#, Gu X#, Xu L#. Comprehensive analysis of circular RNA profiles in skeletal muscles of aging mice and after aerobic exercise intervention. Aging (Albany NY). 2020 Mar 17;12. doi: 10.18632/aging.102932.
4. Zhou B*, Liu C*, Xu L*, Yuan Y, Zhao J, Zhao W, Chen Y, Qiu J, Meng M, Zheng Y, Wang D, Gao X, Li X, Zhao Q, Wei X, Wu D, Zhang H, Hu C, Zhuo X, Zheng M, Wang H#, Lu Y#, Ma X#. N6-methyladenosine Reader Protein Ythdc2 Suppresses Liver Steatosis via Regulation of mRNA Stability of Lipogenic Genes. Hepatology.2020 Mar 9. doi: 10.1002/hep.31220.
5. Perie L, Verma N, Xu L, Ma X, Mueller E. Transcriptional Regulation of ZNF638 in Thermogenic Cells by the cAMP Response Element Binding Protein in Male Mice. J Endocr Soc.2019 Oct 3;3(12):2326-2340. doi: 10.1210/js.2019-00238.
6. Wang D*, Cheng X*, Li Y, Guo M, Zhao W, Qiu J, Zheng Y, Meng M, Ping X, Chen X, Wang S, Luo J, Luo Q, Ma X#, Xu L#. C/EBPδ-Slug-Lox1 axis promotes metastasis of lung adenocarcinoma via oxLDL uptake. Oncogene. 2020 Jan;39(4):833-848. doi: 10.1038/s41388-019-1015-z.
7. Ma X, Feng D, Lu Y, Sun N, Wang J, Xu L. Editorial: Novel Strategies Targeting Obesity and Metabolic Diseases. Front Physiol.2019 May 29;10:668. doi: 10.3389/fphys.2019.00668.
8. Yue L*，Zhao W*, Wang D*, Meng M, Zheng Y, Li Y, Qiu J, Yu J, Yan Y, Lu P, Sun Y, Fu J, Wang J, Zhang Q, Xu L#, Ma X#, Silver nanoparticles inhibit beige fat function and promote adiposity. Mol Metab.2019; Accepted
9. Ma X, Wang D, Zhao W, Xu L. Deciphering the Roles of PPARγ in Adipocytes via Dynamic Change of Transcription Complex. Front. Endocrinol 2018; 9:473.
10. Xu L, Zhao W, Wang D, Ma X^#. Chinese Medicine in the Battleagainst Obesity and Metabolic Diseases.Front Physiol 2018; 9:850.
11.Xu L*, Ma X*, Verma NK, Wang D, Gavrilova O, Proia RL, Finkel T, Mueller E. Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline.Aging Cell2018; 17.
12. Alexaki A, Clarke BA, Gavrilova O, Ma Y, Zhu H, Ma X, Xu L, Tuymetova G, Larman BC, Allende ML, Dunn TM, Proia RL. De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. J Biol Chem2017; 292:3929-3939.
13.Ma X*, Xu L*, Muller E. Forkhead box A3 Mediates Glucocorticoid Receptor Function in Adipose Tissue. Proc Natl Acad Sci USA 2016; 113:3377-3382.
14. Xu L*, Ma X*, Bagattin A, Mueller E. The transcriptional coactivator PGC1α protects against hyperthermic stress via cooperation with the heat shock factor HSF1. Cell Death & Disease2016; 7:e2102.
15. Ma X, Xu L, Mueller E. Calorie hoarding and thrifting: Foxa3 finds a way. Adipocyte 2015; 4:325-328.
16. Ma X*, Xu L*, Alberobello AT, Gavrilova O, Bagattin A, Skarulis M, Liu J, Finkel T, Mueller E. Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis. Cell Metab.2015; 22:695-708.
17. Adler-WailesDC, AlberobelloAT, Ma X, Hugendubler L, SternEA,Mou ZY,HanJC, Kim PW, Sumner AE, Yanovski JA, Mueller E. Analysis of Variants and Mutations in the Human Winged Helix FOXA3 Gene and Associations with Metabolic Traits. Int J Obes (Lond)2015; 39:888-892.
18. Ma X*, Xu L*, Gavrilova O, Mueller E. Role of forkhead box protein A3 inage-associated metabolic decline. Proc Natl Acad Sci USA2014; 111:14289-14294.
19. Du C, Ma X, Meruvu S, Hugendubler L, Mueller E. The adipogenic transcriptional cofactor ZNF638 interacts with splicing regulators and influences alternative splicing. J Lipid Res2014; 55:1886-1896.
20. Xu L*, Panel V*, Ma X*, Du C, Hugendubler L, Gavrilova O, Liu A, McLaughlin T, Kaestner KH, Mueller E. The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion. Mol Cell Biol2013; 33:3392-3399.
21. Qi Y, Li X, Ma X, Xu L, Zhang X, Jiang X, Hong J, Cui B, Ning G, Wang S. The role of osteopontin in the induction of the CD40 ligand in Graves' disease. Clin Endocrinol (Oxf)2014; 80:128-134.
22. Li X*, Qi Y*, Ma X*, Huang F, Guo H, Jiang X, Hong J, Lin D, Cui B, Ning G, Xu L, Wang S. Chemokine (C-C motif) ligand 20, a potential biomarker for Graves' disease, is regulated by osteopontin. PLoS One2013; 8:e64277.
23. Liu R*, Ma X*, Xu L*, Wang D, Jiang X, Zhu W, Cui B, Ning G, Lin D, Wang S. Differential MicroRNA Expression in Peripheral Blood Mononuclear Cells from Graves' Disease Patients. J Clin Endocrinol Metab2012; 97:E968-E972.
24. Xu L*, Ma X*, Wang Y*, Li X, Qi Y, Cui B, Li X, Ning G, Wang S. The expression and pathophysiological role of osteopontin in Graves' disease. J Clin Endocrinol Metab2011; 96:E1866-E1870.
25. Ma X*, Xu L*, Wang S, Cui B, Li X, Xu J, Ning G. Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis. J Hepatol2011; 55:445-452.
26. Xu L*, Ma X*, Cui B, Li X, Ning G, Wang S. Selection of reference genes for qRT-PCR in high fat diet-induced hepatic steatosis mice model. Mol Biotechnol2011; 48:255-262.
27. Xu L*, Ma X*, Li JL, Li X, Xu J, Ning G, Wang S. SRC-3 deficient mice developed fat redistribution under high fat diet. Endocrine2010; 38:60-66.
28. Xu L*, Ma X*, Li JL, Li X, Xu J, Ning G, Wang S. Ablation of steroid receptor coactivator-3 inmice impairs adipogenesis and enhances energy expenditure. Front Med China2010; 4: 229-234.
29. Ma X*, Xu L*, Wang S, Chen H, Xu J, Li X, Ning G. Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. Lab Invest2009; 89: 903-914.
*共同第一作者#通讯作者




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