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西华大学食品与生物工程学院导师教师师资介绍简介-余孝其

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余孝其
性别:男
学院:理学院
职称:教授
学位:博士
学历:
毕业院校:四川大学
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个人简介
教授,博士生导师,教育部********,国家****基金获得者,教育部新世纪优秀人才,新世纪百千****才工程国家级人选,享受国务院特殊津贴专家,四川省学术与技术带头人。现任中国化学会理事,中国化学会化学生物学专业委员会委员,中国化学会超分子化学专业委员会委员,四川省化学化工学会副理事长,西华大学党委常委、副校长。主要从事生物荧光探针、生物医学材料化学等领域的研究。共出版专著1部(Macrocyclic Polyamines: Synthesis and Applications, Published 2017 by Wiley-VCH)、参编教材和专著6章/节;发表SCI收录论文360余篇;获授权专利12项;获教育部自然科学一等奖1项,四川省科技进步奖二等奖2项、三等奖1项,四川省教学成果一等奖1项、二等奖1项。




工作经历
1993.04-1994.10四川大学化学系讲师;1994.10-1996.11四川联合大学化学系副教授;1996.11-1998.07四川联合大学化学系副教授、系副主任;1998.04-2001.03香港大学化学系Research Assistant和Research Associate;1999.07-2005.07四川大学化学学院教授;2005.07-2010.12四川大学教授、科技处副处长;2010.12-2017.06四川大学教授、化学学院院长;2017.06-2018.08四川大学教授、党委组织部部长;2018.08起任西华大学党委常委、副校长。




教育经历
1983.09-1987.07 四川大学化学系读本科;1987.09-1993.03 四川大学化学系有机化学专业硕、博连读研究生。




研究方向
主要从事生物荧光探针、生物医学材料化学、活性分子合成等领域的研究





学术成果
一、科研项目
1.国家基础科学人才培养基金(J**),四川大学放射化学特殊学科点项目,项目负责人,2013.01~2015.12,经费:300万元。
2. 教育部高等学校博士点专项科研基金优先资助领域项目(006),纳米金负载多胺或大环多胺基因转染载体的研究,项目负责人,2013.1~2015.12,经费:40万元。
3. 973课题(2012CB720603),基于核酸的重大疾病诊断新策略和新技术研究,四川大学项目负责人,2012.01~2015.12,经费:50万元。
4. 国家自然科学基金创新研究群体项目(**),目标导向的有机合成和新反应,研究骨干,2014.01~2016.12,经费:600万元。
5. 国家自然科学基金重点项目(**),生物大分子特异识别与调控的有机小分子研究,项目负责人,2013.01~2017.12,经费:300万元。
6. 973课题(2013CB328900),微波加热工艺物料机理与多物理场协同计算,四川大学项目负责人,2013.01-2017.12,经费:180万元。
7. 教育部基础学科拔尖学生培养试验计划研究重点项目,以科研为依托的化学类本科拔尖创新人才培养模式探索与实践,项目负责人,2016.01~2018.12,经费:18万元。
8. 国家自然科学基金面上项目(**),多肽修饰聚乙烯亚胺基因载体的研究,项目负责人,2015.01~2018.12,经费:90万元。
9. 国家自然科学基金面上项目(**),ROS响应的siRNA自递送系统的构建及应用,项目负责人,2019.01~2022.12,直接经费:67万元。
二、获奖情况
1. 化学类拔尖人才国际化培养模式的探索与实践,第八届高等教育四川省教学成果二等奖,2017. 12
2.基于科研引导的研究型大学化学本科创新人才培养体系与实践,第七届高等教育四川省教学成果一等奖,2013. 12
3. 天然药物有效成分分离、类似物合成及药效和临床应用研究,四川省科技进步二等奖,2012.08
4. 简单金属盐催化的C-C键和C-N键形成反应,教育部高等学校科学研究优秀成果奖自然科学一等奖,2010.11
5. 金属胶束模拟水解金属酶的研究,四川省科技进步二等奖,2006.07
6. 生物功能体系的分子模拟,四川省科技进步三等奖,2001.07
三、编撰书目
1. Xiaoqi Yu,Ji Zhang,《Macrocyclic Polyamines: Synthesis and Applications》,Wiley-VCH,2017.12, ISBN: 978-3-527-34187-0
四、授权发明专利
1. 环氧化合物与阳离子聚合物及它们的制备方法, 授权专利号:ZL2012 1 **.5, 第一发明人
2. 固定化土曲霉脂肪酶的制备方法及其应用, 授权专利号:ZL2013 1 **.X, 第一发明人
3. 取代的水杨醛-TCF衍生物及其制备方法和用途, 授权专利号:ZL2014 1 **.3,第一发明人
4. 取代的香豆素-吡啶衍生物及其制备方法和用途, 授权专利号:ZL0.2, 第一发明人
5. 环氧化合物与阳离子聚合物及它们的制备方法,授权专利号:ZL2012 1 **.5,第一发明人
6. 固定化土曲霉脂肪酶的制备方法及其应用,授权专利号:ZL2013 1 **.X,第一发明人
7. 取代的水杨醛-TCF衍生物及其制备方法和用途, 授权专利号:ZL2014 1 **.3,第一发明人
8. 取代的香豆素-吡啶衍生物及其制备方法和用途,授权专利号:ZL0.2,第一发明人
9. 取代的香豆素-噻唑橙衍生物及其制备方法和用途,授权专利号:ZL 4.8,第一发明人
10. 取代的咔唑-吲哚磺酸盐衍生物及其制备方法和用途,授权专利号:ZL 2.X,第一发明人
五、近五年发表的论文

1. Li, K., Li, L.-L., Zhou, Q., Yu, K.-K., Kim, J. S., Yu, X.-Q.*,Reaction-based fluorescent probes for SO2derivatives and their biological applications, Coordin. Chem. Rev.2019, 388, 310-333.
2. He, X., Chen, P., Zhang, J., Luo, T.-Y., Wang, H.-J., Liu, Y.-H., Yu, X.-Q.*,Cationic Polymer-Derived Carbon Dots for Enhanced Gene Delivery and Cell Imaging, Biomater. Sci.2019, 7, 1940-1948.
3. Li, L.-L., Xu, H.-R., Li, K., Yang, Q., Pan, S.-L., Yu, X.-Q.*,Mitochondrial G-quadruplex targeting probe with near-infrared fluorescence emission, Sensor. Actuat. B: Chem.2019, 286, 575-582.
4. Jiang, L., Tian, J., Zhao, F., Yu, S.-S., Shi, D., Wang, X.-J., Yu, X.-Q.*, Pu, L., Fluorescent Recognition of Functional Secondary Amines in the Fluorous Phase, Eur. J. Org. Chem.2019, 14, 2533-2538.
5. Gu, B., Hu, Z.-E., Yang, Z.-J., Li, J., Zhou, Z.-W., Wang, N., Yu, X.-Q.*,Probing the Mechanism of CAL-B-Catalyzed aza-Michael Addition of Aniline Compounds with Acrylates Using Mutation and Molecular Docking Simulations, ChemistrySelect2019, 4, 3848-3854.
6. Feng, M.-L., Li, S.-Q., He, H.-Z., Xi, L.-Y., Chen, S.-Y., Yu, X.-Q.*,Electrochemically initiated intermolecular C–N formation/cyclization of ketones with 2-aminopyridines: an efficient method for the synthesis of imidazo[1,2-a]pyridines, Green Chem.2019, 21, 1619-1624.
7. Yang, X.-L., Xing, X., Li, J., Liu, Y.-H., Wang, N., Yu, X.-Q.*,Enzymatic synthesis of selenium-containing amphiphilic aliphatic polycarbonate as an oxidation-responsive drug delivery vehicle, RSC Adv.2019, 9, 6003-6010.
8. Li, L.-L., He, P.-Y., Shi, L., Pan, S.-L., Li, M.-Y., Zhou, Q., Zhang, H., Wang, N., Li, K., Yu, X.-Q.*,A near-infrared water-soluble fluorescent probe for the detection of biothiols in living cells and Escherichia coli, Anal. Methods2019, 11, 821-826.
9. He, W.-X., Xing, X., Yang, Z.-J., Yu, Y., Wang, N., Yu, X.-Q.*,Biocatalytic One-Pot Three-Component Synthesis of Indoloquinolizines with High Diastereoselectivity, Catal. Lett.2019, 149, 638-643.
10. Xing, X., Jia, J.-Q., Zhang, J.-F., Zhou, Z.-W., Li, J., Wang, N., Yu, X.-Q.*,CALB Immobilized onto Magnetic Nanoparticles for Efficient Kinetic Resolution of Racemic Secondary Alcohols: Long-Term Stability and Reusability, Molecules2019, 24, 490.
11. Wang, N., Chen, X.-C., Ding, R.-L., Yang, X.-L., Li, J., Yu, X.-Q.*, Li, K., Wei, X. Synthesis of high drug loading, reactive oxygen species and esterase dual-responsive polymeric micelles for drug delivery, RSC Adv. 2019, 9, 2371-2378.
12. Yu, Q.-Y., Guo, Y., Zhang, J., Huang, Z., Yu, X.-Q.*,Zn(II) coordination to cyclen-based polycations for enhanced gene delivery, J. Mater. Chem. B2019, 7, 451-459.
13. Xiao, Y.-P., Zhang, J., Liu, Y.-H., Zhang, J.-H., Yu, Q.-Y., Huang, Z., Yu, X.-Q.*,Low molecular weight PEI-based fluorinated polymers for efficient gene delivery, Eur. J. Med. Chem.2019, 162, 602-611.
14. Qin, H.-H., Li, L.-L., Li, K., Yu, X.-Q.*,Novel strategy of constructing fluorescent probe for MAO-B via cascade reaction and its application in imaging MAO-B in human astrocyte, Chin. Chem. Lett.2019, 30, 71-74.
15. Shi, L., Li, K., Li, L.-L., Chen, S.-Y., Li, M.-Y., Zhou, Q., Wang, N., Yu, X.-Q.*,Novel easily available purine-based AIEgens with colour tunability and applications in lipid droplet imaging,Chem. Sci. 2018, 9, 8969-8974.
16. Zhou, Q., Li, K., Liu, Y.-H., Li, L.-L., Yu, K.-K., Zhang, H., Yu, X.-Q.*,Fluorescent Wittig reagent as a novel ratiometric probe for the quantification of 5-formyluracil and its application in cell imaging,Chem. Commun. 2018, 54, 13722-13725.
17. Li, J., Yang, X.-L., Liu, Y.-H., Wu, W.-X., Liu, B.-Y., Wang, N., Yu, X.-Q.*, Chemoenzymatic synthesis of dual-responsive graft copolymers for drug delivery: long-term stability, high loading and cell selectivity,J. Mater. Chem. B 2018, 6, 6993-7003.
18. Zhang, J.-H., Yang, H.-Z., Zhang, J., Liu, Y.-H., He, X., Xiao, Y.-P., Yu, X.-Q.*,Biodegradable Gene Carriers Containing Rigid Aromatic Linkage with Enhanced DNA Binding and Cell Uptake, Polymers2018, 10, 1080.
19. Xun, M.-M., Huang, Z., Xiao, Y.-P., Liu, Y.-H., Zhang, J., Zhang, J.-H., Yu, X.-Q.*,Synthesis and Properties of Low-Molecular-Weight PEI-Based Lipopolymers for Delivery of DNA, Polymers2018, 10, 1060.
20. Iqbah, S., Yu, S., Zhao, F., Wang, Y., Tian, J., Jiang, L., Du, Y., Yu, X.-Q.*, Pu, L. Discriminating three biothiols by using one fluorescent probe, Tetrahedron Lett.2018, 59, 3397-3400.
21. Zhang, Y.-M, Huang, Z., Wu, X.-R., Zhang, J., Liu, Y.-H., Yu, X.-Q.*,A small combinatorial library of lipidoids as gene delivery vectors, ACS Appl. Nano Mater.2018, 1, 3925-3934.
22. Shi, L., Li, K., Cui, P.-C., Li, L.-L., Pan, S.-L., Li, M.-Y., Yu, X.-Q.*,BINOL Derivatives with Aggression-induced Emission,J. Mater. Chem. B 2018, 6, 4413-4416.
23. Wang, X.-J., Shi, D., Xu, Y., Yu, S., Zhao, F., Wang, Y., Hu, L., Tian, J., Yu, X.-Q.*, Pu, L. Reaction of Zn(II) with a BINOL-amino-acid Schiff base: An unusual off-on-off fluorescence response,Tetrahedron Lett. 2018, 59, 2332-2334.
24. Li, M.-Y., Cui, P., Li, K., Feng, J., Zou, M., Yu, X.-Q.*,Dual-site fluorescent probe for highly selective and sensitive detection of sulfite and biothiols,Chin. Chem. Lett. 2018, 29, 992-994.
25. Pan, S.-L., Li, K., Li, L.-L., Li, M.-Y., Shi, L., Liu, Y.-H., Yu, X.-Q.*,A reaction-based ratiometric fluorescent sensor for the detection of Hg(II) ions in both cells and bacteria,Chem. Commun. 2018, 54, 4955-4958.
26. Li, L.-L., Li, K., Li, M.-Y., Shi, L., Liu, Y.-H., Zhang, H., Pan, S.-L., Wang, N., Zhou, Q., Yu, X.-Q.*,BODIPY-Based Two-Photon Fluorescent Probe for Real-Time Monitoring of Lysosomal Viscosity with Fluorescence Lifetime Imaging Microscopy, Anal. Chem. 2018, 90, 5873-5878.
27. Wang, B., Zhang, J., Liu, Y.-H., Zhang, W., Xiao, Y.-P., Zhao, R.-M., Yu, X.-Q.*,A reduction-responsive liposomal nanocarrier with self-reporting ability for efficient gene delivery, J. Mater. Chem. B 2018, 6, 2860-2868.
28. Hu, L.-L., Wang, Y., Duan, P., Du, Y., Tian, J., Shi, D., Wang, X.-J., Yu, S., Yu, X.-Q.*, Pu, L., Fluorescent Discrimination of Primary Alkyl Amines by Using a Binaphthyl Ladder Polymer, Eur. J. Org. Chem. 2018, 16, 1896-1901.
29. Zhao, F., Du, Y., Tian, J., Shi, D., Wang, Y., Hu, L., Yu, S., Yu, X.-Q.*, Pu, L., Enantioselective Fluorescent Recognition of Amino Acids in Aqueous Solution by Using a Chiral Aldehyde Probe, Eur. J. Org. Chem. 2018, 16, 1891-1895.
30. Zhang, W., Wang, N., Yu, Y., Shan, Y.-M., Wang, B., Pu, X.-M., Yu, X.-Q.*,Synthetic Regulation of 1,4-Dihydropyridines for the AIE or AIEE Effect: From Rational Design to Mechanistic Views, Chem. Eur. J. 2018, 24, 4871-4878.
31. Shi, D., Wang, X.-J., Yu, S.-S., Zhao, F., Wang, Y.-C., Tian, J., Hu, L.-L, Yu, X.-Q.*, Pu, L., Fluorescent Recognition of 1,3-Diaminopropane in the Fluorous Phase – Greatly Enhanced Sensitivity and Selectivity, Eur. J. Org. Chem. 2018, 8, 1053-1059.
32. Luo, T.-Y., He, X., Zhang, J., Chen, P., Liu, Y.-H., Wang, H.-J., Yu, X.-Q.*,Photoluminescent F-doped Carbon Dots Prepared by Ring-Opening Reaction for Gene Delivery and Cell Imaging, RSC Adv. 2018, 8, 6053-6062.
33. Huang, Z., Zhao, D.-M., Deng, X., Zhang, J., Zhang, Y.-M., Yu, X.-Q.*,Functionalized asymmetric bola-type amphiphiles for efficient gene and drug delivery, Nanomaterials 2018, 8, 115.
34. Xiao, Y.-P., Zhang, J., Liu, Y.-H., Chen, X.-C., Yu, Q.-Y., Luan, C.-R., Zhang, J.-H., Wei, X., Yu, X.-Q.*,Ring-opening polymerization of diepoxides as an alternative method to overcome PEG dilemma in gene delivery, Polymer 2018, 134, 53-62.
35. Wang, B., Chen, P., Zhang, J., Liu, Y.-H., Huang, Z., Yu, Q.-Y., Zhang, J.-H., Zhang, W., Yu, X.-Q.*, Self-assembled core-shell-corona multifunctional AIE non-viral vector for efficient hepatocytes targeting gene delivery, Polymer Chem. 2017, 8, 7486-7498.
36. Wang, Y.-C., Hu, L.-L., Zhao, F., Yu, S.-S., Tian, J., Shi, D., Wang, X.-J., Yu, X.-Q.*, Pu, L., Polymer Amplified Enantioselectivity in the Fluorescent Recognition of Prolinol, Chem. Eur. J. 2017, 23, 17678-17681.
37. Xiao, Y.-P., Zhang, J., Liu, Y.-H., Huang, Z., Wang, B., Zhang, Y.-M., Yu, X.-Q.*, Cross-linked polymers with fluorinated bridge for efficient gene delivery, J. Mater. Chem. B 2017, 5, 8542-8553.
38. Liu, B.-Y., Wu, W.-X., Liu, Y.-H., Jia, C., Yang, X.-L., Li, J., Wang, N., Yu, X.-Q.*, Water-soluble mitochondria-targeting polymeric prodrug micelles for fluorescence monitoring and high intracellular anticancer efficiency, Polym. Chem. 2017, 8, 5982-5987.
39. Zhang, W., Wang, N., Yang, Z.-J., Li, Y.-R., Yu, Y., Pu, X.-M., Yu, X.-Q.*, Lipase-Initiated Tandem Biginelli Reactions via in situ-Formed Acetaldehydes in One Pot: Discovery of Single-Ring Deep Blue Luminogens, Adv. Synth. Catal. 2017, 359, 3397-3406.
40. Xu, Y.-M., Shi, D., Wang, X.-J., Yu, S.-S., Yu, X.-Q.*, Pu, L., Development of Aldehyde-Based Fluorescent Probes for Highly Selective Recognition of 1,3-Diaminopropane, Eur. J. Org. Chem. 2017, 33, 4990-4994.
41. Yu, Q.-Y., Zhan, Y.-R., Zhang, J., Luan, C.-R., Wang, B., Yu, X.-Q.*, Aromatic modification of low molecular weight PEI for enhanced gene delivery, Polymers 2017, 9, 362.
42. Wang, B., Zhao, R.-M., Zhang, J., Liu, Y.-H., Huang, Z., Yu, Q.-Y., Yu, X.-Q.*, Rigid aromatic linking moiety in cationic lipids for enhanced gene transfection efficiency, Eur. J. Med. Chem. 2017, 136, 585-595.
43. Hu, L.-L., Yu, S.-S., Wang, Y.-C., Yu, X.-Q.*, Pu, L., Enhanced Fluorescence of 3,3′-Diformyl BINOL by Functional Secondary Amines, Org. Lett. 2017, 19, 3779-3782.
44. Yang, J., Li, K., Hou, J.-T., Lu, C.-Y., Li, L.-L., Yu, K.-K., Yu, X.-Q.*, A novel coumarin-based water-soluble fluorescent probe for endogenously generated SO2in living cells, Sci. China Chem. 2017, 60, 793-798.
45. Feng, M.-L., Xi, L.-Y., Chen, S.-Y., Yu, X.-Q.*, Electrooxidative Metal-Free Dehydrogenative α-Sulfonylation of 1H-Indole with Sodium Sulfinates, Eur. J. Org. Chem. 2017, 19, 2746-2750.
46. Li, K., Hou, J.-T., Yang, J., Yu, X.-Q.*, A tumor-specific and mitochondria-targeted fluorescent probe for real-time sensing of hypochlorite in living cells, Chem. Commun. 2017, 53,5539-5541.
47. Wang, H.-J., He, X., Luo, T.-Y., Zhang, J., Liu, Y.-H., Yu, X.-Q.*, Amphiphilic carbon dots as versatile vector for nucleic acid and drug delivery, Nanoscale. 2017, 9, 5935-5947.
48. Jiang, C., Li, L.-L., Yu, X.-Q.*, A pyrene-based fast-responsive fluorescent probe for G-quadruplexes, Anal. Methods 2017, 9, 2397-2400.
49. Chen, L.-M., Yu, S.-S., Xiao, M., Huang, Z., Wen, K.-L., Xu, Y.-M., Zhao, F., Yu, X.-Q.*, Pu, L., Recognition of Chiral Amines by a Terpyridine–ZnII-Complex-Based Circular-Dichroism Sensor, Eur. J. Org. Chem. 2017, 16, 2338-2343.
50. Hou, J.-T., Ren, W. X., Li, K., Seo, J., Sharma, A., Yu, X.-Q.*, Kim, J. S., Fluorescent bioimaging of pH: from design to applications, Chem. Soc. Rev. 2017, 46, 2076-2090.
51. Chang, D.-C., Zhang, Y.-M, Zhang, J., Liu, Y.-H., Yu, X.-Q.*, Cationic lipids with cyclen headgroup: Synthesis and structure-activity relationship studies as non-viral gene vectors, RSC Adv. 2017, 7, 18681-18689.
52. Zhang, Y.-M, Huang, Z., Zhang, J., Wu, W.-X., Liu, Y.-H., Yu, X.-Q.*, Amphiphilic polymers from ring-opening polymerization: a strategy for the enhancement of gene delivery, Biomater. Sci. 2017, 5, 718-729.
53. Wang, S., Chen, S.-Y., Yu, X.-Q.*, C–H functionalization by high-valent Cp*Co(III) catalysis, Chem. Commun.2017, 53, 3165-3180.
54. Xiao, M., Yu, S., Chen, L., Huang, Z., Wen, K., Xu, Y., Zhao, F., Yu, X.-Q.*, Pu, L. Fluorous-Phase-Based Chiral Assay with Circular Dichroism Spectroscopy, Eur. J. Org. Chem.2017, 11, 1413-1417.
55. Jia, J.-Q., Zhang, W.-W., Yang, Z.-J., Yang, X.-L., Wang, N., Yu, X.-Q.*, Novel Magnetic Cross-Linked Cellulase Aggregates with a Potential Application in Lignocellulosic Biomass Bioconversion, Molecules2017, 22, 269.
56. Wang, H.-J.,Zhang, J., Liu, Y.-H., Luo, T.-Y., He, X., Yu, X.-Q.*, Hyaluronic acid based carbon dots for efficient gene delivery and cell imaging, RSC Adv.2017, 7, 15613-15624.
57. Zhang, W., Wang, N., Liu, Y.-H., Jiao, S.-Y., Zhang, W.-W., Pu, X.-M., Yu, X.-Q.*, 1,4-Dihydropyridines: discovery of minimal AIEEgens and their mitochondrial imaging applications, J. Mater. Chem. B2017, 5, 464-469.
58. 李玲玲, 吴明雨, 张宏, 李坤*, 余孝其*,溶酶体靶向的生物硫醇荧光探针的合成及应用研究,Sci Sin Chim, 2017, 47, doi: 10.1360/N032017-00059。
59. 刘艳红,李静,张骥,余孝其*,李坤,阳离子脂质体介导基因转染的实验教学改革,实验科学与技术,2017,15(3),103-106。
60. Luan, C.-R., Liu, Y.-H., Zhang, J.*, Yu, Q.-Y., Huang, Z., Wang, B., Yu, X.-Q.*, Low Molecular Weight Oligomers with Aromatic Backbone as Efficient Nonviral Gene Vectors, ACS Appl. Mater. Interfaces, 2016, 8, 10743?10751.
61. Yu, K.-K., Li, K.*, Qin, H.-H., Zhou, Q., Qian, C.-H., Liu, Y.-H., Yu, X.-Q.*, Construction of pH-Sensitive “Submarine” Based on Gold Nanoparticles with Double Insurance for Intracellular pH Mapping, Quantifying of Whole Cells and in Vivo Applications, ACS Appl. Mater. Interfaces, 2016, 8, 22839?22848.
62. Yang, J., Li, K.*, Hou, J.-T., Li, L.-L., Lu, C.-Y., Xie, Y.-M., Wang, X., Yu, X.-Q.*, Novel Tumor-Specific and Mitochondria-Targeted near-Infrared-Emission Fluorescent Probe for SO2Derivatives in Living Cells, ACS Sens., 2016, 1, 166?172.
63. Xi, L.-Y., Zhang, R.-Y., Shi, L., Chen, S.-Y.*, Yu, X.-Q.*, Iodine-mediated synthesis of 3-acylbenzothiadiazine 1,1-dioxides, Beilstein J. Org. Chem., 2016, 12, 1072–1078.
64. Liu, Y., Li, K.*, Xie, K.-X., Li, L.-L., Yu, K.-K., Wang, X., Yu, X.-Q.*, A water-soluble and fast-response mitochondriatargeted fluorescent probe for colorimetric and ratiometric sensing of endogenously generated SO2derivatives in living cells, Chem. Commun., 2016, 52, 3430—3433.
65. Wang, S., Hou, J.-T., Feng, M.-L., Zhang, X.-Z., Chen, S.-Y.*, Yu, X.-Q.*, Cobalt(III)-catalyzed alkenylation of arenes and 6-arylpurines with terminal alkynes: efficient access to functional dyes, Chem. Commun., 2016, 52, 2709—2712.
66. Liao, Y.-X., Yang, Z.-X., Li, K.*, Yu, X.-Q.*, A Highly Selective Ratiometric Fluorescent Probe for Peroxynitrite Detection in Aqueous Media, Chem. Lett., 2016, 45, 691–693.
67. Liao, C., Chen, Y., Yao, Y., Zhang, S.*, Gu, Z., Yu, X., Cross-Linked Small-Molecule Micelle-Based Drug Delivery System: Concept, Synthesis, and Biological Evaluation, Chem. Mater., 2016, 28, 7757?7764.
68. Xu, Y., Yu, S.*, Chen, Q., Chen, X., Xiao, M., Chen, L., Yu, X.*, Xu, Y., Pu, L.*, Greatly Enhanced Fluorescence by Increasing the Structural Rigidity of an Imine: Enantioselective Recognition of 1,2-Cyclohexanediamine by a Chiral Aldehyde, Chem. Eur. J., 2016, 22, 5963 – 5968.
69. Xu, Y., Yu, S.*, Chen, Q., Chen, X., Li, Y., Yu, X.*, Pu, L.*, Fluorescent Recognition of 1,2-Diamines by a 1,1’-Binaphthyl-Based Trifluoromethyl Ketone, Chem. Eur. J., 2016, 22, 12061–12067.
70. Zhang, C., Liu, P.-X., Huang, L.-Y., Wei S.-P., Wang, L., Yang, S.-Y., Yu, X.-Q., Pu, L.*, Wang, Q.*, Engineering P450 Peroxygenase to Catalyze Highly Enantioselective Epoxidation of cis-b-Methylstyrenes, Chem. Eur. J., 2016, 22, 10969–10975.
71. Xu, Y., Yu, S*, Wang, Y., Hu, L., Zhao F., Chen, X., Li, Y., Yu, X.*, Pu, L.*, Ratiometric Fluorescence Sensors for 1,2-Diamines Based on Trifluoromethyl Ketones, Eur. J. Org. Chem., 2016, 5868–5875.
72. Huang, Z., Zhang, Y.-M., Cheng, Q., Zhang, J.*, Liu, Y.-H., Wang, B., Yu, X,-Q,*, Structure–activity relationship studies of symmetrical cationic bolasomes as non-viral gene vectors, J. Mater. Chem. B, 2016, 4, 5575—5584.
73. Yu, Q.-Y., Liu, Y.-H., Huang, Z., Zhang, J.*, Luan, C.-R., Zhang, Q.-F., Yu, X.-Q.*, Bio-reducible polycations from ring-opening polymerization as potential gene delivery vehicles, Org. Biomol. Chem., 2016, 14, 6470–6478.
74. Zhang, R.-Y., Xi, L.-Y., Shi, L., Zhang, X.-Z., Chen, S.-Y.*, Yu, X.-Q.*, Metal-Free Oxidative Radical Alkynylation/Ring Expansion Rearrangement of Alkenyl Cyclobutanols with Ethynylbenziodoxolones, Org. Lett., 2016, 18, 4024?4027.
75. Du, J., Yu, S.*, Huang, Z., Chen, L., Xu, Y., Zhang, G., Chen, Q., Yu, X.*, Pu, L.*, Highly selective ratiometric fluorescent recognition of histidine by tetraphenylethene– terpyridine–Zn(II) complexes, RSC Adv., 2016, 6, 25319–25329.
76. Ran, Y.-Z., Xu, H.-R., Li, K.*, Yu, K.-K., Yang, J., Yu, X.-Q.*, Development of a mitochondria-targeted fluorescent probe for hydrazine monitoring in living cells, RSC Adv., 2016, 6, 111016–111019.
77. Wu, W.-X., Yang, X.-L., Liu, B.-Y., Deng, Q.-F., Xun, M.-M., Wang, N.*, Yu, X.-Q.*, Lipase-catalyzed synthesis of oxidation-responsive poly(ethylene glycol)-b-poly(b-thioether ester) amphiphilic block copolymers, RSC Adv., 2016, 6, 11870–11879.
78. Xun, M.-M., Zhang, J.-H., Liu, Y.-H., Zhang, J.*, Xiao, Y.-P., Guo, Q., Li, S., Yu, X.-Q.*, Polyethylenimine analogs for improved gene delivery: effect of the type of amino groups, RSC Adv., 2016, 6, 5391–5400.
79. Zhang, X.-Z., Ge, D.-L., Chen, S.-Y.*, Yu, X.-Q.*, A catalyst-free approach to 3-thiocyanato-4Hchromen-4-ones, RSC Adv., 2016, 6, 66320–66323.
80. Li, L.-L., Li, K.*, Liu, Y.-H., Xu, H.-R., Yu, X.-Q.*, Red emission fluorescent probes for visualization of monoamine oxidase in living cells, Scientific Reports, 2016, 6, 31217 / DOI: 10.1038/srep31217.
81. Chen, X., Chen, H., Lu, C., Yang, C., Yu, X., Li, K.*, Xie, Y.*, Novel mitochondria-targeted, nitrogen mustard-based DNA alkylation agents with near infrared fluorescence emission, Talanta, 2016, 161, 888–893.
82. Yu, K.-K., Hou, J.-T., Li, K.*, Yao, Q., Yang, J., Wu, M.-Y., Xie, Y.-M., Yu, X.-Q.*, A single design strategy for dual sensitive pH probe with a suitable range to map pH in living cells, Scientific Reports, 2015, 5:15540/DOI: 10.1038/srep15540.
83. Wen, K., Yu, S.*, Huang, Z., Chen, L., Xiao, M., Yu, X.-Q.*, Pu, L.*, Rational Design of a Fluorescent Sensor to Simultaneously Determine Both the Enantiomeric Composition and the Concentration of Chiral Functional Amines, J. Am. Chem. Soc., 2015, 137, 4517?4524.
84. Wu, M.-Y., Li, K.*, Liu, Y.-H., Yu, K.-K., Xie, Y.-M., Zhou, X.-D.*, Yu, X.-Q.*, Mitochondria-targeted ratiometric fluorescent probe for real time monitoring of pH in living cells, Biomaterials, 2015, 53, 669-678.
85. Hou, J.-T., Li, K.*, Yang, J., Yu, K.-K., Liao, Y.-X., Ran, Y.-Z., Liu, Y.-H., Zhou, X.-D.*, Yu, X.-Q.*, A ratiometric fluorescent probe for in situ quantification of basal mitochondrial hypochlorite in cancer cells, Chem. Commun., 2015, 51, 6781-6784.
86. Chen, S.-Y., Liu, W., Wu, X., Ying, J.,Yu, X.*, Pu, L.*, A Lewis acid activated reaction of Zn with EtI to promote highly enantioselective alkyne additions to aldehydes, Chem. Commun., 2015, 51, 358-361.
87. Liu, Y., Li, K.*, Wu, M.-Y., Liu, Y.-H., Xie, Y.-M.*, Yu, X.-Q.*, A mitochondria-targeted colorimetric and ratiometric fluorescent probe for biological SO2derivatives in living cells, Chem. Commun., 2015,51, 10236-10239.
88. Guo, Q., Liu, Y.-H., Xun, M.-M., Zhang, J.*, Huang, Z., Zhou, X.-D.*, Yu, X.-Q.*, Diol glycidyl ether-bridged low molecular weight PEI as potential gene delivery vehicles, J. Mater. Chem. B, 2015, 3, 2660-2670.
89. Jiao, S.-Y., Li, K.*, Zhang, W., Liu, Y.-H., Huang, Z., Yu, X.-Q.*, Cd(II)-terpyridine-based complex as a ratiometric fluorescent probe for pyrophosphate detection in solution and as an imaging agent in living cells, Dalton Trans., 2015, 44, 1358-1365.
90. Liu, B.-Y., Wu, W.-X., Wang, N.*, Yu, X.-Q.*, Novel biocompatible fluorescent polymeric micelles based on 1,8-naphthalimide derivatives for cell imaging, Polym. Chem., 2015, 6, 364-368.
91. Wu, W.-X., Qu, L., Liu, B.-Y., Zhang, W.-W., Wang, N.*, Yu, X.-Q.*, Lipase-catalyzed synthesis of acid-degradable poly(b-thioether ester) and poly(b-thioether ester-co-lactone) copolymers,Polymer,2015, 59, 187-193.
92. Xun, M.-M., Xiao, Y.-P., Zhang, J.*, Liu, Y.-H., Peng, Q., Guo, Q., Wu, W.-X., Xu, Y., Yu, X.-Q.*, Low molecular weight PEI-based polycationic gene vectors via Michael addition polymerization with improved serum-tolerance, Polymer, 2015, 65, 45-54.
93. Zhang, Q.-F., Luan, C.-R., Yin, D.-X., Zhang, J.*, Liu, Y.-H., Peng, Q., Xu, Y., Yu, X.-Q.*, Amino Acid-Modified Polyethylenimines with Enhanced Gene Delivery Efficiency and Biocompatibility, Polymers, 2015, 7, 2316–2331, doi:10.3390/polym**.
94. Liao, Y.-X., Wang, M.-D., Li, K.*, Yang, Z.-X., Hou, J.-T., Wu, M.-Y., Liu, Y.-H., Yu, X.-Q.*, A highly sensitive and selective “turn-on” fluorescent probe for hypochlorous acid monitoring, RSC Adv., 2015, 5, 18275-18278.
95. Wang, H.-J., He, X., Zhang, Y., Zhang, J.*, Liu, Y.-H., Yu, X.-Q.*, Hydroxyl-containing non-viral lipidic gene vectors with macrocyclic polyamine headgroups, RSC Adv., 2015, 5, 59417-59427.
96. Yang, Q., Zhou, L.-H., Wu, W.-X., Zhang, W., Wang, N.*, Yu, X.-Q.*, Lipase-catalyzed regioselective domino reaction for the synthesis of chromenone derivatives, RSC Adv., 2015, 5, 78927-78932.
97. Zhou, X., Huang, Z., Cao, Y., Yu, S.*, Yu, X., Zhao, G.*, Pu, L.*, Spectroscopic studies on the interaction of terpyridine-CuCl2 with cysteine, RSC Adv., 2015, 5, 53905-53910.
98. Huang, Z., Liu, Y.-H., Zhang, Y.-M., Zhang, J.*, Liu, Q., Yu, X.-Q.*, Cyclen-based cationic lipids containing a pH-sensitive moiety as gene delivery vectors, Org. Biomol. Chem., 2015, 13, 620-630.
99. Xi, L.-Y., Zhang, R.-Y., Zhang, L., Chen, S.-Y.*, Yu, X.-Q.*, An efficient synthesis of quinolines via coppercatalyzed C–N cleavage, Org. Biomol. Chem., 2015, 13, 3924-3930.
100. Jiao, S.-Y., Li, K.*, Wang, X., Huang, Z., Pu, L., Yu, X.-Q.*, Making pyrophosphate visible: the first precipitable and real-time fluorescent sensor for pyrophosphate in aqueous solution, Analyst, 2015, 140, 174-181.
101. Wang, B.-L., Jiang, C., Li, K.*, Liu, Y.-H., Xie, Y.-M., Yu, X.-Q.*, Molecular engineering of a dual emission near-infrared ratiometric fluorophore for the detection of pH at the organism level, Analyst, 2015, 140, 4608-4615.
102. Xu, H.-R., Li, K.*, Jiao, S.-Y., Pan, S.-L., Zeng, J.-R., Yu, X.-Q.*, Tetraphenylethene–pyridine salts as the first self-assembling chemosensor for pyrophosphate, Analyst, 2015, 140, 4182-4188.
103. Hou, J.-T., Yang, J., Li, K.*, Yu, K.-K., Yu, X.-Q.*,A colorimetric and red emissive fluorescent probe for cysteine and itsapplication in bioimaging, Sensors and Actuators B, 2015, 214, 92-100.
104. Zhang, Y.-M., Chang, D.-C., Zhang, J.*, Liu, Y.-H., Yu, X.-Q.*, Cyclen-based double-tailed lipids for DNA delivery: Synthesis and the effect of linking group structures, Bioorg. Med. Chem., 2015, 23, 5756-5763.
105. Hu, C., Wang, N.*, Zhang, W., Zhang, S., Meng, Y., Yu, X.*,Immobilization of Aspergillus terreus lipase in self-assembled hollownanospheres for enantioselective hydrolysis of ketoprofen vinyl ester, J. Biotechnology, 2015, 194, 12-18.
106. Zhang, W.-W., Yang, X.-L., Jia, J.-Q., Wang, N.*, Hu, C.-L., Yu, X.-Q.*,Surfactant-activated magnetic cross-linked enzyme aggregates (magnetic CLEAs) of Thermomyces lanuginosus lipase for biodieselproduction, J. Mol. Catal. B: Enzymatic, 2015, 115, 83-89.
107. Zhang, W.-W., Jia, J.-Q., Wang, N.*, Hu, C.-L., Yang, S.-Y., Yu, X.-Q.*, Improved activity of lipase immobilized in microemulsion-based organogels for (R,S)-ketoprofen ester resolution: Long-term stability and reusability, Biotechnology Reports, 2015, 7, 1-8.
108. Zhang, R.-Y., Xi, L.-Y., Zhang, L., Chen, S.-Y.*, Yu, X.-Q.*,Metal-free synthesis of ynones via direct CeH alkynylation of aldehydes with ethynylbenziodoxolones, Tetrahedron, 2015, 71, 6176-6182.
109. Ge, D.-L., Zhang, X.-Z., Chen, S.-Y.*, Pu, L., Yu, X.-Q.*, Microwave-assisted synthesis of 2-pyridinylethyl indazoles, Tetrahedron Lett., 2015, 56, 4811-4814.
110. Xu, B., Hou, J., Li, K.*, Lu, Z., Yu, X.*, A BINOL Based Fluorescence Sensor for Distinction of D-Glucose, Chin. J. Chem., 2015, 33, 101-106.
111. Xu, H.-R., Li, K.*, Jiao, S.-Y., Li, L.-L., Pan, S.-L., Yu, X.-Q.*, Tetraphenylethene based zinc complexes as fluorescent chemosensors for pyrophosphate sensing, Chinese Chem. Lett., 2015, 26, 877-880.





















































































































































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