杨利霞
职称：讲师
邮箱：yanglixia@uestc.edu.cn
所在系别：生物技术系
研究领域：核酸生物物理



教育背景
2010年6月—2014年9月，中国科学技术大学，化学院，化学物理专业，本科2014年9月—2019年6月，新加坡南洋理工大学，数理学院，生物物理专业，博士
工作履历
2019年8月—现在，电子科技大学，生命科学与技术学院，讲师2019年9月—2020年9月，新加坡南洋理工大学，化学与生物医学工程学院，博士后
科学研究
研究概况
主要从事单分子核酸动力学，核酸纳米结构设计与应用领域的研究。论文、项目、专利、专著、获奖社会职务等概况。
代表性成果
1.Yang, L., Toh, D. K., Krishna, M. S., Zhong, Z., Liu, Y., Wang, S., Gong, Y., and Chen, G. (2020) Tertiary Base Triple Formation in the SRV-1 Frameshifting Pseudoknot Stabilizes Secondary Structure Components, Biochemistry.2.Tan, J.,= Yang, L.,= Ong, A. A. L., Shi, J., Zhong, Z., Lye, M. L., Liu, S., Lisowiec-Wachnicka, J., Kierzek, R., Roca, X., and Chen, G. (2019) A Disease-Causing Intronic Point Mutation C19G Alters Tau Exon 10 Splicing via RNA Secondary Structure Rearrangement, Biochemistry 58, 1565-1578. (= These authors contributed equally to this work).3.Yang, L., Zhong, Z., Tong, C., Jia, H., Liu, Y., and Chen, G. (2018) Single-Molecule Mechanical Folding and Unfolding of RNA Hairpins: Effects of Single A-U to A.C Pair Substitutions and Single Proton Binding and Implications for mRNA Structure-Induced -1 Ribosomal Frameshifting, J Am Chem Soc 140, 8172-8184.4.Hwang, J., Zheng, M., Wiraja, C., Cui, M., Yang, L., and Xu, C.* (2020) Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts. Nanoscale Adv, 2, 5254-5262.5.Wang, K., Yang, L., Wang, S., Guo, L., Ma, J., Tang, J., Bo, W., Wu, Z., Zeng, B., and Gong, Y. (2020) Transient proton transfer of base pair hydrogen bonds induced by intense terahertz radiation, Phys Chem Chem Phys 22, 9316-9321.6.Tang, J., Ma, J., Guo, L., Wang, K., Yang, Y., Bo, W., Yang, L., Wang, Z., Jiang, H., Wu, Z., Zeng, B., and Gong, Y. (2020) Interpretation of the molecular mechanism of the electroporation induced by symmetrical bipolar picosecond pulse trains, BBA–Biomembranes 1862, 183213.7.Kesy, J.,= Patil, K. M.,= Kumar, S. R.,= Shu, Z., Yong, H. Y., Zimmermann, L., Ong, A. A. L., Toh, D. K., Krishna, M. S., Yang, L., Decout, J. L., Luo, D., Prabakaran, M., Chen, G., and Kierzek, E. (2019) A Short Chemically Modified dsRNA-Binding PNA (dbPNA) Inhibits Influenza Viral Replication by Targeting Viral RNA Panhandle Structure, Bioconjugate Chem 30, 931-943. (= These authors contributed equally to this work).8.Puah, R. Y.,= Jia, H.,= Maraswami, M.,= Toh, D. K.,= Ero, R.,= Yang, L., Patil, K. M., Ong, A. A. L., Krishna, M. S., Sun, R., Tong, C., Huang, M., Chen, X., Loh, T. P., Gao, Y. G., Liu, D. X., and Chen, G. (2018) Selective Binding to mRNA Duplex Regions by Chemically Modified Peptide Nucleic Acids Stimulates Ribosomal Frameshifting, Biochemistry 57, 149-159. (= These authors contributed equally to this work).9.Zhong, Z., Yang, L., Zhang, H., Shi, J., Vandana, J. J., Lam, D. T., Olsthoorn, R. C., Lu, L., and Chen, G. (2016) Mechanical unfolding kinetics of the SRV-1 gag-pro mRNA pseudoknot: possible implications for -1 ribosomal frameshifting stimulation, Sci Rep 6, 39549.
教育教学
本科生课程

研究生课程

招生专业

个人/团队主页

职称 讲师 邮箱 yanglixia@uestc.edu.cn
所在系别 生物技术系 研究领域 核酸生物物理
科学研究 招生专业
联系方式 办公地址
团队联系方式 教育教学 2010年6月—2014年9月，中国科学技术大学，化学院，化学物理专业，本科
2014年9月—2019年6月，新加坡南洋理工大学，数理学院，生物物理专业，博士
工作履历 2019年8月—现在，电子科技大学，生命科学与技术学院，讲师
2019年9月—2020年9月，新加坡南洋理工大学，化学与生物医学工程学院，博士后 研究概况 主要从事单分子核酸动力学，核酸纳米结构设计与应用领域的研究。
论文、项目、专利、专著、获奖社会职务等概况。
代表性成果 1.Yang, L., Toh, D. K., Krishna, M. S., Zhong, Z., Liu, Y., Wang, S., Gong, Y., and Chen, G. (2020) Tertiary Base Triple Formation in the SRV-1 Frameshifting Pseudoknot Stabilizes Secondary Structure Components, Biochemistry.
2.Tan, J.,= Yang, L.,= Ong, A. A. L., Shi, J., Zhong, Z., Lye, M. L., Liu, S., Lisowiec-Wachnicka, J., Kierzek, R., Roca, X., and Chen, G. (2019) A Disease-Causing Intronic Point Mutation C19G Alters Tau Exon 10 Splicing via RNA Secondary Structure Rearrangement, Biochemistry 58, 1565-1578. (= These authors contributed equally to this work).
3.Yang, L., Zhong, Z., Tong, C., Jia, H., Liu, Y., and Chen, G. (2018) Single-Molecule Mechanical Folding and Unfolding of RNA Hairpins: Effects of Single A-U to A.C Pair Substitutions and Single Proton Binding and Implications for mRNA Structure-Induced -1 Ribosomal Frameshifting, J Am Chem Soc 140, 8172-8184.
4.Hwang, J., Zheng, M., Wiraja, C., Cui, M., Yang, L., and Xu, C.* (2020) Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts. Nanoscale Adv, 2, 5254-5262.
5.Wang, K., Yang, L., Wang, S., Guo, L., Ma, J., Tang, J., Bo, W., Wu, Z., Zeng, B., and Gong, Y. (2020) Transient proton transfer of base pair hydrogen bonds induced by intense terahertz radiation, Phys Chem Chem Phys 22, 9316-9321.
6.Tang, J., Ma, J., Guo, L., Wang, K., Yang, Y., Bo, W., Yang, L., Wang, Z., Jiang, H., Wu, Z., Zeng, B., and Gong, Y. (2020) Interpretation of the molecular mechanism of the electroporation induced by symmetrical bipolar picosecond pulse trains, BBA–Biomembranes 1862, 183213.
7.Kesy, J.,= Patil, K. M.,= Kumar, S. R.,= Shu, Z., Yong, H. Y., Zimmermann, L., Ong, A. A. L., Toh, D. K., Krishna, M. S., Yang, L., Decout, J. L., Luo, D., Prabakaran, M., Chen, G., and Kierzek, E. (2019) A Short Chemically Modified dsRNA-Binding PNA (dbPNA) Inhibits Influenza Viral Replication by Targeting Viral RNA Panhandle Structure, Bioconjugate Chem 30, 931-943. (= These authors contributed equally to this work).
8.Puah, R. Y.,= Jia, H.,= Maraswami, M.,= Toh, D. K.,= Ero, R.,= Yang, L., Patil, K. M., Ong, A. A. L., Krishna, M. S., Sun, R., Tong, C., Huang, M., Chen, X., Loh, T. P., Gao, Y. G., Liu, D. X., and Chen, G. (2018) Selective Binding to mRNA Duplex Regions by Chemically Modified Peptide Nucleic Acids Stimulates Ribosomal Frameshifting, Biochemistry 57, 149-159. (= These authors contributed equally to this work).
9.Zhong, Z., Yang, L., Zhang, H., Shi, J., Vandana, J. J., Lam, D. T., Olsthoorn, R. C., Lu, L., and Chen, G. (2016) Mechanical unfolding kinetics of the SRV-1 gag-pro mRNA pseudoknot: possible implications for -1 ribosomal frameshifting stimulation, Sci Rep 6, 39549. 教育教学
本科生课程 研究生课程
个人团队主页 代表性学术成果
荣誉与奖励 团队主页