李亭亭
职称：特聘副研究员
邮箱：litingting@uestc.edu.cn
所在系别：生物技术系
研究领域：生物力学，肿瘤耐药与代谢相关研究



教育背景
2008年9月—2012年6月，佳木斯大学，药学院，化学专业，本科2012年9月—2018年12月，电子科技大学，生命科学与技术学院，生物医学工程专业，硕博连读2016年12月—2018年11月，德克萨斯大学MD Anderson癌症中心，癌症系统成像部门，生物医学工程专业，联合培养博士
工作履历
2019年2月至今，电子科技大学，生命科学与技术学院，特聘副研究员
科学研究
研究概况
长期从事生物功能界面及3D基质力学微环境的构筑及应用，致力于具有细胞调控作用的新型生物材料及其在肿瘤防治相关研究。在ACS Nano, Nat Commun, Acta Biomater, ACS Appl Mater Interfaces 等国际期刊上发表SCI论文20余篇。担任Expert Opin Ther Targets, Mater Sci & Eng C 等国际期刊审稿人。
代表性成果
项目： 3D基质力学微环境通过FAK-YAP/TAZ调控肿瘤耐药性的生物力学机制研究，国家自然基金青年基金(No.**)代表性论文：[1]T. T. Li, X. Qin, Y. Li, X. Shen, S. Li, H. Yang, C. Wu, C. Zheng, J. Zhu, F. You, Y. Y. Liu*, Cell Membrane Coated-Biomimetic Nanoplatforms Toward Cancer Theranostics. Front Bioeng Biotechnol. 8(371 (2020). [2]T. T. Li, Y. Geng, H. Zhang, J. Wang, Y. Feng, Z. Chen, X. Xie, X. Qin, S. Li, C. Wu, Y. Y. Liu*, H. Yang, A versatile nanoplatform for synergistic chemo-photothermal therapy and multimodal imaging against breast cancer. Expert Opin Drug Deliv. 17(5), 725-733 (2020).[3]T. T. Li, S. S. Shi, S. Goel, X. Shen, X. X. Xie, Z.Y. Chen, H. X. Zhang, L. Li, S. Li, X. Qin, H. Yang, C. H. Wu, Y. Y. Liu* Recent advancements in mesoporous silica nanoparticles towards therapeutic applications for cancer, Acta biomaterialia, 89 (2019) 1-13. [4]T. T. Li, X. Shen, Y. Geng, Z.Y. Chen, L. Li, S. Li, H. Yang, C. H. Wu, H. J. Zeng, Y. Y. Liu*. Folate-functionalized magnetic-mesoporous silica nanoparticles for drug/gene codelivery to potentiate the antitumor efficacy. ACS Applied Materials & Interfaces, 2016,8 (22):13748-13758.[5]T. T. Li, X. Shen, X. X. Xie, Z. Y. Chen, S. Li, X. Qin, H. Yang, C. H. Wu, Y. Y. Liu*. Irinotecan/IR-820 coloaded nanocomposite as a cooperative nanoplatform for combinational therapy of tumor. Nanomedicine(Lond), 2018,13 (6):595-603.[6]T. T. Li, X. Shen, Y. Chen, C. C. Zhang, J. Yan, H. Yang, C. H. Wu, H. J Zeng, Y. Y. Liu*. Polyetherimide-grafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging. International Journal of Nanomedicine, 2015,10 4279-4291.[7] J. Zhao, X. Wen, L. Tian, T. T. Li, C. Xu, X. Wen, M.P. Melancon, S. Gupta, B. Shen, W. Peng, C. Li, Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer, Nature communications, 10 (2019) 899.[8] X. Shen, T. T. Li, Z. Chen, X. Xie, H. Zhang, Y. Feng, S. Li, X. Qin, H. Yang, C. Wu, C. Zheng, J. Zhu, F. You, Y. Liu, NIR-Light-Triggered Anticancer Strategy for Dual-Modality Imaging-Guided Combination Therapy via a Bioinspired Hybrid PLGA Nanoplatform, Molecular pharmaceutics, 16 (2019) 1367-1384.[7] X. Qin, T. T. Li, S. Li, H. Yang, C. Wu, C. Zheng, F. You, Y. Liu, The tumor biochemical and biophysical microenvironments synergistically contribute to cancer cell malignancy, Cellular & molecular immunology, (2019).[8]X. Shen, T. T. Li, Z. Y. Chen, Y. Geng, X. X. Xie, S. Li, H. Yang, C. H. Wu, Y. Y. Liu*. Luminescent/magnetic PLGA-based hybrid nanocomposites: a smart nanocarrier system for targeted codelivery and dual-modality imaging in cancer theranostics[J]. International Journal of Nanomedicine, 2017,12 4299-4322.[9]Z. F. Gao, T. T. Li, X. L. Xu, Y. Y. Liu, H. Q. Luo, N. B. Li*. Green light-emitting polyepinephrine-based fluorescent organic dots and its application in intracellular metal ions sensing. Biosensors & Bioelectronics, 2016,83 134-141.[10]M. Wu, T. T. Li, L. Chen, S. Peng,W. Liao, R. Bai,X. Zhao, H. Yang, C. H. Wu, H. J. Zeng, Y. Y. Liu*. Essential oils from Inula japonica and Angelicae dahuricae enhance sensitivity of MCF-7/ADR breast cancer cells to doxorubicin via multiple mechanisms. Journal of Ethnopharmacology,2016,180 18-27.[11]J. Zhao, Z. Xiao, T. T. Li, H. Chen,Y. Yuan, YA. Wang, CH. Hsiao, D.S.Chow, WW. Overwijk, C. Li*. Stromal modulation reverses primary resistance to immune checkpoint blockade in pancreatic cancer. ACS Nano, 2018, doi: 10.1021/acsnano.8b02481.
教育教学
本科生课程

研究生课程

招生专业
硕士：071000生物学 (04细胞生物学) 083100生物医学工程(08电子科技大学-加拿大麦吉尔大学生物医学工程-神经科学双硕士教育项目)
个人/团队主页
https://biophysics.uestc.edu.cn
职称 特聘副研究员 邮箱 litingting@uestc.edu.cn
所在系别 生物技术系 研究领域 生物力学，肿瘤耐药与代谢相关研究
科学研究 招生专业 硕士：071000生物学 (04细胞生物学) 083100生物医学工程(08电子科技大学-加拿大麦吉尔大学生物医学工程-神经科学双硕士教育项目)
联系方式 办公地址
团队联系方式 教育教学 2008年9月—2012年6月，佳木斯大学，药学院，化学专业，本科
2012年9月—2018年12月，电子科技大学，生命科学与技术学院，生物医学工程专业，硕博连读
2016年12月—2018年11月，德克萨斯大学MD Anderson癌症中心，癌症系统成像部门，生物医学工程专业，联合培养博士
工作履历 2019年2月至今，电子科技大学，生命科学与技术学院，特聘副研究员 研究概况 长期从事生物功能界面及3D基质力学微环境的构筑及应用，致力于具有细胞调控作用的新型生物材料及其在肿瘤防治相关研究。在ACS Nano, Nat Commun, Acta Biomater, ACS Appl Mater Interfaces 等国际期刊上发表SCI论文20余篇。担任Expert Opin Ther Targets, Mater Sci & Eng C 等国际期刊审稿人。
代表性成果 项目： 3D基质力学微环境通过FAK-YAP/TAZ调控肿瘤耐药性的生物力学机制研究，国家自然基金青年基金(No.**)
代表性论文：
[1] T. T. Li, X. Qin, Y. Li, X. Shen, S. Li, H. Yang, C. Wu, C. Zheng, J. Zhu, F. You, Y. Y. Liu*, Cell Membrane Coated-Biomimetic Nanoplatforms Toward Cancer Theranostics. Front Bioeng Biotechnol. 8(371 (2020).
[2] T. T. Li, Y. Geng, H. Zhang, J. Wang, Y. Feng, Z. Chen, X. Xie, X. Qin, S. Li, C. Wu, Y. Y. Liu*, H. Yang, A versatile nanoplatform for synergistic chemo-photothermal therapy and multimodal imaging against breast cancer. Expert Opin Drug Deliv. 17(5), 725-733 (2020).
[3] T. T. Li, S. S. Shi, S. Goel, X. Shen, X. X. Xie, Z.Y. Chen, H. X. Zhang, L. Li, S. Li, X. Qin, H. Yang, C. H. Wu, Y. Y. Liu* Recent advancements in mesoporous silica nanoparticles towards therapeutic applications for cancer, Acta biomaterialia, 89 (2019) 1-13.
[4] T. T. Li, X. Shen, Y. Geng, Z.Y. Chen, L. Li, S. Li, H. Yang, C. H. Wu, H. J. Zeng, Y. Y. Liu*. Folate-functionalized magnetic-mesoporous silica nanoparticles for drug/gene codelivery to potentiate the antitumor efficacy. ACS Applied Materials & Interfaces, 2016,8 (22):13748-13758.
[5] T. T. Li, X. Shen, X. X. Xie, Z. Y. Chen, S. Li, X. Qin, H. Yang, C. H. Wu, Y. Y. Liu*. Irinotecan/IR-820 coloaded nanocomposite as a cooperative nanoplatform for combinational therapy of tumor. Nanomedicine(Lond), 2018,13 (6):595-603.
[6] T. T. Li, X. Shen, Y. Chen, C. C. Zhang, J. Yan, H. Yang, C. H. Wu, H. J Zeng, Y. Y. Liu*. Polyetherimide-grafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging. International Journal of Nanomedicine, 2015,10 4279-4291.
[7] J. Zhao, X. Wen, L. Tian, T. T. Li, C. Xu, X. Wen, M.P. Melancon, S. Gupta, B. Shen, W. Peng, C. Li, Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer, Nature communications, 10 (2019) 899.
[8] X. Shen, T. T. Li, Z. Chen, X. Xie, H. Zhang, Y. Feng, S. Li, X. Qin, H. Yang, C. Wu, C. Zheng, J. Zhu, F. You, Y. Liu, NIR-Light-Triggered Anticancer Strategy for Dual-Modality Imaging-Guided Combination Therapy via a Bioinspired Hybrid PLGA Nanoplatform, Molecular pharmaceutics, 16 (2019) 1367-1384.
[7] X. Qin, T. T. Li, S. Li, H. Yang, C. Wu, C. Zheng, F. You, Y. Liu, The tumor biochemical and biophysical microenvironments synergistically contribute to cancer cell malignancy, Cellular & molecular immunology, (2019).
[8] X. Shen, T. T. Li, Z. Y. Chen, Y. Geng, X. X. Xie, S. Li, H. Yang, C. H. Wu, Y. Y. Liu*. Luminescent/magnetic PLGA-based hybrid nanocomposites: a smart nanocarrier system for targeted codelivery and dual-modality imaging in cancer theranostics[J]. International Journal of Nanomedicine, 2017,12 4299-4322.
[9] Z. F. Gao, T. T. Li, X. L. Xu, Y. Y. Liu, H. Q. Luo, N. B. Li*. Green light-emitting polyepinephrine-based fluorescent organic dots and its application in intracellular metal ions sensing. Biosensors & Bioelectronics, 2016,83 134-141.
[10] M. Wu, T. T. Li, L. Chen, S. Peng,W. Liao, R. Bai,X. Zhao, H. Yang, C. H. Wu, H. J. Zeng, Y. Y. Liu*. Essential oils from Inula japonica and Angelicae dahuricae enhance sensitivity of MCF-7/ADR breast cancer cells to doxorubicin via multiple mechanisms. Journal of Ethnopharmacology,2016,180 18-27.
[11] J. Zhao, Z. Xiao, T. T. Li, H. Chen,Y. Yuan, YA. Wang, CH. Hsiao, D.S.Chow, WW. Overwijk, C. Li*. Stromal modulation reverses primary resistance to immune checkpoint blockade in pancreatic cancer. ACS Nano, 2018, doi: 10.1021/acsnano.8b02481. 教育教学
本科生课程 研究生课程
个人团队主页 https://biophysics.uestc.edu.cn 代表性学术成果
荣誉与奖励 团队主页