周绍兵的个人主页
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基本信息
周绍兵
博士，教授，博士生导师
博士学科：高分子材料
工作单位：材料科学与工程学院
联系方式
通信地址：四川省成都市二环路北一段111号西南交通大学材料科学与工程学院
电子邮箱：shaobingzhou@swjtu.edu.cn;shaobingzhou@hotmail.com
办公电话：**
传真：**
个人简历 周绍兵，博士，教授，博士生导师，教育部新世纪优秀人才，四川省学术和技术带头人，成都市突出贡献优秀专家。研究方向是生物医用高分子材料的合成及其在药物控制释放靶向制剂、形状记忆智能材料和组织工程支架方面的应用基础研究。1996年四川大学化学系获学士学位,2003年于中国科学院成都有机化学研究所获博士学位,2004年作为优秀人才引进到西南交通大学材材料先进技术教育部重点实验室工作,建立了生物医用高分子材料合成和药物控制释放制剂实验室，2011年到美国哈佛大学作访问学者。主持过国家自然科学基金项目6项,国家重大研究计划子课题1项，教育部新世纪优秀人才基金1项，四川省杰出青年基金1项。目前在Advanced Materials (影响因子17.49），Acs Nano(影响因子12.8),Advanced Functional Materials(影响因子11.82), Chemistry of Materials, Biomaterials, Journal of Controlled Release和Macromolecules等SCI收录期刊发表文章100余篇，文章SCI他引2000余次,单篇最高SCI他引170次,合作出版外文专著1部(贡献1章),作为第一发明人申请中国发明专利10余项，7项获得授权。2003年荣获中国科学院院长优秀奖，2010年荣获“第八届詹天佑科学技术奖专项基金奖”,2011年荣获“第十一届四川省青年科技奖”。目前，任国际期刊American Journal of Materials Scienceand Technology副主编，国际期刊Advanced Materials Letter 编委,还担任Advanced Materials (影响因子17.4),Angewandte Chemie InternationalEdition (影响因子11.73)、Advanced Functional Materials (影响因子11.8）、Biomaterials(影响因子8.52)、Macromolecules、Journal of Controlled Release、Molecular Pharmaceutics等40余种国际期刊评审人。
在指导的研究生中, 其中8位研究生毕业论文获四川省优秀硕士论文奖, 1位博士生毕业论文获四川省优秀博士论文奖,13位研究生获校优秀硕士论文。2010年和2011年连续两年被评为本科毕业设计优秀指导教师。 2014年被学校评为首届西南交通大学“十佳研究生导师”荣誉称号。
研究方向
(1) 可生物降解高分子新材料的合成；(2) 药物控制释放靶向新制剂的研究； (3) 可生物降解形状记忆高分子材料及复合材料的研究；(4) 可生物降解高分子静电纺丝纤维组织工程支架的研究。
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
科学研究目前主持科研项目情况
1. 国家自然科学基金面上项目，基于双重响应聚合物胶束的抗肿瘤主动靶向给药系统（**），项目经费：78万元、起止年度：2016.1-2019.12。
2. 国家自然科学基金面上项目，具有三重形状记忆功能的高分子表面微图案及其与细胞作用机制（**），项目经费：82万元、起止年度：2014.1-2017.12。
3. 高等学校博士学科点专项科研基金项目(博导类)，基于氢键作用的形状记忆高分子表面微结构的研究（**029）、项目经费：12万元、起止年度：2013.1-2015.12
4. 国家自然科学基金面上项目，携载药物的可降解形状记忆高分子器件的制备及其性能研究（**），项目经费：32万元，起止年度：2008.1-2010.12。
5. 国家自然科学基金，具有温敏性的磁靶向可降解聚合物抗肿瘤药物胶束的研究（**），项目经费：37万元，起止年度：2010.1-2012.12。
6. 国家自然科学基金面上项目，聚醚-聚酸酐胶束的形貌调控及其对肿瘤细胞生长影响的研究（**），项目经费：60万元，起止年度：2012.1-2015.12。
7. 国家重大科学研究计划（973计划）子课题，生长因子在微纳结构材料中的高活性固载及控释2012CB933602, 项目经费：135万元，起止年度：2012.1-2016.12。
8. 教育部新世纪优秀人才基金，蛋白和多肽类生物活性大分子控制释放系统的研究（NCET-07-0719）项目经费：50万元，2008.1-2010.12。
9. 四川省杰出青年科技基金，具有药物控释功能的可降解形状记忆高分子器件的研究 (08ZQ026-040)，项目经费：12万元，2008.1-2010.12。
10. 西南交通大学“杨华之星”项目，项目经费：30万元，2009.9-2012.9。
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
论文成果发表的SCI收录论文目录（注：* 表示通讯作者）
Jie Wang, Guang Yang, Xing Guo, Zhaomin Tang, Zhendong Zhong, Shaobing Zhou*, Redox-responsive polyanhydride micelles for cancer therapy, Biomaterials, 2014, 35, 3080-3090. Ye Liu, Ying Li, Hongmei Chen, Guang Yang, Xiaotong Zheng, Shaobing Zhou*, Water-induced shape-memory poly(D,L-lactide)/microcrystalline cellulose composites, Carbohydrate Polymers,104 (2014) 101–108. Xian Liu, Kun Zhao, Tao Gong, Jian Song, Chongyun Bao, En Luo, Jie Weng and Shaobing Zhou*, Delivery of Growth Factors Using a Smart Porous Nanocomposite Scaffold to Repair a Mandibular Bone Defect, Biomacromolecules, 2014,15, 1019-1030. Jinrong Li, Rong Fu, Long Li, Guang Yang, Shan Ding, Zhendong Zhong, Shaobing Zhou*, Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid, Pharm Res, DOI 10.1007/s11095-013-1266-2. Long Li, Guang Yang, Jinrong Li, Shan Ding, Shaobing Zhou*,Cell behaviors on magnetic electrospun poly-d, l-lactide nanofibers，Materials Science and Engineering C 34 (2014) 252–261. Lin Wang, Xifeng Yang, Hongmei Chen, Tao Gong, Wenbing Li, Guang Yang, and Shaobing Zhou*, Design of Triple-Shape Memory Polyurethane with Photo-crosslinking of Cinnamon Groups, ACS Applied Materials & Interfaces, 2013, 5, 10520?10528. Lin Wang, Xifeng Yang,Hongmei Chen, Guang Yang, Tao Gong, Wenbing Li and Shaobing Zhou*，Multi-stimuli sensitive shape memory poly(vinyl alcohol)-graft-polyurethane，Polym. Chem., 2013,4, 4461-4468. Shaobing Zhou*, Jing Fan, Sujit S. Datta, Ming Guo, Xing Guo and David A. Weitz*, Thermally Switched Release from Nanoparticle Colloidosomes, Advanced Functional Materials, 2013, 23, 5925–5929. Tao Chen, Xing Guo,Aijun Zhao, Jie Wang,Chunli Shi and Shaobing Zhou*，Morphological transition of self-assembled architectures from PEG-based ether-anhydride terpolymers，Soft Matter, 2013, 9, 3021-3031. Wenbing Li, Tao Gong, Hongmei Chen, Lin Wang, Jinrong Li and Shaobing Zhou*，Tuning surface micropattern features using a shape memory functional polymer，RSC Adv., 2013, 3, 9865–9874. Hongmei Chen, Ye Liu, Tao Gong, Lin Wang, Keqing Zhao and Shaobing Zhou*，Use of intermolecular hydrogen bonding to synthesize triple-shape memory supermolecular composites，RSC Adv., 2013, 3, 7048–7056. Xing Guo, Chunli Shi, Jie Wang, Shubin Di, Shaobing Zhou*，pH-triggered intracellular release from actively targeting polymer Micelles，Biomaterials, 34 (2013) 4544-4554.Zhao Zhang, Qianqian Qu, Jinrong Li, Shaobing Zhou*，The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells，Macromol. Biosci. 2013, 13, 789–798. Shan Ding, Jinrong Li, Chao Luo, Long Li, Guang Yang and Shaobing Zhou*，Synergistic e ff ect of released dexamethasone and surface nanoroughness on mesenchymal stem cell differentiation，Biomater. Sci., 2013, 1, 1091–1100.
Tao Gong,Wenbing Li, Hongmei Chen, LinWang, Shijun Shao, Shaobing Zhou*，Remotely actuatedshape memory effect of electrospun composite nanofibers，ActaBiomaterialia 8 (2012) 1248–1259. XiongjunYu, LinWang, MaotaoHuang, TaoGong, WenbingLi, YalingCao, DaijinJi, PingWang, JingWang and ShaobingZhou*,A shape memory stent of poly(ε-caprolactone-co-dl-lactide) copolymer for potentialtreatment of esophageal stenosis, Journal of Materials Science: Materials in Medicine, 2012, 23, 581-589.Qi Zhou, Xing Guo, Tao Chen, Zhao Zhang, ShijunShao, Chao Luo, Jinrong Li, and Shaobing Zhou*, Target-Specific Cellular Uptake of Folate-Decorated BiodegradablePolymer Micelles, J.Phys. Chem. B, 2011, 115 (43), pp 12662–12670. Shijun Shao, Long Li, Guang Yang, Jingrong Li, ChaoLuo, Tao Gong, Shaobing Zhou*,Controlled green tea polyphenols releasefrom electrospun PCL/MWCNTs composite nanofibers,InternationalJournal of Pharmaceutics ,2011,421,310–320. ShijunShao, Shaobing Zhou*, Long Li,Jinrong Li, Chao Luo, Jianxin Wang, Xiaohong Li and Jie Weng, Osteoblast function on electricallyconductive electrospun PLA/MWCNTs nanofibers, Biomaterials,2011, 32, 2821-2833.Chi Huang, Yangbo Zhou, Zhaomin Tang, Xing Guo, ZhiyongQian and Shaobing Zhou*，Synthesis of multifunctional Fe3O4core/hydroxyapatite shell nanocomposites by biomineralization，Dalton Trans., 2011,40,5026-5031. YuXiao, Tao Gong, Shaobing Zhou*，Thefunctionalization of multi-walled carbon nanotubes by in situ deposition ofhydroxyapatite，Biomaterials ，2010，31 ，5182-5190. （SCI, IF：6.646） ChiHuang,Yangbo Zhou,Yong Jin,Xiaofeng Zhou,Zhaomin Tang, Xing Guo and Shaobing Zhou*，Preparation and characterization of temperature-responsiveand magnetic nanomicelles，J. Mater. Chem., 2011, 21 (15), 5660 – 5670.WeijiaWang, Shaobing Zhou*, Laiyang Guo, Wei Zhi, XIaohong Li,JieWeng,Investigation of endocytosis and cytotoxicity of poly-d,l-lactide-poly(ethylene glycol) nano/micro- particles in osteoblast cells, InternationalJournal of Nanomedicine 2010:5 557–566.Qiuxiang Su, Aijun Zhao, Hongsen Peng, and Shaobing Zhou?，Preparation andCharacterization of Biodegradable Electrospun Polyanhydride Nano/Microfibers，Journal ofNanoscience and Nanotechnology,2010. 10, 6369-6375. Lin Sun, Chi Huang, Tao Gong, Shaobing Zhou*，Abiocompatible approach to surface modification: Biodegradable polymerfunctionalized super-paramagnetic iron oxide nanoparticles，Materials Science andEngineering C，2010， 30，583–589. WeijiaWang, Shaobing Zhou*, Lin Sun, Chi Huang, Controlled delivery ofparacetamol and protein at different stages from core–shell biodegradablemicrospheres, Carbohydrate Polymers, 79 (2010) 437–444.AijunZhao， Shaobing Zhou*， Qi Zhou，Tao Chen，Thermosensitive Micelles from PEG-BasedEther-anhydride Triblock Copolymers，Pharm Res，2010，27，1627-1643. YuXiao, Shaobing Zhou*, Lin Wang,Xiaotong Zheng, Tao Gong，Crosslinked poly(ε-caprolactone)/poly(sebacic anhydride) compositescombining biodegradation, controlled drug release and shape memory effect，Composites:Part B 41 (2010) 537–542. AijunZhao, Qi Zhou, Tao Chen, Jie Weng, ShaobingZhou*，Amphiphilic PEG-based ether-anhydride terpolymers: Synthesis,characterization, and micellization，Journal of Applied Polymer Science，2010,118（6）：3576–3585. WeijiaWang, Shijun Shao, Chao Luo, ShaobingZhou*, Chitosan hollow nanospheresfabricated from biodegradable poly-d,l-lactide-poly(ethylene glycol)nanoparticle templates, European Journal of Pharmaceuticsand Biopharmaceutics, 76 (2010) 376–383. YuXiao, Shaobing Zhou*, Lin Wang, andTao Gong，Electro-activeShape Memory Properties of Poly(ε-caprolactone)/Functionalized MultiwalledCarbon Nanotube Nanocomposite，ACS Appl. Mater. Interfaces, 2010, 2 (12), pp 3506–3514.Hongsen Peng, Shaobing Zhou*, Jing Jiang, TaoGuo, Xiaotong Zheng, and Xiongjun Yu，Pressure-Induced CrystalMemory Effect of Spider Silk Proteins，J. Phys. Chem. B 2009, 113, 4636–4641. XiongjunYu, Shaobing Zhou*, Xiaotong Zheng, Yu Xiao and Tao Guo，Influenceof in Vitro Degradation of a Biodegradable Nanocomposite on Its Shape Memory Effect，J. Phys. Chem. C, 2009, 113 (41), pp17630–17635.TaoGuo, Shaobing Zhou*, Xiaotong Zheng and Jing Jiang, Modeling andInvestigation of Interfacial Interaction between PLA and One Type of DeficientHydroxyapatite,J. Phys. Chem. A, 2009, 113 (25), pp7112–7123. Xiongjun Yu, Shaobing Zhou*, XiaotongZheng, Tao Guo, Yu Xiaoand BotaoSong, A Biodegradable Shape Memory Nanocomposite with Dual-versatilityof Thermal and Magnetic Field Sensitivity. Nanotechnology. 2009，20,235702. Xiaotong Zheng, Shaobing Zhou*, Yu Xiao,Xiongjun Yu, Xiaohong Li，Peizhuo Wu，Shapememoryeffectofpoly(D,L-lactide)/Fe3O4，nanocompositesbyinductiveheatingofmagnetiteparticles，ColloidsandSurfaces B:Biointerfaces，71(2009),pp.67-72.LinSun, Shaobing Zhou*, Weijia Wang, Xiaohong Li, Jianxin Wang,Jie Weng, Preparation and characterizationof porous biodegradable microspheres used for controlled protein delivery, Colloidsand Surfaces A: Physicochem. Eng. Aspects 345 (2009) 173–181. XiaotongZheng, Shaobing Zhou*, Yu Xiao, Xiongjun Yu, Bo Feng. In situpreparation and characterization of a novel Gelatin/ Poly(D,L-lactide)/Hydroxyapatite nanocomposite. Journal of Biomedical Materials ResearchPart B: Applied Biomaterials.Volume91B, Issue1, Date:October 2009,Pages:181-190. ShaobingZhou*,Xiaotong Zheng, Xiongjun Yu,et al，Hydrogen Bonding Interaction of Poly(D,L-Lactide)/hydroxyapatiteNanocomposites，Chemistry of Materials, 2007，19（2），247– 253.??? JingSun， Shaobing Zhou*,et al., Synthesis and Characterization of Biocompatible Fe3O4Nanoparticles, Journal of Biomedical MaterialsResearch,Part A, 2007,80A(2), 333-341. （SCI, IF：2.5） XiaotongZheng, Shaobing Zhou*, et al., Shapememory properties of poly(D,L-lactide)/ hydroxyapatite composites，Biomaterials，2006，27（24），4288–4295.??? （2008年第4季度入选TOP25 Hottest Articles且排名第7） Lin Sun, Shaobing Zhou*, Weijia Wang, Qiuxiang Su, Xiaohong Li and Jie Weng, Preparation and characterization of protein-loadedpolyanhydride microspheres, Journal of Materials Science: Materialsin Medicine, 2009,20，2035-2042. Shaobing Zhou*, Qiuxiang Su,et al，A novel insitu synthesis of dicalcium phosphate dehydrate nanocrystals in biodegradablepolymer matrix，Materials Science and Engineering A， 2006，430（1-2），341–345.Shaobing Zhou*, Bing Song, Xiaohong Li, Invitro Degradation and Release profiles for Poly-dl-lactide Film ContainingParacetamol, Journal of Materials Science: Materials inMedicine,2007,18（8）1623-1626.Xiaotong Zheng, Shaobing Zhou*, Xiongjun Yu, Xiaohong Li, Bo Feng, Shuxin Qu, JieWeng，Effect of In vitro degradation of poly(D,L-lactide)/-tricalciumcomposite on its shape-memory properties，Journal of Biomedical Materials ResearchPart B: Applied Biomaterials. 2008，Volume 86BIssue 1,Pages170–180. Shaobing Zhou*,Xianmo Deng,Hua Yang, Biodegradablecopolymer of poly(ethylene glycol)-co-poly (ε-caprol actone):characterizationand its use in controlled release system. Biomaterials, 2003, 24(20), 3563-3570. （SCI, IF：5.196） Shaobing Zhou,*Hongsen Peng,Xiongjun Yu, Xiaotong Zheng,Wenguo Cui, ZairongZhang, Xiaohong Li,Jianxin Wang, Jie Weng,Wenxiang Jia,and Fei Li，Preparation and Characterization of a NovelElectrospun Spider Silk Fibroin/Poly(D,L-lactide) Composite Fiber, J. Phys. Chem. B.; 2008; 112(36); 11209-11216. HongsenPeng, Shaobing Zhou*, Tao Guo, Yanshan Li, Xiaohong Li, JianxinWang, Jie Weng, In vitro degradation and releaseprofiles for electrospun polymeric fibers containing paracetanol,Colloidsand Surfaces B: Biointerfaces 66 (2008), pp.206-212.Shaobing Zhou*, Jing Sun, Lin Sun, Yanqin Dai, LipingLiu, Xiaohong Li, Jianxin Wang, Jie Weng, Wenxiang Jia, Zairong Zhang，Preparationand characterization of interferon-loaded magnetic biodegradable microspheres，Journal of Biomedical Materials Research Part B:Applied Biomaterials. Volume 87B, Issue 1, Date: October 2008, Pages:189-196.Shaobing Zhou*, Xianmo Deng, Xiaohong Li,et al.,Investigationon a Novel Core-Coated Microspheres Protein Delivery System, Journal of Controlled Release, 2001,75(1-2),27-36.?? Shaobing Zhou*,Xueyan Liao,Xiaohong Li,Xianmo Deng,et al.Poly-D,L-lactide-co-poly(ethylene glycol) microspheres as potential vaccinedelivery systems.Journal ofControlled Release, 2003，86(2-3)：195-205. (SCI, IF 4.01)XianmoDeng, Shaobing Zhou,Xiaohong Li,etal.,In vitro Degradation and Release profiles for Poly-dl-Lactide-poly(ethyleneglycol) Microspheres Containing Human Serum Albumin. Journal of Controlled Release,2001, 71(2),165-173. Shaobing Zhou*,Xianmo Deng,Shuiying He,XiaohongLi,Wenxiang Jia, et al., Study on biodegradable microspheres containingrecombinant interferon. J.Pharm.Pharmacol.2002,54:1287-12192. Shaobing Zhou*,Xianmo Deng,Xiaohong Li,et al.,Investigation on Preparation and Protein Release of Biodegradable PolymerMicrospheres as Drug Delivery System,Journal of Applied polymer science,2002,84,778-784.Shaobing Zhou*,Xianmo Deng,In Vitro DegradationCharacteristics of Poly-dl-lactide-poly(ethylene glycol) MicrospheresContaining Human Serum Albumin. Reactive and functional polymer,2002,51,93-100. Shaobing Zhou*, Xianmo Deng, Wenxiang Jia,etal.,Synthesis and characterization of biodegradable low-molecular-weightaliphatic polyesters and their use inprotein delivery system, Journal of Applied polymer Sciences , 2004, 91(3), 1848–1856.Shaobing Zhou*, Jinggang Xu,Xianmo Deng，et al.,Synthesis and Characterization of BiodegradablePoly(-caprolactone)- Polyglycolide-Poly(ethylene glycol) Monomethyl EtherRandom Copolymer，Macromolecular Materials and Engineering，2004,289（6），576-580.ShaobingZhou*, Xueyan Liao, Xianmo Deng, Heming Li,etal.,Preparation and Characterization of Biodegradable Microspheres ContainingHepatitis B Surface Antigen, Macromolecular Bioscience,2004,4,(1)1,47-52.YuanYang, Li Liu, Shaobing Zhou*,et al.Novel Biodegradable Polymers as Gene Carriers. Macromol. Biosci. 2004,4, 1113–1117.
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
荣誉奖励 2003年荣获中国科学院院长优秀奖;
2010年荣获“第八届詹天佑科学技术奖专项基金奖”；
2011年荣获“第十一届四川省青年科技奖”；
2010年和2011年连续两年被评为本科毕业设计优秀指导教师；
2014年被评为首届“西南交通大学十佳研究生导师”荣誉称号
2014年荣获唐立新优秀学者奖
2014年荣获四川省学术和技术带头人
在指导的研究生中, 其中8位研究生毕业论文获四川省优秀硕士论文奖, 1位博士生毕业论文获四川省优秀博士论文奖,13位研究生论文获校优秀硕士论文。
祝贺研究生荣获国家奖学金!!!!!
祝贺博士研究生郭星、龚涛、唐昭敏三位同学荣获2014年度“博士研究生国家奖学金”；硕士研究生赵坤荣获2014年度“硕士研究生国家奖学金”。此前，博士研究生龚涛荣获2012年度“博士研究生国家奖学金”，博士研究生郭星荣获2013年度“博士研究生国家奖学金”.
研究生国家奖学金是由国家教育部、财政部设立，中央财政出资，用于奖励普通高等学校中表现优异的全日制研究生，为发展中国特色研究生教育，促进研究生培养机制改革，提高研究生培养质量。博士研究生国家奖学金奖励标准为每生每年3万元；硕士研究生国家奖学金奖励标准为每生每年2万元。
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
科研团队博士后：刘显
博士研究生：陈红梅，王林，李龙，郭星，杨光，孙会丽，龚涛，唐昭敏，王毅
硕士研究生：史春丽，丁珊，杨希凤，刘野，王杰，赵坤，屈倩倩，李丹，李莹，狄淑斌，王文玺，周光亮，王毅，张累
已毕业研究生：郑晓彤（博士），罗超，周洋波，陈涛，李文兵，李金绒，张钊，孙敬，苏秋香，彭红森，孙林，俞雄军，郭涛，肖雨，王卫佳，赵艾军，黄驰，周奇，邵仕军
(1) 靶向药物控制释放新制剂的研究
a. 具有主动靶向的pH敏感抗肿瘤药物胶束
如图所示，该叶酸靶向的pH敏感载药胶束能特异性识别肿瘤细胞表面的叶酸受体，实现主动靶向，在肿瘤细胞内酸性条件下腙键发生断裂，快速的释放药物，体内实验证实这一体系能显著得抑制肿瘤生长，同时能降低化疗药物对正常组织的毒副作用。
图 高分子键合纳米药物的体内靶向(a)和对肿瘤的治疗效果图(b)
*Xing Guo, Chunli Shi, Jie Wang, Shubin Di, Shaobing Zhou*，pH-triggered intracellular release from actively targeting polymer Micelles，Biomaterials, 34 (2013) 4544-4554.
b. 具有还原敏感型聚酸酐抗肿瘤药物胶束
如图2所示，以抗肿瘤药物姜黄素为模型，我们成功制备了新型聚酸酐载药胶束，用于肿瘤治疗，在谷胱甘肽作用下能实现药物近零次释放，且体内实验证明该胶束能在肿瘤细胞内快速释放药物，对肿瘤生长具有明显地抑制效果（如图所示）
图 还原敏感聚酸酐胶束的释药机理和体内肿瘤抑制效果
*Jie Wang, Guang Yang, Xing Guo, Zhaomin Tang, Zhendong Zhong, Shaobing Zhou*, Redox-responsive polyanhydride micelles for cancer therapy, Biomaterials, 2014, 35, 3080-3090.
(2) 生物医用形状记忆高分子材料及复合材料的合成及其性能研究
a. 三重形状记忆聚氨酯材料的合成及性能表征
Anewtriple shapememorypolyurethane(TSMPU)withpendantcinnamongroupswas synthesized via a photo crosslinking of cinnamon groups irradiated under λ > 280 nm ultraviolet light.
*Lin Wang, Xifeng Yang, Hongmei Chen, Tao Gong, Wenbing Li, Guang Yang, and Shaobing Zhou*, Design of Triple-Shape Memory Polyurethane with Photo-crosslinking of Cinnamon Groups, ACS Applied Materials & Interfaces, 2013, 5, 10520-10528.
b. 形状记忆多孔组织工程支架
将可降解的形状记忆高分子材料先制备成孔隙贯通的海绵状多孔支架，再通过压缩使该支架变形成体积较小的支架，这样就可方便地将其植入骨缺损部位，在体温刺激下该压缩支架在骨缺损部位可产生良好形状恢复，而将缺损部位填充完全(如图所示)
携载生长因子的形状记忆高分子支架在体温刺激下在骨缺损部位的形状恢复图
*Xian Liu, Kun Zhao, Tao Gong, Jian Song, Chongyun Bao, En Luo, Jie Weng and Shaobing Zhou*, Delivery of Growth Factors Using a Smart Porous Nanocomposite Scaffold to Repair a Mandibular Bone Defect, Biomacromolecules, 2014,15, 1019-1030.
（3）静电纺丝可吸收高分子纤维在药物释放体系和组织工程方面的应用研究
a. 磁性高分子组织工程支架
图示为磁性响应性纤维支架
*Long Li, Guang Yang, Jinrong Li, Shan Ding, Shaobing Zhou*,Cell behaviors on magnetic electrospun poly-d, l-lactide nanofibers，Materials Science and Engineering C 34 (2014) 252–261.
b. 载药静电纺丝纤维用于瘢痕修复
我们针对皮肤瘢痕疙瘩这种临床上的难治疾病，开展了以携载双组份药物的可吸收高分子纤维膜作为一种新型的医用敷料，通过经皮给药方式传递药物修复瘢痕疙瘩的治疗方法（如图5所示）。经过对建有瘢痕疙瘩模型的裸鼠治疗实验证明，载药纤维不但有明显地抗菌功能，还能显著的软化瘢痕疙瘩，瘢痕疙瘩的体积变化比用传统硅凝胶敷贴组明显。
图 携载双组份药物的高分子电纺纤维膜的经皮给药示意图
*Jinrong Li, Rong Fu, Long Li, Guang Yang, Shan Ding, Zhendong Zhong, Shaobing Zhou*, Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid, Pharm Res, DOI 10.1007/s11095-013-1266-2.
c. 静电纺丝高分子可吸收纤维用于电刺激组织工程支架的研究
静电纺丝可以制备高孔隙率，高通透性的三维组织工程支架,纤维可以作为生长因子等生物活性因子，药物的载体，同时可以参杂其他有机或无机材料以提高静电纺丝纤维的功能行，以及更好的模拟细胞外基质的结构和功能。
* Osteoblast function on electrically conductive electrospun PLA/MWCNTs nanofibers. Shijun Shao, Shaobing Zhou*. Biomaterials 2011,32, 2821-2833.
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
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课程教学1.硕士生课程
(1)《高等生物材料》
(2)《药物控制释放与组织工程》
(3)《生物材料导论》
(4)《结构化学》
2.本科生课程
(1)《药物控制释放》
(2)《生物材料合成实验技术》
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招生信息欢迎有化学,生物医学,高分子材料,生物学,医学,材料学或药剂学等专业背景的学生报考硕士,博士研究生。长期招聘博士后研究人员。
祝贺研究生荣获国家奖学金!!!!!
祝贺博士研究生郭星、龚涛、唐昭敏三位同学荣获2014年度“博士研究生国家奖学金”；硕士研究生赵坤荣获2014年度“硕士研究生国家奖学金”。此前，博士研究生龚涛荣获2012年度“博士研究生国家奖学金”，博士研究生郭星荣获2013年度“博士研究生国家奖学金”.
研究生国家奖学金是由国家教育部、财政部设立，中央财政出资，用于奖励普通高等学校中表现优异的全日制研究生，为发展中国特色研究生教育，促进研究生培养机制改革，提高研究生培养质量。博士研究生国家奖学金奖励标准为每生每年3万元；硕士研究生国家奖学金奖励标准为每生每年2万元。
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ResearchPublicationHonourTeamCourseOpeningChineseEnglish
Prof. Zhou's personal page
Welcome to my website!
Basic InformationProf. Zhou Shaobing
Organization: School of Materials Scienceand Engineering Contact Address: Schoolof Materials Science and Engineering, Key Laboratory of Advanced Technologiesof Material, Minister of Education, Southwest Jiaotong University, Chengdu610031, Sichuan, PR ChinaE-mail: shaobingzhou@swjtu.edu.cnshaobingzhou@hotmail.com Office Tel: **Fax: **
Resume
Shaobing Zhou received his B.S. degree in polymer chemistry from Sichuan University in 1996and Ph.D. degree in organic chemistry from Chengdu Institute of OrganicChemistry, Chinese Academy of Sciences in 2003. He was promoted in 2005 to FullProfessor of polymer chemistry at School of Materials Science and Engineering,Southwest Jiaotong University. His research interests include the synthesis andcharacterization of biodegradable polymers, drug controlled release system, shape memory polymer composites and electrospunbiodegradable polymer fibers as tissue engineering scaffold.From year 2001to present,he is the principle investigator of four National Natural ScienceFoundations of China, and he joined seven state-level researchwork including one State Key Basic Research Plan (973 plan). In 2003, he wonChinese Academy of Sciences Dean Award. In 2007, hewas awarded New Century Excellent Talent in University by Ministry of Educationof China. In 2008, he was awarded SichuanProminent Young Talent by Sichuan Province. In 2009, he was approved to ChengduOutstanding Contribution and Excellent Expert by Chengdu city government.In 2010, he won Zhan Tianyou SpecialAward for Youth Award of Ministry of Railways of China.In 2011, he won Sichuan Youth Science and Technology Award of Sichuan Provincegovernment.
He is the author or coauthor of more than 70 refereedarticles, 1 book chapter and 8 Chinese patents/patent applications. He has beencited over 1300 times and has an h-index of 23. Currentlyhe is one of associate editors of the journal: American Journal ofMaterials Science and Technology and on the Editorial Board of the journalAdvanced Materials Letter, and is also an ad-hoc reviewer for 27 internationaljournals such as Angew Chem Int Edit, Biomaterials, Macromolecules, Journal ofControlled release. . Research interests Synthesis of biodegradable polymersDrug Controlledrelease systemBiodegradable shape memorypolymers and composites Biodegradable electrospun polymer fibers for tissue engineering scafford.
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周绍兵
博士，教授，博士生导师
博士学科：高分子材料
工作单位：材料科学与工程学院
联系方式
通信地址：四川省成都市二环路北一段111号西南交通大学材料科学与工程学院
电子邮箱：shaobingzhou@swjtu.edu.cn;shaobingzhou@hotmail.com
办公电话：**
传真：**
个人简历 周绍兵，博士，教授，博士生导师，教育部新世纪优秀人才，四川省学术和技术带头人，成都市突出贡献优秀专家。研究方向是生物医用高分子材料的合成及其在药物控制释放靶向制剂、形状记忆智能材料和组织工程支架方面的应用基础研究。1996年四川大学化学系获学士学位,2003年于中国科学院成都有机化学研究所获博士学位,2004年作为优秀人才引进到西南交通大学材材料先进技术教育部重点实验室工作,建立了生物医用高分子材料合成和药物控制释放制剂实验室，2011年到美国哈佛大学作访问学者。主持过国家自然科学基金项目6项,国家重大研究计划子课题1项，教育部新世纪优秀人才基金1项，四川省杰出青年基金1项。目前在Advanced Materials (影响因子17.49），Acs Nano(影响因子12.8),Advanced Functional Materials(影响因子11.82), Chemistry of Materials, Biomaterials, Journal of Controlled Release和Macromolecules等SCI收录期刊发表文章100余篇，文章SCI他引2000余次,单篇最高SCI他引170次,合作出版外文专著1部(贡献1章),作为第一发明人申请中国发明专利10余项，7项获得授权。2003年荣获中国科学院院长优秀奖，2010年荣获“第八届詹天佑科学技术奖专项基金奖”,2011年荣获“第十一届四川省青年科技奖”。目前，任国际期刊American Journal of Materials Scienceand Technology副主编，国际期刊Advanced Materials Letter 编委,还担任Advanced Materials (影响因子17.4),Angewandte Chemie InternationalEdition (影响因子11.73)、Advanced Functional Materials (影响因子11.8）、Biomaterials(影响因子8.52)、Macromolecules、Journal of Controlled Release、Molecular Pharmaceutics等40余种国际期刊评审人。
在指导的研究生中, 其中8位研究生毕业论文获四川省优秀硕士论文奖, 1位博士生毕业论文获四川省优秀博士论文奖,13位研究生获校优秀硕士论文。2010年和2011年连续两年被评为本科毕业设计优秀指导教师。 2014年被学校评为首届西南交通大学“十佳研究生导师”荣誉称号。
研究方向
(1) 可生物降解高分子新材料的合成；(2) 药物控制释放靶向新制剂的研究； (3) 可生物降解形状记忆高分子材料及复合材料的研究；(4) 可生物降解高分子静电纺丝纤维组织工程支架的研究。
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科学研究目前主持科研项目情况
1. 国家自然科学基金面上项目，基于双重响应聚合物胶束的抗肿瘤主动靶向给药系统（**），项目经费：78万元、起止年度：2016.1-2019.12。
2. 国家自然科学基金面上项目，具有三重形状记忆功能的高分子表面微图案及其与细胞作用机制（**），项目经费：82万元、起止年度：2014.1-2017.12。
3. 高等学校博士学科点专项科研基金项目(博导类)，基于氢键作用的形状记忆高分子表面微结构的研究（**029）、项目经费：12万元、起止年度：2013.1-2015.12
4. 国家自然科学基金面上项目，携载药物的可降解形状记忆高分子器件的制备及其性能研究（**），项目经费：32万元，起止年度：2008.1-2010.12。
5. 国家自然科学基金，具有温敏性的磁靶向可降解聚合物抗肿瘤药物胶束的研究（**），项目经费：37万元，起止年度：2010.1-2012.12。
6. 国家自然科学基金面上项目，聚醚-聚酸酐胶束的形貌调控及其对肿瘤细胞生长影响的研究（**），项目经费：60万元，起止年度：2012.1-2015.12。
7. 国家重大科学研究计划（973计划）子课题，生长因子在微纳结构材料中的高活性固载及控释2012CB933602, 项目经费：135万元，起止年度：2012.1-2016.12。
8. 教育部新世纪优秀人才基金，蛋白和多肽类生物活性大分子控制释放系统的研究（NCET-07-0719）项目经费：50万元，2008.1-2010.12。
9. 四川省杰出青年科技基金，具有药物控释功能的可降解形状记忆高分子器件的研究 (08ZQ026-040)，项目经费：12万元，2008.1-2010.12。
10. 西南交通大学“杨华之星”项目，项目经费：30万元，2009.9-2012.9。
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论文成果发表的SCI收录论文目录（注：* 表示通讯作者）
Jie Wang, Guang Yang, Xing Guo, Zhaomin Tang, Zhendong Zhong, Shaobing Zhou*, Redox-responsive polyanhydride micelles for cancer therapy, Biomaterials, 2014, 35, 3080-3090. Ye Liu, Ying Li, Hongmei Chen, Guang Yang, Xiaotong Zheng, Shaobing Zhou*, Water-induced shape-memory poly(D,L-lactide)/microcrystalline cellulose composites, Carbohydrate Polymers,104 (2014) 101–108. Xian Liu, Kun Zhao, Tao Gong, Jian Song, Chongyun Bao, En Luo, Jie Weng and Shaobing Zhou*, Delivery of Growth Factors Using a Smart Porous Nanocomposite Scaffold to Repair a Mandibular Bone Defect, Biomacromolecules, 2014,15, 1019-1030. Jinrong Li, Rong Fu, Long Li, Guang Yang, Shan Ding, Zhendong Zhong, Shaobing Zhou*, Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid, Pharm Res, DOI 10.1007/s11095-013-1266-2. Long Li, Guang Yang, Jinrong Li, Shan Ding, Shaobing Zhou*,Cell behaviors on magnetic electrospun poly-d, l-lactide nanofibers，Materials Science and Engineering C 34 (2014) 252–261. Lin Wang, Xifeng Yang, Hongmei Chen, Tao Gong, Wenbing Li, Guang Yang, and Shaobing Zhou*, Design of Triple-Shape Memory Polyurethane with Photo-crosslinking of Cinnamon Groups, ACS Applied Materials & Interfaces, 2013, 5, 10520?10528. Lin Wang, Xifeng Yang,Hongmei Chen, Guang Yang, Tao Gong, Wenbing Li and Shaobing Zhou*，Multi-stimuli sensitive shape memory poly(vinyl alcohol)-graft-polyurethane，Polym. Chem., 2013,4, 4461-4468. Shaobing Zhou*, Jing Fan, Sujit S. Datta, Ming Guo, Xing Guo and David A. Weitz*, Thermally Switched Release from Nanoparticle Colloidosomes, Advanced Functional Materials, 2013, 23, 5925–5929. Tao Chen, Xing Guo,Aijun Zhao, Jie Wang,Chunli Shi and Shaobing Zhou*，Morphological transition of self-assembled architectures from PEG-based ether-anhydride terpolymers，Soft Matter, 2013, 9, 3021-3031. Wenbing Li, Tao Gong, Hongmei Chen, Lin Wang, Jinrong Li and Shaobing Zhou*，Tuning surface micropattern features using a shape memory functional polymer，RSC Adv., 2013, 3, 9865–9874. Hongmei Chen, Ye Liu, Tao Gong, Lin Wang, Keqing Zhao and Shaobing Zhou*，Use of intermolecular hydrogen bonding to synthesize triple-shape memory supermolecular composites，RSC Adv., 2013, 3, 7048–7056. Xing Guo, Chunli Shi, Jie Wang, Shubin Di, Shaobing Zhou*，pH-triggered intracellular release from actively targeting polymer Micelles，Biomaterials, 34 (2013) 4544-4554.Zhao Zhang, Qianqian Qu, Jinrong Li, Shaobing Zhou*，The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells，Macromol. Biosci. 2013, 13, 789–798. Shan Ding, Jinrong Li, Chao Luo, Long Li, Guang Yang and Shaobing Zhou*，Synergistic e ff ect of released dexamethasone and surface nanoroughness on mesenchymal stem cell differentiation，Biomater. Sci., 2013, 1, 1091–1100.
Tao Gong,Wenbing Li, Hongmei Chen, LinWang, Shijun Shao, Shaobing Zhou*，Remotely actuatedshape memory effect of electrospun composite nanofibers，ActaBiomaterialia 8 (2012) 1248–1259. XiongjunYu, LinWang, MaotaoHuang, TaoGong, WenbingLi, YalingCao, DaijinJi, PingWang, JingWang and ShaobingZhou*,A shape memory stent of poly(ε-caprolactone-co-dl-lactide) copolymer for potentialtreatment of esophageal stenosis, Journal of Materials Science: Materials in Medicine, 2012, 23, 581-589.Qi Zhou, Xing Guo, Tao Chen, Zhao Zhang, ShijunShao, Chao Luo, Jinrong Li, and Shaobing Zhou*, Target-Specific Cellular Uptake of Folate-Decorated BiodegradablePolymer Micelles, J.Phys. Chem. B, 2011, 115 (43), pp 12662–12670. Shijun Shao, Long Li, Guang Yang, Jingrong Li, ChaoLuo, Tao Gong, Shaobing Zhou*,Controlled green tea polyphenols releasefrom electrospun PCL/MWCNTs composite nanofibers,InternationalJournal of Pharmaceutics ,2011,421,310–320. ShijunShao, Shaobing Zhou*, Long Li,Jinrong Li, Chao Luo, Jianxin Wang, Xiaohong Li and Jie Weng, Osteoblast function on electricallyconductive electrospun PLA/MWCNTs nanofibers, Biomaterials,2011, 32, 2821-2833.Chi Huang, Yangbo Zhou, Zhaomin Tang, Xing Guo, ZhiyongQian and Shaobing Zhou*，Synthesis of multifunctional Fe3O4core/hydroxyapatite shell nanocomposites by biomineralization，Dalton Trans., 2011,40,5026-5031. YuXiao, Tao Gong, Shaobing Zhou*，Thefunctionalization of multi-walled carbon nanotubes by in situ deposition ofhydroxyapatite，Biomaterials ，2010，31 ，5182-5190. （SCI, IF：6.646） ChiHuang,Yangbo Zhou,Yong Jin,Xiaofeng Zhou,Zhaomin Tang, Xing Guo and Shaobing Zhou*，Preparation and characterization of temperature-responsiveand magnetic nanomicelles，J. Mater. Chem., 2011, 21 (15), 5660 – 5670.WeijiaWang, Shaobing Zhou*, Laiyang Guo, Wei Zhi, XIaohong Li,JieWeng,Investigation of endocytosis and cytotoxicity of poly-d,l-lactide-poly(ethylene glycol) nano/micro- particles in osteoblast cells, InternationalJournal of Nanomedicine 2010:5 557–566.Qiuxiang Su, Aijun Zhao, Hongsen Peng, and Shaobing Zhou?，Preparation andCharacterization of Biodegradable Electrospun Polyanhydride Nano/Microfibers，Journal ofNanoscience and Nanotechnology,2010. 10, 6369-6375. Lin Sun, Chi Huang, Tao Gong, Shaobing Zhou*，Abiocompatible approach to surface modification: Biodegradable polymerfunctionalized super-paramagnetic iron oxide nanoparticles，Materials Science andEngineering C，2010， 30，583–589. WeijiaWang, Shaobing Zhou*, Lin Sun, Chi Huang, Controlled delivery ofparacetamol and protein at different stages from core–shell biodegradablemicrospheres, Carbohydrate Polymers, 79 (2010) 437–444.AijunZhao， Shaobing Zhou*， Qi Zhou，Tao Chen，Thermosensitive Micelles from PEG-BasedEther-anhydride Triblock Copolymers，Pharm Res，2010，27，1627-1643. YuXiao, Shaobing Zhou*, Lin Wang,Xiaotong Zheng, Tao Gong，Crosslinked poly(ε-caprolactone)/poly(sebacic anhydride) compositescombining biodegradation, controlled drug release and shape memory effect，Composites:Part B 41 (2010) 537–542. AijunZhao, Qi Zhou, Tao Chen, Jie Weng, ShaobingZhou*，Amphiphilic PEG-based ether-anhydride terpolymers: Synthesis,characterization, and micellization，Journal of Applied Polymer Science，2010,118（6）：3576–3585. WeijiaWang, Shijun Shao, Chao Luo, ShaobingZhou*, Chitosan hollow nanospheresfabricated from biodegradable poly-d,l-lactide-poly(ethylene glycol)nanoparticle templates, European Journal of Pharmaceuticsand Biopharmaceutics, 76 (2010) 376–383. YuXiao, Shaobing Zhou*, Lin Wang, andTao Gong，Electro-activeShape Memory Properties of Poly(ε-caprolactone)/Functionalized MultiwalledCarbon Nanotube Nanocomposite，ACS Appl. Mater. Interfaces, 2010, 2 (12), pp 3506–3514.Hongsen Peng, Shaobing Zhou*, Jing Jiang, TaoGuo, Xiaotong Zheng, and Xiongjun Yu，Pressure-Induced CrystalMemory Effect of Spider Silk Proteins，J. Phys. Chem. B 2009, 113, 4636–4641. XiongjunYu, Shaobing Zhou*, Xiaotong Zheng, Yu Xiao and Tao Guo，Influenceof in Vitro Degradation of a Biodegradable Nanocomposite on Its Shape Memory Effect，J. Phys. Chem. C, 2009, 113 (41), pp17630–17635.TaoGuo, Shaobing Zhou*, Xiaotong Zheng and Jing Jiang, Modeling andInvestigation of Interfacial Interaction between PLA and One Type of DeficientHydroxyapatite,J. Phys. Chem. A, 2009, 113 (25), pp7112–7123. Xiongjun Yu, Shaobing Zhou*, XiaotongZheng, Tao Guo, Yu Xiaoand BotaoSong, A Biodegradable Shape Memory Nanocomposite with Dual-versatilityof Thermal and Magnetic Field Sensitivity. Nanotechnology. 2009，20,235702. Xiaotong Zheng, Shaobing Zhou*, Yu Xiao,Xiongjun Yu, Xiaohong Li，Peizhuo Wu，Shapememoryeffectofpoly(D,L-lactide)/Fe3O4，nanocompositesbyinductiveheatingofmagnetiteparticles，ColloidsandSurfaces B:Biointerfaces，71(2009),pp.67-72.LinSun, Shaobing Zhou*, Weijia Wang, Xiaohong Li, Jianxin Wang,Jie Weng, Preparation and characterizationof porous biodegradable microspheres used for controlled protein delivery, Colloidsand Surfaces A: Physicochem. Eng. Aspects 345 (2009) 173–181. XiaotongZheng, Shaobing Zhou*, Yu Xiao, Xiongjun Yu, Bo Feng. In situpreparation and characterization of a novel Gelatin/ Poly(D,L-lactide)/Hydroxyapatite nanocomposite. Journal of Biomedical Materials ResearchPart B: Applied Biomaterials.Volume91B, Issue1, Date:October 2009,Pages:181-190. ShaobingZhou*,Xiaotong Zheng, Xiongjun Yu,et al，Hydrogen Bonding Interaction of Poly(D,L-Lactide)/hydroxyapatiteNanocomposites，Chemistry of Materials, 2007，19（2），247– 253.??? JingSun， Shaobing Zhou*,et al., Synthesis and Characterization of Biocompatible Fe3O4Nanoparticles, Journal of Biomedical MaterialsResearch,Part A, 2007,80A(2), 333-341. （SCI, IF：2.5） XiaotongZheng, Shaobing Zhou*, et al., Shapememory properties of poly(D,L-lactide)/ hydroxyapatite composites，Biomaterials，2006，27（24），4288–4295.??? （2008年第4季度入选TOP25 Hottest Articles且排名第7） Lin Sun, Shaobing Zhou*, Weijia Wang, Qiuxiang Su, Xiaohong Li and Jie Weng, Preparation and characterization of protein-loadedpolyanhydride microspheres, Journal of Materials Science: Materialsin Medicine, 2009,20，2035-2042. Shaobing Zhou*, Qiuxiang Su,et al，A novel insitu synthesis of dicalcium phosphate dehydrate nanocrystals in biodegradablepolymer matrix，Materials Science and Engineering A， 2006，430（1-2），341–345.Shaobing Zhou*, Bing Song, Xiaohong Li, Invitro Degradation and Release profiles for Poly-dl-lactide Film ContainingParacetamol, Journal of Materials Science: Materials inMedicine,2007,18（8）1623-1626.Xiaotong Zheng, Shaobing Zhou*, Xiongjun Yu, Xiaohong Li, Bo Feng, Shuxin Qu, JieWeng，Effect of In vitro degradation of poly(D,L-lactide)/-tricalciumcomposite on its shape-memory properties，Journal of Biomedical Materials ResearchPart B: Applied Biomaterials. 2008，Volume 86BIssue 1,Pages170–180. Shaobing Zhou*,Xianmo Deng,Hua Yang, Biodegradablecopolymer of poly(ethylene glycol)-co-poly (ε-caprol actone):characterizationand its use in controlled release system. Biomaterials, 2003, 24(20), 3563-3570. （SCI, IF：5.196） Shaobing Zhou,*Hongsen Peng,Xiongjun Yu, Xiaotong Zheng,Wenguo Cui, ZairongZhang, Xiaohong Li,Jianxin Wang, Jie Weng,Wenxiang Jia,and Fei Li，Preparation and Characterization of a NovelElectrospun Spider Silk Fibroin/Poly(D,L-lactide) Composite Fiber, J. Phys. Chem. B.; 2008; 112(36); 11209-11216. HongsenPeng, Shaobing Zhou*, Tao Guo, Yanshan Li, Xiaohong Li, JianxinWang, Jie Weng, In vitro degradation and releaseprofiles for electrospun polymeric fibers containing paracetanol,Colloidsand Surfaces B: Biointerfaces 66 (2008), pp.206-212.Shaobing Zhou*, Jing Sun, Lin Sun, Yanqin Dai, LipingLiu, Xiaohong Li, Jianxin Wang, Jie Weng, Wenxiang Jia, Zairong Zhang，Preparationand characterization of interferon-loaded magnetic biodegradable microspheres，Journal of Biomedical Materials Research Part B:Applied Biomaterials. Volume 87B, Issue 1, Date: October 2008, Pages:189-196.Shaobing Zhou*, Xianmo Deng, Xiaohong Li,et al.,Investigationon a Novel Core-Coated Microspheres Protein Delivery System, Journal of Controlled Release, 2001,75(1-2),27-36.?? Shaobing Zhou*,Xueyan Liao,Xiaohong Li,Xianmo Deng,et al.Poly-D,L-lactide-co-poly(ethylene glycol) microspheres as potential vaccinedelivery systems.Journal ofControlled Release, 2003，86(2-3)：195-205. (SCI, IF 4.01)XianmoDeng, Shaobing Zhou,Xiaohong Li,etal.,In vitro Degradation and Release profiles for Poly-dl-Lactide-poly(ethyleneglycol) Microspheres Containing Human Serum Albumin. Journal of Controlled Release,2001, 71(2),165-173. Shaobing Zhou*,Xianmo Deng,Shuiying He,XiaohongLi,Wenxiang Jia, et al., Study on biodegradable microspheres containingrecombinant interferon. J.Pharm.Pharmacol.2002,54:1287-12192. Shaobing Zhou*,Xianmo Deng,Xiaohong Li,et al.,Investigation on Preparation and Protein Release of Biodegradable PolymerMicrospheres as Drug Delivery System,Journal of Applied polymer science,2002,84,778-784.Shaobing Zhou*,Xianmo Deng,In Vitro DegradationCharacteristics of Poly-dl-lactide-poly(ethylene glycol) MicrospheresContaining Human Serum Albumin. Reactive and functional polymer,2002,51,93-100. Shaobing Zhou*, Xianmo Deng, Wenxiang Jia,etal.,Synthesis and characterization of biodegradable low-molecular-weightaliphatic polyesters and their use inprotein delivery system, Journal of Applied polymer Sciences , 2004, 91(3), 1848–1856.Shaobing Zhou*, Jinggang Xu,Xianmo Deng，et al.,Synthesis and Characterization of BiodegradablePoly(-caprolactone)- Polyglycolide-Poly(ethylene glycol) Monomethyl EtherRandom Copolymer，Macromolecular Materials and Engineering，2004,289（6），576-580.ShaobingZhou*, Xueyan Liao, Xianmo Deng, Heming Li,etal.,Preparation and Characterization of Biodegradable Microspheres ContainingHepatitis B Surface Antigen, Macromolecular Bioscience,2004,4,(1)1,47-52.YuanYang, Li Liu, Shaobing Zhou*,et al.Novel Biodegradable Polymers as Gene Carriers. Macromol. Biosci. 2004,4, 1113–1117.
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
荣誉奖励 2003年荣获中国科学院院长优秀奖;
2010年荣获“第八届詹天佑科学技术奖专项基金奖”；
2011年荣获“第十一届四川省青年科技奖”；
2010年和2011年连续两年被评为本科毕业设计优秀指导教师；
2014年被评为首届“西南交通大学十佳研究生导师”荣誉称号
2014年荣获唐立新优秀学者奖
2014年荣获四川省学术和技术带头人
在指导的研究生中, 其中8位研究生毕业论文获四川省优秀硕士论文奖, 1位博士生毕业论文获四川省优秀博士论文奖,13位研究生论文获校优秀硕士论文。
祝贺研究生荣获国家奖学金!!!!!
祝贺博士研究生郭星、龚涛、唐昭敏三位同学荣获2014年度“博士研究生国家奖学金”；硕士研究生赵坤荣获2014年度“硕士研究生国家奖学金”。此前，博士研究生龚涛荣获2012年度“博士研究生国家奖学金”，博士研究生郭星荣获2013年度“博士研究生国家奖学金”.
研究生国家奖学金是由国家教育部、财政部设立，中央财政出资，用于奖励普通高等学校中表现优异的全日制研究生，为发展中国特色研究生教育，促进研究生培养机制改革，提高研究生培养质量。博士研究生国家奖学金奖励标准为每生每年3万元；硕士研究生国家奖学金奖励标准为每生每年2万元。
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科研团队博士后：刘显
博士研究生：陈红梅，王林，李龙，郭星，杨光，孙会丽，龚涛，唐昭敏，王毅
硕士研究生：史春丽，丁珊，杨希凤，刘野，王杰，赵坤，屈倩倩，李丹，李莹，狄淑斌，王文玺，周光亮，王毅，张累
已毕业研究生：郑晓彤（博士），罗超，周洋波，陈涛，李文兵，李金绒，张钊，孙敬，苏秋香，彭红森，孙林，俞雄军，郭涛，肖雨，王卫佳，赵艾军，黄驰，周奇，邵仕军
(1) 靶向药物控制释放新制剂的研究
a. 具有主动靶向的pH敏感抗肿瘤药物胶束
如图所示，该叶酸靶向的pH敏感载药胶束能特异性识别肿瘤细胞表面的叶酸受体，实现主动靶向，在肿瘤细胞内酸性条件下腙键发生断裂，快速的释放药物，体内实验证实这一体系能显著得抑制肿瘤生长，同时能降低化疗药物对正常组织的毒副作用。
图 高分子键合纳米药物的体内靶向(a)和对肿瘤的治疗效果图(b)
*Xing Guo, Chunli Shi, Jie Wang, Shubin Di, Shaobing Zhou*，pH-triggered intracellular release from actively targeting polymer Micelles，Biomaterials, 34 (2013) 4544-4554.
b. 具有还原敏感型聚酸酐抗肿瘤药物胶束
如图2所示，以抗肿瘤药物姜黄素为模型，我们成功制备了新型聚酸酐载药胶束，用于肿瘤治疗，在谷胱甘肽作用下能实现药物近零次释放，且体内实验证明该胶束能在肿瘤细胞内快速释放药物，对肿瘤生长具有明显地抑制效果（如图所示）
图 还原敏感聚酸酐胶束的释药机理和体内肿瘤抑制效果
*Jie Wang, Guang Yang, Xing Guo, Zhaomin Tang, Zhendong Zhong, Shaobing Zhou*, Redox-responsive polyanhydride micelles for cancer therapy, Biomaterials, 2014, 35, 3080-3090.
(2) 生物医用形状记忆高分子材料及复合材料的合成及其性能研究
a. 三重形状记忆聚氨酯材料的合成及性能表征
Anewtriple shapememorypolyurethane(TSMPU)withpendantcinnamongroupswas synthesized via a photo crosslinking of cinnamon groups irradiated under λ > 280 nm ultraviolet light.
*Lin Wang, Xifeng Yang, Hongmei Chen, Tao Gong, Wenbing Li, Guang Yang, and Shaobing Zhou*, Design of Triple-Shape Memory Polyurethane with Photo-crosslinking of Cinnamon Groups, ACS Applied Materials & Interfaces, 2013, 5, 10520-10528.
b. 形状记忆多孔组织工程支架
将可降解的形状记忆高分子材料先制备成孔隙贯通的海绵状多孔支架，再通过压缩使该支架变形成体积较小的支架，这样就可方便地将其植入骨缺损部位，在体温刺激下该压缩支架在骨缺损部位可产生良好形状恢复，而将缺损部位填充完全(如图所示)
携载生长因子的形状记忆高分子支架在体温刺激下在骨缺损部位的形状恢复图
*Xian Liu, Kun Zhao, Tao Gong, Jian Song, Chongyun Bao, En Luo, Jie Weng and Shaobing Zhou*, Delivery of Growth Factors Using a Smart Porous Nanocomposite Scaffold to Repair a Mandibular Bone Defect, Biomacromolecules, 2014,15, 1019-1030.
（3）静电纺丝可吸收高分子纤维在药物释放体系和组织工程方面的应用研究
a. 磁性高分子组织工程支架
图示为磁性响应性纤维支架
*Long Li, Guang Yang, Jinrong Li, Shan Ding, Shaobing Zhou*,Cell behaviors on magnetic electrospun poly-d, l-lactide nanofibers，Materials Science and Engineering C 34 (2014) 252–261.
b. 载药静电纺丝纤维用于瘢痕修复
我们针对皮肤瘢痕疙瘩这种临床上的难治疾病，开展了以携载双组份药物的可吸收高分子纤维膜作为一种新型的医用敷料，通过经皮给药方式传递药物修复瘢痕疙瘩的治疗方法（如图5所示）。经过对建有瘢痕疙瘩模型的裸鼠治疗实验证明，载药纤维不但有明显地抗菌功能，还能显著的软化瘢痕疙瘩，瘢痕疙瘩的体积变化比用传统硅凝胶敷贴组明显。
图 携载双组份药物的高分子电纺纤维膜的经皮给药示意图
*Jinrong Li, Rong Fu, Long Li, Guang Yang, Shan Ding, Zhendong Zhong, Shaobing Zhou*, Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid, Pharm Res, DOI 10.1007/s11095-013-1266-2.
c. 静电纺丝高分子可吸收纤维用于电刺激组织工程支架的研究
静电纺丝可以制备高孔隙率，高通透性的三维组织工程支架,纤维可以作为生长因子等生物活性因子，药物的载体，同时可以参杂其他有机或无机材料以提高静电纺丝纤维的功能行，以及更好的模拟细胞外基质的结构和功能。
* Osteoblast function on electrically conductive electrospun PLA/MWCNTs nanofibers. Shijun Shao, Shaobing Zhou*. Biomaterials 2011,32, 2821-2833.
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
课程教学1.硕士生课程
(1)《高等生物材料》
(2)《药物控制释放与组织工程》
(3)《生物材料导论》
(4)《结构化学》
2.本科生课程
(1)《药物控制释放》
(2)《生物材料合成实验技术》
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
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招生信息欢迎有化学,生物医学,高分子材料,生物学,医学,材料学或药剂学等专业背景的学生报考硕士,博士研究生。长期招聘博士后研究人员。
祝贺研究生荣获国家奖学金!!!!!
祝贺博士研究生郭星、龚涛、唐昭敏三位同学荣获2014年度“博士研究生国家奖学金”；硕士研究生赵坤荣获2014年度“硕士研究生国家奖学金”。此前，博士研究生龚涛荣获2012年度“博士研究生国家奖学金”，博士研究生郭星荣获2013年度“博士研究生国家奖学金”.
研究生国家奖学金是由国家教育部、财政部设立，中央财政出资，用于奖励普通高等学校中表现优异的全日制研究生，为发展中国特色研究生教育，促进研究生培养机制改革，提高研究生培养质量。博士研究生国家奖学金奖励标准为每生每年3万元；硕士研究生国家奖学金奖励标准为每生每年2万元。
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ResearchPublicationHonourTeamCourseOpeningChineseEnglish
Prof. Zhou's personal page
Welcome to my website!
Basic InformationProf. Zhou Shaobing
Organization: School of Materials Scienceand Engineering Contact Address: Schoolof Materials Science and Engineering, Key Laboratory of Advanced Technologiesof Material, Minister of Education, Southwest Jiaotong University, Chengdu610031, Sichuan, PR ChinaE-mail: shaobingzhou@swjtu.edu.cnshaobingzhou@hotmail.com Office Tel: **Fax: **
Resume
Shaobing Zhou received his B.S. degree in polymer chemistry from Sichuan University in 1996and Ph.D. degree in organic chemistry from Chengdu Institute of OrganicChemistry, Chinese Academy of Sciences in 2003. He was promoted in 2005 to FullProfessor of polymer chemistry at School of Materials Science and Engineering,Southwest Jiaotong University. His research interests include the synthesis andcharacterization of biodegradable polymers, drug controlled release system, shape memory polymer composites and electrospunbiodegradable polymer fibers as tissue engineering scaffold.From year 2001to present,he is the principle investigator of four National Natural ScienceFoundations of China, and he joined seven state-level researchwork including one State Key Basic Research Plan (973 plan). In 2003, he wonChinese Academy of Sciences Dean Award. In 2007, hewas awarded New Century Excellent Talent in University by Ministry of Educationof China. In 2008, he was awarded SichuanProminent Young Talent by Sichuan Province. In 2009, he was approved to ChengduOutstanding Contribution and Excellent Expert by Chengdu city government.In 2010, he won Zhan Tianyou SpecialAward for Youth Award of Ministry of Railways of China.In 2011, he won Sichuan Youth Science and Technology Award of Sichuan Provincegovernment.
He is the author or coauthor of more than 70 refereedarticles, 1 book chapter and 8 Chinese patents/patent applications. He has beencited over 1300 times and has an h-index of 23. Currentlyhe is one of associate editors of the journal: American Journal ofMaterials Science and Technology and on the Editorial Board of the journalAdvanced Materials Letter, and is also an ad-hoc reviewer for 27 internationaljournals such as Angew Chem Int Edit, Biomaterials, Macromolecules, Journal ofControlled release. . Research interests Synthesis of biodegradable polymersDrug Controlledrelease systemBiodegradable shape memorypolymers and composites Biodegradable electrospun polymer fibers for tissue engineering scafford.
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1. 国家自然科学基金面上项目，基于双重响应聚合物胶束的抗肿瘤主动靶向给药系统（**），项目经费：78万元、起止年度：2016.1-2019.12。
2. 国家自然科学基金面上项目，具有三重形状记忆功能的高分子表面微图案及其与细胞作用机制（**），项目经费：82万元、起止年度：2014.1-2017.12。
3. 高等学校博士学科点专项科研基金项目(博导类)，基于氢键作用的形状记忆高分子表面微结构的研究（**029）、项目经费：12万元、起止年度：2013.1-2015.12
4. 国家自然科学基金面上项目，携载药物的可降解形状记忆高分子器件的制备及其性能研究（**），项目经费：32万元，起止年度：2008.1-2010.12。
5. 国家自然科学基金，具有温敏性的磁靶向可降解聚合物抗肿瘤药物胶束的研究（**），项目经费：37万元，起止年度：2010.1-2012.12。
6. 国家自然科学基金面上项目，聚醚-聚酸酐胶束的形貌调控及其对肿瘤细胞生长影响的研究（**），项目经费：60万元，起止年度：2012.1-2015.12。
7. 国家重大科学研究计划（973计划）子课题，生长因子在微纳结构材料中的高活性固载及控释2012CB933602, 项目经费：135万元，起止年度：2012.1-2016.12。
8. 教育部新世纪优秀人才基金，蛋白和多肽类生物活性大分子控制释放系统的研究（NCET-07-0719）项目经费：50万元，2008.1-2010.12。
9. 四川省杰出青年科技基金，具有药物控释功能的可降解形状记忆高分子器件的研究 (08ZQ026-040)，项目经费：12万元，2008.1-2010.12。
10. 西南交通大学“杨华之星”项目，项目经费：30万元，2009.9-2012.9。
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周绍兵的个人主页
论文成果发表的SCI收录论文目录（注：* 表示通讯作者）
Jie Wang, Guang Yang, Xing Guo, Zhaomin Tang, Zhendong Zhong, Shaobing Zhou*, Redox-responsive polyanhydride micelles for cancer therapy, Biomaterials, 2014, 35, 3080-3090. Ye Liu, Ying Li, Hongmei Chen, Guang Yang, Xiaotong Zheng, Shaobing Zhou*, Water-induced shape-memory poly(D,L-lactide)/microcrystalline cellulose composites, Carbohydrate Polymers,104 (2014) 101–108. Xian Liu, Kun Zhao, Tao Gong, Jian Song, Chongyun Bao, En Luo, Jie Weng and Shaobing Zhou*, Delivery of Growth Factors Using a Smart Porous Nanocomposite Scaffold to Repair a Mandibular Bone Defect, Biomacromolecules, 2014,15, 1019-1030. Jinrong Li, Rong Fu, Long Li, Guang Yang, Shan Ding, Zhendong Zhong, Shaobing Zhou*, Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid, Pharm Res, DOI 10.1007/s11095-013-1266-2. Long Li, Guang Yang, Jinrong Li, Shan Ding, Shaobing Zhou*,Cell behaviors on magnetic electrospun poly-d, l-lactide nanofibers，Materials Science and Engineering C 34 (2014) 252–261. Lin Wang, Xifeng Yang, Hongmei Chen, Tao Gong, Wenbing Li, Guang Yang, and Shaobing Zhou*, Design of Triple-Shape Memory Polyurethane with Photo-crosslinking of Cinnamon Groups, ACS Applied Materials & Interfaces, 2013, 5, 10520?10528. Lin Wang, Xifeng Yang,Hongmei Chen, Guang Yang, Tao Gong, Wenbing Li and Shaobing Zhou*，Multi-stimuli sensitive shape memory poly(vinyl alcohol)-graft-polyurethane，Polym. Chem., 2013,4, 4461-4468. Shaobing Zhou*, Jing Fan, Sujit S. Datta, Ming Guo, Xing Guo and David A. Weitz*, Thermally Switched Release from Nanoparticle Colloidosomes, Advanced Functional Materials, 2013, 23, 5925–5929. Tao Chen, Xing Guo,Aijun Zhao, Jie Wang,Chunli Shi and Shaobing Zhou*，Morphological transition of self-assembled architectures from PEG-based ether-anhydride terpolymers，Soft Matter, 2013, 9, 3021-3031. Wenbing Li, Tao Gong, Hongmei Chen, Lin Wang, Jinrong Li and Shaobing Zhou*，Tuning surface micropattern features using a shape memory functional polymer，RSC Adv., 2013, 3, 9865–9874. Hongmei Chen, Ye Liu, Tao Gong, Lin Wang, Keqing Zhao and Shaobing Zhou*，Use of intermolecular hydrogen bonding to synthesize triple-shape memory supermolecular composites，RSC Adv., 2013, 3, 7048–7056. Xing Guo, Chunli Shi, Jie Wang, Shubin Di, Shaobing Zhou*，pH-triggered intracellular release from actively targeting polymer Micelles，Biomaterials, 34 (2013) 4544-4554.Zhao Zhang, Qianqian Qu, Jinrong Li, Shaobing Zhou*，The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells，Macromol. Biosci. 2013, 13, 789–798. Shan Ding, Jinrong Li, Chao Luo, Long Li, Guang Yang and Shaobing Zhou*，Synergistic e ff ect of released dexamethasone and surface nanoroughness on mesenchymal stem cell differentiation，Biomater. Sci., 2013, 1, 1091–1100.
Tao Gong,Wenbing Li, Hongmei Chen, LinWang, Shijun Shao, Shaobing Zhou*，Remotely actuatedshape memory effect of electrospun composite nanofibers，ActaBiomaterialia 8 (2012) 1248–1259. XiongjunYu, LinWang, MaotaoHuang, TaoGong, WenbingLi, YalingCao, DaijinJi, PingWang, JingWang and ShaobingZhou*,A shape memory stent of poly(ε-caprolactone-co-dl-lactide) copolymer for potentialtreatment of esophageal stenosis, Journal of Materials Science: Materials in Medicine, 2012, 23, 581-589.Qi Zhou, Xing Guo, Tao Chen, Zhao Zhang, ShijunShao, Chao Luo, Jinrong Li, and Shaobing Zhou*, Target-Specific Cellular Uptake of Folate-Decorated BiodegradablePolymer Micelles, J.Phys. Chem. B, 2011, 115 (43), pp 12662–12670. Shijun Shao, Long Li, Guang Yang, Jingrong Li, ChaoLuo, Tao Gong, Shaobing Zhou*,Controlled green tea polyphenols releasefrom electrospun PCL/MWCNTs composite nanofibers,InternationalJournal of Pharmaceutics ,2011,421,310–320. ShijunShao, Shaobing Zhou*, Long Li,Jinrong Li, Chao Luo, Jianxin Wang, Xiaohong Li and Jie Weng, Osteoblast function on electricallyconductive electrospun PLA/MWCNTs nanofibers, Biomaterials,2011, 32, 2821-2833.Chi Huang, Yangbo Zhou, Zhaomin Tang, Xing Guo, ZhiyongQian and Shaobing Zhou*，Synthesis of multifunctional Fe3O4core/hydroxyapatite shell nanocomposites by biomineralization，Dalton Trans., 2011,40,5026-5031. YuXiao, Tao Gong, Shaobing Zhou*，Thefunctionalization of multi-walled carbon nanotubes by in situ deposition ofhydroxyapatite，Biomaterials ，2010，31 ，5182-5190. （SCI, IF：6.646） ChiHuang,Yangbo Zhou,Yong Jin,Xiaofeng Zhou,Zhaomin Tang, Xing Guo and Shaobing Zhou*，Preparation and characterization of temperature-responsiveand magnetic nanomicelles，J. Mater. Chem., 2011, 21 (15), 5660 – 5670.WeijiaWang, Shaobing Zhou*, Laiyang Guo, Wei Zhi, XIaohong Li,JieWeng,Investigation of endocytosis and cytotoxicity of poly-d,l-lactide-poly(ethylene glycol) nano/micro- particles in osteoblast cells, InternationalJournal of Nanomedicine 2010:5 557–566.Qiuxiang Su, Aijun Zhao, Hongsen Peng, and Shaobing Zhou?，Preparation andCharacterization of Biodegradable Electrospun Polyanhydride Nano/Microfibers，Journal ofNanoscience and Nanotechnology,2010. 10, 6369-6375. Lin Sun, Chi Huang, Tao Gong, Shaobing Zhou*，Abiocompatible approach to surface modification: Biodegradable polymerfunctionalized super-paramagnetic iron oxide nanoparticles，Materials Science andEngineering C，2010， 30，583–589. WeijiaWang, Shaobing Zhou*, Lin Sun, Chi Huang, Controlled delivery ofparacetamol and protein at different stages from core–shell biodegradablemicrospheres, Carbohydrate Polymers, 79 (2010) 437–444.AijunZhao， Shaobing Zhou*， Qi Zhou，Tao Chen，Thermosensitive Micelles from PEG-BasedEther-anhydride Triblock Copolymers，Pharm Res，2010，27，1627-1643. YuXiao, Shaobing Zhou*, Lin Wang,Xiaotong Zheng, Tao Gong，Crosslinked poly(ε-caprolactone)/poly(sebacic anhydride) compositescombining biodegradation, controlled drug release and shape memory effect，Composites:Part B 41 (2010) 537–542. AijunZhao, Qi Zhou, Tao Chen, Jie Weng, ShaobingZhou*，Amphiphilic PEG-based ether-anhydride terpolymers: Synthesis,characterization, and micellization，Journal of Applied Polymer Science，2010,118（6）：3576–3585. WeijiaWang, Shijun Shao, Chao Luo, ShaobingZhou*, Chitosan hollow nanospheresfabricated from biodegradable poly-d,l-lactide-poly(ethylene glycol)nanoparticle templates, European Journal of Pharmaceuticsand Biopharmaceutics, 76 (2010) 376–383. YuXiao, Shaobing Zhou*, Lin Wang, andTao Gong，Electro-activeShape Memory Properties of Poly(ε-caprolactone)/Functionalized MultiwalledCarbon Nanotube Nanocomposite，ACS Appl. Mater. Interfaces, 2010, 2 (12), pp 3506–3514.Hongsen Peng, Shaobing Zhou*, Jing Jiang, TaoGuo, Xiaotong Zheng, and Xiongjun Yu，Pressure-Induced CrystalMemory Effect of Spider Silk Proteins，J. Phys. Chem. B 2009, 113, 4636–4641. XiongjunYu, Shaobing Zhou*, Xiaotong Zheng, Yu Xiao and Tao Guo，Influenceof in Vitro Degradation of a Biodegradable Nanocomposite on Its Shape Memory Effect，J. Phys. Chem. C, 2009, 113 (41), pp17630–17635.TaoGuo, Shaobing Zhou*, Xiaotong Zheng and Jing Jiang, Modeling andInvestigation of Interfacial Interaction between PLA and One Type of DeficientHydroxyapatite,J. Phys. Chem. A, 2009, 113 (25), pp7112–7123. Xiongjun Yu, Shaobing Zhou*, XiaotongZheng, Tao Guo, Yu Xiaoand BotaoSong, A Biodegradable Shape Memory Nanocomposite with Dual-versatilityof Thermal and Magnetic Field Sensitivity. Nanotechnology. 2009，20,235702. Xiaotong Zheng, Shaobing Zhou*, Yu Xiao,Xiongjun Yu, Xiaohong Li，Peizhuo Wu，Shapememoryeffectofpoly(D,L-lactide)/Fe3O4，nanocompositesbyinductiveheatingofmagnetiteparticles，ColloidsandSurfaces B:Biointerfaces，71(2009),pp.67-72.LinSun, Shaobing Zhou*, Weijia Wang, Xiaohong Li, Jianxin Wang,Jie Weng, Preparation and characterizationof porous biodegradable microspheres used for controlled protein delivery, Colloidsand Surfaces A: Physicochem. Eng. Aspects 345 (2009) 173–181. XiaotongZheng, Shaobing Zhou*, Yu Xiao, Xiongjun Yu, Bo Feng. In situpreparation and characterization of a novel Gelatin/ Poly(D,L-lactide)/Hydroxyapatite nanocomposite. Journal of Biomedical Materials ResearchPart B: Applied Biomaterials.Volume91B, Issue1, Date:October 2009,Pages:181-190. ShaobingZhou*,Xiaotong Zheng, Xiongjun Yu,et al，Hydrogen Bonding Interaction of Poly(D,L-Lactide)/hydroxyapatiteNanocomposites，Chemistry of Materials, 2007，19（2），247– 253.??? JingSun， Shaobing Zhou*,et al., Synthesis and Characterization of Biocompatible Fe3O4Nanoparticles, Journal of Biomedical MaterialsResearch,Part A, 2007,80A(2), 333-341. （SCI, IF：2.5） XiaotongZheng, Shaobing Zhou*, et al., Shapememory properties of poly(D,L-lactide)/ hydroxyapatite composites，Biomaterials，2006，27（24），4288–4295.??? （2008年第4季度入选TOP25 Hottest Articles且排名第7） Lin Sun, Shaobing Zhou*, Weijia Wang, Qiuxiang Su, Xiaohong Li and Jie Weng, Preparation and characterization of protein-loadedpolyanhydride microspheres, Journal of Materials Science: Materialsin Medicine, 2009,20，2035-2042. Shaobing Zhou*, Qiuxiang Su,et al，A novel insitu synthesis of dicalcium phosphate dehydrate nanocrystals in biodegradablepolymer matrix，Materials Science and Engineering A， 2006，430（1-2），341–345.Shaobing Zhou*, Bing Song, Xiaohong Li, Invitro Degradation and Release profiles for Poly-dl-lactide Film ContainingParacetamol, Journal of Materials Science: Materials inMedicine,2007,18（8）1623-1626.Xiaotong Zheng, Shaobing Zhou*, Xiongjun Yu, Xiaohong Li, Bo Feng, Shuxin Qu, JieWeng，Effect of In vitro degradation of poly(D,L-lactide)/-tricalciumcomposite on its shape-memory properties，Journal of Biomedical Materials ResearchPart B: Applied Biomaterials. 2008，Volume 86BIssue 1,Pages170–180. Shaobing Zhou*,Xianmo Deng,Hua Yang, Biodegradablecopolymer of poly(ethylene glycol)-co-poly (ε-caprol actone):characterizationand its use in controlled release system. Biomaterials, 2003, 24(20), 3563-3570. （SCI, IF：5.196） Shaobing Zhou,*Hongsen Peng,Xiongjun Yu, Xiaotong Zheng,Wenguo Cui, ZairongZhang, Xiaohong Li,Jianxin Wang, Jie Weng,Wenxiang Jia,and Fei Li，Preparation and Characterization of a NovelElectrospun Spider Silk Fibroin/Poly(D,L-lactide) Composite Fiber, J. Phys. Chem. B.; 2008; 112(36); 11209-11216. HongsenPeng, Shaobing Zhou*, Tao Guo, Yanshan Li, Xiaohong Li, JianxinWang, Jie Weng, In vitro degradation and releaseprofiles for electrospun polymeric fibers containing paracetanol,Colloidsand Surfaces B: Biointerfaces 66 (2008), pp.206-212.Shaobing Zhou*, Jing Sun, Lin Sun, Yanqin Dai, LipingLiu, Xiaohong Li, Jianxin Wang, Jie Weng, Wenxiang Jia, Zairong Zhang，Preparationand characterization of interferon-loaded magnetic biodegradable microspheres，Journal of Biomedical Materials Research Part B:Applied Biomaterials. Volume 87B, Issue 1, Date: October 2008, Pages:189-196.Shaobing Zhou*, Xianmo Deng, Xiaohong Li,et al.,Investigationon a Novel Core-Coated Microspheres Protein Delivery System, Journal of Controlled Release, 2001,75(1-2),27-36.?? Shaobing Zhou*,Xueyan Liao,Xiaohong Li,Xianmo Deng,et al.Poly-D,L-lactide-co-poly(ethylene glycol) microspheres as potential vaccinedelivery systems.Journal ofControlled Release, 2003，86(2-3)：195-205. (SCI, IF 4.01)XianmoDeng, Shaobing Zhou,Xiaohong Li,etal.,In vitro Degradation and Release profiles for Poly-dl-Lactide-poly(ethyleneglycol) Microspheres Containing Human Serum Albumin. Journal of Controlled Release,2001, 71(2),165-173. Shaobing Zhou*,Xianmo Deng,Shuiying He,XiaohongLi,Wenxiang Jia, et al., Study on biodegradable microspheres containingrecombinant interferon. J.Pharm.Pharmacol.2002,54:1287-12192. Shaobing Zhou*,Xianmo Deng,Xiaohong Li,et al.,Investigation on Preparation and Protein Release of Biodegradable PolymerMicrospheres as Drug Delivery System,Journal of Applied polymer science,2002,84,778-784.Shaobing Zhou*,Xianmo Deng,In Vitro DegradationCharacteristics of Poly-dl-lactide-poly(ethylene glycol) MicrospheresContaining Human Serum Albumin. Reactive and functional polymer,2002,51,93-100. Shaobing Zhou*, Xianmo Deng, Wenxiang Jia,etal.,Synthesis and characterization of biodegradable low-molecular-weightaliphatic polyesters and their use inprotein delivery system, Journal of Applied polymer Sciences , 2004, 91(3), 1848–1856.Shaobing Zhou*, Jinggang Xu,Xianmo Deng，et al.,Synthesis and Characterization of BiodegradablePoly(-caprolactone)- Polyglycolide-Poly(ethylene glycol) Monomethyl EtherRandom Copolymer，Macromolecular Materials and Engineering，2004,289（6），576-580.ShaobingZhou*, Xueyan Liao, Xianmo Deng, Heming Li,etal.,Preparation and Characterization of Biodegradable Microspheres ContainingHepatitis B Surface Antigen, Macromolecular Bioscience,2004,4,(1)1,47-52.YuanYang, Li Liu, Shaobing Zhou*,et al.Novel Biodegradable Polymers as Gene Carriers. Macromol. Biosci. 2004,4, 1113–1117.
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
荣誉奖励 2003年荣获中国科学院院长优秀奖;
2010年荣获“第八届詹天佑科学技术奖专项基金奖”；
2011年荣获“第十一届四川省青年科技奖”；
2010年和2011年连续两年被评为本科毕业设计优秀指导教师；
2014年被评为首届“西南交通大学十佳研究生导师”荣誉称号
2014年荣获唐立新优秀学者奖
2014年荣获四川省学术和技术带头人
在指导的研究生中, 其中8位研究生毕业论文获四川省优秀硕士论文奖, 1位博士生毕业论文获四川省优秀博士论文奖,13位研究生论文获校优秀硕士论文。
祝贺研究生荣获国家奖学金!!!!!
祝贺博士研究生郭星、龚涛、唐昭敏三位同学荣获2014年度“博士研究生国家奖学金”；硕士研究生赵坤荣获2014年度“硕士研究生国家奖学金”。此前，博士研究生龚涛荣获2012年度“博士研究生国家奖学金”，博士研究生郭星荣获2013年度“博士研究生国家奖学金”.
研究生国家奖学金是由国家教育部、财政部设立，中央财政出资，用于奖励普通高等学校中表现优异的全日制研究生，为发展中国特色研究生教育，促进研究生培养机制改革，提高研究生培养质量。博士研究生国家奖学金奖励标准为每生每年3万元；硕士研究生国家奖学金奖励标准为每生每年2万元。
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
科研团队博士后：刘显
博士研究生：陈红梅，王林，李龙，郭星，杨光，孙会丽，龚涛，唐昭敏，王毅
硕士研究生：史春丽，丁珊，杨希凤，刘野，王杰，赵坤，屈倩倩，李丹，李莹，狄淑斌，王文玺，周光亮，王毅，张累
已毕业研究生：郑晓彤（博士），罗超，周洋波，陈涛，李文兵，李金绒，张钊，孙敬，苏秋香，彭红森，孙林，俞雄军，郭涛，肖雨，王卫佳，赵艾军，黄驰，周奇，邵仕军
(1) 靶向药物控制释放新制剂的研究
a. 具有主动靶向的pH敏感抗肿瘤药物胶束
如图所示，该叶酸靶向的pH敏感载药胶束能特异性识别肿瘤细胞表面的叶酸受体，实现主动靶向，在肿瘤细胞内酸性条件下腙键发生断裂，快速的释放药物，体内实验证实这一体系能显著得抑制肿瘤生长，同时能降低化疗药物对正常组织的毒副作用。
图 高分子键合纳米药物的体内靶向(a)和对肿瘤的治疗效果图(b)
*Xing Guo, Chunli Shi, Jie Wang, Shubin Di, Shaobing Zhou*，pH-triggered intracellular release from actively targeting polymer Micelles，Biomaterials, 34 (2013) 4544-4554.
b. 具有还原敏感型聚酸酐抗肿瘤药物胶束
如图2所示，以抗肿瘤药物姜黄素为模型，我们成功制备了新型聚酸酐载药胶束，用于肿瘤治疗，在谷胱甘肽作用下能实现药物近零次释放，且体内实验证明该胶束能在肿瘤细胞内快速释放药物，对肿瘤生长具有明显地抑制效果（如图所示）
图 还原敏感聚酸酐胶束的释药机理和体内肿瘤抑制效果
*Jie Wang, Guang Yang, Xing Guo, Zhaomin Tang, Zhendong Zhong, Shaobing Zhou*, Redox-responsive polyanhydride micelles for cancer therapy, Biomaterials, 2014, 35, 3080-3090.
(2) 生物医用形状记忆高分子材料及复合材料的合成及其性能研究
a. 三重形状记忆聚氨酯材料的合成及性能表征
Anewtriple shapememorypolyurethane(TSMPU)withpendantcinnamongroupswas synthesized via a photo crosslinking of cinnamon groups irradiated under λ > 280 nm ultraviolet light.
*Lin Wang, Xifeng Yang, Hongmei Chen, Tao Gong, Wenbing Li, Guang Yang, and Shaobing Zhou*, Design of Triple-Shape Memory Polyurethane with Photo-crosslinking of Cinnamon Groups, ACS Applied Materials & Interfaces, 2013, 5, 10520-10528.
b. 形状记忆多孔组织工程支架
将可降解的形状记忆高分子材料先制备成孔隙贯通的海绵状多孔支架，再通过压缩使该支架变形成体积较小的支架，这样就可方便地将其植入骨缺损部位，在体温刺激下该压缩支架在骨缺损部位可产生良好形状恢复，而将缺损部位填充完全(如图所示)
携载生长因子的形状记忆高分子支架在体温刺激下在骨缺损部位的形状恢复图
*Xian Liu, Kun Zhao, Tao Gong, Jian Song, Chongyun Bao, En Luo, Jie Weng and Shaobing Zhou*, Delivery of Growth Factors Using a Smart Porous Nanocomposite Scaffold to Repair a Mandibular Bone Defect, Biomacromolecules, 2014,15, 1019-1030.
（3）静电纺丝可吸收高分子纤维在药物释放体系和组织工程方面的应用研究
a. 磁性高分子组织工程支架
图示为磁性响应性纤维支架
*Long Li, Guang Yang, Jinrong Li, Shan Ding, Shaobing Zhou*,Cell behaviors on magnetic electrospun poly-d, l-lactide nanofibers，Materials Science and Engineering C 34 (2014) 252–261.
b. 载药静电纺丝纤维用于瘢痕修复
我们针对皮肤瘢痕疙瘩这种临床上的难治疾病，开展了以携载双组份药物的可吸收高分子纤维膜作为一种新型的医用敷料，通过经皮给药方式传递药物修复瘢痕疙瘩的治疗方法（如图5所示）。经过对建有瘢痕疙瘩模型的裸鼠治疗实验证明，载药纤维不但有明显地抗菌功能，还能显著的软化瘢痕疙瘩，瘢痕疙瘩的体积变化比用传统硅凝胶敷贴组明显。
图 携载双组份药物的高分子电纺纤维膜的经皮给药示意图
*Jinrong Li, Rong Fu, Long Li, Guang Yang, Shan Ding, Zhendong Zhong, Shaobing Zhou*, Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid, Pharm Res, DOI 10.1007/s11095-013-1266-2.
c. 静电纺丝高分子可吸收纤维用于电刺激组织工程支架的研究
静电纺丝可以制备高孔隙率，高通透性的三维组织工程支架,纤维可以作为生长因子等生物活性因子，药物的载体，同时可以参杂其他有机或无机材料以提高静电纺丝纤维的功能行，以及更好的模拟细胞外基质的结构和功能。
* Osteoblast function on electrically conductive electrospun PLA/MWCNTs nanofibers. Shijun Shao, Shaobing Zhou*. Biomaterials 2011,32, 2821-2833.
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
课程教学1.硕士生课程
(1)《高等生物材料》
(2)《药物控制释放与组织工程》
(3)《生物材料导论》
(4)《结构化学》
2.本科生课程
(1)《药物控制释放》
(2)《生物材料合成实验技术》
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
招生信息欢迎有化学,生物医学,高分子材料,生物学,医学,材料学或药剂学等专业背景的学生报考硕士,博士研究生。长期招聘博士后研究人员。
祝贺研究生荣获国家奖学金!!!!!
祝贺博士研究生郭星、龚涛、唐昭敏三位同学荣获2014年度“博士研究生国家奖学金”；硕士研究生赵坤荣获2014年度“硕士研究生国家奖学金”。此前，博士研究生龚涛荣获2012年度“博士研究生国家奖学金”，博士研究生郭星荣获2013年度“博士研究生国家奖学金”.
研究生国家奖学金是由国家教育部、财政部设立，中央财政出资，用于奖励普通高等学校中表现优异的全日制研究生，为发展中国特色研究生教育，促进研究生培养机制改革，提高研究生培养质量。博士研究生国家奖学金奖励标准为每生每年3万元；硕士研究生国家奖学金奖励标准为每生每年2万元。
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
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Basic InformationProf. Zhou Shaobing
Organization: School of Materials Scienceand Engineering Contact Address: Schoolof Materials Science and Engineering, Key Laboratory of Advanced Technologiesof Material, Minister of Education, Southwest Jiaotong University, Chengdu610031, Sichuan, PR ChinaE-mail: shaobingzhou@swjtu.edu.cnshaobingzhou@hotmail.com Office Tel: **Fax: **
Resume
Shaobing Zhou received his B.S. degree in polymer chemistry from Sichuan University in 1996and Ph.D. degree in organic chemistry from Chengdu Institute of OrganicChemistry, Chinese Academy of Sciences in 2003. He was promoted in 2005 to FullProfessor of polymer chemistry at School of Materials Science and Engineering,Southwest Jiaotong University. His research interests include the synthesis andcharacterization of biodegradable polymers, drug controlled release system, shape memory polymer composites and electrospunbiodegradable polymer fibers as tissue engineering scaffold.From year 2001to present,he is the principle investigator of four National Natural ScienceFoundations of China, and he joined seven state-level researchwork including one State Key Basic Research Plan (973 plan). In 2003, he wonChinese Academy of Sciences Dean Award. In 2007, hewas awarded New Century Excellent Talent in University by Ministry of Educationof China. In 2008, he was awarded SichuanProminent Young Talent by Sichuan Province. In 2009, he was approved to ChengduOutstanding Contribution and Excellent Expert by Chengdu city government.In 2010, he won Zhan Tianyou SpecialAward for Youth Award of Ministry of Railways of China.In 2011, he won Sichuan Youth Science and Technology Award of Sichuan Provincegovernment.
He is the author or coauthor of more than 70 refereedarticles, 1 book chapter and 8 Chinese patents/patent applications. He has beencited over 1300 times and has an h-index of 23. Currentlyhe is one of associate editors of the journal: American Journal ofMaterials Science and Technology and on the Editorial Board of the journalAdvanced Materials Letter, and is also an ad-hoc reviewer for 27 internationaljournals such as Angew Chem Int Edit, Biomaterials, Macromolecules, Journal ofControlled release. . Research interests Synthesis of biodegradable polymersDrug Controlledrelease systemBiodegradable shape memorypolymers and composites Biodegradable electrospun polymer fibers for tissue engineering scafford.
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
2010年荣获“第八届詹天佑科学技术奖专项基金奖”；
2011年荣获“第十一届四川省青年科技奖”；
2010年和2011年连续两年被评为本科毕业设计优秀指导教师；
2014年被评为首届“西南交通大学十佳研究生导师”荣誉称号
2014年荣获唐立新优秀学者奖
2014年荣获四川省学术和技术带头人
在指导的研究生中, 其中8位研究生毕业论文获四川省优秀硕士论文奖, 1位博士生毕业论文获四川省优秀博士论文奖,13位研究生论文获校优秀硕士论文。
祝贺研究生荣获国家奖学金!!!!!
祝贺博士研究生郭星、龚涛、唐昭敏三位同学荣获2014年度“博士研究生国家奖学金”；硕士研究生赵坤荣获2014年度“硕士研究生国家奖学金”。此前，博士研究生龚涛荣获2012年度“博士研究生国家奖学金”，博士研究生郭星荣获2013年度“博士研究生国家奖学金”.
研究生国家奖学金是由国家教育部、财政部设立，中央财政出资，用于奖励普通高等学校中表现优异的全日制研究生，为发展中国特色研究生教育，促进研究生培养机制改革，提高研究生培养质量。博士研究生国家奖学金奖励标准为每生每年3万元；硕士研究生国家奖学金奖励标准为每生每年2万元。
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
科研团队博士后：刘显
博士研究生：陈红梅，王林，李龙，郭星，杨光，孙会丽，龚涛，唐昭敏，王毅
硕士研究生：史春丽，丁珊，杨希凤，刘野，王杰，赵坤，屈倩倩，李丹，李莹，狄淑斌，王文玺，周光亮，王毅，张累
已毕业研究生：郑晓彤（博士），罗超，周洋波，陈涛，李文兵，李金绒，张钊，孙敬，苏秋香，彭红森，孙林，俞雄军，郭涛，肖雨，王卫佳，赵艾军，黄驰，周奇，邵仕军
(1) 靶向药物控制释放新制剂的研究
a. 具有主动靶向的pH敏感抗肿瘤药物胶束
如图所示，该叶酸靶向的pH敏感载药胶束能特异性识别肿瘤细胞表面的叶酸受体，实现主动靶向，在肿瘤细胞内酸性条件下腙键发生断裂，快速的释放药物，体内实验证实这一体系能显著得抑制肿瘤生长，同时能降低化疗药物对正常组织的毒副作用。
图 高分子键合纳米药物的体内靶向(a)和对肿瘤的治疗效果图(b)
*Xing Guo, Chunli Shi, Jie Wang, Shubin Di, Shaobing Zhou*，pH-triggered intracellular release from actively targeting polymer Micelles，Biomaterials, 34 (2013) 4544-4554.
b. 具有还原敏感型聚酸酐抗肿瘤药物胶束
如图2所示，以抗肿瘤药物姜黄素为模型，我们成功制备了新型聚酸酐载药胶束，用于肿瘤治疗，在谷胱甘肽作用下能实现药物近零次释放，且体内实验证明该胶束能在肿瘤细胞内快速释放药物，对肿瘤生长具有明显地抑制效果（如图所示）
图 还原敏感聚酸酐胶束的释药机理和体内肿瘤抑制效果
*Jie Wang, Guang Yang, Xing Guo, Zhaomin Tang, Zhendong Zhong, Shaobing Zhou*, Redox-responsive polyanhydride micelles for cancer therapy, Biomaterials, 2014, 35, 3080-3090.
(2) 生物医用形状记忆高分子材料及复合材料的合成及其性能研究
a. 三重形状记忆聚氨酯材料的合成及性能表征
Anewtriple shapememorypolyurethane(TSMPU)withpendantcinnamongroupswas synthesized via a photo crosslinking of cinnamon groups irradiated under λ > 280 nm ultraviolet light.
*Lin Wang, Xifeng Yang, Hongmei Chen, Tao Gong, Wenbing Li, Guang Yang, and Shaobing Zhou*, Design of Triple-Shape Memory Polyurethane with Photo-crosslinking of Cinnamon Groups, ACS Applied Materials & Interfaces, 2013, 5, 10520-10528.
b. 形状记忆多孔组织工程支架
将可降解的形状记忆高分子材料先制备成孔隙贯通的海绵状多孔支架，再通过压缩使该支架变形成体积较小的支架，这样就可方便地将其植入骨缺损部位，在体温刺激下该压缩支架在骨缺损部位可产生良好形状恢复，而将缺损部位填充完全(如图所示)
携载生长因子的形状记忆高分子支架在体温刺激下在骨缺损部位的形状恢复图
*Xian Liu, Kun Zhao, Tao Gong, Jian Song, Chongyun Bao, En Luo, Jie Weng and Shaobing Zhou*, Delivery of Growth Factors Using a Smart Porous Nanocomposite Scaffold to Repair a Mandibular Bone Defect, Biomacromolecules, 2014,15, 1019-1030.
（3）静电纺丝可吸收高分子纤维在药物释放体系和组织工程方面的应用研究
a. 磁性高分子组织工程支架
图示为磁性响应性纤维支架
*Long Li, Guang Yang, Jinrong Li, Shan Ding, Shaobing Zhou*,Cell behaviors on magnetic electrospun poly-d, l-lactide nanofibers，Materials Science and Engineering C 34 (2014) 252–261.
b. 载药静电纺丝纤维用于瘢痕修复
我们针对皮肤瘢痕疙瘩这种临床上的难治疾病，开展了以携载双组份药物的可吸收高分子纤维膜作为一种新型的医用敷料，通过经皮给药方式传递药物修复瘢痕疙瘩的治疗方法（如图5所示）。经过对建有瘢痕疙瘩模型的裸鼠治疗实验证明，载药纤维不但有明显地抗菌功能，还能显著的软化瘢痕疙瘩，瘢痕疙瘩的体积变化比用传统硅凝胶敷贴组明显。
图 携载双组份药物的高分子电纺纤维膜的经皮给药示意图
*Jinrong Li, Rong Fu, Long Li, Guang Yang, Shan Ding, Zhendong Zhong, Shaobing Zhou*, Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid, Pharm Res, DOI 10.1007/s11095-013-1266-2.
c. 静电纺丝高分子可吸收纤维用于电刺激组织工程支架的研究
静电纺丝可以制备高孔隙率，高通透性的三维组织工程支架,纤维可以作为生长因子等生物活性因子，药物的载体，同时可以参杂其他有机或无机材料以提高静电纺丝纤维的功能行，以及更好的模拟细胞外基质的结构和功能。
* Osteoblast function on electrically conductive electrospun PLA/MWCNTs nanofibers. Shijun Shao, Shaobing Zhou*. Biomaterials 2011,32, 2821-2833.
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
课程教学1.硕士生课程
(1)《高等生物材料》
(2)《药物控制释放与组织工程》
(3)《生物材料导论》
(4)《结构化学》
2.本科生课程
(1)《药物控制释放》
(2)《生物材料合成实验技术》
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
-----------------------------------------------------------------
个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
招生信息欢迎有化学,生物医学,高分子材料,生物学,医学,材料学或药剂学等专业背景的学生报考硕士,博士研究生。长期招聘博士后研究人员。
祝贺研究生荣获国家奖学金!!!!!
祝贺博士研究生郭星、龚涛、唐昭敏三位同学荣获2014年度“博士研究生国家奖学金”；硕士研究生赵坤荣获2014年度“硕士研究生国家奖学金”。此前，博士研究生龚涛荣获2012年度“博士研究生国家奖学金”，博士研究生郭星荣获2013年度“博士研究生国家奖学金”.
研究生国家奖学金是由国家教育部、财政部设立，中央财政出资，用于奖励普通高等学校中表现优异的全日制研究生，为发展中国特色研究生教育，促进研究生培养机制改革，提高研究生培养质量。博士研究生国家奖学金奖励标准为每生每年3万元；硕士研究生国家奖学金奖励标准为每生每年2万元。
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
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Prof. Zhou's personal page
Welcome to my website!
Basic InformationProf. Zhou Shaobing
Organization: School of Materials Scienceand Engineering Contact Address: Schoolof Materials Science and Engineering, Key Laboratory of Advanced Technologiesof Material, Minister of Education, Southwest Jiaotong University, Chengdu610031, Sichuan, PR ChinaE-mail: shaobingzhou@swjtu.edu.cnshaobingzhou@hotmail.com Office Tel: **Fax: **
Resume
Shaobing Zhou received his B.S. degree in polymer chemistry from Sichuan University in 1996and Ph.D. degree in organic chemistry from Chengdu Institute of OrganicChemistry, Chinese Academy of Sciences in 2003. He was promoted in 2005 to FullProfessor of polymer chemistry at School of Materials Science and Engineering,Southwest Jiaotong University. His research interests include the synthesis andcharacterization of biodegradable polymers, drug controlled release system, shape memory polymer composites and electrospunbiodegradable polymer fibers as tissue engineering scaffold.From year 2001to present,he is the principle investigator of four National Natural ScienceFoundations of China, and he joined seven state-level researchwork including one State Key Basic Research Plan (973 plan). In 2003, he wonChinese Academy of Sciences Dean Award. In 2007, hewas awarded New Century Excellent Talent in University by Ministry of Educationof China. In 2008, he was awarded SichuanProminent Young Talent by Sichuan Province. In 2009, he was approved to ChengduOutstanding Contribution and Excellent Expert by Chengdu city government.In 2010, he won Zhan Tianyou SpecialAward for Youth Award of Ministry of Railways of China.In 2011, he won Sichuan Youth Science and Technology Award of Sichuan Provincegovernment.
He is the author or coauthor of more than 70 refereedarticles, 1 book chapter and 8 Chinese patents/patent applications. He has beencited over 1300 times and has an h-index of 23. Currentlyhe is one of associate editors of the journal: American Journal ofMaterials Science and Technology and on the Editorial Board of the journalAdvanced Materials Letter, and is also an ad-hoc reviewer for 27 internationaljournals such as Angew Chem Int Edit, Biomaterials, Macromolecules, Journal ofControlled release. . Research interests Synthesis of biodegradable polymersDrug Controlledrelease systemBiodegradable shape memorypolymers and composites Biodegradable electrospun polymer fibers for tissue engineering scafford.
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
(1)《高等生物材料》
(2)《药物控制释放与组织工程》
(3)《生物材料导论》
(4)《结构化学》
2.本科生课程
(1)《药物控制释放》
(2)《生物材料合成实验技术》
Copyright ? 2011 http://inc.swjtu.edu.cn 西南交通大学信息网络中心
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个人信息科学研究论文成果荣誉奖励科研团队课程教学招生信息English
周绍兵的个人主页
