杜小刚,男,1977年出生,博士导师
工作单位 生命科学学院
行政职务 生物工程与应用生物学系系主任
单位电话
电子邮箱 duxiaogang@sicau.edu.cn
招生专业 【博士】:071011生物物理学,【学硕】:071011生物物理学，【专硕】:086000生物与医药
◆个人简历
杜小刚，男，教授，硕士生导师，四川省学术和技术带头人后备人选。工作于四川农业大学生命科学学院，任生物工程与应用生物学系主任。近年来共发表SCI论文40余篇，主持省部省部级项目4项，参研省部省部级项目1项。目前主要动物分子免疫学，及疫苗免疫机制的研究。
◆工作经历
2020/12至现在，四川农业大学, 生命科学学院, 教授
2010/10－2012/09，美国塔夫斯大学，营养免疫与老年研究中心，博士后
2009/12－2020/11至今，四川农业大学，生命科学学院，副教授
2007/07－2009/11，四川农业大学，生命科学与理学院生物系，讲师
◆教育经历
2004/09－2007/07，中国农业大学，生物学院生理学系，博士
2001/09－2004/07，云南农业大学，动物科技学院动物医学系，硕士
1997/09－2001/07，四川畜牧兽医学院(现西南大学)，动物医学系，学士
◆获奖荣誉
四川省学术和技术带头人后备人选
◆研究领域
从事鱼类分子免疫学研究。
◆科研项目
1.海参多肽免疫调节及抗肿瘤作用机制的研究，四川省人力资源和社会保障厅，2016-2018，在研，主持。
2.鸭髓样单核细胞生长因子(dMGF)的克隆和生物活性分析，四川省教育厅重点基金项目，2010.7，结题，主持。
3.枸杞提取物分离纯化及其对免疫系统影响的研究,四川省教育，2013.12，结题，主持。
4.油茶籽壳提取物保健品的开发与应用，四川省教育，2015.1-2015.12, 结题，主持。
5.凉山半细毛羊抑制素α亚基（INHα）融合蛋白对动物繁殖性能的影响，四川省教育厅，2012.07，结题，排名第2。
◆发表论文
1 Li Y, Han J, Wu J, Li D, Yang X, Huang A, Bu G, Meng F, Kong F, Cao X, Han X, Pan X, Yang S, Zeng X, Du X. Transcriptome-based evaluation and validation of suitable housekeeping gene for quantification real-time PCR under specific experiment condition in teleost fishes. Fish Shellfish Immunol. 2020 Jan; 98: 218-223. doi.org/10.1016/j.fsi.2020.01.018
3 Li Y, Xia P, Wu J, Huang A, Bu G, Meng F, Kong F, Cao X, Han X, Yu G, Pan X, Yang S, Zeng X, Du X*（通讯作者）. The potential sensing molecules and signal cascades for protecting teleost fshes against lipopolysaccharide. Fish Shellfish Immunol. 2019 Dec; 97: 235-247. doi.org/10.1016/j.fsi.2019.12.050
4 Li Y, Qiu W, Zhang Z, Han X, Bu G, Meng F, Kong F, Cao X, Huang A, Feng Z, Li Y, Zeng X,?Du X Oral oyster polypeptides protect ovary against D-galactose-induced premature ovarian failure in C57BL/6 mice, Journal of The Science of Food and Agriculture 100 (2019) 92-101
5 Du X, Li D, Li Y, Wu J, Huang A, Bu G, Meng F, Kong F, Cao X, Han X, Pan X, Yu G, Yang S, Zeng X. Clone, identifcation and functional character of two toll-like receptor 5 molecules in Schizothorax prenanti. Fish Shellfish Immunol. 2019 Oct; 95: 81-92. doi.org/10.1016/j.fsi.2019.10.027
6 Du X, Wu J, Li Y, Xia P, Li D, Yang X, Yu G, Bu G, Huang A, Meng F, Kong F, Cao X, Han X, Pan X, Yang S, Zeng X. Multiple subtypes of TLR22 molecule from Schizothorax prenanti present the functional diversity in ligand recognition and signal activation. Fish Shellfish Immunol. 2019 Aug; 93: 986-996. doi.org/10.1016/j.dci.2020.103630
7 Li Y, Wu J, Li D, Huang A, Bu G, Meng F, Kong F, Cao X, Han X, Pan X, Fan W, Yang S, Wang J, Zeng X, Du X*（通讯作者）.Teleost-specific TLR25 identified from Schizothorax prenanti may recognize bacterial/viral components and activate NF-κB and type I IFNs signaling pathways.Fish Shellfish Immunol. 2018 Nov;82:361-370. doi: 10.1016/j.fsi.2018.08.007
8 Li Y, Wu J, Li D, Huang A, Bu G, Meng F, Kong F, Cao X, Han X, Pan X, Fan W, Yang S, Zeng X, Du X*（通讯作者）.Transcriptome analysis of spleen reveals the signal transduction of toll-like receptors after Aeromonas hydrophila infection in Schizothorax prenanti. Fish Shellfish Immunol. 2018 Oct 25;84:816-824. doi: 10.1016/j.fsi.2018.10.064
9 Du X, Lian F, Li Y, Li D, Wu D, Feng Q, Feng Z, Li Y, Bu G, Meng F, Cao X, Chen Z, Zeng X.Peptides from Colochirus robustus Enhance Immune Function via Activating CD3- and ZAP-70-Mediated Signaling in C57BL/6 Mice. Int J Mol Sci. 2017 Oct 8;18(10). pii: E2110. doi: 10.3390/ijms**
10 Du X, Li Y, Li D, Lian F, Yang S, Wu J, Liu H, Bu G, Meng F, Cao X, Zeng X, Zhang H, Chen Z.Transcriptome profiling of spleen provides insights into the antiviral mechanism in Schizothorax prenanti after poly (I: C) challenge. Fish Shellfish Immunol. 2017 Fish Shellfish Immunol. 2017 Mar;62:13-23.
11 Du X, Wang J, Niu X, Smith D, Wu D, Meydani SN. Dietary Wolfberry Supplementation Enhances the Protective Effect of Flu Vaccine against Influenza Challenge in Aged Mice. J Nutr. 2014 Feb;144(2):224-9.
12 Wang J, Niu X, Du X, Smith D, Meydani SN, Wu D. Dietary supplementation with white button mushrooms augments the protective immune response to Salmonella vaccine in mice. J Nutr. 2014 Jan;144(1):98-105..
13 Feng H, Du X*, Liu J, Han X, Cao X, Zeng X. Novel polysaccharide from Radix Cyathulae officinalis Kuan can improve immune response to ovalbumin in mice. Int J Biol Macromol. 2014 Jan 10;65C:121-128.(*Contributed equally)）
14. Han X, Cheng W, Chen Z, Du X, Cao X, Zeng X.Active immunisation against pregnenolone reduces testicular steroidogenesis and GnRH synthesis in rabbits. Anim Reprod Sci. 2014 Mar;145(3-4):161-9.
15. Wang J, Vanegas SM, Du X, Noble T, Zingg JM, Meydani M, Meydani SN, Wu D.Caloric restriction favorably impacts metabolic and immune/inflammatory profiles in obese mice but curcumin/piperine consumption adds no further benefit. Nutr Metab (Lond). 2013 Mar 27;10(1):29. doi: 10.1186/1743-7075-10-29.
16 Xiaogang Du, Junpeng Wang, Xinli Niu, Donald Smith, Karine Vidal, Dayong Wu, Simin Nikbin Meydani. Dietary wolfberry supplementation enhances protective effect of flu vaccine against influenza infection in aged mice.The FASEB Journal 04/2013; 27(Meeting Abstract Supplement):357.2.(IF=5.7)
17 Haibo Feng, Xiaogang Du*, Jing Tang, Xiaohan Cao Xingfa Han, Zhiyu Chen, Yanger Chen, Xianyin Zeng Enhancement of the immune responses to foot-and-mouth disease vaccination in mice by oral administration of aNovel polysaccharide from the roots of Radix Cyathulae officinalis Kuan (RC). Cellular Immunology; 281 (2013) 111–121(*Contributed equally)
18 Du X, Zhao B, Li J, Cao X, Diao M, Feng H, Chen X, Chen Z, Zeng X.Astragalus polysaccharides enhance immune responses of HBV DNA vaccination via promoting the dendritic cell maturation and suppressing Treg frequency in mice.Int Immunopharmacol.2012；14(4):463-470.
19 Du X, Chen X, Zhao B, et al. Astragalus polysaccharides enhance the humoral and cellular immune responses of hepatitis B surface antigen vaccination through inhibiting the expression of transforming growth factor beta and the frequency of regulatory T cells. FEMS Immunol Med Microbiol 2011; 63: 228-235
20 Du X, Yanyan Geng, Zhou Huang, Yanger Chen, Huaiyu Zhang,, Hanmei Liu, zhiyu Chen, Zhihuan Wu, Tianzeng Song and Xianyin Zeng. Effects of Zingiber officinale extract on antioxidation and lipid peroxidation in mice after exposure to 60Co-γ-ray. African Journal of Biotechnology,2012;11(11): 2609-2615.
21 Yanyan Geng, Xiaogang Du, Xiaohan Cao, Yanger Chen, Huaiyu Zhang, Hanmei Liu, Zhiyu Chen and Xianyin Zeng. The therapeutic effects of Zingiber officinale extract on mice irradiated by 60Coγ-ray. Journal of Medicinal Plants Research，2012; 6(13), 2590-2600.
22. Xiaogang Du Huzhu Pan, Chengyun Zhang, Huaiyu Zhang, Hanmei Liu, Zhiyu Chen and & Zeng X Zingiber officinale extract modulates g-rays-induced immunosuppression in mice. Journal of Medicinal Plants Research, 2010;4. (16): 1647-1655.
23. Xiaogang Du, Zihuan Wu, Chengyun Zhang, Huaiyu Zhang, Hanmei Liu, Zhiyu Chen, Xianyin Zeng The effect of immunization against Xinjiang fine woolsheep inhibin a on the reproductive traits of rats. African Journal of Agricultural Research 2011; 6: 5040-5046.
24.Xiaogang Du, Guoxin Zheng, Huali Jin, et al. The adjuvant effects of co-stimulatory molecules on cellular and memory responses to HBsAg DNA vaccination. J Gene Med 2007;9(2):136-46.
25.Wenjuan Zhang*, Xiaogang Du*, Gan Zhao, et al. Levamisole is a potential facilitator for the activation of Th1 responses of the subunit HBV vaccination. Vaccine , 2009; 27(36): 4938-66. (*Contributed equally)
26Yifang Zhang*, Xiaogang Du*, Wengui Li, et al. Genetic diversity of the S10 RNA segment of field and vaccine strains of bluetongue virus from the P. R. China. Arch Virol, 2010. 155(2):281-6.(*Contributed equally)
27 Effects of active immunization against GnRH versus surgical castration on hypothalamic-pituitary function in boars. Han X, Zhou Y, Zeng Y, Sui F, Liu Y, Tan Y, Cao X, Du X, Meng F, Zeng X.Theriogenology. 2017 Jul 15;97:89-97.
28 Physiological interactions between the hypothalamic-pituitary-gonadal axis and spleen in rams actively immunized against GnRH. Han X, Ren X, Zeng Y, Zhou Y, Song T, Cao X, Du X, Meng F, Tan Y, Liu Y, Feng J, Chu M, Zeng X. Int Immunopharmacol. 2016 Sep;38:275-83
29.Yanxing Hu, Huali Jin, Xiaogang Du, ea al. Effects of chronic heat stress on immune responses of 6the foot-and-mouth disease DNA vaccination. DNA Cell Biol 2007;26(8):619-26
30Huali Jin, Xiao Chong, Gan Zhao, Xiaogang Du, et al. Induction of immature dendritic cell apoptosis by foot and mouth disease virus is an integrin receptor mediated event before viral infection. Journal of Cellular Biochemistry 2007;102(4):980-91.
31HualiJin, Youming Kang, Lin Zhao, Xiao Chong, Yanxing Hu, Xiaogang Du, et al. Induction of Adaptive T Regulatory Cells That Suppress the Allergic Response by Coimmunization of DNA and Protein Vaccines. J Immunol 2008;180(8):5360-72.
32Huali Jin, Xiao Wang, Xiao Chong, Yang Yu, Youming Kang, Xiaogang Du, et al. Protective Immune Responses against Foot-and-Mouth Disease Virus by Vaccination with a DNA Vaccine Expressing Virus-Like Particles. Viral Immunol 2007;20(3):429-40.
33Youming Kang, Huali Jin, Guoxin Zheng, Xiaogang Du , et al. Co-inoculation of DNA and protein vaccines induces antigen-specific T cell suppression. Biochem Biophys Res Commun 2007;353(4):1034-9.
34.Jinyao Li, Huali Jin, Fuchuan Zhang, Xiaogang Du, et al. Treatment of autoimmune ovarian disease by co-administration with mouse zona pellucida protein 3 and DNA vaccine through induction of adaptive regulatory T cells. J Gene Med 2008;10(7):810-20.
35 .Ping Tai JW, Huali Jin ,Xiaoming Song, Jun Yan,Youmin Kang, Lin Zhao, Xiaojin An, Xiaogang Du, et al. Induction of regulatory T cells by physiological level estrogen. Journal of Cellular Physiology 2007;214(2):456-64.
36Junpeng Wang, Baowei Su, Zheng Ding, Xiaogang Du, et al. Cimetidine enhances immune response of HBV DNA vaccination via impairment of the regulatory function of regulatory T cells. Biochem Biophys Res Commun 2008;372(3):491-6.
37.Xiao Wang , Huanli Jin, Xiaogang Du, et al. The protective efficacy against Schistosoma japonicum infection by immunization with DNA vaccine and levamisole as adjuvant in mice. Vaccine 2008;26(15):1832-45.
38.Xiao Wang, Xingyu Zhang, Youming Kang, Huali Jin, Xiaogang Du,et al. Interleukin-15 enhance DNA vaccine elicited mucosal and systemic immunity against foot and mouth disease virus. Vaccine 2008;26(40):5135-44.
39.Chong Xiao, Huali Jin, Yanxin Hu, Youming Kang, Junpeng Wang, Xiaogang Du, et al. Enhanced protective efficacy and reduced viral load of foot-and-mouth disease DNA vaccine with co-stimulatory molecules as the molecular adjuvants. Antiviral Res 2007;76(1):11-20.
40. Gan Zhao, Huali Jin, Jinyao Li, Baowei Su, Xiaogang Du,et al. PyNTTTTGT prototype oligonucleotide IMT504, a novel effective adjuvant of the FMDV DNA vaccine. Viral Immunol 2009;22(2):131-8.
◆教学活动
承担研究生《生物物理学与技术》、《专业英语与论文写作》等课程。
◆指导学生
指导已毕业硕士5名，在读硕士6名。