兰轲 博士

单 位：四川大学华西药学院
通讯地址：成都市人民南路三段17号
电话/传真：
电子邮件：lanwoco@scu.edu.cn
网页：http://www.scu.edu.cn/medical/info/1012/1004.htm
Publon: https://publons.com/researcher/**/ke-lan/
Researchgate: https://www.researchgate.net/profile/Ke_Lan

简历
1996.09~2001.06，四川大学华西药学院，临床药学，本科
2001.09~2004.06，四川大学华西药学院，生物药剂学，硕士研究生
2004.09~2007.06，四川大学华西药学院，生物药剂学，博士研究生
2015.03~2016.02，夏威夷大学癌症研究中心代谢组学实验室，访问****
2011.07~，四川大学华西药学院，讲师，副教授


研究兴趣与方向
课题组致力于药物代谢与药物代谢组学研究。近年来专注于重要药物代谢酶CYP3A在人类胆汁酸代谢中的生物学功能及其药物代谢组学转化研究，获得了以下几个方面的进展：（1）提出并初步验证了药物代谢酶在宿主-肠道微生物协同代谢中的生物学功能假说；（2）阐明了人类CYP3A4/CYP3A7选择性催化的次级胆汁酸 （DCA、GDCA 和TDCA）的三级代谢通路、立体选择性氧化位点、动力学特征和潜在生物学功能；（3）开发了首个表征胎儿特征性CYP3A7酶活性的高特异性体外探针反应——DCA/GDCA/TDCA的19-氧化反应。



学术任职及荣誉
2019：ASPET会员 2018：Young Scientist Awards for Best Poster, 6th APISSX, Zhejiang University, Hangzhou 2017：第三届刘昌孝人才奖"优秀青年科技工作者奖（提名奖）" 2018~今：中国药理学会药物代谢专业委员会青年委员 2017~今：《中国临床药理学杂志》青年编委 2017~今：国家药品监督管理局药物临床试验检查员 2015~今：Editorial Board Member of Eur J Drug Metab Pharmacokinet2019~今：中国实验动物学会屏障医学专业委员会委员
近年发表的代表论文
1. Chen YJ, Zhang J, Zhu PP, Tan XW, Lin QH, Wang WX, Yin SS, Gao LZ, Su MM, Liu CX, Xu L, Jia W, Sevrioukova IF*, Lan K*. Stereoselective oxidation kinetics of deoxycholate in recombinant and microsomal CYP3A enzymes: deoxycholate 19-hydroxylation is an in vitro marker of CYP3A7 activity. Drug Metab Dispos, 2019, 47 (6) 574-581. 2. Zhang J, Gao LZ, Chen YJ, Zhu PP, Yin SS, Su MM, Ni Y, Miao J, Wu WL, Chen H, Brouwer KLR, Liu CX, Xu L, Jia W*, Lan K*. Continuum of host-gut microbial co-metabolism: CYP3A4/3A7 are responsible for tertiary oxidations of deoxycholate species. Drug Metab Dispos, 2019, 47(3): 283-294. (Cover Illustration) 3. Singh J*, Elbarbry F*, Lan K*, Grabowski T*. Animal Pharmacokinetic/Pharmacodynamic Studies (APPS) Reporting Guidelines. Eur J Drug Metab Pharmacokinet, 2018, 43(5): 483–494. 4. Zhu P, Zhang J, Chen Y, Yin S, Su M, Xie G, Brouwer KLR, Liu C, Lan K*, Jia W*. Analysis of human C24 bile acids metabolome in serum and urine based on enzyme-digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids. Anal Bioanal Chem. 2018, 410(21): 5287-5300. 5. Yin S, Su M, Xie G, Li X, Wei R, Liu C, Lan K*, Jia W*. Factors affecting separation and detection of bile acids by liquid chromatography coupled with mass spectrometry at negative mode. Anal Bioanal Chem. 2017, 409(23):5533-5545. 6. Fan X, Yin SS, Li XJ, Yang K, Xu L, Lan K*. Hydroxylation metabolisms of crassicauline A in rats under toxic dose. Eur J Drug Metab Pharmacokinet, 2017, 42(5): 857-869. 7. Lan K, Su M, Xie G, Ferslew BC, Brouwer KL, Rajani C, Liu C, Jia W*. Key role of 12-hydroxy group for the negative ion fragmentation of unconjugated C24 bile acids. Anal Chem, 2016, 88 (14): 7041-7048. 8. Yang J, Wang AQ, Li XJ, Fan X, Yin SS, Lan K*. A chemical profiling strategy for semi-quantitative analysis of flavonoids in Ginkgo extracts. J Pharm Biomed Anal, 2016, 123: 147-154. 9. Lan K*, Li XJ, Du G, Xu L. Characterizations of the hydrolyzed products of ginkgolide A and ginkgolide B based on liquid chromatography coupled with mass spectrometry analysis. J Pharm Biomed Anal, 2016, 118:113-122. 10. Li XJ, Yang K, Du G, Xu L, Lan K*. Understanding the regioselective hydrolysis of ginkgolide B under physiological environments based on generations, detections, identifications and semi-quantitative determinations of the hydrolyzed products. Anal Bioanal Chem. 2015, 407(26): 7945-7956. 11. Li XJ, Wang YQ, Yang J, Fan X, Wang L, Yang K, Lan K*. Semi-quantitative determination of monocarboxylate forms of ginkgolide B in plasma by UPLC-MS. Anal Bioanal Chem. 2015, 407(14): 4121-4129. 12. Lan K, Xie G, Jia W*. Towards polypharmacokinetics: pharmacokinetics of multi-component drugs and herbal medicines using a metabolomics approach. Evid Based Complement Alternat Med. 2013, 819147. 13. Wang A, Wang Z, Yu W, Zhong T, Dai W, Xu L, Gong T, Lan K*. Self-Reference chemical profiling in the comprehensive dissolution test of herbal medicines. J Pharm Biomed Anal, 2012, 70: 117-125. 14. Wang Z, Hu H, Chen F, Zou L, Yang M, Wang A, Foulsham JE, Lan K*. Metabolic profiling assisted quality assessment of Rhodiola rosea extracts by high performance liquid chromatography. Planta Med, 2012, 78(7):740-746. 15. Wang AQ, Wei BP, Zhang Y, Wang YJ, Xu L, Lan K*. An ultra-high sensitive bioanalytical method for plasma melatonin by liquid chromatography–tandem mass spectrometry using water as calibration matrix. J Chromatogr B Analyt Technol Biomed Life Sci, 2011, 879(23): 2259-2264. 16. Lan K*, Jia W*. An integrated metabolomics and pharmacokinetics strategy for multi-component drugs evaluation. Curr Drug Metab, 2010, 11(1): 105-114.

编辑：四川大学华西药学院