简历
教育经历
1994/9–1998/7，四川大学化学学院，学士
2000/9–2003/7，四川大学化学学院，硕士，导师：陈华
2003/9–2006/7，四川大学化学学院，博士，导师：陈华
科研与学术工作经历
2006/7-2009/7，四川大学化学学院，任教
2009/7-至今，四川大学化学学院，副教授
2011/4-2012/4，法国雷恩一大，访问****，师从Henri Doucet教授
2013/9-2015/3，美国Scripps研究所，访问****，师从余金权教授

主要研究方向
1.过渡金属催化的新型碳-碳，碳-杂偶联反应研究，包括Heck，Suzuki，Sonagashira等传统交叉偶联反应等；
2.发展新的杂环化合物的构建及衍生方法；
3.缺电芳杂环的官能化反应研究；
4.导向C-H键官能化反应；
5. 不对称氢甲酰化反应研究

主要工作业绩
1.国家自然科学基金面上项目，**, 新型联吡啶双膦配体的设计合成及其在氢甲酰化中的应用研究, 2021.1-2024.12， 63万，主持
2. 国家自然科学基金面上项目，**, 缺电杂芳环的C-H官能化反应—惰性C-H键活化新策略研究， 2019/01-2022/12， 65万，主持
3. 四川省科技计划项目，2018GZ0312，缺电杂芳环的C-H官能化反应，2018.1-2019.12， 20万，主持
4. 四川大学-泸州合作项目，2018CDLZ-13，基于C-H活化方法的吡啶药物分子合成研究及生物活性测试，2019.1-2020.12， 30万，主持
5. 绿色催化四川省高校重点实验室开放基金项目，LZJ1901，基于联吡啶骨架新型膦配体的合成和应用研究，2019.07-2021.06，5万，主持
6. 国家自然科学基金面上项目，**,负载金属催化剂表面羟基和溶剂水对羧基加氢的作用机理研究，2011/01-2014/12，36万，已结题，主研
7. 国家自然科学基金青年基金项目，**，含氮四膦配体及其钯配合物的合成，表征及其催化Heck反应研究，2013/01--2015/12,25万元，已结题，主持
在Science；J. Am. Chem. Soc.；Angew.Chem. Int. Ed.；Org. Lett.；Chem.Commun.；J. Org. Chem. Adv. Synth.Catal.；Eur. J. Org. Chem.；J.Mol.Catal.A:Chem.; Appl.Catal.A:General等杂志上发表论文100多篇，授权发明专利3项；主持和参研自然科学基金及企业合作项目10余项。

代表性成果 (获奖成果、专著、论文、专利)
代表性论文
1. Tang, J.; Chen, X.; Zhao, C. Q.; Li, W. J.; Li, S.; Zheng, X. L.*; Yuan, M. L.; Fu, H. Y.*; Li, R. X.; Chen, H. Iodination/Amidation of the N-Alkyl (Iso)quinolinium Salts. J Org Chem 2021, 86, 716
2. Li, S.; Li, W.-J.; Yang, X.; Sun, R.; Tang, J.; Zheng, X.-L.; Yuan, M.-L.; Li, R.-X.; Chen, H.; Fu, H.-Y. *, Selective direct C–H polyfluoroarylation of electron-deficient N-heterocyclic compounds. Organic Chemistry Frontiers 2020, 7 (23), 3887-3895;
3. Li, W.; Tang, J.; Li, S.; Zheng, X.; Yuan, M.; Xu, B.; Jiang, W.; Haiyan, F. *; Li, R.; Chen, H., Stereodivergent Synthesis of Alkenylpyridines via Pd/Cu Catalyzed C-H Alkenylation of Pyridinium Salts with Alkynes. Organic letters 2020, 22 (20), 7814-7819;
4. Nie, X.; Zheng, Y.; Ji, L.; Fu, H. *; Chen, H.; Li, R. *, Acceptorless dehydrogenation of amines to nitriles catalyzed by N-heterocyclic carbene-nitrogen-phosphine chelated bimetallic ruthenium (II) complex. Journal of Catalysis 2020, 391, 378-385;
5. Xu, K.; Li, W.; Sun, R.; Luo, L.; Chen, X.; Zhang, C.; Zheng, X.; Yuan, M.; Fu, H. *; Li, R.; Chen, H., Synthesis of 2-Formylpyrroles from Pyridinium Iodide Salts. Organic letters 2020, 22 (15), 6107-6111;
6. Yang, X.; Sun, R.; Li, S.; Zheng, X.; Yuan, M.; Xu, B.; Jiang, W.; Chen, H.; Fu, H. *; Li, R. *, Regioselective Direct C-H Trifluoromethylation of Pyridine. Organic letters 2020, 22 (18), 7108-7112
7. Zheng, Y.; Nie, X.; Long, Y.; Ji, L.; Fu, H*.; Zheng, X.; Chen, H.; Li, R*. Ruthenium-catalyzed synthesis of N-substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines. Chem Commun 2019, 55,12384-12387
8. Liu, H. M.; Jian, L.; Li, C.; Zhang, C. C.; Fu, H. Y.*; Zheng, X. L.; Chen, H.; Li, R. X.*, Dehydrogenation of Alcohols to Carboxylic Acid Catalyzed by in Situ-Generated Facial Ruthenium-CPP Complex. J Org Chem, 2019. 84(14): p. 9151-9160.
9. Li, W.; Liu, H.; Chen, X.; Li, S.; Zheng, R.; Zhang, C.; Zheng, X.; Yuan, M.; Li, R.; Fu, H.*; Chen, H*. Palladium-catalyzed direct ortho-alkynylation of aryl acetamides with low catalyst loading. Tetrahedron Letters. 2019, 60, 1875
10. Yang, X.; Sun, R.; Zhang, C.; Zheng, X.*; Yuan, M.; Fu, H.*; Li, R.; Chen, H., Iridium-Catalyzed Benzylamine C-H Alkenylation Enabled by Pentafluorobenzoyl as the Directing Group. Org Lett, 2019. 21(4): p. 1002-1006.
11.Hao, T. T.; Liang, H. R.; Ou-Yang, Y. H.; Yin, C. Z.; Zheng, X. L.; Yuan, M. L.; Li, R. X.; Fu, H. Y.*; Chen, H.*, Palladium-Catalyzed Domino Reaction for Stereoselective Synthesis of Multisubstituted Olefins: Construction of Blue Luminogens. J Org Chem, 2018. 83(8): p. 4441-4454.
12.Jia, F.; Yin, C.; Zeng, Y.; Sun, R.; Ge, Y. C.; Xu, D.; Li, R.; Chen, H.; Zhang, C*.; Fu, H.*, Mechanism of Direct C-H Arylation of Pyridine via a Transient Activator Strategy: A Combined Computational and Experimental Study. J Org Chem, 2018. 83(17): p. 10389-10397.
13.Sun, R.; Yang, X.; Chen, X.; Zhang, C.; Zhao, X.; Wang, X.; Zheng, X.; Yuan, M.; Fu, H.*; Li, R.; Chen, H.*, Rh(III)-Catalyzed [4 + 2] Self-Annulation of N-Vinylarylamides. Org Lett, 2018. 20(21): p. 6755-6759.
14.Yin, C.; Zhong, K.; Li, W.; Yang, X.; Sun, R.; Zhang, C.; Zheng, X.; Yuan, M.; Li, R.; Lan, Y.; Fu, H*.; Chen, H*, C6-Selective Direct Arylation of 2-Phenylpyridine via an Activated N-methylpyridinium Salt: A Combined Experimental and Theoretical Study. Advanced Synthesis & Catalysis, 2018. 360(20): p. 3990-3998
15.Zeng, Y.; Zhang, C.; Yin, C.; Sun, M.; Fu, H.*; Zheng, X.; Yuan, M.; Li, R.; Chen, H. *, Direct C-H Functionalization of Pyridine via a Transient Activator Strategy: Synthesis of 2,6-Diarylpyridines. Org Lett 2017, 19 (8), 1970-1973.
16.Huang, J.; Wang, W.; He, H.-Y.; Jian, L.; Fu, H.-Y. *; Zheng, X.-L.; Chen, H.; Li, R.-X.*, An Approach to the Synthesis of 1-Propenylnaphthols and 3-Arylnaphtho[2,1-b]furans. The Journal of Organic Chemistry 2017, 82 (5), 2523-2534.
17.Fu, H.; Shen, P. X.; He, J.; Zhang, F.; Li, S.; Wang, P.; Liu, T.; Yu, J. Q., Ligand-Enabled Alkynylation of C(sp3 )-H Bonds with Palladium(II) Catalysts. Angewandte Chemie 2017, 56 (7), 1873-1876.
18.Li, W.; Yin, C.; Yang, X.; Liu, H.; Zheng, X.; Yuan, M.; Li, R.; Fu, H.; Chen, H.Cu(ii)-Mediated keto C(sp(3))-H bond alpha-acyloxylation of N,N-dialkylamides with aromatic carboxylic acids. Org Biomol Chem, 2017. 15(36): p. 7594-7599
19.Liu, H.; Han, W.; Li, C.; Ma, Z.; Li, R.; Zheng, X.; Fu, H. *; Chen, H. *, Practical Synthesis of Phenanthridinones by Palladium-Catalyzed One-Pot C-C and C-N Coupling Reaction: Extending the Substrate Scope too-Chlorobenzamides. European Journal of Organic Chemistry 2016, 2016 (2), 389-393.
20.Wang, W.; Huang, J.; Zhou, R.; Jiang, Z.-J.; Fu, H.-Y. *; Zheng, X.-L.; Chen, H.; Li, R.-X.*, A Simple and Efficient Access to Naphtho[b]furans by Claisen Rearrangement/Cyclization of Bromonaphthyl 3-Phenylallyl Ethers. Advanced Synthesis & Catalysis 2015, 357 (11), 2442-2446.
21.Ma, Z.; Liu, H.; Zhang, C.; Zheng, X.; Yuan, M.; Fu, H. *; Li, R.; Chen, H. *, One-Pot Synthesis of Symmetrical 2,6-DiarylpyridinesviaPalladium/Copper-Catalyzed Sequential Decarboxylative and Direct C?H Arylation. Advanced Synthesis & Catalysis 2015, 357 (6), 1143-1148.
22.Ge, Y.; Cheng, Y.; Fu, H. *; Zheng, X.; Li, R.; Chen, H. *; Li, X., Suzuki-Miyaura cross-coupling reaction catalyzed by a highly stable Pd(P-Phos)Cl-2 complex at room temperature under air. Chinese Journal of Catalysis 2013, 34 (9), 1667-1673.
23.Fu, H.; Chen, H.; Doucet, H., Palladium-catalyzed selective decarboxylative coupling reaction versus direct C?H arylation for arylation of heteroaromatics. Applied Organometallic Chemistry 2013, 27 (10), 595-600.
24.Fu, H. Y.; Zhao, L.; Bruneau, C.; Doucet, H., Palladium-Catalysed Direct Heteroarylations of Heteroaromatics Using Esters as Blocking Groups at C2 of Bromofuran and Bromothiophene Derivatives: A One-Step Access to Biheteroaryls. Synlett 2012, (14), 2077-2082.
25.Fu, H. Y.; Chen, L.; Doucet, H., Phosphine-Free Palladium-Catalyzed Direct Arylation of Imidazo 1,2-a pyridines with Aryl Bromides at Low Catalyst Loading. Journal of Organic Chemistry 2012, 77 (9), 4473-4478.
26.Pi, X.; Zhou, Y.; Zhou, L.; Yuan, M.; Li, R.; Fu, H. *; Chen, H.*, Dicyclopentadiene Hydroformylation in an Aqueous/Organic Two Phase System in the Presence of a Cationic Surfactant. Chinese Journal of Catalysis 2011, 32 (4), 566-571.
27.Liu, H.; Yuan, M.; Guo, C.; Li, R.; Fu, H. *; Chen, H. *; Li, X., Selective Hydrogenation of Cinnamaldehyde to Cinnamyl Alcohol over Ru/ZrO2 center dot xH(2)O Catalyst. Chinese Journal of Catalysis 2011, 32 (7), 1256-1261.
28.Fu, H. Y.; Doucet, H., Methyl 2-Furoate: An Alternative Reagent to Furan for Palladium-Catalysed Direct Arylation. European Journal of Organic Chemistry 2011, (35), 7163-7173.
29.Fu, H.; Yuan, M.; Chen, H.; Li, R.; Li, X., Progress of Olefin Hydroformylation Catalyzed by Water-Soluble Rhodium-Phosphine Complexes. Chinese Journal of Catalysis 2010, 31 (3), 251-260.
30.Mao, H.; Fu, H. *; Chen, H. *; Li, R.; Li, X., Synergistic Effect of TPPTS and TPPDS on the Regioselectivity for 1-Decene Hydroaminomethylation in a Two-Phase Catalytic System. Chinese Journal of Catalysis 2009, 30 (12), 1192-1196.
31.Fu, H.; Li, M.; Mao, H.; Lin, Q.; Yuan, M.; Li, X.; Chen, H., Aqueous biphasic catalytic hydroformylation of higher olefins: Promotion effect of cationic gemini and trimeric surfactants. Catalysis Communications 2008, 9 (7), 1539-1544.
32.Fu, H.; Li, M.; Chen, J.; Zhang, R.; Jiang, W.; Yuan, M.; Chen, H.; Li, X., Application of a new amphiphilic phosphine in the aqueous biphasic catalytic hydroformylation of long chain olefins. Journal of Molecular Catalysis a-Chemical 2008, 292 (1-2), 21-27.
33.Fu, H.; Li, M.; Chen, H.; Li, X., Higher olefin hydroformylation in organic/aqueous biphasic system accelerated by double long-chain cationic surfactants. Journal of Molecular Catalysis a-Chemical 2006, 259 (1-2), 156-160.
34.Fu, H.; Guo, Y.; Lin, Q.; Chen, H.; Li, X., Cocatalytic effect of new surface-active phosphine in long-chain olefin hydroformylation. Chinese Journal of Catalysis 2006, 27 (12), 1053-1058.
授权专利：
1. 一种缩醛胺异喹啉酮类化合物的制备方法，付海燕，孙锐，陈华，郑学丽，李瑞祥，袁茂林，ZL7.8(2019)
2. 一种菲类化合物及其制备工艺，付海燕，浩涛涛，陈华，中国专利， ZL 20** (2018)
3. 一种吡啶类化合物双碳氢活化芳基化的方法，付海燕, 曾阳，陈华，郑学丽，袁茂林，李瑞祥，中国专利，ZL3.3 (2018)