吴安国个人简介



学院/部门：新药发现及成药性评价重点实验室四川省医学重点实验室；中药活性筛选及成药性评价泸州市重点实验室,药学院
电邮地址：wuanguo@swmu.edu.cn
电话：**
地址：四川省泸州市江阳区西南医科大学忠山校区心源楼225
研究简介：主要研究领域为：①中药活性成分筛选方法的建立及其有效成分的分离鉴定；②中药活性成分基于自噬及泛素蛋白酶系统在神经退行性疾病及肿瘤方向的作用及机制研究。目前为Phytomedicine；Acta Pharmacologica Sinica；Neural regeneration research；Current Analytical Chemistry；Pharmaceutical Biology；Journal of Herbal Medicine；Frontiers in Pharmacology等多家SCI的特邀审稿人。曾任Bioinorganic Chemistry and Applications的特刊编辑。为中国药理学会会员，四川省药理学会会员，四川省药理学会肿瘤药理专委会委员，四川省药理学会心脑血管专委会委员；世中联中医药免疫专业委员会理事。在多个SCI杂志包括Signal Transduction and Target Therapy; Aging Research Reviews; cancers，Pharmacological research，free radical and biology medicine，scientific report等发表多篇论文，总影响因子达到100余分，单篇引用次数为70余次。作为项目负责人，获批1项国家自然科学基金，3项省部级课题，多项厅局级课题。
学习及工作经历：
1. 10/2017-至今, 副教授，药学院, 西南医科大学
2. 10/2016-10/2017，博士后，澳门科技大学中药质量研究国家重点实验室，博士后导师：罗婉君教授
3. 10/2012-10/2016，博士研究生，澳门科技大学中药质量研究国家重点实验室，博士后导师：刘良院士
4. 10/2012-10/2016，化学工程师，广州康臣药业有限公司
5. 9/2008-7/2011，硕士研究生，广州中医药大学
6. 9/2004-7/2008，学士，陕西中医药大学
部分发表的论文
Daniel J. Klionsky, Amal Kamal Abdel-Aziz, ......, An-Guo Wu, ......, Steven Zuryn, and Werner Zwerschke. Guidelines for the use and interpretation of assays for monitoring autophagy (4^th edition). Autophagy. 2020, doi.org/10.1080/**.2020.**. (IF: 9.808, JCR: Q1).
An-Guo Wu ^1?,, Rong Pan ^1?, Betty Yuen-Kwan Law ^2?, Wen-Qiao Qiu ¹, Jian-Ming Wu ¹, Chang-Long He ¹, Vincent Kam-Wai Wong ², Chong-Lin Yu ^1*, Xiao-Gang Zhou ^1*, Da-Lian Qin^1* Targeting autophagy as a therapeutic strategy for identification of liganans from Peristrophe japonica in Parkinson's disease. Signal Transduction and Targeted Therapy. (IF: 13.493, JCR: Q1).
An-Guo Wu a,?, Xiao-Gang Zhou a,?, Gan Qiao a, Lu Yu a, Yong Tang a, Lu Yan a, Wen-Qiao Qiu a, Rong Pan c, Chong-Lin Yu c, Betty Yuen-Kwan Law d,*, Da-Lian Qin a,b,*,Jian-Ming Wu a,b,* Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases. Ageing Research Reviews. 2020, S1568-1637(20)30337-8. (IF: 10.616, JCR: Q1)
Rui Xiong, Xiao‐Gang Zhou, Yong Tang, Jian‐Ming Wu,Yue‐Shan Sun, Jin‐Feng Teng, Rong Pan, Betty Yuen‐Kwan Law, Ya Zhao, Wen‐Qiao Qiu, Xiu‐Ling Wang, Sha Liu, Yi‐Ling Wang, Lu Yu, Chong‐Lin Yu, Qi‐Bing Mei, Da‐Lian Qin*, An‐Guo Wu*. Lychee seed polyphenol protects the blood–brain barrier through inhibiting Aβ(25–35)‐induced NLRP3 inflammasome activation via the AMPK/mTOR/ULK1‐mediated autophagy in bEnd.3 cells and APP/PS1 mice. Phytotherapy Research. 2020 DOI: 10.1002/ptr.6849. (IF: 4.087, JCR: Q1)
Wen-Qiao Qiu, RongPan, YongTang, Xiao-GangZhou, Jian-MingWu, LuYu, Betty Yuen-KwanLaw, WeiAi, Chong-LinYu, Da-LianQin, An-Guo Wu. Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction. October 2020 Biomedicine & Pharmacotherapy 130:110575 (IF: 4.545, JCR: Q1)
Sun, Y. ^?; Jiang, X. ^?; Pan, R.; Zhou, X.; Qin, D.; Xiong, R.; Wang, Y.; Qiu, W.; Wu, A.*; Wu, J*. Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells. Front Pharmacol 2020, 11, 116, doi:10.3389/fphar.2020.00116. (IF: 4.225, JCR: Q1)
Sang Z^?, Wang K^?, Shi J, Liu W, Cheng X, Zhu G, Wang Y, Zhao Y, Qiao Z, Wu A*, Tan Z*. The development of advanced structural framework as multi-target-directed ligands for the treatment of Alzheimer's disease. Eur J Med Chem. 2020 Apr 15;192:112180. doi: 10.1016/j.ejmech.2020.112180. (IF: 5.572, JCR: Q1).
Jin-Feng Teng 1,?, Da-Lian Qin 1,?, Xiao-Gang Zhou 1,?, Qi-Bing Mei 1, Yong Tang 1, Rui Xiong 1, Wen-Qiao Qiu 1, Rong Pan 3, Betty Yuen-Kwan Law 4, Vincent Kam-Wai Wong 4, Chong-Lin Yu 3, Han-An Long 1, Xiu-Li Xiao 1, Feng Zhang 1, Jian-Ming Wu 1,2,* and An-Guo Wu 1,2,*. Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer, Cancers; 2020, 12(1), 193. Published 13 Jan 2020. Doi: 10.3390/cancers** (IF: 6.162, JCR: Q1).
Rui Xiong^?, Xiu-Ling Wang^?, Jian-Ming Wu^?, Yong Tang, Wen-Qiao Qiu, Xin Shen, Jin-Feng Teng, Rong Pan, Ya Zhao, Lu Yu, Jian Liu, Hai-Xia Chen, Da-Lian Qin ^*, Chong-Lin Yu^*, and An-Guo Wu^* Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway. Journal of Ethnopharmacology, 2020;251(2020):112548. Available online 7 January 2020, 112548. (IF: 3.69, JCR: Q1).
Yueshan Sun^?, Anguo Wu^?, Xiu Li^?, Dalian Qin, Bingjin Jin, Jian Liu, Yong Tang, Jianming Wu & Chonglin Yu. The seed of Litchi chinensis fraction ameliorates hippocampal neuronal injury in an Aβ 25-35 -induced Alzheimer’s disease rat model via the AKT/GSK-3β pathway. Pharm Biol. 2020 Dec;58(1):35-43. doi: 10.1080/**.2019.**. (IF: 2.971, JCR: Q2).
Sun X?, Wu A?, Kwan Law BY, Liu C, Zeng W, Ling Qiu AC, Han Y, He Y, Wai Wong VK. The active components derived from Penthorum chinensePursh protect against oxidative-stress-induced vascular injury via autophagy induction. Free Radical Biol Med. 2020 Jan;146:160-180. (IF: 6.17 JCR: Q1)
An-Guo Wu, Jin-Feng Teng, Vincent Kam-Wai Wong, Xiao-Gang Zhou, Wen-Qiao Qiu, Yong Tang, Jian-Ming Wu, Rui Xiong, Rong Pan, Yi-Ling wang, Bin Tang, Tian-Yi Ding, Lu Yu, Wu Zeng, Da-Lian Qin, Betty Yuen-Kwan Law. Novel Steroidal Saponin Isolated from Trillium tschonoskii Maxim. Exhibits Anti-Oxidative Effect via Autophagy Induction in cellular and Caenorhabditis elegans models. Phytomedicine. 2019 Dec; 65:153088. (IF: 4.268, JCR: Q1)
Teng JF, Qin DL, Mei QB, Qiu WQ, Pan R, Xiong R, Zhao Y, Law BYK, Wong VK, Tang Y, Yu CL, Zhang F, Wu JM, Wu AG. Polyphyllin VI, a saponin from Trillium tschonoskii Maxim. induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer. Pharmacol Res. 2019; 147:104396. (IF: 5.893, JCR: Q1)
Wu Anguo, Zhao Ya, Qiu Wenqiao, Teng Jinfeng, Xiong Rui, Wu Jianming, and Qin Dalian. SMU-A inhibits Aβ-induced NLRP3 inflammasome via autophagy mediated by the AMPK/ULK1 and Raf/MEK/ERK pathways in microglia. The FASEB Journal 2019 33:1_supplement, 806.5-806. (IF: 5.361, JCR: Q1)
Lu Yu^#, An-Guo Wu^#, Vincent Kam-Wai Wong, Li-Qun Qu, Ni Zhang, Da-lian Qin, Wu Zeng, Bin Tang, Hui-Miao Wang, Qiong Wang, Betty Yuen-Kwan Law. The new application of UHPLC-DAD-TOF/MS in identification of inhibitors on β-amyloid fibrillation from Scutellaria baicalensis. Front Pharmacol, 2019 Mar 18; 10: 194. (IF: 4.225, JCR: Q1)
Ya Zhao 1?, Yuan Zeng 1?, Anguo Wu 1?, Chonglin Yu 2, Yong Tang 1, Xiuling Wang 1, Rui Xiong 1, Haixia Chen 1 , Jianming Wu 1*, and Dalian Qin 1*. Lychee Seed Fraction Inhibits Aβ(1-42)-Induced Neuroinflammation in BV-2 Cells via NF-κB Signaling Pathway. Frontiers in Pharmacology. 2018 Apr; 9: 380. (IF: 3.845, JCR: Q1)
Wu AG, Zeng W, Wong VK, Zhu YZ, Lo AC, Liu L, Law BY. Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice. Pharmacol Res. 2017 Jan; 115: 25-44. (IF: 4.897, JCR: Q1)
An-Guo Wu, Vincent Kam Wai Wong, Wu Zeng, Liang Liu, Betty Yuen Kwan Law. Identification of novel autophagic Radix Polygalae fraction by cell membrane chromatography and UHPLC-(Q)TOF-MS for degradation of neurodegenerative disease proteins. Sci Rep. 2015 Nov 24; 5:17199. (IF: 5.228, JCR: Q1)
An-guo Wu, Ting-ting Duan, Dan Tang, Zhao-guang Zheng, Jia-xiao Zhu, Ru-shang Wang, et al. Review the application of chromatography in the analysis of nitric oxide- derived nitrite and nitrate ions in biological fluids. Curr Anal Chem. 2014;10 (4), 609-621. (IF: 1.194, JCR: Q3)
20. An-Guo Wu, Vincent Kam-Wai Wong, Su-Wei Xu, Wai-Kit Chan, Choi-In Ng, Liang Liu, Betty Yuen-Kwan Law. Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells. Int J Mol Sci, 2013 Nov 15; 14(11):22618-41. (IF: 2.339, JCR: Q2) Anguo Wu, Tingting Duan, Dan Tang, Youhua Xu, Liang Feng, Zhaoguang Zheng, el al. Determination of nitric oxide-derived nitrite and nitrate in biological samples by HPLC coupled to nitrite oxidation, Chromatographia. 2013 Aug 4; 76: 1649-1655. (IF: 1.437, JCR: Q3)
WU An-guo, ZENG Bao, HUANG Meng-qiu, LI Sheng-mei, CHEN Jian-nan, and LAI Xiao-ping*. The Absorption and Transport of Magnolol in Caco-2 Cell Model. Chin J Integr Med, 2013 Mar; 19(3): 206-211. (IF: 1.401, JCR: Q2)

申请/授权的专利：
1. Betty Yuen-Kwan Law, An-Guo Wu, Vincent Kam-Wai Wong, Liang Liu. “A Novel Autophagy Enhancer for Treatment of Neurodegenerative Diseases”. AU, Granted.
2. Betty Yuen-Kwan Law, An-Guo Wu, Vincent Kam-Wai Wong, Liang Liu. “Active Autophagic Fraction from Radix Polygalae for Treatment of Neurodegenerative Diseases”. AU, Granted.
3. Betty Yuen-Kwan Law, An-Guo Wu, Vincent Kam-Wai Wong, Liang Liu Wu Zeng. “Triterpenoid obtainable from Hedera Helix for treatment of neurodegenerative diseases”. AU, Granted.
4. Betty Yuen-Kwan Law, An-Guo Wu, Vincent Kam-Wai Wong, Liang Liu. “Autophagy enhancer for treatment of neurodegenerative diseases” US 9,005,677 B2, Granted.
5. Betty Yuen-Kwan Law, An-Guo Wu, Vincent Kam-Wai Wong, Liang Liu Wu Zeng. “Triterpenoid obtainable from Hedera Helix for treatment of neurodegenerative diseases” USA1, Granted
6. 郑兆广;朱荃;石兴华;黄晓玲;王汝上;汤丹;何宝;程慧荃;段婷婷;顾斐;钟俊玲;朱家校;吴安国;黄艳霞;冉凤. 香豆素在制备AGEs形成抑制剂中的应用. CN8.7,授权
7. 秦大莲 ; 吴建明 ; 王秀玲 ; 唐勇 ; 吴安国 ; 黄飞鸿。荔枝核活性成分在制备改善胰岛素抵抗的药物中的用途. CNA，在审，2018
8. 吴安国 罗婉君 秦大莲 黄锦伟 吴建明 唐勇 余录 滕金凤 邱文乔。一种延龄草皂苷在制备保护神经药物中的应用。申请号：4.3. 申请日：2019-08-22
9. 吴安国 吴建明 秦大莲 孙悦珊 唐勇 潘蓉 姜雪琴 邱文乔。 七叶皂苷类化合物用于治疗亨廷顿舞蹈症及帕金森症的应用。申请号：9.1. 申请日：2019-08-22
10. 吴安国，潘蓉，秦大莲，周晓钢，唐勇，吴建明，何长龙，邱文乔一种中草药提取物、提取方法和用途。申请号：9.5，申请日：2020-08-31

主持的课题：
1. 基于SHP2调控的自噬-NLRP3炎性小体途径探讨远志皂苷抑制神经炎症 的作用及机制研究（**），国家自然科学青年基金，项目负责人
2. 基于高内涵成像系统从中药中筛选的自噬与泛素蛋白酶系统激活剂作用于神经退行性疾病的机制研究，四川省人力资源与社会保障厅，项目负责人
3. 远志皂苷通过调控LKB1/AMPK信号轴抑制亨廷顿早期神经炎症的机制研究(2018JY0474),2018年7月至2021年7月,四川省科技厅, 项目负责人
4. 慢性阻塞性肺病急性加重住院患者的注册登记研究及中西医协同治疗感染导致的慢阻肺急性加重观察性疗效比较研究项目；宋庆龄基金，项目负责人
5. 泸州荔枝核花青素基于自噬通过LRP1/AMPK抑制神经炎症的大健康产品开发，泸州市-西南医科大学联合项目（重点），项目负责人
6. 宜宾县特色竹叶的饮品或茶品开发研究，2017-YBXNYD-3（10/13），宜宾县基地项目，子项目负责人
7. UHPLC-MS/MS同时测定PCP的花、茎和叶中4个主要的鞣花鞣质型黄酮类成份及其体内含量的测定（2017-ZRZD-015），西南医科大学课题，项目负责人
8. 基于自噬与泛素化蛋白降解途径中药在神经退行性疾病及肿瘤中的应用，2020年度四川省科技厅国（境）外高端人才引进项目，项目负责人