焦威职 务:职 称:副研究员学 历:博士研究生电 话:传 真:通讯地址:成都市人民南路四段9号
邮政编码:610041电子邮件:jiaowei@cib.ac.cn
个人简历　　2002年毕业于内蒙古大学化学系，获理学学士学位。2008年毕业于中国科学院成都生物研究所药物化学专业，获理学博士学位。2015年，瑞士洛桑联邦理工大学（école Polytechnique Fédérale de Lausanne, EPFL），生物有机化学专业学习。现就职于中科院成都生物研究所，副研究员。主要从事天然药物活性成分的构效关系研究和释药系统构建，以获得可成药的候选药物分子；活性分子特殊母核的合成方法学及计算化学反应机理研究；计算机辅助药物设计和药物活性机制研究。现在国际TOP期刊J. Med. Chem.，Chem. Commun.，Adv. Synth. Catal.等发表论文40余篇，申请发明专利2项。
研究方向　　1. 药物先导化合物的构效关系研究和释药系统构建；
　　2. 活性分子特殊母核的合成方法学研究；
　　3. 计算机辅助药物设计和机理研究。
社会任职及荣誉（含获奖） 　　2018-至今，四川省科技青年联合会理事
　　2017年入选中科院西部之光人才计划（A类）
　　2017年入选四川省高层次归国留学人才

承担科研项目情况主持国家、省部级项目10余项，包括国家自然科学基金面上项目，西部之光人才计划A类，中国科学院战略生物资源服务网络计划，国家自然科学基金青年项目，西部之光人才计划西部博士项目，中科院知识创新项目，科技部重大专项子项目，“973”国家重点基础研究发展计划子项目，四川省技术支撑计划子项目等。
“传统中药千金子中Jokinol型二萜抗肿瘤多药耐药调控剂的研究”，国家自然科学基金面上项目，65万，主持；“活性天然化合物发现、评价与转化”，中国科学院战略生物资源服务网络计划，120万，主持；“Lathyrane型活性二萜化合物的研究”，西部之光人才计划A类，70万，主持。
代表论著　　[1] Pang Y., Li J. T., Ma X. F., Jiao W.*, Shao H. W., Transition-metal-free regioselective direct C-H trifluoromethylation and perfluoroalkylation of isoquinolines and other heteroarenes, Chem. Commun., 56, 7813–7816, 2020 .
　　[2] Zhang X. K., Pan Y., Wang H. B., Liang C., Ma X. F., Jiao W.*, Shao H. W., Strategy to construct 1,2,3‐triazoles by K₂CO₃‐mediated [4+1] annulation reactions of N‐acetyl hydrazones with bifunctional amino reagents, Adv. Synth. Catal., 2020, doi:10.1002/adsc..
　　[3] Zhang X. K., Pan Y., Liang P., Ma X. F., Jiao W.*, Shao H. W., An Effective Method for the Synthesis of 1,3-Dihydro-2H-indazoles via N-N Bond Formation, Adv. Synth. Catal., 361, 5552–5557, 2019.
　　[4] Jiao W.*, Wan Z. M., Chen S., Lu R. H., Chen X. Z., Fang D. M., Wang J. F., Pu S. C., Huang X., Gao H. X., Shao H. W., Lathyrol Diterpenes as Modulators of P-Glycoprotein Dependent Multidrug Resistance: Structure-Activity Relationship Studies on Euphorbia Factor L-3 Derivatives, J. Med. Chem., 58(9), 3720–3738, 2015.
　　[5] Jiao W., Wu Z. J., Chen X. Z., Lu R. H., Shao H. W., Rhopeptin A: First Cyclopeptide Isolated from Rhodobryum giganteum, Helv. Chim. Acta, 96, 114–118, 2013.
　　[6] Jiao W.*, Chen X. Z., Wang H. B., Lu R. H., Shao H. W., A New Hepatotoxic Triterpenoid Ketone from Curculigo orchioides, Fitoterapia, 84, 1–5, 2013.
　　[7] Jiao W., Fang D. M., Wu Z. J., Chen J. Z., Shao H. W., Zhang G. L., Analysis of Lathyrane Diterpenes Using Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry, Rapid Commun. Mass Spectrom., 27, 276–280, 2013.
　　[8] Jiao W.,Dong, W. W.,Li, Z. F., Deng M. C.,Lu, R. H., Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures Bioorg. Med. Chem., 17, 4786–4792, 2009.
　　[9] Jiao W.,Yu K. B.,Lu, R. H., Configuration Confirmation of Euphorbia Factor L-1 by Single-crystal X-ray Diffraction, Chin. J. Struct. Chem.,27, 1431–1434, 2008.
　　[10] Jiao W., Mao Z. H., Dong W. W., Deng M. C., Lu R. H., Euphorbia Factor L8: a Diterpenoid from the Seeds of Euphorbia lathyris, Acta Crystallogr. E, 64, o331, 2008.
　　[11] Jiao W., Mao Z. H., Lu R. H., Euphorbia Factor L2: an Ester of 7？hydroxyLathyrol, Acta Crystallogr. E, 63, o4613, 2007.
　　[12] Wang Z. Z., Jiao W., He G. Y., Lu R. H., One-step Regioselective Green Synthesis of 2, 3-mannoepoxy-β-cyclodextrin under Aqueous Conditions, Mon. Chem., 140, 79–81, 2009.
　　[13] Dong W. W., Jiao W., Deng M. C., Yang C. B., Yue J. M., Lu R. H., A New Steroid Glycoside Derivative from Acorus calamus L., J. Chin. Chem. Soc., 55, 1277–1279, 2008.
　　[14] Wang X. L., Jiao W., Liao X., Peng S. L., Ding L. S., Monoterpene Glycosides from the Roots of Paeonia lactiflora, Chin. Chem. Lett., 17(7), 916–918, 2006.
　　[15] Igbe I. Shen X. F., Jiao W., Qiang Z., Deng T., Wang F., Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase, Oncotarget, 8, 113734–113748, 2017.
　　[16] Deng M. C., Dong W. W., Jiao W., Lu R. H., New Eremophilane Sesquiterpenes from the Roots of Ligularia fischeri, Helv. Chim. Acta, 92, 495–501, 2009.
　　[17] Wang X. L., Gesang S. L., Jiao W., Liao X., Ding L. S., Two New Sesquiterpenoid Glucosides from the Aerial Parts of Saussurea involucrate, J. Integr. Plant Biol., 49(5), 609–614, 2007.
　　[18] Chen X. Z., Lu S. M., Li G. Y., Jiao W., Huang T. F., Yang T., Fang D. M., Biphenyls from Aerial Parts of Ribes takare, Chin. Chem. Lett., 25(1), 127–130, 2014.
　　[19] Wang C., Ma X. F., Zhang J. C., Tang Q., Jiao W., Shao H. W., Methanesulfonic-Acid-Catalysed Ring Opening and Glycosylation of 1,2-(Acetylcyclopropane)-Annulated D-Lyxofuranose, Eur. J. Org. Chem., 21, 4592–4599, 2014.
　　[20] Shen X. D., Xia J. H., Liang P., Ma X. F., Jiao W., Shao H. W., Zn(OTf)2 Promoted Rearrangement of 1,2-cyclopropanated Sugars with Amines: A Convenient Method for the Synthesis of 3-polyhydroxyalkyl-substituted Pyrrole Derivatives, Org. Biomol. Chem., 13, 10865–10873, 2015.
　　[21] Lu R. H., Yang C., Cao Y. J., Tong H. L., Jiao W., Wada T., Wang Z. Z., Mori T., Inoue Y., Enantiodifferentiating Photoisomerization of Cyclooctene Included and Sensitized by Aroyl-beta-Cyclodextrins: A Critical Enantioselectivity Control by Substituents, J. Org. Chem., 73, 7695–7701, 2008.
　　[22] Lu R. H., Yang C., Cao Y. J., Wang Z. Z., Wada T., Jiao W., Mori T., Inoue Y., Supramolecular Enantiodifferentiating Photoisomerization of Cyclooctene with Modified Beta-cyclodextrins: Critical Control by A Host Structure, Chem. Commun., (3), 374–376, 2008.
　　[23] Yuan W., Xiao J. H., Zhang X. K., Liang P., Zhang J. C., Jiao W., Shao H.W., An efficient method for the stereoselective synthesis of N-substituted trihydroxypiperidine derivatives promoted by p-TsOH, Tetrahedron, 72, 3994–4000, 2016.
　　[24] Yuan W., Pan Y., Zhang X. K., Liang P., Zhang J. C., Jiao W., Shao H. W., Direct and highly stereoselective synthesis of quinolizidine iminosugars promoted by L-proline-Et₃N, Org. Biomol. Chem., 16(47), 9230–9236, 2018.
　　[25] Zhang X. K., Pan Y., Liang P., Pang L., Ma X. F., Jiao W., Shao H.W., Oxadiazepine Synthesis by Formal [4+3] Cycloaddition of o-Chloromethyl Arylsulfonamides with Nitrones Promoted by NaHCO₃, Adv. Synth. Catal., 360(16), 3015–3019, 2018.
　　[26] Liang P., Pan Y., Ma X. F., Jiao W., Shao H. W., A facile method for the synthesis of fused perhydropyrano[2,3-b]pyrans promoted by Yb(OTf)₃, Chem. Commun., 54(30), 3763–3766, 2018.