李光勋职 务:职 称:副研究员学 历:博士研究生电 话:传 真:通讯地址:四川省成都市高新区科园南路93号
邮政编码:610041电子邮件:ligx@cib.ac.cn
个人简历　　李光勋，1982年生，副研究员，硕士生导师，中国科学院青年创新促进会会员。研究方向：不对称有机小分子催化，氮杂环类活性分子的合成与筛选，药物工艺改进等。先后以第一作者或通讯作者在Angew. Chem., Int. Ed.，Org. lett., Chem. Commun. 等国际一流刊物发表sci论文20余篇。申请国家发明专利1项，授权1项。主持国家自然科学基金项目，四川省自然科学基金项目，参与完成国家自然科学基金面上项目，国家优秀青年基金项目等。
　　教育经历
　　2001.9-2005.7 四川农业大学林学园艺学院，获学士学位
　　2005.9-2008.7 中科院沈阳应用生态所，获硕士学位
　　2008.9-2011.7 中科院成都生物所，获博士学位
　　工作经历
　　2011.09-2013.08中科院成都有机化学所开展博士后研究
　　2013.09-至今 中科院成都生物研究所副研究员

研究方向不对称有机小分子催化，氮杂环类活性分子的合成与筛选，药物工艺改进等

社会任职及荣誉（含获奖）
承担科研项目情况　　1. 国家自然科学基金青年基金：“生物启发的有机烷基化试剂的开发与应用”（2015-2017）
　　2. 四川省自然科学基金面上（重点）：若干具有潜在药物活性分子的设计与合成（重点）（2017-2019）
　　3. 中国科学院青年创新促进会会员：（2018-2021）

代表论著
　　1. Guangxun Li, Chen Rong, Wu Lei, Fu Qingquan, Zhang Xiaomei, TangZhuo, Alkyl transfer from C-C cleavage, Angewandte Chemie International Edition, 2013, 52(32), 8432-8436. Highlighted by Synfacts 2013, 9(9), 1012.
　　2. Guangxun Li*, Liu Hongxin, Lv Gang, Wang Yingwei, Fu Qingquan, Tang Zhuo, Enantioselective Organocatalytic Transfer Hydrogenation of 1,2-Dihydroquinoline through Formation of Aza-o-xylylene. Organic Letters, 2015, 17(17), 4125-4127.
　　3. Guangxun Li,* Ling Tang, Hongxin Liu,Yingwei Wang,Gang Zhao, and Zhuo Tang*, Investigation and Application of Amphoteric α-Amino Aldehyde: An in Situ Generated Species Based on Heyns Rearrangement, Organic Letters, 2016, 18(18), 4526？4529.
　　4. Xuwen Ren, Guangxun Li*^, Jin Huang, Weidong Wang, Yongpo Zhang, Guomin Xing, Chunyan Gao, Gang Zhao, Jinzhong Zhao^*, Zhuo Tang^*, Step-Controlled Povarov-Type Reaction with 1,2-Dihydroquinolines as Precursors of Dienophiles: Direct Synthesis of Spirocyclic Bi-tetrahydroquinolines and Functionalized 1,2-Dihydroquinolines, Organic Letters, 2017, 19, 58？61
　　5. Guangxun Li *, Liu Hongxin, Wang Yingwei, Zhang Shiqi, Lai Shujun, Tang Ling, Zhao Jinzhong, Tang Zhuo, The catalytic enantioselectivesynthesis of tetrahydroquinolines containing all-carbon quaternary stereocenters via the formation of aza-ortho-xylylene with 1,2-dihydroquinoline as a precursor. Chemical Communications, 2016, 52(11), 2304-2306.
　　6. Guangxun Li, Wu Lei, Lv Gang, Liu Hongxin Fu Qingquan, Zhang Xiaomei, Tang Zhuo, Alkyl transfer from C-C cleavage: replacing the nitro group of nitro-olefins, Chemical Communications, 2014, 50(47), 6246-6248.
　　7. Lai Shujun, Ren Xuwen, Zhao Jinzhong, Tang Zhuo, Guangxun Li *, Simple Br？nsted acid catalyzed C–H functionalization: efficient access to poly-substituted pyridines. Tetrahedron Letters, 2016, 57(27–28), 2957-2961.
　　8. Guangxun Li, Wang Zhizhong, Lu Runhua, Tang Zhuo, Enantiodifferentiating photoisomerization of cyclooctene included and sensitized by benzoate modified β-cyclodextrin derivatives: switching of product chirality by solvent. Tetrahedron Letters, 2011, 52(24), 3097-3101.
　　9. Guangxun Li, Fu Qingquan, Zhang Xiaomei, Jiang Jun, Tang Zhuo, First asymmetric intermolecular bromoesterification catalyzed by chiral Br？nsted acid. Tetrahedron: Asymmetry, 2012, 23(3–4), 245-251.
　　10.GuangXun Li, Wu Lei, Fu QingQuan, Tang Zhuo, Zhang XiaoMei, First way of enantioselective synthesis of moxifloxacin intermediate. Science China Chemistry, 2013, 56(3), 307-311.
　　11.Wu Lei, Guangxun Li, Fu Qingquan, Yu Luoting and Tang Zhuo, Organocatalytic asymmetric Michael reaction with acylsilane donors, Organic & Biomolecular Chemistry, 2013, 11(3), 443-447.
　　12.Wu Lei, Guangxun Li, He Migu, Wang Yingwei, Zhao Gang, Tang Zhuo, First Example of Organocatalytic Asymmetric Mannich Reaction between Aldimines of Glycinates and Sulphonyl Imines, Canadian Journal of Chemistry, 2016, 94, 769-772.
　　13.Shiqi Zhang, Guangxun Li, Hongxin Liu,Yingwei Wang,Yuan Cao,Gang Zhao,^*and Zhuo Tang^*_, Bio-inspired enantioselective full transamination with readily available cyclodextrin, RSC Adv., 2017,7, 4203-4208.
　　14.Yingwei Wang, Guangxun Li, Hongxin Liu, Zhuo Tang^*, Yuan Cao and Gang Zhao^*, Kinetic resolution of indolines through reductive amination of aldehydes by chiral Br？nsted acid, Tetrahedron Letters, 2017, 58, 2993-2996.
　　15.Yingwei Wang, Guangxun Li, Hongxin Liu, Zhuo Tang^*, Yuan Cao and Gang Zhao^*, A tandem annulation with a [1,3]-hydride transfer as the key step leading to isochromans, Chem. Commun., 2017,53, 10652-10655.
　　16.Jin Huang, Guangxun Li*, Guobin Yang, Jinzhong Zhao, and Zhuo Tang*, Br？nsted Acid Catalyzed Substrate-Controlled and Site-selective Friedel-Crafts Alkylation: A New Strategy for Post-modification of 1,2-Dihydroquinolines, Asian Journal of Organic Chemistry, 2017, 6,1741-1744.
　　17.Guobing Yang, Guangxun. Li*, Jin.Huang, Zhuo. Tang* and Jingzhong. Zhao*, One Pot Three-Component Reaction for Preparation of Dihydroquinolines with Two Different Ketones and Aromatic Amines, Org. Biomol. Chem., 2017, 15, 10167-10171.
　　18.Hongxin Liu, Guangxun Li*, Ying-wei Wang, Shiqi Zhang, Zhuo Tang*, Bioinspired Catalysis: Self-Assembly of a Protein and DNA as a Catalyst for the Aldol Reaction in Aqueous Media, Synlett, 2018, 29, 560–565.
　　19.Long-junMa, Guangxun Li*, JinHuang, JinZhu*, ZhuoTang*, Using Sulfinamides as High Oxidation State Sulfur Reagent for Preparation of Sulfenamides, Tetrahedron Letters, 2018, 59, 1600-1603.
　　20.吕刚, 李光勋, 唐卓, 一种制备盐酸西那卡塞的新方法, 合成化学, 24(6), 537-539, 2016.
　　21.唐琳，刘红鑫，李光勋，唐卓，一种氨基酸衍生物消旋的新方法，合成化学, DOI：10.15952/j.cnki.cjsc.1005-1511, 2017.
　　22.李光勋, 王力华, 陈玮. 正交实验优选文冠果壳中文冠果壳苷提取工艺, 食品科学, 30(2): 58-60， 2009.
　　授权专利
　　1. (S,S)-八氢-6H-吡咯并[2,4-b]吡啶的制备方法（CN5.8），第二完成人