韩波，研究员，博士生导师，成都中医药大学药学院副院长，主要研究方向为中药药效物质的分子网络机制、结构优化、多维构效关系和创新药物研发，2020年获四川省科技进步一等奖（排名第一）。入选国家“****”（青年拔尖人才）、国家中医药管理局“青年岐黄****”、四川省学术技术带头人、首批青年中医药求真****，四川省“天府****”，四川省中医药管理局学术技术带头人、全国高等中医药院校优秀青年。获得全国百篇优秀博士论文奖、四川省青年科技奖等。
先后主持国家自然科学基金（面上项目3项及青年基金1项，主研重点项目1项）、十三五“重大新药创制”科技重大专项（“中药防治耐药菌创新结构药物研发”课题）、教育部百篇优秀博士论文基金、四川省科技重大前沿项目等十余项国家及省部级科研项目。获得“四川省****基金”、“中国博士后科学基金特助”、“中国博士后科学基金面上项目”等人才项目资助。发表SCI收录论文74篇；第一或通讯作者论文60篇；在第一或通讯作者论文中：IF＞40论文1篇，IF＞10论文5篇，IF＞5论文34篇，引用次数＞100论文3篇，ESI高被引论文1篇，Nature Index自然指数期刊13篇。获得授权专利13项；出版专著7部；参与制定国际标准1项。目前担任中国科技期刊卓越行动计划项目《中华中医药杂志》青年编委、世界中医药学会联合会“中药上市后再评价专业委员会”常务理事、Current Topics in Medicinal Chemistry期刊客座主编、成都市青年联合会委员、成都市知联会医药卫生专委会秘书。
※ 基金资助情况
[1]中国科技部，"重大新药创制"十三五 科技重大专项，2018ZX**-008-002，中药防治耐药菌创新结构药物研发，2019-01至2020-12，在研，主持
[2]国家自然科学基金委员会，面上项目，**，山茱萸环烯醚萜调控自噬-炎症相互作用治疗糖尿病肾病的机制和多维构效关系，2021.01至2024.12，在研，主持
[3]国家自然科学基金委员会，面上项目，**，马钱子生物碱诱导程序性细胞死亡的“效与毒”整合作用机制以及立体构效关系研究，2018-01至2021-12，在研，主持
[4]国家自然科学基金委员会，重点项目，**，附子”毒与效“的多维评价与整合分析研究，2017-01至2021-12，在研，参与
[5]四川省科学技术厅，应用基础研究重大前沿项目，2017JY0323，中药防治耐药菌新品种筛选及关键创新技术建立，2017-01至2020-12，在研，主持
[6]国家自然科学基金委员会，面上项目，**，钩藤生物碱调控α-突触核蛋白依赖的自噬-溶酶体途径治疗帕金森病的作用机制和构效关系研究，2016-01至2019-12，已结题，主持
[7]四川省科学技术厅，****基金，2014JQ0020，基于“立体构效关系模型”融合生物信息学研究青黛治疗慢粒白血病的药效物质基础和分子机制，2014-01至2016-12，已结题，主持
[8]国家自然科学基金委员会，青年项目，**，基于双催化体系不对称合成结构多样性杂环骨架，2014-01至2016-12，已结题，主持
[9]中国教育部，全国百篇优秀博士论文作者专项基金，201487，立体选择性构建结构多样性的药物骨架，2014-01至2018-12，主持
[10]中国博士后科学基金委员会，特别资助项目，2013T60843，基于生物信息学研究大青叶治疗CML的药效物质基础，2013-01 至 2014-12，已结题，主持
[11]中国博士后科学基金委员会，面上项目，2012M511915，抗肿瘤吲哚衍生物的设计、合成及活性研究，2012-01 至 2013-12，主持
[12]中国教育部，博士学科点专项科研基金，201**，新型紫杉醇衍生物的设计、合成及活性研究，2012-01 至 2014-12，主持
※ 近年来主要代表性论文
[1]Han, B.; He, X.-H.; Liu, Y.-Q.; He, G.; Peng, C.*; Li, J.-L.* Asymmetric Organocatalysis: an Enabling Technology for Medicinal Chemistry. Chemistry Society Review, 2020, 12. Accepted. IF: 42.846
[2]Li, J.-L.; Liu, Y.-Q.; Zou, W.-L.; Zeng, R.; Zhang, X.; Liu, Y.; Han, B.*; He, Y.; Leng, H.-J.; Li, Q.-Z.* Radical Acylfluoroalkylation of Olefins through N-Heterocyclic Carbene Organocatalysis. Angewandte Chemie-International Edition 2020, 59(5), 1863. IF: 12.959
[3]Zhang, X.; Li, Xiang.; Li, J.-L.*; Wang, Q.-W.; Zou, W.-L.; Liu, Y.-Q.; Jia, Z.-Q.; Peng, F.*; Han, B.* Regiodivergent construction of medium-sized heterocycles from vinylethylene carbonates and allylidenemalononitriles. Chemical Science 2020, 11, 2888.IF: 9.346
[4]Peng, F.; Zhao, Q.; Huang, W.; Liu, S.-J.; Zhong, Y.-J.; Mao, Q.; Zhang, N.; He, G.*; Han, B.* Amine-catalyzed and functional group-controlled chemo- and regioselective synthesis of multi-functionalized CF3-benzene via a metal-free process. Green Chemistry 2019, 21(22), 6179. IF: 9.480
[5]Tang, X.; Zhang, N.; He, G.*; Li, C.-H.; Huang, W.; Wang, X.-Y.; Zhan, G.*; Han, B.* Unconventional [2+3] Cyclization Involving [1,4]-Sulfonyl Transfer to Construct Polysubstituted Fluorazones as Inhibitors of Indoleamine 2,3-Dioxygenase 1.Organic Letters,2020, 22(20), 7909. IF: 6.091
[6]Wang, B.; Peng, F.; Huang, W.; Zhou, J.; Zhang, N.; Sheng, J.; Haruehanroengra, P.; He, G.; Han, B.* Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma. Acta Pharmaceutica Sinica B, 22020, 10(8): 1492-1510. IF: 7.097
[7]Ji, Y.-L.; He, X.-H.; Li, G.; Ai, Y.-Y; Li, H.-P.; Peng C.; Han, B.* Substrate-directed chemo- and regioselective synthesis of polyfunctionalized trifluoromethyl-arenes via organocatalytic benzannulation. Organic Chemistry Frontiers2020, 7, 563. IF: 5.155
[8]Zhu, H.-P.; Xie, K.; He, X.-H.; Huang, W.; Zeng, R.; Fan, Y.; Peng, C.; He, G.*; Han, B.* Organocatalytic diastereoselective 3+2 cyclization of MBH carbonates with dinucleophiles: synthesis of bicyclic imidazoline derivatives that inhibit MDM2-p53 interaction. Chemical Communications 2019, 55(76), 11374. IF: 5.996
[9]Xie, X.; Xiang, L.; Peng, C.*; Han, B*. Catalytic Asymmetric Synthesis of Spiropyrazolones and their Application in Medicinal Chemistry. Chemical Record 2019, 19(11), 2209. IF: 6.163
[10]Single-Electron Transfer Reactions Enabled by N‐Heterocyclic Carbene OrganocatalysisChemistry-A European Journal2020, 10.1002/chem..IF:5.160
[11]Peng, F.; Zhang, N.; Wang, C.; Wang, X.; Huang, W.; Peng, C.; He, G.*; Han, B*. Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNF alpha-NLRP3 signalling axis. Cell Proliferation 2019, e12701. IF: 5.753
[12]Li, X.; Guo, L.; Peng, C.*; Han, B*. Organocatalytic Asymmetric Cascade Reactions Based on Gamma-Nitro Carbonyl Compound. Chemical Record 2019, 19(2-3), 394. IF: 6.163
[13]He, X.-H.; Ji, Y.-L.; Peng, C.*; Han, B.* Organocatalytic Asymmetric Synthesis of Cyclic Compounds Bearing a Trifluoromethylated Stereogenic Center: Recent Developments. Advanced Synthesis & Catalysis 2019, 361(9), 1923.IF: 5.851
[14]Zhao, Q.; Peng, C.*; Huang, H.; Liu, S.-J.; Zhong, Y.-J.; Huang, W.; He, G.*; Han, B*. Asymmetric synthesis of tetrahydroisoquinoline-fused spirooxindoles as Ras- GTP inhibitors that inhibit colon adenocarcinoma cell proliferation and invasion. Chemical Communications 2018, 54(60), 8359. IF: 5.996
[15]Xie, X.; Huang, W.; Peng, C.*; Han, B.* Organocatalytic Asymmetric Synthesis of Six-Membered Carbocycle-Based Spiro Compounds. Advanced Synthesis & Catalysis 2018, 360(2), 194. IF: 5.851
[16]Wang, X.; Wu, F.; Li, G.; Zhang, N.; Song, X.; Zheng, Y.; Gong, C.; Han, B.*; He, G.* Lipid-modified cell-penetrating peptide-based self-assembly micelles for co-delivery of narciclasine and siULK1 in hepatocellular carcinoma therapy. Acta Biomaterialia 2018, 74, 414. IF: 7.242
[17]He, X.-H.; Yang, L.; Ji, Y.-L.; Zhao, Q.; Yang, M.-C.; Huang, W.; Peng, C.*; Han, B.* Chemo- and Stereoselective Cross Rauhut-Currier-Type Reaction of Tri-substituted Alkenes Containing Trifluoromethyl Groups. Chemistry-A European Journal, 2018, 24(8): 1947-1955.IF: 5.160
[18]Leng, H.-J.; Li, Q.-Z.; Zeng, R.; Dai, Q.-S.; Zhu, H.-P.; Liu, Y.; Huang, W.; Han, B.*; Li, J.-L.* Asymmetric Construction of Spiropyrazolone Skeletons via Amine-Catalyzed 3+3 Annulation. Advanced Synthesis & Catalysis 2018, 360(2), 229. IF: 5.851
[19]Zhang, Y.; Wang, C.; Huang, W.; Haruehanroengra, P.; Peng, C.; Sheng, J.; Han, B.*; He, G*. Application of organocatalysis in bioorganometallic chemistry: asymmetric synthesis of multifunctionalized spirocyclic pyrazolone-ferrocene hybrids as novel RalA inhibitors. Organic Chemistry Frontiers 2018, 5(14), 2229. IF: 5.155
[20]Cao, C.; Huang, W.; Zhang, N.; Wu, F.; Xu, T.; Pan, X.; Peng, C.*;Han, B.* Narciclasine induces autophagy-dependent apoptosis in triple-negative breast cancer cells by regulating the AMPK-ULK1 axis. Cell Proliferation 2018, e12518. IF: 5.753
[21]Tang, X.; Yang, M.-C.; Ye, C.; Liu, L.; Zhou, H.-L.; Jiang, X.-J.; You, X.-L.; Han, B.*; Cui, H.-L.* Catalyst-free 3+2 cyclization of imines and Morita-Baylis-Hillman carbonates: a general route to tetrahydropyrrolo 2,1-a isoquinolines and dihydropyrrolo 2,1-a isoquinolines. Organic Chemistry Frontiers 2017, 4(11), 2128. IF: 5.155
[22]Yang, M.-C.; Peng, C.*; Huang, H.; Yang, L.; He, X.-H.; Huang, W.; Cio, H.-L.; He, G.*; Han, B.* Organocatalytic Asymmetric Synthesis of Spiro-oxindole Piperidine Derivatives That Reduce Cancer Cell Proliferation by Inhibiting MDM2-p53 Interaction. Organic Letters 2017, 19(24), 6752. IF: 6.091
[23]Yang, L.; Huang, W.; He, X.-H.; Yang, M.-C.; Li, X.; He, G.; Peng, C.*; Han, B.* Stereoselective Synthesis of Hydropyrano 3,2-b indoles via Organocatalytic Asymmetric Inverse-Electron-Demand Oxa-Diels-Alder Reaction. Advanced Synthesis & Catalysis 2016, 358(18), 2970. IF: 5.851
[24]Leng, H.-J.; Peng, F.; Zingales, S.; Huang, W.; Wang, B.; Zhao, Q.; Zhou, R.; He, G.*; Peng, C.*; Han, B.* Core-Scaffold-Inspired Asymmetric Synthesis of Polysubstituted Chiral Hexahydropyridazines that Potently Inhibit Breast Cancer Cell Proliferation by Inducing Apoptosis. Chemistry-A European Journal, 2015, 21, 18100-18108. IF:5.160
[25]Zhou, R.; Wu, Q.; Guo, M.; Huang, W.; He, X.; Yang, L.; Peng, F.; He, G.*;Han, B.* Organocatalytic cascade reaction for the asymmetric synthesis of novel chroman-fused spirooxindoles that potently inhibit cancer cell proliferation. Chemical Communications 2015, 51(66), 13113. IF: 5.996
[26]Han, B.; Huang, W.; Ren, W.; He, G.; Wang, J.-h.*; Peng, C.* Asymmetric Synthesis of Cyclohexane-Fused Drug-Like Spirocyclic Scaffolds Containing Six Contiguous Stereogenic Centers via Organocatalytic Cascade Reactions. Advanced Synthesis & Catalysis 2015, 357(2-3), 561. IF: 5.851
[27]He, G.; Wu, F.; Huang, W.; Zhou, R.; Ouyang, L.; Han, B.* One-Pot Asymmetric Synthesis of Substituted Tetrahydrofurans via a Multicatalytic Benzoin/Michael/Acetalization Cascade. Advanced Synthesis & Catalysis 2014, 356(10), 2311. IF: 5.851
[28]Han, B.; Xie, X.; Huang, W.; Li, X.; Yang, L.; Peng, C.* Organocatalytic Morita-Baylis-Hillman/Michael/Acetalization Cascade: Procedure-Controlled Diastereodivergence in the Asymmetric Synthesis of Fully Substituted Tetrahydropyrans. Advanced Synthesis & Catalysis 2014, 356(17), 3676. IF: 5.851
[29]Li, X.; Yang, L.; Peng, C.; Xie, X.; Leng, H.-J.; Wang, B.; Tang, Z.-W.; He, G.; Ouyang, L.; Huang, W.*; Han, B.* Organocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold. Chemical Communications 2013, 49(77), 8692. IF: 5.996
[30]Xie, X.; Peng, C.*; He, G.; Leng, H.-J.; Wang, B.; Huang, W.*; Han, B.* Asymmetric synthesis of a structurally and stereochemically complex spirooxindole pyran scaffold through an organocatalytic multicomponent cascade reaction. Chemical Communications, 2012, 48(85): 10487. IF: 5.996
[31]Han, B.; Xiao, Y.-C.; Yao, Y.; Chen, Y.-C.* Lewis Acid Catalyzed Intramolecular Direct Ene Reaction of Indoles. Angewandte Chemie-International Edition 2010, 49, 10189. IF: 12.959
[32]Han, B.; Xiao, Y.-C.; He, Z.-Q.; Chen, Y.-C.* Asymmetric Michael Addition of γ,γ-Disubstituted α,β-Unsaturated Aldehydes to Nitroolefins via Dienamine Catalysis. Organic Letter. 2009, 11, 4660. IF: 6.091
[33]Han, B.; He, Z.-Q.; Li, J.-L.; Li, R.; Jiang, K.; Liu, T.-Y.; Chen, Y.-C.* Organocatalytic Regio- and Stereoselective Inverse-Electron-Demand Aza-Diels–Alder Reaction of α,β-Unsaturated Aldehydes and N-Tosyl-1-aza-1,3-butadienes. Angewandte Chemie-International Edition 2009, 48, 5474. IF: 12.959
[34]Han, B.; Li, J.-L.; Ma, S.; Zhang, S.-J.; Chen, Y.-C.* Organocatalytic Asymmetric Inverse-Electron-Demand Aza-Diels-Alder Reaction of N-Sulfonyl-1-aza-1,3-butadienes and Aldehydes. Angewandte Chemie-International Edition2008, 47, 9971. IF: 12.959