导师简介
导师姓名杨明世性别男出生年月1972年7月导师类别硕导, 博导
研究方向基于颗粒设计的生物大分子类药物的递送，可连续性生产及未来个体化联合给药的设计
联系电话职称/院士教授
E-mailmingshi.yang@sund.ku.dk导师学位博士
学院（工作单位）药学院
信箱（地址）32号信箱

【简介】
自1997年以来，杨明世教授一直致力于药物新剂型，制剂新技术和新型给药系统的研究。研究领域涉及生物大分子类药物（蛋白，多肽及siRNA）的递送、微球和纳米球颗粒的设计、难溶性药物口服生物利用度的提高。目前研究致力于基于颗粒设计的生物大分子类药物的递送，可连续性生产及未来个体化联合给药的设计。至2015年6月，在国内外科学期刊发表69篇论文，其中SCI收载54篇，国内外会议摘要和学报62篇，参编著作2本。自2009年起，已培养博士后1名，博士生6名，硕士生12名，接收访问学者3名次。目前正指导博士后1名，博士生6名，硕士生4名。主要科研资助来源为丹麦创新科技署，丹麦灵北制药基金，哥本哈根大学博士生基金，中国科学院- 丹麦诺和诺德基金和辽宁省攀登学者人才项目。
【学历】
1994年6月，延边大学医学院药学系，学士
1997年6月，延边大学药学院药学系，硕士
2003年6月，沈阳药科大学药剂专业，博士
【工作简历】
1997.07-1999.08，延边大学药学院药学系，助教
2003.10-2005.03，日本歧阜药科大学，博士后研究员
2005.04-2006.08，丹麦药科大学药剂学和分析化学系，博士后研究员
2006.09-2009.03，丹麦诺和诺德制药公司，研究员
2009.06-至今丹麦哥本哈根大学医学院药学系，副教授
2015.01-至今 沈阳药科大学药学院，教授
【获奖及兼职】
2002，中国药学会药剂年会优秀论文奖， 二等奖，（排名1）
2004，辽宁省优秀博士论文奖，优博奖
2005，全国优秀博士论文奖，提名奖
2006，辽宁省自然科学学术成果奖， 二等奖， （排名2）
2011，Asian Journal of Pharmaceutical Science，编委
2011，Journal of Pharmaceutical Technology and Drug Research，编委
2012，中国颗粒协会生物颗粒分会，委员
2014，复旦大学智能化递药教育部和全军重点实验室，高级访问学者
2015，中国辽宁省攀登学者
2015，Acta PharmaceuticaSinica B，编委
【Peer reviewed international publications】
57. P. C. Christophersen, M. Fan?, L. Saaby, M. Yang, H. M. Nielsen, H. Mu. Characterization of Particulate Drug Delivery Systems for Oral Delivery of Peptide and Protein Drugs. Current Pharmaceutical Design, 2015(in press)
56. D Cun, F Wan, M Yang. Formulation Strategies and Particle Engineering Technologies for Pulmonary Delivery of Biopharmaceuticals. Current Pharmaceutical Design, 2015 (in press)
55. N Borkar, B Li, R Holm, AEH?kansson, A Müllertz, M Yang, H Mu. Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media. Euro J Pharm Biopharm. 2015;89:216-23 doi: 10.1016/j.ejpb.2014.12.014.
54. Bohr A, Wan F, Wan F, Kristensen J, Dyas M, Stride E, Baldursdottír S, Edirisinghe M, Yang M. Pharmaceutical microparticle engineering with electrospraying: the role of mixed solvent systems in particle formation and characteristics. Journal of Materials Science: Materials in Medicine. 2015;26(2):61
53. JP Pajander, S Matero, J Sloth, F Wan, J Rantanen, M Yang＊. Raman mapping of mannitol/lysozyme particles produced via spray drying and single droplet drying. Pharm Res. 2015 Jun;32(6):1993-2002. DOI: 10.1007/s11095-014-1592-z
52. Christophersen PC, Birch D, Saarinen J, Isom?ki A, Nielsen HM, Yang M, Strachan C, Mu H. Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy. J Controlled Release 2014, 197C:111-120. doi: 10.1016/j.jconrel.2014.10.023.
51. Wan F, Maltesen MJ, Andersen SK, Bjerregaard S, Baldursdottir SG, Foged C, Rantanen J, Yang M＊. Modulating Protein Release Profiles by Incorporating Hyaluronic Acid into PLGA MicroparticlesVia a Spray Dryer Equipped with a 3-Fluid Nozzle. Pharm. Res. 2014, 31(11):2940-51. DOI: 10.1007/s11095-014-1387-2.
50. Li X, Yu M, Fan W, Gan Y, Hovgaard L, Yang M. Orally active targeted drug delivery systems for proteins and peptides. Expert opinion on drug delivery. 2014, 11, 1-13
49. Christophersen PC, Vaghela P, Müllertz M, Yang M, Nielsen HM, Mu H. Solid lipid particles for oral delivery of peptide and protein drugs III - The effect of fedstate conditions on the release and degradation of desmopressin. AAPS J. 2014, 16(4):875-883.
48. Liu G., Hansen T.B., Qu H., Yang M., Pajander J.P., Rantanen J., Christensen L.P. Crystallization of Piroxicam Solid Forms and the Effects of Additives. Chemical Engineering & Technology 2014, 37(8), 1297-1304.
47. Christophersen P.C.B, Zhang L., Müllertz A., Nielsen H.M., Yang M., Mu H. Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs II - The Digestion of Trilaurin Protects Desmopressin from Proteolytic Degradation. Pharm. Res. 2014, 31(9):2420-8. doi: 10.1007/s11095-014-1337-z.
46. Shi L-L, Xu W-J, Cao Q-R, Yang M., Cui J-H. Preparation, characterization and in vitro evaluation of polyvinyl alcohol/sodium alginate based oral dissolving film containing sildenafil citrate. Pharmazie 2014, 69(5):327-34
45. Wan F., Maltesen M.J., Andersen S.K., Bjerregaard S., Foged C., Rantanen J., Yang M.＊One-step production of protein loaded PLGA microparticles via spray drying using 3-fluid nozzle. Pharm. Res. 2014, 31(8):1967-1977.
44. Xia D., Cui F., Gan Y., Mu H., Yang M.＊ Design of Lipid Matrix Particles for Fenofibrate: Effect of Polymorphism of Glycerol Monostearate on Drug Incorporation and Release. J Pharm Sci 2014, 103, 697–705.
43. N Borkar, D Xia, R Holm, Y Gan,A Müllertz, M Yang, H Mu. Investigating the correlation between in vivo absorption and in vitro release offenofibrate from lipid matrix particles in biorelevant medium. Euro J Pharm Sci. 51 (2014) 204–210.
42. Bohr A, Boetker JP, Rades T, Rantanen J, Yang M＊. Application of spray-drying and electrospraying/electospinning for poorly water-soluble drugs: a particle engineering approach. Current Pharmaceutical Design. 2014, 20, 325-348
41. Wu J.X., van den Berg F., Rantanen J., Rades T., Yang M. Current advances and future trends in characterizing poorly water-soluble drugs using spectroscopic, imaging and data analytical techniques. Current Pharmaceutical Design, 2014, 20, 436-453.
40. X. Li, S. Guo, C. Zhu, Q. Zhu, Y. Gan, J. Rantanen, U.L. Rahbek, L. Hovgaard, M. Yang＊.Core shell corona nanolipoparticles for oral insulin delivery: efficient intestinal mucosa permeability and enhanced insulin absorption. Biomaterials. 2013, 34, (37) 9678–9687.
39. F Wan, J-X Wu, A Bohr, SG Baldursdottir, MJ Maltesen, S Bjerregaard, C Foged, J Rantanen, M Yang＊. Impact of PLGA molecular behavior in the feed solution on the drug release kinetics of spray dried microparticles. Polymer 2013, 54 (21) 5920–5927.
38. PC Christophersen, L Zhang, M Yang, HM Nielsen, A Müllertz, H Mu. Elucidating the release mechanism of proteins from lipid particles during lipolysis. Euro J Pharm Biopharm. 85(2013):473-80. 10.1016/j.ejpb.2013.07.017
37. Ingvarsson PI, Yang M, Mulvad H, Nielsen HM, Rantanen J, Foged C. Engineering of an Inhalable DDA/TDB Liposomal Adjuvant: A Quality by Design Approach Towards Optimization of the Spray Drying Process. Pharm Res. 30 (2013) 2772-2784.
36. Sander C, Nielsen HS, S?gaard SR, Jensen C, Yang M, Jacobsen J, Rantanen J. Process development for spray drying of sticky pharmaceuticals; case study of mucoadhesive nicotine microparticles for compressed medicated chewing gum. Int J Pharm. 2013, 452(1-2):434-437
35. F. Wan, A. Bohr, M. J. Maltesen, S. Bjerregaard, C. Foged, J. Rantanen, M. Yang＊. Particle engineering technologies for improving the delivery of peptide and protein drugs. J. Drug Del. Sci. Tech., 23 (2013) 355-363.
34. Cao Q-R, Piao Y-N, Choi J-S, Liu Y, Yang M, Cui J-H. Design, in vitro release characterization and pharmacokinetics of novel controlled release pellets containing levodropropizine. PharmaceutDev Tech. 19 (2014) 296-303.
33. Grohganz H., Lee Y-Y., Rantanen J., Yang M. The influence of lysozyme on mannitol polymorphism in freeze-dried and spray-dried formulations depends on the selection of the drying process. Int J Pharm. 447(2013):224-230.
32. Ingvarsson PT, Schmidt ST, Christensen D, Larsen NB, Hinrichs WL, Andersen P, Rantanen J, Nielsen HM,Yang M＊. Camilla Foged. Designing CAF-adjuvanted dry powder vaccines: Spray drying preserves the adjuvant activity of CAF01. J Control Release, 167(2013):256-264. doi: 10.1016/j.jconrel.2013.01.031.
31. F. Wan, A. Bohr, M. J. Maltesen, S. Bjerregaard, C. Foged, J. Rantanen, M. Yang＊. Critical solvent properties affecting the particle formation process and characteristics of celecoxib-loaded PLGA microparticlesvia spray-drying. Pharm Res. 30 (2013)1065-1076.
30. Q.R. Cao, J.S. Choi, Y. Liu, W.J. Xu, M. Yang, B.J. Lee, J.H. Cui. A formulation approach for development of HPMC-based sustained release tablets for tolterodine tartrate with a low release variation. Drug Dev. Ind. Pharm. 2013, 39(11):1720-30.
29. Yang, M.; Yamamoto , H.; Kurashima, H.; Takeuchi, H.; Yokoyama, T.; Tsujimoto, H.; Kawashima, Y. Design and evaluation of inhalable chitosan-modified poly (DL-lactic-co-glycolic acid) nanocomposite particles. Euro J Pharm Sci. 47 (2012) 235–243.
28. Yang, M.; Yamamoto , H.; Kurashima, H.; Takeuchi, H.; Yokoyama, T.; Tsujimoto, H.; Kawashima, Y. Design and evaluation of poly (DL-lactic-co-glycolic acid) nanocomposite particles containing salmon calcitonin for inhalation. Euro J Pharm Sci. 46 (2012) 374-380.
27. Bohr A.; Yang M.; Baldursdóttir S.; Kristensen J.; Dyas M.; Stride E.; Edirisinghe M. Particle formation and characteristics of Celecoxib-loaded poly(lactic-co-glycolic acid) microparticles prepared in different solvents using electrospraying. Polymer 53 (2012) 3220-3229.
26. Baldinger A, Clerdent L, Rantanen J,Yang M, Grohganz H. Quality by design approach in the optimization of the spray-drying process. Pharm Dev Technol. 2012, 17:389-397.
25. Xia, D; Ouyang, M; Wu, J; Jiang, Y; Piao, H; Sun, S; Zheng, L; Rantanen, J; Cui, F; Yang, M. Polymer-mediated anti-solvent crystallization of nitrendipine: Monodispersed spherical crystals and growth mechanism. Pharm Res. 2012, 29:158-169.
24. Xia D., Wu J.X., Cui F., Qu H., Rades T., Rantanen J., Yang M＊. Solvent-mediated amorphous-to-crystalline transformation of nitrendipine in amorphous particle suspensions containing polymers. Euro J Pharm Sci. 2012, 46(5):446-454.
23. Wu J.X.; Xia D.; van den Berg F.; Amigo J.M.; Rades T.; Yang M.; Rantanen J. A novel image analysis methodology for online monitoring of nucleation and crystal growth during solid state phase transformations. Int J Pharm. 2012, 433(1-2):60-70.
22. Lebrun, P.; Krier, F.; Mantanus, J.; Grohganz, H.; Yang, M.; Rozet, E.; Boulanger, B.; Evrard, B.; Rantanen, J.; Hubert, P. Design space approach in the optimization of the spray-drying process. Euro J Pharm Biopharm 80 (2012) 226–234.
21. Wan, F.; M?ller, E.H; Yang, M.＊; Jorgensen, L. Formulation technologies to overcome unfavorable properties of peptides and proteins for pulmonary delivery. Drug Discovery Today, Technologies. 9 (2012), 141-146.
20. Li X.; Chang S.; Du G.; Li Y.; Yang M.; Wei P. Encapsulation of azithromycin into polymeric microspheres by reduced pressure-solvent evaporation method. Int J Pharm. 433(2012):79-88.
19. Cao, Q-R; Liu, Y; Xu, W-J; Lee, B-J; Yang, M.; Cui, J-H. Enhanced oral bioavailability of novel mucoadhesive pellets containing valsartan prepared by a dry powder-coating technique. Int J Pharm 434 (2012) 325– 333.
18. Li, X.; Chen, D.; Le C.; Zhu. C.; Gan, Y.; Hovgaard, L.; Yang, M. Novel mucus-penetrating liposomes as potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake. Int J Nanomedicine. 2011,6:3151-3162.
17. Wu, J-X.; Yang, M.; van den Berg, F.; Pajander, J.; Rades, T.; Rantanen, J. Influence of evaporation rate and formulation factors on solid dispersion physical stability. Euro J Pharm Sci 44 (2011) 610–620.
16. Lee, Y; Wu, J; Yang, M＊; Young, PM; van den Berg, FW; Rantanen, J. Particle size dependence of polymorphism in spray-dried mannitol. Euro J Pharm Sci. 2011, 44(1-2), 41-48.
15. Ingvarsson, P; Yang, M; Nielsen, H; Rantanen, J; Foged, C. Stabilization of liposomes during drying. Expert Opinion on Drug Delivery. 2011, 8(3), 375-388.
14. Cun, D; Foged, C; Yang, M; Froekjaer, S; Nielsen, H. Preparation and Characterization of Poly (DL-lactide-co-glycolide) Nanoparticles for siRNA Delivery. Int J Pharm, 2010, 390, 70-75.
13. Cun, D; Cui, F; Yang, L; Yang, M; Yu, Y; Yang, R. Characterization and Release Mechanism of Melittin Entrapped Poly (lactic acid-co-glycolic acid) Microspheres. J. Drug Deliv. Sci. Technol. 18, 267-272, 2008.
12. Yang, M＊; Velaga, S; Yamamoto, H; Takeuchi, H; Kawashima, H; Hovgaard, L; van de Weert, M; Frokjaer S. Characterisation of salmon calcitonin in spray-dried powder for inhalation Effect of chitosan. Int J Pharm, 331, 176-181, 2007.
11. Yang, M; Yamamoto H; Kurashima, H; Takeuchi H; Kawashima Y. In vitro and in vivo inhalation characterization of pH-dependent HP-55 nanospheres containing salmon calcitonin. Asian J. Pharm. Sci. 2, 1-10, 2007.
10. Cui, F; Pang, X; Yang, M; Wang, X; Kawashima, Y. Preparation of nimodipine microspheres contained in a solid dispersion by the emulsion-solvent-diffusion method and evaluation of their in vitro and in vivo characteristics. Asian J. Pharm. Sci. 1, 1-6, 2006.
9. You, J; Cui, F; Li, Q; Han, X; Yu, Y; Yang, M. A novel formulation design about water-insoluble oily drug: preparation of zedoary turmeric oil microspheres with self-emulsifying ability and evaluation in rabbits. Int. J. Pharm. 288, 315-323, 2005.
8. Yang, M; Cui, F; You, B; Yang, M; Tao, A; Cun, D; Kawashima, Y. In vivo evaluation of two novel controlled-release nitrendipine formulations. Drug Dev. Ind. Pharm. 31, 589-595, 2005.
7. Yang, M; Cui, F; Fan, Y; You, B; Ren, K; Feng, H; Kawashima, Y. Effect of three types of additives in poor solvent on preparation of sustained-release nitrendipine microspheres by the quasi-emulsion solvent diffusion method. J. Drug Deliv. Sci. Technol. 15, 129-135, 2005.
6. Cui, F; Cun, D; Tao, A; Yang, M; Shi, K; Zhao, M; Guan, Y. Preparation and characterization of melittin-loaded poly (dl-lactic acid) or poly (dl-lactic-co-glycolic acid) microspheres made by the double emulsion method. J. Controlled Release, 107, 310-319, 2005.
5. Yang, M; Cui, F; You, B; Wang, L; Yue, P; Kawashima, Y. A novel pH-dependent gradient-release delivery system for nitrendipine II. Investigations of the factors affecting the release behaviors of the system. Int. J. Pharm. 286, 99-109, 2004.
4. Yang, M; Cui, F; You, B; You, J; Wang, L; Zhang, L; Kawashima, Y. A novel pH-dependent gradient-release delivery system for nitrendipine I. Manufacturing, evaluation in vitro and bioavailability in healthy dogs. J. Controlled Release 98, 219-229, 2004. 3. Yang, M; Cui, F; You, B; Fan, Y; Wang, L; Yue, P; Yang, H. Preparation of sustained-release nitrendipine microspheres with Eudragit RS and Aerosil using quasi-emulsion solvent diffusion method. Int. J. Pharm. 259, 103-113, 2003.
2. Cui, F; Yang, M; Jiang, Y; Cun, D; Lin, W; Fan, Y; Kawashima, Y. Design of sustained-release nitrendipine microspheres having solid dispersion structure by quasi-emulsion solvent diffusion method. J. Controlled Release 91, 375-384, 2003.
1. Cui, F; Fan, Y; Yang, M; Liu, D; Gao, P; Kawashima, Y. Preparation of enteric microspheres of oleanolic acid dihemiphthalate sodium by a spherical crystallization technique using a salting-out action. S.T.P. Pharma Sci. 12, 313-318, 2003.
【Book chapter】
1. Yang, M; Frokjaer, S. Novel formulation approaches for peptides and proteins injectables. Book: Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines. Edited by Lene Jorgensen, Hanne M?rck Nielsen. John Wilely& Sons, Ltd, 2009.
2. Christophersen P.C.B., Yang M., Mu H. The assessment of bioavailability of omega-3 fatty acids. Book: Encapsulation and Controlled Release Technologies in Food Systems, Second Edition. Edited by JamilehLakkis. JOHN WILEY & SONS, LTD. 2014.