??????? 王璞博士，现任东北大学生命科学与健康学院教授。1997-2007年先后于沈阳药科大学药学院药剂学系和生命科学与生物制药学院微生物与生化药学系获得本科、硕士和博士学位。2008-2012年在美国约翰霍普金斯大学从事博士后研究工作。2012年8月作为国外引进人才回到东北大学生命科学与健康学院工作，继续从事环氧合酶-2（Cycloloxygenase-2, COX-2）通过炎症机制调控退行性疾病发病机制领域的研究。目前承担国家自然科学基金面上项目、青年项目，教育部支持计划项目等。在SCI收录杂志包括Oncogene、Oncotarget、Aging Cell、Journal of Biological Chemistry、Aging Cell和Scientific Reports等发表30余篇论文；发表通讯作者或第一作者论文20余篇；他引300余次；参编学术专著4部；申请国家发明专利2项；多次受邀在国内外做大会学术报告；担任多种学术杂志审稿人。2014年入选“辽宁省高端人才引进工程”?
科研方向
???????? 主要从事环氧合酶-2（Cyclooxygenase-2, COX-2）代谢紊乱参与阿尔茨海默病（Alzheimer’s Disease, AD）和骨关节炎（Osteoarthritis, OA）发病机理的研究。应用体外细胞模型和体内小鼠模型相结合的方式，探讨COX-2通过调控炎症因子的表达影响AD和OA发病的分子机制，试图揭示非甾体抗炎药（NSAIDs）作为COX-2抑制剂类药物治疗AD和OA发病的分子机理。进而对COX-2调控AD和OA发病的信号传导通路进行阐述，发现AD和OA发病的分子靶点，为药物开发提供新思路，新靶标。
主持基金项目
1. 国家自然科学基金面上项目：环氧合酶-2代谢紊乱促进b-淀粉样蛋白在阿尔茨海默病中产生、传播和沉积的神经病理学机制研究、项目负责人。
2. 国家自然科学基金青年科学基金项目：生理平流剪切应力通过COX-2/MMPs信号通路参与机械损伤诱发骨关节炎的作用机制研究、项目负责人。
3. 基本科研业务费“青年教师科研创新基金”项目：环氧合酶-2通过炎症机制调控tau蛋白磷酸化、传播和沉积的分子机制研究、项目负责人。
4. 辽宁省教育厅“高校杰出青年学者成长计划”项目：环氧合酶-2通过调控炎症因子的表达影响阿尔茨海默病发病的机理研究、项目负责人。
5. 基本科研业务费优秀科技人才培育基金项目：环氧合酶-2调控阿尔茨海默病发生、发展机制研究、项目负责人。
发表论文
1. Pu Wang, Pei-Pei Guan, Jing-Wen Guo, Long-Long Cao, Guo-Biao Xu, Xin Yu, Yue Wang, Zhan-You Wang*. Prostaglandin I2 upregulates the expression of anterior pharynx-defective-1a and -1b in amyloid precursor protein/presenilin1 transgenic mice. Aging cell, 2016, In press.
2. Pu Wang, Pei-Pei Guan, Xin Yu, Li-Chao Zhang, Ya-Nan Su, Zhan-You Wang*. Prostaglandin I2 attenuates prostaglandin E2-stimulated expression of interferon γ in a β-Amyloid Protein- and NF-κB-dependent mechanism. Scientific Reports, 2016, In press.
3. Pu Wang, Xin Yu, Pei-Pei Guan, Jing-Wen Guo, Yue Wang, Yan Zhang, Hang Zhao, Zhan-You Wang*. Magnesium ion influx reduces neuroinflammation in Aβ precursor protein/Presenilin 1 transgenic mice by suppressing the expression of interleukin-1β. Cellular & Molecular Immunology, 2015, In press.
4. Xin Yu, Pei-Pei Guan, Jing-Wen Guo, Yue Wang, Long-Long Cao, Guo-Biao Xu, Konstantinos Konstantopoulos, Zhan-You Wang*, Pu Wang*. By suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice. The FASEB Journal, 2015, 29: 5044-5058.
5. Pu Wang*, SH Chen, WC Hung, Colin Paul, Fei Zhu, Pei-Pei Guan, DL Huso, A Kontrogianni-Konstantopoulos, Konstantinos Konstantopoulos*. Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways. Oncogene, 2015, 34: 4558-4569.
6. Pu Wang, Pei-Pei Guan, Tao Wang, Xin Yu, Jian-Jun Guo, Zhan-You Wang*. Aggravation of Alzheimer’s disease due to the COX-2-mediated reciprocal regulation of IL-1b and Ab between glial and neuron cells. Aging cell, 2014, 13, 605-615.
7. Pu Wang, Pei-Pei Guan, Tao Wang, Xin Yu, Jian-Jun Guo, Konstantinos Konstantopoulos, Zhan-You Wang*. Interleukin-1β and cyclic AMP mediate the invasion of sheared chondrosarcoma cells via a matrix metalloproteinase-1-dependent mechanism. Biochim Biophys Acta-Molecular Cell Research, 2014, 1843, 923-933.
8. Pu Wang, Pei-Pei Guan, Chuang Guo, Fei Zhu, Konstantinos Konstantopoulos*, Zhan-You Wang*. Fluid shear stress-induced osteoarthritis: roles of cyclooxygenase-2 and its metabolic products in inducing the expression of proinflammatory cytokines and matrix metalloproteinases. The FASEB Journal, 2013, 27, 4664-4677.
9. Pu Wang, Fei Zhu, Konstantinos Konstantopoulos*. The antagonistic actions of endogenous interleukin-1β and 15-deoxy-Δ12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes. Journal of Biological Chemistry, 2012, 287, 31877-31893.
10. Pu Wang, Fei Zhu, Konstantinos Konstantopoulos*. Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ12,14-PGJ2. PLoSONE, 2011, e27630.
11. Pu Wang, Fei Zhu, Zi-Qiu Tong, Konstantinos Konstantopoulos*. Response of chondrocytes
to shear stress:antagonistic effects of the binding partners Toll-like Receptor 4 and caveolin-1. The FASEB Journal, 2011, 25, 3401-3415.
12. Pu Wang, Su Xu, Pei-Xing Wu, Jing-Hai Zhang, Toshinori Sato, Sadako Yamagata, Tatsuya Yamagata*. GM3 suppresses anchorage-independent growth via Rho GDP dissociation inhibitor (GDI) beta in melanoma B16 cells. Cancer Science, 2011, 162, 1476-1485.
13. Pu Wang, Fei Zhu, Konstantinos Konstantopoulos*. Shear-induced interleukin-6 synthesis in chondrocytes: The distinct roles of EP2 and EP3 receptors in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kB activation. Journal of Biological Chemistry, 2010, 285, 24793-24804.
14. Pu Wang, Fei Zhu, Konstantinos Konstantopoulos*. Prostaglandin E2 Induces Interleukin-6 Expression in Human Chondrocytes via cAMP/Protein Kinase A- and Phosphatidylinositol 3-Kinase-dependent NF-kB Activation. American Journal of Physiology-Cell Physiology, 2010, 298, 1445-1456.
书籍章节
1. Pu Wang, Pei-Pei Guan, Su Xu, Zhan-You Wang, Sadako Yamagata, and Tatsuya Yamagata. Emerging GM3 Regulated Biomarkers in Malignant Melanoma. Recent Advances in the Biology, Therapy and Management of Melanoma, Dr. Lester Davids (Ed.), 2013, ISBN: 978-953-51-0976-1, InTech, DOI: 10.5772/54941.
2. Pu Wang, Sadako Yamagata, Tatsuya Yamagata. Changing the nature of melanoma cells by manipulation of ganglioside expression. Breakthroughs in Melanoma Research, Dr. Yohei Tanaka (Ed.), 2011, ISBN: 978-953-307-291-3, InTech, DOI: 10. 5772/21566.
3. Pu Wang, Xiao-Dong Wang, Pei-Xing Wu, Jing-Hai Zhang, Toshinori Sato, Sadako Yamagata, Tatsuya Yamagata. GM3 upregulation of matrix metalloproteinase-9 possibly through PI3K, Akt, Rictor, RhoGDI-2 and TNF-a pathways in mouse melanoma B16 cells. Advances in Experimental Medicine and Biology, 2011,705, 335-348.
专利
1. 王璞、郭静文、关佩沛、王占友，一种脑靶向的塞来昔布量子点脂质体混悬液及其制备方法，中国.
2. 高慧玲、郭静文、王占友、王璞，一种青霉胺鼻凝胶剂及其制备方法，中国.
联系方式
地址：沈阳市沈河区文化东路89号，东北大学生命科学与健康学院神经科学研究所
邮编：110015
E-mail: wangpu@mail.neu.edu.cn
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