?????? 刘弘光博士， 教授。2003年毕业于中国医科大学临床医学专业，2003-2006年在中国医科大学发育生物学系获硕士学位，2007-2010年在北京协和医学院放射医学研究所学习获博士学位。攻读博士期间，2008至2010年在美国斯坦福大学程震教授实验室学习分子影像学技术。2010年至2012年在斯坦福大学医学院分子影像中心做博士后，从事分子探针和药物的设计及评价、癌症检测和治疗、以及生物纳米技术等研究。2013年至今，在东北大学生命科学与健康学院工作。在SCI收录期刊发表论文41篇。获得2010年美国核医学会（SNM）分子影像学年轻学者奖第一名（Molecular Imaging Young Investigator Award）。持有多项美国专利，多次参加分子影像协会年会和美国核医学年会，并做大会报告和交流研究论文等。
科研方向
主要从事肿瘤靶向分子探针的研制和新型分子影像学显像技术开发
1. 分子显像：利用多种影像技术在活体内进行细胞和分子水平的生物过程研究
2. 分子探针：设计、合成和体内外评价分子探针
3. 肿瘤放射靶向治疗：利用治疗性核素标记靶向探针用于治疗肿瘤
发表论文
1. Liu H, Liu S, Miao Z, Deng Z, Shen B, Hong X, Cheng Z “Development of 18F-labeled picolinamide probes for PET imaging of malignant melanoma.” J Med Chem 2013; 56: 3: 895-901.
2. Kothapalli SR, Liu H, Liao JC, Cheng Z, Gambhir SS “Endoscopic imaging of Cerenkov luminescence.” Biomed Opt Express 2012; 3: 6: 1215-25.
3. Liu H, Carpenter CM, Jiang H, Pratx G, Sun C, Buchin MP, Gambhir SS, Xing L, Cheng Z “Intraoperative imaging of tumors using Cerenkov luminescence endoscopy: a feasibility experimental study.” J Nucl Med 2012; 53: 10: 1579-84.
4. Liu S, Liu H, Jiang H, Xu Y, Zhang H, Cheng Z “One-step radiosynthesis of 1?F-AlF-NOTA-RGD? for tumor angiogenesis PET imaging.” Eur J Nucl Med Mol Imaging 2011; 38: 9: 1732-41.
5. Liu S, Liu H, Ren G, Kimura RH, Cochran JR, Cheng Z “PET Imaging of Integrin Positive Tumors Using F Labeled Knottin Peptides.” Theranostics 2011; 1: 403-12.
6. Liu H, Ren G, Liu S, Zhang X, Chen L, Han P, Cheng Z “Optical imaging of reporter gene expression using a positron-emission-tomography probe.” J Biomed Opt 2010 Nov-Dec; 15: 6: 060505.
7. Liu H, Ren G, Miao Z, Zhang X, Tang X, Han P, Gambhir SS, Cheng Z “Molecular optical imaging with radioactive probes.” PLoS One 2010; 5: 3: e9470.
8. Liu H, Zhang X, Xing B, Han P, Gambhir SS, Cheng Z “Radiation-luminescence-excited quantum dots for in vivo multiplexed optical imaging.” Small 2010; 6: 10: 1087-91.
9. Jiang L, Miao Z, Liu H, Ren G, Bao A, Cutler CS, Shi H, Cheng Z “177Lu-labeled RGD-BBN heterodimeric peptide for targeting prostate carcinoma.” Nucl Med Commun 2013.
10. Hackel BJ, Kimura RH, Miao Z, Liu H, Sathirachinda A, Cheng Z, Chin FT, Gambhir SS “18F-Fluorobenzoate-Labeled Cystine Knot Peptides for PET Imaging of Integrin αvβ6.” J Nucl Med 2013.
11. Yang M, Cheng K, Qi S, Liu H, Jiang Y, Jiang H, Li J, Chen K, Zhang H, Cheng Z “Affibody modified and radiolabeled gold-Iron oxide hetero-nanostructures for tumor PET, optical and MR imaging.” Biomaterials 2013; 34: 11: 2796-806.
12. Natarajan A, Habte F, Liu H, Sathirachinda A, Hu X, Cheng Z, Nagamine CM, Gambhir SS “Evaluation of (89)Zr-rituximab Tracer by Cerenkov Luminescence Imaging and Correlation with PET in a Humanized Transgenic Mouse Model to Image NHL.” Mol Imaging Biol 2013.
13. Persson M, Liu H, Madsen J, Cheng Z, Kjaer A “First (18)F-labeled ligand for PET imaging of uPAR: In vivo studies in human prostate cancer xenografts.” Nucl Med Biol 2013; 40: 5: 618-24.
14. Habte F, Ren G, Doyle TC, Liu H, Cheng Z, Paik DS “Impact of a Multiple Mice Holder on Quantitation of High-Throughput MicroPET Imaging With and Without Ct Attenuation Correction.” Mol Imaging Biol 2013.
15. Zhao P, Yang X, Qi S, Liu H, Jiang H, Hoppmann S, Cao Q, Chua MS, So SK, Cheng Z “Molecular imaging of hepatocellular carcinoma xenografts with epidermal growth factor receptor targeted affibody probes.” Biomed Res Int 2013; 2013: 759057.
16. Qin C, Cheng K, Chen K, Hu X, Liu Y, Lan X, Zhang Y, Liu H, Xu Y, Bu L, Su X, Zhu X, Meng S, Cheng Z “Tyrosinase as a multifunctional reporter gene for Photoacoustic/MRI/PET triple modality molecular imaging.” Sci Rep 2013; 3: 1490.
17. Hoppmann S, Qi S, Miao Z, Liu H, Jiang H, Cutler CS, Bao A, Cheng Z “177Lu-DO3A-HSA-Z EGFR:1907: characterization as a potential radiopharmaceutical for radionuclide therapy of EGFR-expressing head and neck carcinomas.” J BiolInorgChem 2012; 17: 5: 709-18.
18. Li J, Chen K, Liu H, Cheng K, Yang M, Zhang J, Cheng JD, Zhang Y, Cheng Z “Activatable near-infrared fluorescent probe for in vivo imaging of fibroblast activation protein-alpha.” BioconjugChem 2012; 23: 8: 1704-11.
19. Xu Y, Liu H, Chang E, Jiang H, Cheng Z “Cerenkov Luminescence Imaging (CLI) for cancer therapy monitoring.” J Vis Exp 2012; 69: e4341.
20. Parashurama N, O’Sullivan TD, De La Zerda A, El Kalassi P, Cho S, Liu H, Teed R, Levy H, Rosenberg J, Cheng Z, Levi O, Harris JS, Gambhir SS “Continuous sensing of tumor-targeted molecular probes with a vertical cavity surface emitting laser-based biosensor.” J Biomed Opt 2012; 17: 11: 117004.
21. Qi S, Miao Z, Liu H, Xu Y, Feng Y, Cheng Z “Evaluation of Four Affibody-Based Near-Infrared Fluorescent Probes for Optical Imaging of Epidermal Growth Factor Receptor Positive Tumors.” BioconjugChem 2012.
22. Seo J, Ren G, Liu H, Miao Z, Park M, Wang Y, Miller TM, Barron AE, Cheng Z “In Vivo Biodistribution and Small Animal PET of (64)Cu-Labeled Antimicrobial Peptoids.” BioconjugChem 2012.
23. Ren G, Webster JM, Liu Z, Zhang R, Miao Z, Liu H, Gambhir SS, Syud FA, Cheng Z “In vivo targeting of HER2-positive tumor using 2-helix affibody molecules.” Amino Acids 2012; 43: 1: 405-13.
24. Miao Z, Ren G, Liu H, Qi S, Wu S, Cheng Z “PET of EGFR expression with an 18F-labeled affibody molecule.” J Nucl Med 2012; 53: 7: 1110-8.
25. Xu Y, Chang E, Liu H, Jiang H, Gambhir SS, Cheng Z “Proof-of-concept study of monitoring cancer drug therapy with cerenkov luminescence imaging.” J Nucl Med 2012; 53: 2: 312-7.
26. Carpenter CM, Sun C, Pratx G, Liu H, Cheng Z, Xing L “Radioluminescentnanophosphors enable multiplexed small-animal imaging.” Opt Express 2012; 20: 11: 11598-604.
27. Miao Z, Ren G, Jiang L, Liu H, Webster JM, Zhang R, Namavari M, Gambhir SS, Syud F, Cheng Z “A novel 18F-labeled two-helix scaffold protein for PET imaging of HER2-positive tumor.” Eur J Nucl Med Mol Imaging 2011; 38: 11: 1977-84.
28. Xu Y, Liu H, Cheng Z “Harnessing the power of radionuclides for optical imaging: Cerenkov luminescence imaging.” J Nucl Med 2011; 52: 12: 2009-18.
29. Zhang X, Liu H, Miao Z, Kimura R, Fan F, Cheng Z “Macrocyclicchelator assembled RGD multimers for tumor targeting.” Bioorg Med ChemLett 2011; 21: 11: 3423-6.
30. Ren G, Blum G, Verdoes M, Liu H, Syed S, Edgington LE, Gheysens O, Miao Z, Jiang H, Gambhir SS, Bogyo M, Cheng Z “Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe.” PLoS One 2011; 6: 11: e28029.
31. Jiang L, Miao Z, Kimura RH, Liu H, Cochran JR, Culter CS, Bao A, Li P, Cheng Z “Preliminary evaluation of (177)Lu-labeled knottin peptides for integrin receptor-targeted radionuclide therapy.” Eur J Nucl Med Mol Imaging 2011; 38: 4: 613-22.
32. Hoppmann S, Miao Z, Liu S, Liu H, Ren G, Bao A, Cheng Z “Radiolabeled affibody-albumin bioconjugates for HER2-positive cancer targeting.” BioconjugChem 2011; 22: 3: 413-21.
33. Sun C, Pratx G, Carpenter CM, Liu H, Cheng Z, Gambhir SS, Xing L “Synthesis and radioluminescence of PEGylatedEu(3+) -doped nanophosphors as bioimaging probes.” Adv Mater 2011; 23: 24: H195-9.
34. Miao Z, Ren G, Liu H, Jiang L, Cheng Z “Cy5.5-labeled Affibody molecule for near-infrared fluorescent optical imaging of epidermal growth factor receptor positive tumors.” J Biomed Opt 2010 May-Jun; 15: 3: 036007.
35. Cheng Z, De Jesus OP, Kramer DJ, De A, Webster JM, Gheysens O, Levi J, Namavari M, Wang S, Park JM, Zhang R, Liu H, Lee B, Syud FA, Gambhir SS “64Cu-labeled affibody molecules for imaging of HER2 expressing tumors.” Mol Imaging Biol 2010; 12: 3: 316-24.
36. Jiang L, Kimura RH, Miao Z, Silverman AP, Ren G, Liu H, Li P, Gambhir SS, Cochran JR, Cheng Z “Evaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrin.” J Nucl Med 2010; 51: 2: 251-8.
37. Ren G, Liu S, Liu H, Miao Z, Cheng Z “Radiofluorinated rhenium cyclized α-MSH analogues for PET imaging of melanocortin receptor 1.” BioconjugChem 2010; 21: 12: 2355-60.
38. Miao Z, Ren G, Liu H, Jiang L, Cheng Z “Small-animal PET imaging of human epidermal growth factor receptor positive tumor with a 64Cu labeled affibody protein.” BioconjugChem 2010; 21: 5: 947-54.
39. Miao Z, Ren G, Liu H, Kimura RH, Jiang L, Cochran JR, Gambhir SS, Cheng Z “An engineered knottin peptide labeled with 18F for PET imaging of integrin expression.” BioconjugChem 2009; 20: 12: 2342-7.
40. Ren G, Miao Z, Liu H, Jiang L, Limpa-Amara N, Mahmood A, Gambhir SS, Cheng Z “Melanin-targeted preclinical PET imaging of melanoma metastasis.” J Nucl Med 2009; 50: 10: 1692-9.
41. Ren G, Liu Z, Miao Z, Liu H, Subbarayan M, Chin FT, Zhang L, Gambhir SS, Cheng Z “PET of malignant melanoma using 18F-labeled metallopeptides.” J Nucl Med 2009; 50: 11: 1865-72.
联系方式
地址：沈阳市沈河区文化东路89号，东北大学生命科学与健康学院分子医学研究所
邮编：110015
E-mail: simonliu@mail.neu.edu.cn
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