韩璐璐
院系：生命科学与技术学院
办公电话：**
电子信箱：luluhan@dlut.edu.cn
更新时间：2016-2-29
其他专业：生物医学工程



个人简介
韩璐璐，女，2006年和2012年分别在湖南大学和浙江大学获得学士和博士学位，博士期间于西班牙生物材料中心访问交流。2012.8在大连理工大学生命科学与技术学院从事师资博士后工作。2014.8留校成为大连理工大学讲师及硕士生导师。作为负责人主持国家自然科学基金、中国博士后特别资助项目、博士后面上项目。在 Biomaterials等本领域权威期刊上发表SCI论文20余篇。

研究领域（研究课题）
1. 血液中循环癌细胞的识别及检测
主要研究新型生物材料对血液中扩散癌细胞的抓捕及检测。
2. 去除血液毒素的生物医用材料
研究新型生物材料去除血液中蛋白结合的疏水毒素，解决临床上此类毒素难以去除的问题。
3. 血液相容性医用材料
设计血液相容的抗凝血或抗补体激活的生物材料表面，解决血液接触材料引起的凝血、炎症反应等一系列问题。

近年主持的科研项目：
1. 国家自然科学基金：补体相容的磷脂/聚电解质复合生物活性仿生膜（**），2014.1 -2016.12。
2. 中国博士后科学基金特别资助: 仿红细胞的体内隐形磷脂/聚电解质复合靶向癌症载体，2014.1-2016.12。
3. 中国博士后科学基金：补体相容的磷脂/聚电解质复合生物活性仿生膜（2013M541219），2013.6-2014.8。
4. 大连理工大学基本科研业务费专项：基于氧化石墨烯的血液相容性材料（DUT12RC(3)70），2012.12-2014.12。

硕博研究方向
1. 血液中循环癌细胞的识别及检测
2. 去除血液毒素的生物医用材料
3. 血液相容性医用材料

出版著作和论文
1． Lulu Han, Jindan Wu, Tanchen Ren, Zhengwei Mao, Yang Guo, and Changyou Gao. Polyelectrolyte Multilayer Patterns Created by Capillary Force and Their Impact on Cell Migration. Chinese Journal of Chemistry, 2014, 32 (1):66-7.
2． Tanchen Ren, Shan Yu, Zhengwei Mao, Sergio Enrique Moya, Lulu Han, and Changyou Gao. Complementary Density Gradient of Poly(hydroxyethyl methacrylate) and YIGSR Selectively Guides Migration of Endotheliocytes. Biomacromolecules. DOI: 10.1021/bm500385n.
3． Jindan Wu, Zhengwei Mao, Lulu Han, Yizhi Zhao, Jiabin Xia, Changyou Gao. A density gradient of basic fibroblast growth factor guides directional migration of vascular smooth muscle cells. Colloids and Surfaces B: Biointerfaces, 2014, 117: 290-295.
4． Lulu Han, Zhengwei Mao, Jindan Wu, Yang Guo, Tanchen Ren, Changyou Gao. Directional cell migration through cell–cell interaction on polyelectrolyte multilayers with swelling gradients. Biomaterials, 2013, 34 (4): 975–984.
5． Lulu Han, Zhengwei Mao, Jindan Wu, Yang Guo, Tanchen Ren, Changyou Gao. Unidirectional migration of single smooth muscle cells under the synergetic effects of gradient swelling cue and parallel groove patterns. Colloids and Surfaces B: Biointerfaces, 2013, 111: 1-6.
6． Houliang Wei, Lulu Han, Jun Ren, Lingyun Jia. Anticoagulant Surface Coating Using Composite Polysaccharides with Embedded Heparin-Releasing Mesoporous Silica. ACS Applied Materials & Interfaces, 2013, 5(23), 12571–12578.
7． Jindan Wu, Zhengwei Mao, Lulu Han, Jiabin Xia, Yizhi Zhao, Changyou Gao. Directional migration of vascular smooth muscle cells guided by synergetic surface gradient and chemical pattern of poly(ethylene glycol) brushes. Journal of Bioactive and Compatible Polymers, 2013, 28 (6): 605-620.
8． Jindan Wu, Zhengwei Mao, Yifeng Hong, Lulu Han, Changyou Gao. Conjugation of Basic Fibroblast Growth Factor on a Heparin Gradient for Regulating the Migration of Different Types of Cells. Bioconjugate Chemistry, 2013, 24 (8): 1302–1313.
9． Houliang Wei, Jun Ren, Bo Han, Li Xu, Lulu Han, Lingyun Jia. Stability of polydopamine and poly(DOPA) melanin-like films on the surface of polymer membranes under strongly acidic and alkaline conditions. Colloids and Surfaces B: Biointerfaces, 2013, 110: 22-28.
10． Lulu Han, Zhengwei Mao, Jindan Wu, Yuying Zhang, Changyou Gao. Influences of surface chemistry and swelling of salt-treated polyelectrolyte multilayers on migration of smooth muscle cells. Journal of the Royal Society Interface, 2012, 9 (77): 3455-3468.
11． Lulu Han, Zhengwei Mao, He Wuliyasu, Jindan Wu, Xiao Gong, Yuguang Yang, Changyou Gao. Modulating the structure and properties of poly(sodium4-styrenesulfonate)/ poly(diallyldimethylammonium chloride) multilayers with concentrated salt solutions. Langmuir, 2012, 28 (1): 193-199.
12． Joseba Irigoyen, Lulu Han, Irantzu Llarena1, Zhenwei Mao, Changyou Gao, Sergio E. Moya. Responsive Polyelectrolyte multilayers assembled at high ionic strength with an unusual collapse at low ionic strength. Macromolecular Rapid Communications, 2012, 33 (22): 1964–1969.
13． Xiao Gong, Lulu Han, Jianrong Gao, Changyou Gao. Stability of polyelectrolyte multilayer micropatterns in response to post-treatments. Colloids and Surfaces a-Physicochemical and Engineering Aspects, 2012, 396: 299-304.
14． Jindan Wu, Zhengwei Mao, Huaping Tan, Lulu Han, Tanchen Ren, Changyou Gao. Gradient biomaterials and their influences on cell migration. Interface Focus, 2012, 2 (3): 337-355.
15． Xiao Gong, Lulu Han, Yanan Yue, Jianrong Gao, Changyou Gao. Influence of assembly pH on compression and Ag nanoparticle synthesis of polyelectrolyte multilayers. Journal of Colloid and Interface Science, 2011, 355 (2): 368–373.
16． Lulu Han, Jing Zhou, Xiao Gong, Jie Yang, Changyou Gao. Force-free patterning of polyelectrolyte multilayers under solvent assistance. Macromolecular Materials and Engineering, 2010, 295 (8): 716-725.
17． Han Lulu, Zhou Jing, Gong Xiao, Gao Changyou. Solvent-assisted polymer micro-molding. Chinese Science Bulletin, 2009, 54: 2193-2204.
18． Xiao Gong, Jie Yang, Lulu Han, Changyou Gao.. Influence of Drying Time of Polyelectrolyte Multilayers on the Compression-Induced Pattern Formation. Langmuir, 2008, 24 (24):13925–13933.


工作成果（奖励、专利等）
专利：高长有，韩璐璐，周晶，龚晓；聚电解质多层膜上构建物理图案的方法（**9）。