刘宇博
院系：盘锦校区生命与医药学院
办公电话：
电子信箱：liuyubo@dlut.edu.cn
更新时间：2015-7-13
其他专业：生物化学与分子生物学生物化工



个人简介
学习简历：
2005/09-2009/07大连理工大学，生物技术专业，学士
2009/09-2014/12大连理工大学，生物化工专业，博士

工作简历：
2015/3-今大连理工大学生命与医药学院，讲师


硕博研究方向
1. Bcl-2抑制剂类靶向抗癌药的 设计、合成和活性研究。
2. 利用有机小分子Bcl-2抑制剂研究肿瘤信号转导通路。

出版著作和论文
代表性论文：
1.Yubo Liu, Zhichao Zhang, Ting Song, Furong Liang, Mingzhou Xie, Hongkun Sheng. (2013) Resistance to BH3 mimetic S1 in SCLC cells that up-regulate and phosphorylate Bcl-2 through ERK1/2. British Journal of Pharmacology, 169, 1612-1623. (SCI, IF: 5.0, 一区)
2.Yubo Liu, Zhiqiang Li, Ting Song, Zuguang Xue, Zhichao Zhang. (2013) Mechanisms of Anti-leukemic Activity of the Bcl-2 Homology Domain-3 Mimetic S1. Biomedicine & Pharmacotherapy, 67, 451-556. (SCI, IF: 2.1, 三区)
3.Yubo Liu，Mingzhou Xie，Ting Song，Hongkun Sheng, Xiaoyan Yu, Zhichao Zhang. (2015) A novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins，including phosphorylated Mcl-1. Pigment Cell & Melanoma Research, 28(2): 161-170. (SCI, IF: 5.6, 一区)
4.Zhichao Zhang, Yubo Liu, Ting Song, Zuguang Xue, Xiaoyun Shen, Furong Liang, Yan Zhao, Zhiqiang Li, Hongkun Sheng. (2013) An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1. British Journal of cancer 108, 1870-1878. (SCI, IF: 4.8, 一区)
5.Yubo Liu, Zhichao Zhang. (2013) Resistance to BH3 mimetic S1 in non-small cell lung cancer cells that phosphorylate Bim through ERK1/2 and lead to its proteasomal degradation. Journal of Thoracic Oncology, 8, S1061. (IF: 5.8,一区)
6.Yubo Liu, Zhichao Zhang. (2013) Resistance to BH3 mimetic S1 in SCLC cells that up-regulate and phosphorylate Bcl-2 through ERK1/2. Journal of Thoracic Oncology, 2013, 8, S767. (IF: 5.8,一区)
7.Zhichao Zhang, Yan Zhao, Ting Song, Yubo Liu, Xiangqian Li, Pengchen Su, Shenghui Xie. (2013) Study of binding thermodynamics in the optimization of BH3 mimetics. Chemical Biology & Drug Design, 82, 4, 394-400. (SCI, IF: 2.5, 二区)
8.Ting Song, Furong Liang, Zhichao Zhang, Yubo Liu, Hongkun Sheng, Mingzhou Xie. (2013) S1 kills MCF-7/ADR cells more than MCF-7 cells: A protective mechanism of endoplasmic reticulum stress. Biomedicine & Pharmacotherapy, 67, 451-556 (SCI, IF: 2.1, 三区)
9.Ting Song, Xilong Chang, Zhichao Zhang, Yubo Liu, Xiaoyun Shen. (2012) S1, a Novel Pan-BH3 Mimetic, Induces Apoptosis in Mcl-1-Overexpressing Cells Through Bak. Journal of Pharmacological Sciences 119, 330-340. (SCI, IF: 2.3, 三区)
10.Xing Huang, Chuang Wang, Song Li, Yubo Liu, Zhichao Zhang. (2014) Highly Sensitive Visualization of Inorganic Mercury in Mouse Neurons Using a Fluorescent Probe. Journal of Fluorescence. 24 (4), 1313-1317. (SCI, IF: 1.7, 三区)
11.Yubo Liu, Zhichao Zhang. An anti-apoptotic Bcl-2 family protein index predicts the response of leukemic cells to the pan-Bcl-2 inhibitor S1. AACR Annual Meeting 2013. Cancer Research: 2013, 73, 1710.
12.李景煜，刘宇博，宋婷，沈晓云，张志超。（2012）BH3模拟物S1诱导人类白血病细胞株K562凋亡的作用机制。白血病·淋巴瘤 2012年21卷第12期。
13.邢欣荣，刘宇博，程智逵，伍会健（2008）组蛋白修饰酶对基因转录的调控.生理科学进展 2008年第39卷第4期。


在读学生人数
硕士生一人