性　　别： 男
出生日期： 1961.11
职　　称： 研究员
工作单位： 中国科学院
行政职务： 无
联系电话： 86-
电子信箱： pinnie@ihb.ac.cn
学术任职： 中国水产学会鱼病专业委员会主任委员、湖北省免疫学会副理事长、中国动物学会寄生虫学专业委员会理事
荣誉称号： 曾获国家科技进步二等奖
指导专业： 水生生物学（水生所）研究方向：生物学
其他专业： 无
更新时间： 2018-11-6
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个人简介
1961年生，博士，特聘研究员、博士生导师。1982年毕业于华中农学院（现华中农业大学），获学士学位；1984年毕业于中山大学，获硕士学位；1990年在英国Exeter大学获博士学位；1996年在中国科学院水生生物研究所被聘为研究员、博士生导师；曾任中国科学院水生生物研究所副所长、所学术委员会副主任，闽江学者特聘教授；现任淡水生态与生物技术国家重点实验室主任。
社会兼职包括中国水产学会鱼病专业委员会主任委员、湖北省免疫学会副理事长、中国动物学会寄生虫学专业委员会理事；广东省水产经济动物病原生物学与流行病学重点实验室学术委员会主任；《水生生物学报》、《水产学报》、《中国水产科学》、《长江流域资源与环境》、《中国渔业质量与标准》、《Chinese Journal of Oceanology and Limnology》、《Parasites & Vectors》、《Aquaculture & Fisheries》等刊物的编委。
曾主持国家重点基础研究发展计划（973计划）项目、中国科学院知识创新工程重要方向性项目、国家自然科学基金委员会重点项目和面上项目等研究任务。目前承担国家自然科学基金委员会重点项目和重点国际合作项目，以及中国科学院战略性先导科技专项子课题的研究任务。研究方向包括鱼类的免疫系统和免疫反应，鱼类细菌病的致病机理以及免疫防治，寄生虫种群生态和宿主-寄生虫的相互作用。近期研究工作主要集中在鱼类的模式识别受体、鱼类和低等脊椎动物的干扰素系统、柱状黄杆菌和爱德华氏菌的致病机理与免疫防治；同时致力于探讨我国日本血吸虫和其中间宿主的遗传多样性、以及鱼类寄生虫的系统发育等方面的研究。已发表研究论文150余篇，其中SCI收录论文100余篇，他引超过2500次；培养博士学位研究生26名，硕士学位研究生6名。2005年获国家科技进步二等奖（排名第四）。



研究方向：
鱼类的免疫系统和免疫反应，鱼类细菌病的致病机理以及免疫防治。寄生虫种群生态和宿主-寄生虫的相互作用

职务：


社会任职：


获奖及荣誉：
曾获国家科技进步二等奖（排名第四）


代表论著：
2016
1.Gan, Z., Chen, S.N., Huang, B., Hou, J. & Nie, P. (acepted). Intronless and intron-containing type IFN genes coexist in amphibian Xenopus tropicalis: insights into the origin and evolution of type I IFNs in vertebrates. Developmental and Comparative Immunology.
2.Chen, S.N., Zhang, X.W., Li, L., Ruan, B.Y., Huang, B., Huang, W.S., Zou, P.F., Fu, J.P., Zhao, L.J., Li, N. & Nie, P. (2016). Type III IFNs in tetrapod vertebrates: conservation and variation in gene composition, and functional characterization in lizard reptiles. Developmental and Comparative Immunology 61: 208-224.
3.Gan, Z., Chen, S., Hou, J., Huo, H., Zhang, X., Ruan, B., Laghari, Z.A., Li, L., Lu, Y. & Nie, P., (2016). Molecular and functional characterization of peptidoglycanrecognition protein SC2 (PGRP-SC2) from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae. Fish and Shellfish Immunology 54: 1-10.
4.Lu, J.F., Wang, W.N., Wang, G.L., Zhang, H., Zhou, Y., Gao, Z.P., Nie, P. & Nie, P. (2016). Edwardsiella tardaEscE (Orf13 Protein) is a type III secretion system-secreted protein that is required for the injection of effectors, secretion of translocators, and pathogenesis in fish. Infection and Immunity 84: 2-10.
5.Lu, L.-F., Li, S., Lu, X.-B., LaPatra, S.E., Zhang, N., Zhang, X.-J., Chen, D.-D., Nie, P. & Zhang, Y.-A. (2016). Spring viremia of carp virus protein suppresses fish IFNf1 production by targeting the mitochondrial antiviral signaling protein. Journal of Immunology 196: 3744-3753.
6.Luo Z. Liu, Z. Fu, J., Zhang, Q., Huang, B. & Nie, P. (2016). Immunogenicity and protective role of antigenic regions from fi ve outer membrane proteins of Flavobacterium columnare in grass carp Ctenopharyngodon idella.Chinese Journal of Oceanology and Limnology34: 1247-1257.
7.Xu, Q., Jiang, Y., Wangkahart, E., Zou, J., Chang, M., Yang, D., Secombes, C.J., Nie, P. & Wang, T. (2016). Sequence and sxpression analysis of interferon regulatory factor 10 (IRF10) in three diverse teleost fish reveals tts role in antiviral defense. PLoS One 11: e**. doi:10.1371/journal.pone.**.
8.Yi, J., Xiao, S.B., Zeng, Z.X., Lu, J.F., Liu, L.Y., Laghari, Z.A., Nie, P., Yu, H.B., Xie, H.X. (2016). EseE of Edwardsiella tarda augments secretion of translocon protein EseC and expression of the escC-eseE Operon. Infection and Immunity 84: 2336-2344.
9.Zhang, Y., Nie, P., Lin, L. (2016). Complete genome sequence of the fish pathogen Flavobacterium columnare Pf1. Genome Announcements 4: e00900-16.
10.Zhang, L., Liu, Z., Fu, J., Zhang, Q., Huang, B., Nie, P. (2016). Immunogenicity and protective role of antigenic regions from five outer membrane proteins of Flavobacterium columnare in grass carp Ctenopharyngodon idella. Chinese Journal of Oceanology and Limnology 34: 1247-1257.
11.Zou, P.F., Chang, M.X., Li, Y., Xue, N.N., Li, J.H., Chen, S.N. & Nie, P. (2016). NOD2 in zebrafish funtions in a antibacterial and also antiviral responses via NF-kB, and also MDA5, RIG-1 and MAVS. Fish and Shellfish Immunology 55: 173-185.
2015
12.Locke, S.A., Al-Nasiri, F.S., Caffara, M., Drago, F., Kalbe, M., Lapierre, A.L., McLaughlin, J.D., Nie, P., Overstreat, R.B., Souza, G.T.R., Takemoto, R.M. & Marcogliese, D.J. (2015). Diversity, specificity and speciation in larval Diplostomidae (Platyhelminthes: Digenea) in the eyes of freshwater fish, as revealed by DNA barcodes. International Journal for Parasitology 45: 841-855. Doi: 10.1016/j.ijpara.2015.07.001
13.Huang, B., Jia, Q.Q., Liang, Y., Huang, W.S. & Nie, P. (2015). Interferon regulatory factor 10 (IRF10): cloning in orange spotted grouper, Epinephelus coioides, and evolutionary analysis in vertebrates. Fish & Shellfish Immunology 46(2): 669-677.
14.Li, N., Qin, T., Zhang, X.L., Huang, B., Liu, Z.X., Xie, H.X., Zhang, J., McBride, M.J. & Nie, P. (2015). Development and use of a gene deletion strategy to examine the two chondroitin lyases in virulence of Flavobacterium columnare. Applied and Environmental Microbiology 81(21): 7349-7402. doi:10.1128/AEM.01586-15.
15.Gao, Z.P., Nie, P., Lu, J.F., Liu, L.Y., Xiao, T.Y., Liu, W., Liu, J.S. & Xie, H.X. (2015). Type III secretion system translocon component EseB forms filaments on and mediates autoaggrelation of and biofilm formation by Edwardsiella tarda. Applied and Environmental Microbiology 81 81:000–000. doi:10.1128/AEM.01254-15.
16.Chen, W.Q., Hu, Y.W., Zou, P.F., Ren, S.S., Nie, P. & Chang, M.X. (2015). MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Developmental and Comparative Immunology 49: 19-30.
17.Qi, Z.T., Jiang, Y.S., Holland, J.W., Nie, P., Secombes, C.J. & Wang, T. (2015). Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynuchus mykiss). Fish and Shellfish Immunology 44: 389-398.
18.Xie, H.X., Lu, J.F., Zhou, Y., Yi, J., Yu, X.-J., Leung, K.Y. & Nie, P. (2015). Identifcation and functional characterization of the novel Edwardsiella tarda effector EseJ. Infection and Immunity 83: 1650-1660.
19.Zou, P.F., Chang, M.X., Li, Y., Zhang, S.H., Fu, J.P., Chen, S.N. & Nie, P. (2015). Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish and Shellfish Immunology 43: 13-24.
2014
20.Zou, P.F., Chang, M.X., Xue, N.N., Liu, X.Q., Li, J.H., Fu, J.P., Chen, S.N. &Nie, P.(2014). Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant.Immunology141: 192-202.
21.Fu, J.P., Chen, S.N., Zou, P.F., Huang, B., Guo, Z., Zeng, L.B., Qin, Q.W. &Nie, P.(2014). IFN-γ in turtle: Conservation in sequence and signalling and role in inhibiting iridovirus replication in Chinese soft-shelled turtlePelodiscus sinensis.Developmental and Comparative Immunology43: 87-95.
22.Hu, Y.W., Yu, Z.L., Xue, N.N.,Nie, P.& Chang, M.X. (2014). Expression and protective role of two novel NACHT-containing proteins in pathogen infection.Developmental and Comparative Immunology46: 323-332.
23.Huang, B., Huang, W.S. &Nie, P.(2014). Cloning and expression analyses of interferon regulatory factor (IRF) 3 and 7 genes in European eel,Anguilla anguillawith the identification of genes involved in IFN production.Fish & Shellfish Immunology 37: 239-247.
24.Li, J.H., Yu, Z.L., Xue, N.N., Zou, P.F., Hu, J.Y.,Nie, P.& Chang, M.X. (2014). Molecular cloning and functional characterization of peptidoglycan recognition protein 6 in grass carpCtenopharyngodon idella.Developmental and Comparative Immunology42: 244-255.
25.Li, S., Lu, L.F., Feng, H., Wu, N., Chen, D.D., Zhang, Y.B., Gui, J.F.,Nie, P.& Zhang, Y.-A. (2014). IFN regulator factor 10 is a negative regulator of the IFN responses in fish.Journal of Immunology193: 1100-1109.
26.Liu, Y., Whipps, C.M., Nie, P., Gu, Z. (2014). Myxobolus oralis sp. n. (Myxosporea: Bivalvulida) infecting the palate in the mouth of gibel carp Carassius auratus gibelio (Cypriniformes: Cyprinidae). Folia Parasitologica 61: 505-511.
27.Tian, J.Y., Qi, Z.T., Chang, M.X. & Nie, P. (2014). Complementary DNA sequences of the constant regions of T-cell antigen receptors α, β and g in mandarin fish, Siniperca chuatsi Basilewsky, and their transcriptional changes after stimulation with Flavobacterium columnare. Journal of Fish Diseases 37: 89-101.
28.Wang, X.H., Wang, K.R., Nie, P., Chen, X.H. & Ao, J.Q. (2014). Establishment and characterization of a head kidney cell line from large yellow croaker Pseudosciaena crocea. Journal of Fish Biology 84: 1551-1161.
29.Xie, H.X., Lu, J.F., Rolhion, N., Holden, D.W.,Nie, P., Zhou, Y. & Yu, X.J. (2014).Edwardsiella tarda-induced cytotoxicity depends on its type III secretion system and flagellin.Infection and Immunity82: 3436-3445.
30.Xu, Q.Q., Li, R.G., Monte, M.M., Jiang, Y.S.,Nie, P., Holland, J.W., Secombes, C.J. & Wang, T. (2014). Sequence and expression analysis of rainbow trout CXCR2, CXCR3a and CXCR3b aids interpretation of lineage-specific conversion, loss and expansion of these receptors during vertebrate evolution. Developmental and Comparative Immunology 45: 201-213.
31.Xu, Q.Q., Yang, D.Q., Tuo, R., Wan, J., Chang, M.X. & Nie, P. (2014) Gene cloning and induced expression pattern of IRF4 and IRF10 in the Asian swamp eel (Monopterus albus). Zoological Research 35: 380-388.
32.Yu, Z.L., Li. J.H, Xue, N.N., Nie, P. & Chang, M.X. (2014). Expression and functional characterization of PGRP6 splice variants in grass carp Ctenopharyngodon idella. Developmental and Comparative Immunology 47: 264-274.
33.Hu, X.J., Hu, X.P., Wen, C.G., Gao, Q., Xie, Y.H., Hu, B.Q., Wu, D., Tao, Z.Y., Li, A.H. (2014). Molecularcloning and characterization of cathepsin L from freshwater mussel, Cristaria plicata. Fish & Shellfish Immunology 40: 446-454.
34.Qi, Z.T., Chang, L.J., Zhang, Q.H., Wang, Z.S., Qiu, M., Huang, Y., Gao, Q. (2014). Molecular cloning, expression and in silico analysis of a long type peptidoglycan recognition protein from tongue sole, Cynoglossus semilaevis.Acta Ichthyologica et Piscatoria 44: 181-190.
2013
35.Chang, M.X., Zou, J.,Nie, P., Huang, B., Yu, Z.L., Collet, B. & Secombes, C.J. (2013). Intracellular interferons in fish: A unique means to combat viral infection.PLoS Pathogens9: e**.
36.Chen, J., Xu, Q.Q., Wang, T., Collet, B., Corripio-Miyar, Y., Bird, S., Xie, P.,Nie, P., Secombes, C.J. & Zou, J. (2013). Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish.Developmental and Comparative Immunology41: 137-152.
37.Chen, S.N., Huang, B., Zhang, X.W., Li, Y., Zhao, L.J., Li, N., Gao, Q. &Nie, P.(2013). IFN-gand its receptors in a reptile reveal the evolutionary conservation of type II IFNs in vertebrates.Developmental and Comparative Immunology41: 587-596.
38.Fu, J.P., Luo, Z., Yan, Y., Zou, P.F., Zhang, S.H., Qin, Q.W. &Nie, P.(2013). Establishment of a cell line from Chinese soft-shelled turtlePelodiscus sinensiswith the practicability of transfection and viral replication.Fish Pathology48: 126-134.
39.Guo, Z. &Nie, P.(2013). Sequencing and expression analysis of CD3γ/δ and CD3ε chains in mandarin fish,Siniperca chuatsi.Chinese Journal of Oceanology and Limnology31: 106-117.
40.Guo, Z., Wang, G.L., Fu, J.P. &Nie, P.(2013). Characterization and expression of CD8 molecules in mandarin fishSiniperca chuatsi.Journal of Fish Biology82, 189-205.
41.Huang, B., Huang, W.S. &Nie, P.(2013). Characterization of four Mx isoforms in the European eel,Anguilla anguilla.Fish & Shellfish Immunology35: 1048-1054.
42.Li, J.H., Chang, M.X., Xue, N.N.,Nie, P.(2013). Functional characterization of short peptidoglycan recognition protein, PGRP5 in grass carpCtenopharyngodon idella.Fish & Shellfish Immunology35: 221-230.
43.Pan, T.S. &Nie, P.(2013). The complete mitochondrial genome ofPallisentis celatus(Acanthocephala) with phylogenetic analysis of acanthocephalans and rotifers.Folia Parasitologica60: 181-191.
44.Zhao, L.J., Lu, J.F.,Nie, P., Li, A.H., Xiong, B.X. & Xie, H.X. (2013). Roles of plasmid-encoded proteins, EseH, EseI and EscD in invasion, replication and virulence ofEdwardsiella ictaluri.Veterinary Microbiology166: 233-241.
2012
45.Li, N., Zhang, L.Q., Zhang, J., Liu, Z.X., Huang, B., Zhang, S.H. & Nie, P. (2012) Type I restriction-modification system and its resistance in electroporation efficiency in Flavobacterium columnare. Veterinary Microbiology160: 61-68.
46.Zhao, Q.P., Jiang, M.S., Dong. H.F. & Nie, P. (2012). Diversification of Schistosoma japonicum in Mainland China revealed by mitochondrial DNA. PLoS Neglected Tropical Diseases 6:e1503.
47.Zhang, S.H., Zhu, D.D., Chang, M.X., Zhao, Q.P., Jiao, R., Huang, B., Fu, J.P., Liu, Z.X. & Nie P. (2012). Three goose-type lysozymes in the gastropod Oncomelania hupensis: cDNA sequences and lytic activity of recombinant proteins. Developmental & Comparative Immunology 36:241-246.
48.Zhang, J., Zou, H., Wang, L.F., Huang, B., Li, N., Wang, G.T. & Nie, P. (2012). Construction of two selectable markers for integrative/conjugative plasmids in Flavobacterium columnare. Chinese Journalof Oceanology and Limnology 30:269-278.
49.Wang, H., Zhao, Q.P., Nie, P., Jiang, M.S. & Song, J.(2012). Identification of differentially expressed genes in Oncomelania hupensis chronically infected with Schistosoma japonicum. Experimental Parasitology 130:374-383.
50.Liu, Z.X,, Liu, G,Y., Li, N., Xiao, F.S., Xie, H.X. & Nie, P.(2012). Identification of immunogenic proteins of Flavobacterium columnare by two-dimensional electrophoresis immunoblotting with antibacterial sera from grass carp, Ctenopharyngodon idella (Valenciennes). Journal of Fish Diseases, 35: 255-263.
51.Wang, G., Li J., Zou, P., Xie, H., Huang, B., Nie, P. & Chang, M. (2012). Expression pattern, promoter activity and bactericidal property of β-defensin from the mandarin fish Siniperca chuatsi. Fish &Shellfish Immunology 33: 522-531.
2011
52.Chang, M.X., Collet, B., Nie, P., Lester, K., Campbell, S. & Secombes, C.J., Zou, J. (2011). Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in Rainbow trout (Oncorhynchus mykiss).Journal of Virology 85:8403-8412.
53.Chang, M.X., Wang, T., Nie, P., Zou, J. & Secombes, C.J. (2011). Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains. Fish &Shellfish Immunology 30:118-127.
54.Guo, H.Z., Zou, P.F., Fu, J.P., Guo, Z., Zhu, B.K., Nie, P. & Chang, M.X.(2011). Characterization of two C-type lectin-like domain (CTLD)-containing proteins from the cDNA library of Chinese mitten crab Eriocheir sinensis. Fish &Shellfish Immunology 30:515-524.
55.Li, W.X., Song, R., Wu, S.G., Zou, H., Nie, P. & Wang, G.T. (2011). Seasonal occurrence of helminths in the anadromous fish Coilia nasus (Engraulidae): parasite indicators of fish migratory movements. Journal ofParasitology 97:192-196.
56.Wei, Y.C., Pan, T.S., Chang, M.X., Huang, B., Xu, Z., Luo, T.R. & Nie, P. (2011). Cloning and expression of Toll-like receptors 1 and 2 from a teleost fish, the orange-spotted grouper Epinephelus coioides. Veterinary Immunology & Immunopathology 141: 173-182.
57.Yan, W., Nie, P. & Lu, Y. (2011). Establishment, characterization and viral susceptibility of a new cell line derived from goldfish, Carassius auratus (L.), tail fin. Journal of Fish Diseases 34:757-768.
2010
58.Chang, M.X., Chen, W.Q. & Nie, P. (2010). Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling. Developmental & Comparative Immunology 34:1-13.
59.Chen, D., Guo, X. & Nie, P. (2010). Phylogenetic studies of sinipercid fish (Perciformes: Sinipercidae) based on multiple genes, with first application of an immune-related gene, the virus-induced protein (viperin) gene. Molecular Phylogenettics & Evolution 55:1167-1176.
60.Chen, W.Q., Xu, Q.Q., Chang, M.X., Nie, P. & Peng, K.M. (2010). Molecular characterization and expression analysis of nuclear oligomerization domain proteins NOD1 and NOD2 in grass carp Ctenopharyngodon idella. Fish &Shellfish Immunology 28:18-29.
61.Chen, W.Q., Xu, Q.Q., Chang, M.X., Zou, J., Secombes, C.J., Peng, K.M. & Nie, P. (2010). Molecular characterization and expression analysis of the IFN-gamma related gene (IFN-gammarel) in grass carp Ctenopharyngodon idella. Veterinary Immunology & Immunopathology 134:199-207.
62.Huang, B., Qi, Z.T., Xu, Z. & Nie, P. (2010). Global characterization of interferon regulatory factor (IRF) genes in vertebrates: glimpse of the diversification in evolution. BMC Immunology 11:22.
63.Li, N., Zhang, J., Zhang, L.Q. & Nie, P. (2010). Difference in genes between a high virulence strain G4 and a low virulence strain G18 of Flavobacterium columnare by using suppression subtractive hybridization. Journal of Fish Diseases 33: 403-412.
64.Li, W.X., Wang, G.T., Yao, W.J. & Nie, P. (2010). Frequency distribution and seasonal dynamics of intestinal helminths in the yellowhead catfish Pelteobagrus fulvidraco from Liangzi Lake, China. Comparative Parasitology 77:31-36.
65.Qi, Z., Nie, P., Secombes, C.J. & Zou, J. (2010). Intron-containing type I and type III IFN coexist in amphibians: refuting the concept that a retroposition event gave rise to type I IFNs. Journal of Immunology 184:5038-5046.
66.Tan, X.L., Shi, X.L., Liu, G.J., Xu, H.L. & Nie, P. (2010). An approach to analyzing taxonomic patterns of protozoan communities for monitoring water quality in Songhua River, northeast China. Hydrobiologia 638: 193-201.
67.Wang, T., Gao, Q., Nie, P. & Secombes, C.J. (2010). Identification of suppressor of cytokine signalling (SOCS) 6, 7, 9 and CISH in rainbow trout Oncorhynchus mykiss and analysis of their expression in relation to other known trout SOCS. Fish &Shellfish Immunology 29:656-667.
68.Xiao, F.S., Wang, Y.P., Yan, W., Chang, M.X., Yao, W.J., Xu, Q.Q., Wang, X.X., Gao, Q. & Nie, P. (2010). Ig heavy chain genes and their locus in grass carp Ctenopharyngodon idella. Fish &Shellfish Immunology 29:594-599.
69.Xie, H.X., Yu, H.B., Zheng, J., Nie, P., Foster, L.J., Mok, Y.K., Finlay, B.B. & Leung, K.Y. (2010). EseG, an effector of the type III secretion system of Edwardsiella tarda, triggers microtubule destabilization. Infection & Immunity 78:5011-5021.
70.Xu, Q.Q., Chang, M.X., Xiao, F.S., Huang, B. & Nie, P. (2010). The gene and virus-induced expression of IRF-5 in grass carp Ctenopharyngodon idella. Veterinary Immunology & Immunopathology 134:269-278.
71.Zhang, S.H., Zhao, Q.P., Jiao, R., Gao, Q. & Nie, P. (2010). Identification of polymorphic microsatellites for the intermediate host Oncomelania hupensis of Schistosoma japonicum in China. Malacologia 53:147-153.
72.Zhao, Q.P., Jiang, M.S., Littlewood, D.T. & Nie, P. (2010). Distinct genetic diversity of Oncomelania hupensis, intermediate host of Schistosoma japonicum in mainland China as revealed by ITS sequences. PLoS Neglected Tropical Diseases 4:e611.
73.Zhao, Q.P., Zhang, S.H., Deng, Z.R., Jiang, M.S. & Nie, P. (2010). Conservation and variation in mitochondrial genomes of gastropods Oncomelania hupensis and Tricula hortensis, intermediate host snails of Schistosoma in China. Molecular Phylogenettics & Evolution 57:215-226.
2009
74.Chang, M.X., Nie, P., Collet, B., Secombes, C.J. & Zou, J. (2009). Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts. Immunogenetics 61:315-325.
75.Chang, M.X., Wang, Y.P. & Nie, P. (2009). Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways. Fish &Shellfish Immunology 26:264-274.
76.Gao, D., Wang, G.T., Chen, X.T. & Nie, P. (2009). Metallothionein-2 gene from the mandarin fish Siniperca chuatsi: cDNA cloning, tissue expression, and immunohistochemical localization. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology149:18-25.
77.Gao, Q., Nie, P., Thompson, K.D, Adams, A., Wang, T., Secombes, C.J. & Zou, J. (2009). The search for the IFN-gamma receptor in fish: Functional and expression analysis of putative binding and signalling chains in rainbow trout Oncorhynchus mykiss. Developmental & Comparative Immunology 33:920-931.
78.Li, W.X., Nie, P., Wang, G.T. & Yao, W.J. (2009). Communities of gastrointestinal helminths of fish in historically connected habitats: habitat fragmentation effect in a carnivorous catfish Pelteobagrus fulvidraco from seven lakes in flood plain of the Yangtze River, China. Parasites &Vectors2: 22.
79.Li, Y., Sun, B.J., Wu, H.J. & Nie, P. (2009). Effects of pure microcystin-LR on the transcription of immune related genes and heat shock proteins in larval stage of zebrafish (Danio rerio). Aquaculture289:154-160.
80.Liu, Y., Chang, M.X., Wu, S.G. & Nie, P. (2009). Characterization of C-C chemokine receptor subfamily in teleost fish. Molecular Immunology 46:498-504.
81.Tian, J.Y., Sun, B., Luo, Y., Zhang, Y. & Nie, P. (2009). Distribution of IgM, IgD and IgZ in mandarin fish, Siniperca chuatsi lymphoid tissues and their transcriptional changes after Flavobacterium columnare stimulation. Aquaculture 288:14-21.
82.Tian, J.Y., Xie, H.X., Zhang, Y.A., Xu, Z., Yao, W.J. & Nie, P. (2009). Ontogeny of IgM-producing cells in the mandarin fish Siniperca chuatsi identified by in situ hybridisation. Veterinary Immunology & Immunopathology 132:146-152.
83.Wei, L.L., Sun, B.J., Chang, M.X., Liu, Y. & Nie, P. (2009). Effects of cyanobacterial toxin microcystin-LR on the transcription levels of immune-related genes in grass carp Ctenopharyngodon idella. Environmental Biology of Fishes 85:231-238.
84.Wu, S.G., Wang, G.T., Xi, B.W., Xiong, F., Liu, T. & Nie, P. (2009). Population genetic structure of the parasitic nematode Camallanus cotti inferred from DNA sequences of ITS1 rDNA and the mitochondrial COI gene. Veterinary Parasitology 164:248-256.
85.Xi, B.W., Wang, G.T., Wu, S.G. & Nie, P. (2009). New record of genus Atractolytocestus in China with redescription of A. sagittatus (Cestoda, Caryophyllidea) from Cyprinus carpio. Acta Zootaxonomica Sinica 34: 407-410.
86.Xiong, F., Wang, G.T., Wu, S.G. & Nie, P. (2009). Development of Eustrongylides ignotus (Nematoda: Dioctophmida) in domestic ducks (Anas platyrhynchos domestica (L.). Journal of Parasitology 95: 1035-1039.
87.Xu, Z., Wang, G.L. & Nie, P. (2009). IgM, IgD and IgY and their expression pattern in the Chinese soft-shelled turtle Pelodiscus sinensis. Molecular Immunology 46, 2124-2132.
88.Xu, Z., Chang, M.X., Qi, Z.T., Huang, B. & Nie, P. (2009).Immunoglobulin joining (J) chain and its expression in the Chinese soft-shelled turtle (Pelodiscus sinensis). Veterinary Immunology & Immunopathology 131:268-272.
89.Zou, J., Chang, M., Nie, P. & Secombes, C.J. ( 2009). Origin and evolution of the RIG-I like RNA helicase gene family.BMC Evolutionary Biology 9:85.
2008
90.Chang, M.X. & Nie, P. (2008). RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare. Veterinary Immunology & Immunopathology 124:295-301.
91.Gao, D., Wang, G.T., Xi, B.W., Yao, W.J. & Nie, P. (2008). A new species of Allocreadium (Trematoda: Allocreadiidae) from freshwater fishes in the Danjiangkou Reservoir in China. Journal of Parasitology 94:176-180.
92.Gao, Y., Chang, M.X., Sun, B.J. & Nie, P.(2008). TRAIL in the mandarin fish Siniperca chuatsi: gene and its apoptotic effect in HeLa cells. Fish &Shellfish Immunology 24:55-66.
93.Li, W.X., Wang, G.T. & Nie, P. (2008).Genetic variation of fish parasite populations in historically connected habitats: undetected habitat fragmentation effect on populations of the nematode Procamallanus fulvidraconis in the catfish Pelteobagrus fulvidraco. Journal of Parasitology 94:643-647.
94.Liu, G.Y., Nie, P., Zhang, J. & Li, N. (2008). Proteomic analysis of the sarcosine-insoluble outer membrane fraction of Flavobacterium columnare. Journal of Fish Diseases 31:269-276.
95.Moravec, F., Nie, P. & Wang, G.T. (2008). Redescription and systematic status of Neocapilaria phoxini Yu et Wang, 1994 (Nematoda: Capillariidae). Folia Parasitologica 55: 316-318.
96.Qi, Z.T. & Nie, P. (2008). Comparative study and expression analysis of the interferon gamma gene locus cytokines in Xenopus tropicalis. Immunogenetics 60:699-710.
97.Song ,Y., Wang, G.T., Yao, W.J., Gao, Q. & Nie, P. (2008).Phylogeny of freshwater parasitic copepods in the Ergasilidae (Copepoda: Poecilostomatoida) based on 18S and 28S rDNA sequences. Parasitology Research 102:299-306.
98.Wei, L.L., Sun, B.J. & Nie, P. (2008). Ultrastructural alteration of lymphocytes in spleen and pronephros of grass carp (Ctenopharyngodon idella) experimentally exposed to microcystin-LR. Aquaculture 280:270-275.
99.Wei, L.L., Sun, B.J., Song, L.R. & Nie,P. (2008). Gene expression profiles in liver of zebrafish treated with microcystin-LR. Environmental Toxicology and Pharmacology 26:6-12.
100.Wu, S.G., Wang, G.T., Xi, B.W., Gao, D. & Nie, P. (2008). Molecular characteristics of Camallanus spp. (Spirurida: Camallanidae) in fishes from China based on its rDNA sequences. Journal of Parasitology 94:731-736.
101.Xu, Z.Y., Nie, P., Chang, M.X. & Sun, B.J. (2008). Cloning, characterization and expression analysis of SIMP (source of immunodominant MHC-associated peptides) in grass carp Ctenopharyngodon idella. Fish &Shellfish Immunology 24:701-714.
2007
102.Chang, M.X., Nie, P. & Wei, L.L. (2007). Short and long peptidoglycan recognition proteins (PGRPs) in zebrafish, with findings of multiple PGRP homologs in teleost fish. Molecular Immunology 44:3005-3023.
103.Chang, M.X. & Nie, P. (2007). Intelectin gene from the grass carp Ctenopharyngodon idella: cDNA cloning, tissue expression, and immunohistochemical localization. Fish &Shellfish Immunology 23:128-140.
104.Chang, M.X., Sun, B.J. & Nie, P. (2007). The first non-mammalian CXCR3 in a teleost fish: gene and expression in blood cells and central nervous system in the grass carp (Ctenopharyngodon idella). Molecular Immunology 44:1123-1134.
105.Chen, D.L., Guo, X.G. & Nie, P. (2007). Non-monophyly of fish in the Sinipercidae (Perciformes) as inferred from cytochrome b gene. Hydrobiologia583:77-89.
106.Chen, D.L., Wang, G.T., Yao, W.J. & Nie, P. (2007). Utility of ITS1-5.8S-ITS2 sequences for species discrimination and phylogenetic inference of two closely related bucephalid digeneans (Digenea: Bucephalidae): Dollfustrema vaneyi and Dollfustrema hefeiensisParasitology Research 101:791-800.
107.Gao, Q., Chen, M.X., Yao, W.J., Gao, Y., Song, Y., Wang, G.T., Wang, M.X. & Nie, P. (2007).Phylogeny of diplozoids in five genera of the subfamily diplozoinae palombi, 1949 as inferred from ITS-2 rDNA sequences. Parasitology134:695-703.
108.Harun, N.O., Zou, J., Zhang, Y.A., Nie, P. & Secombes, C.J. (2007). The biological effects of rainbow trout (Oncorhynchus mykiss) recombinant interleukin-8. Developmental & Comparative Immunology 32:673-681.
109.Li, L., Chang, M.X. & Nie, P. (2007). Molecular cloning, promoter analysis and induced expression of the complement component C9 gene in the grass carp Ctenopharyngodon idella. Veterinary Immunology & Immunopathology 118:270-282.
110.Sun, B.J., Chang, M.X., Song, Y., Yao, W.J. & Nie, P. (2007). Gene structure and transcription of IRF-1 and IRF-7 in the mandarin fish Siniperca chuatsi. Veterinary Immunology & Immunopathology 116:26-36.
111.Sun, B.J., Xie, H.X., Song, Y. & Nie, P. (2007). Gene structure of an antimicrobial peptide from mandarin fish, Siniperca chuatsi (Basilewsky), suggests that moronecidins and pleurocidins belong in one family: the piscidins. Journal of Fish Diseases 30:335-343.
112.Wu, S.G., Wang, G.T., Xi, B.W., Gao, D. &Nie, P. (2007). Population dynamics and maturation cycle of Camallanus cotti (Nematoda: Camallanidae) in the Chinese hooksnout carp Opsariichthys bidens (Osteichthyes: Cyprinidae) from a reservoir in China. Veterinary Parasitology 147, 125-131.




学习经历
起止年月
学校
所学专业
学历
学位

1978/02-1982/01
华中农学院
淡水渔业
本科 学士
1982/02-1984/12
中山大学 动物学 硕士研究生
硕士
1987/12-1990/07
英国Exeter大学
生命科学 博士研究生 博士

工作经历
起止年月
工作单位
任职

1984/12-至今
中国科学院水生生物研究所
科研人员

1996/09-至今
中国科学院水生生物研究所
研究员
1999/09-2007/10
中国科学院水生生物研究所
副所长

2011/04-2014/03
集美大学水产学院
教授

2011/10-至今
中国科学院水生生物研究所淡水生态与生物技术国家重点实验室
主任


承担科研课题情况
序号
项目名称
项目来源
起止年月
经费
(万元)
主持/参加
完成情况

1
鳜伽玛-干扰素的剪接异构体及其受体的转录调控与功能
国家自然科学基金委员会重点项目
2013/01-2017/12
310 2017年底结题

2
鱼类伽玛干扰素的分泌调控、信号传导及其免疫功能研究
国家自然科学基金委员会国际（地区）合作与交流项目
2014/01-2018/12
270 2017年底结题

3
鲤抗病分子模块解析
中国科学院战略先导科技专项（A类）子课题
2013-2017
进行中


科研获奖情况
序号
获奖项目名称
奖励类别（等级）
授予单位
获奖时间
本人排名

1 低洼盐碱地池塘规模化养殖技术研究与示范
国家科学技术进步奖二等
国务院
2007 4




授权专利情况
序号
专利名称
授权专利号
年份
专利类别
（发明/实用新型）
本人排名





论文与专著情况
序号
论文、专著名称
学术期刊或出版社名称
发表(出版)年份
论文
检索情况
作(著）者
名次

1 Zebrafish as a model for the study of host-virus interactions
Innate Antiviral Immunity: Methods and Protocols, Methods in Molecular Biology, V. 1656, DOI 10.1007/978-1-4939-7237-1_2, Springer
2017 2/2
2 Retinoic-acid-inducible gene I (RIG-I)-like receptors (RLRs) in fish: current knowledge and future perspectives
Immunology, 151: 16-25
2017 SCI 3/3
3 Intronless and intron-containing type I IFNgenes coexist in amphibian Xenopus tropicalis: Insights into the origin and evolution of type I IFNs in vertebrates
Developmental and Comparative Immunology, 67: 166-176
2017 SCI 5/5
4 Two type II IFN members, IFN-g and IFN-g related (rel), regulate
differentially IRF1 and IRF11 in zebrafish
Fish and Shellfish Immunology, 65: 103-110
2017 SCI 7/7
5 Evolution of IFN-λ in tetrapod vertebrates and its functional
characterization in green anole lizard (Anolis carolinensis)
Developmental and Comparative Immunology, 61: 208-224
2016 SCI 11/11
6 Identification and functional characterization of the novel Edwardsiella tarda effector EseJ
Infection and Immunity, 83: 1650-1660
2015 SCI 7/7
7 Gene deletion strategy to examine the involvement of the two chondroitin lyases in Flavobacterium columnare virulence
Applied and Environmental Microbiology, 81: 7394-7402
2015 SCI 9/9
8 IFN-γ in turtle: Conservation in sequence and signalling and role in
inhibiting iridovirus replication in Chinese soft-shelled turtle Pelodiscus
sinensis
Developmental and Comparative Immunology, 43: 87-95
2014 SCI 8/8
9 Melanoma differentiation-associated gene 5 in zebrafish provoking
higher interferon-promoter activity through signalling enhancing of
its shorter splicing variant
Immunology, 141, 192-202
2013 SCI 8/8
10 IFN-γ and its receptors in a reptile reveal the evolutionary conservation of type II IFNs in vertebrates
Developmentaland Comparative Immunology, 41: 587-596
2013 SCI 8/8

指导研究生情况
在读人数
10 已毕业人数

所指导研究生在读期间取得的成绩和荣誉、就业去向等情况介绍