姚若斯
硕士生导师

职称：副教授
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学院：第一临床医学院
yaors908@163.com







个人简介
姚若斯，理学博士，副教授。毕业于东北师范大学，2015年7月入职徐州医科大学血液病研究所，目前主要从事多发性骨髓瘤分子靶向治疗及表观遗传发病机制的研究。主持国家自然科学基金一项，江苏省自然科学基金一项，国家博士后科学基金（面上项目）二等资助一项，国家博士后科学基金（特别资助）一项。2019年获得江苏省科协青年科技人才托举工程资助。以第一作者或通讯作者在Cancer Research、Experimental Hematology、American Journal of Translational Research、Drug Design, Development and Therapy、Molecules、Journal of Biomolecular Structure & Dynamics、Bioscience Reports等国际刊物上发表SCI论文10余篇，单篇最高影响因子IF：9.727。






发表论文:
Identification of a Novel c-Myc Inhibitor 7594-0037 by Structure-Based Virtual Screening and Investigation of Its Anti-Cancer Effect on Multiple Myeloma

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PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer

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Anticancer effect of histone deacetylase inhibitor scriptaid as a single agent for hepatocellular carcinoma

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Integrating molecular dynamics simulation and molecular mechanics/generalized Born surface area calculation into pharmacophore modelling: a case study on the proviral integration site for Moloney muri

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Histone deacetylase inhibitor NaBut suppresses cell proliferation and induces apoptosis by targeting p21 in multiple myeloma

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Scriptaid inhibits cell survival, cell cycle, and promotes apoptosis in multiple myeloma via epigenetic regulation of p21

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Identification of a novel c-Myc inhibitor with antitumor effects on multiple myeloma cells

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Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt/β-catenin pathway.

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Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration

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Anti-Proliferative Activity of HPOB against Multiple Myeloma Cells via p21 Transcriptional Activation
教材专著:

科研项目:
细胞恶性转化的表观遗传学机制研

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精氨酸甲基转移酶PRMT7在多发性

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PRMT7 在多发性骨髓瘤发生发展中

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支架蛋白WDR5协同PRMT7调控骨髓

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RMT7 在多发性骨髓瘤浸润过程中

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PRMT7在骨髓瘤干细胞发生发展中
获奖成果: