陈碧
硕士生导师

职称：副教授
***

学院：第一临床医学院
chenbi207@126.com







个人简介

陈碧，男，医学博士、副主任医师、副教授，呼吸与危重症医学科副主任（主持工作），现任中国医师协会呼吸医师分会间质性肺疾病工作委员会委员、江苏省医学会呼吸病学分会委员、江苏省医师协会内科医师分会委员、江苏省医师协会呼吸医师分会委员、江苏省医学会呼吸病学分会肺间质病学组成员、江苏省老年学学会中西医结合诊疗专业委员会副主任委员、江苏省康复医学会呼吸康复专业委员会青年委员、徐州市呼吸病专业委员会委员。从事呼吸内科临床和科研工作10余年，在间质肺疾病、重症肺部感染和呼吸衰竭等肺部疾病诊治等方面积累了丰富的临床经验，尤其擅长肺部疑难病的诊治，曾赴德国埃森大学鲁尔肺科医院研修。
获江苏省科教强卫工程“青年医学重点人才”和江苏省第十五批次“六大人才高峰”高层次人才称号。近年来承担国家自然科学基金项目、省市课题共5项，担任《徐州医科大学学报》青年编委，近5年来以第一/通讯作者在《Cancer Letters》、《Transl Lung Cancer Res》、《Respirology》和《clinical science》和《中华结核和呼吸杂志》等国内外期刊发表论文30余篇，其中SCI收录13篇。参编专著3部，参与制定了《中国肺结节病诊断和治疗专家共识》和《特发性肺纤维化急性加重诊断和治疗中国专家共识》。






成果奖励（近五年）
1. 瘦素在支气管哮喘中的作用机制和临床研究，徐州市政府，科学技术进步奖，三等奖，2016
2. 脂联素对肥胖哮喘大鼠气道炎症和重构的影响，徐州市政府，科学技术进步奖，三等奖，2013



科研项目（近五年）

1.国家自然科学基金青年科学基金项目，**，FXR调控EMT和肺成纤维细胞活化参与肺纤维化的机制研究，2017/01-2019/12，18万元，结题，主持
2.国家自然科学基金重大研究计划培育项目，**，法尼酯X受体FXR介导炎性微环境-肿瘤交互作用促进肺癌发生发展研究，2017/01- 2018/12，94万元，结题，主要参与者
3.江苏省青年医学人才项目，QNRC**，FXR参与肺纤维化的机制研究，2016/01-2020/12，25万元，在研，主持
4.江苏省“六大人才高峰”高层次人才项目，WSN-081，FXR抑制剂抗肺纤维化的作用与机制研究，2018/11 -2021/11，4万元，在研，主持
5.基质蛋白Periostin参与OSAHS所致气道重塑的机制和临床研究，KC18058，徐州市科技项目，5万元，2018/08-2020/07，在研，共同主持



论文情况（近五年）
（1）Chen Cheng^#, Zhifeng Wang^#, Jingqiao Wang^#, Chao Ding , Chuang Sun, Pingli Liu, Xiaoqiang Xu, Yanan Liu,Bi Chen*, Bing Gu*.Characterization of the lung microbiome and exploration of potential bacterial biomarkers for lung cancer. Transl Lung Cancer Res. 2020;9(3):693-704. doi:10.21037/tlcr-19-590.IF=5.132, 1区
（2）Lei Ji^#, Yanan Liu^#, Pingli Liu , Guijuan Ji, Jun He, Yuying Gan , Shuyang Zhu,Bi Chen* , Wenhui Zhang*. Serum periostin and TNF-α levels in patients with obstructive sleep apnea-hypopnea syndrome [published online ahead of print, 2020 Jun 22]. Sleep Breath. 2020;10.1007/s11325-020-02124-y. doi:10.1007/s11325-020-02124-y.IF= 2.162, 4区
（3）Yanan Liu^#, Chu Wang^#, Hao Chen , Maowei Zhang , Jiechen Zhu, Xiaojiao Zhang , Lei Ji , Shuyang Zhu , Wenhui Zhang* , Bi Chen*. The profibrotic effects of chronic microaspiration of bile acids on lungs of rats at different stages. Int Immunopharmacol. 2020;84:106545. doi:10.1016/j.intimp.2020.106545.IF= 3.943, 3区
（4）Zhang Y, Du H, Li Y, Yuan Y,Chen B*, Sun S*. Elevated TRIM23 expression predicts cisplatin resistance in lung adenocarcinoma. Cancer Science. 2019 ,111 (2), 637-646.IF=4.751, 2区
（5）Guo M, Liu Y, Han X, Han F, Zhu J, Zhu S,Chen B*. Tobacco smoking aggravates airway inflammation by upregulating endothelin-2 and activating the c-Jun amino terminal kinase pathway in asthma. International Immunopharmacology, 2019 Oct 16;77:105916.IF=3.943，3区
（6）He Du # ,Bi Chen #, Nan-Lin Jiao , Yan-Hua Liu , San-Yuan Sun, You-Wei Zhang. Elevated Glutathione Peroxidase 2 Expression Promotes Cisplatin Resistance in Lung Adenocarcinoma. Oxid Med Cell Longev. 2020;2020:**. Published 2020 Mar 6. doi:10.1155/2020/**.IF= 5.076, 2区
（7）Xueqing Liu^#,Bi Chen^#, Wenjie You^#, Shan Xue, Hui Qin, Handong Jiang*, The membrane bile acid receptor TGR5 drives cell growth and migration via activation of the JAK2/STAT3 signaling pathway in non-small cell lung cancer, Cancer Lett, 2018, 412: 194-207. IF=6.491 1区
（8）Bi Chen^#, Wen-Jie You^#, Xue-Qing Liu^#, Shan Xue, Hui Qin, Han-Dong Jiang*, Chronic microaspiration of bile acids induces lung fibrosis through multiple mechanisms in rats. Clin Sci (Lond), 2017, 131(10): 951-963.IF=5.22 2区
（9）Bi Chen, Hou-rong Cai, Shan Xue, Wen-Jie You, Bin Liu, Han-dong Jiang*, Bile acids induce activation of alveolar epithelial cells and lung fibroblasts through farnesoid X receptor-dependent and independent pathways, Respirology, 2016, 21(6): 1075-1080 IF=3.256，2区
（10）Bi Chen^#, Wen-Jie You^#, Shan Xue^#, Hui Qin, Xu-Ji Zhao, Miao Zhang, Xue-Qing Liu, Shu-Yang Zhu, Han-Dong Jiang*, Overexpression of farnesoid X receptor in small airways contributes to epithelial to mesenchymal transition and COX-2 expression in chronic obstructive pulmonary disease, J Thorac Dis, 2016, 8(11): 3063-3074IF=2.365，4区
（11）Wen-Jie You^#,Bi Chen^#, Xue-Qing Liu^#, Shan Xue, Hui Qin,, Han-Dong Jiang*, Farnesoid X receptor, a novel proto-oncogene in non-small cell lung cancer, promotes tumor growth via directly transactivating CCND1. Sci Rep, 2017, 7(1):591.IF=4.122，3区
（12）Wenjie You^#,Bi Chen^#, Jing Li, Juan Shou, Shan Xue, Xueqing Liu, Handong Jiang*, Pulmonary migratory infiltrates due to mycoplasma infection: case report and review of the literature, J Thorac Dis, 2016; 8(6): E393-398 IF=2.365，4区
（13）Chen H, Zhang M, Zhang W, Li Y, Zhu J, Zhang X, Zhao L, Zhu S,Chen B*, Downregulation of BarH-like homeobox 2 promotes cell proliferation, migration and aerobic glycolysis through Wnt/β-catenin signaling, and predicts a poor prognosis in non-small cell lung carcinoma, Thorac Cancer, 2018, 9(3):390-399IF=2.569 3区
（14）陈碧，蒋捍东*，胃食管反流病与特发性肺纤维化，中华结核和呼吸杂志，2016，39（02）：137 ~139
（15）陈碧，张文辉*，陈玉玲，胡晨，卞宏，何军，季磊，朱述阳，阻塞性睡眠呼吸暂停低通气综合征与颈动脉粥样硬化的相关性及持续气道正压通气治疗的作用，中华医学杂志，2015, 95（34）：2791 ~2795










发表论文:
The profibrotic effects of chronic microaspiration of bile acids on lungs of rats at different stages

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Serum periostin and TNF-α levels in patients with obstructive sleep apnea-hypopnea syndrome

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Characterization of the lung microbiome and exploration of potential bacterial biomarkers for lung cancer

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Elevated Glutathione Peroxidase 2 Expression Promotes Cisplatin Resistance in Lung Adenocarcinoma

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Elevated TRIM23 expression predicts cisplatin resistance in lung adenocarcinoma.

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Tobacco smoking aggravates airway inflammation by upregulating endothelin-2 and activating the c-Jun amino terminal kinase pathway in asthma

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Farnesoid X Receptor Constructs an Immunosuppressive Microenvironment and Sensitizes FXRhighPD-L1low NSCLC to Anti-PD-1 Immunotherapy

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Downregulation of BarH-like homeobox 2 promotes cell proliferation, migration and aerobic glycolysis through Wnt/β-catenin signaling, and predicts a poor prognosis in non-small cell lung carcinoma

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The membrane bile acid receptor TGR5 drives cell growth and migration via activation of the JAK2/STAT3 signaling pathway in non-small cell lung cancer

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Chronic microaspiration of bile acids induces lung fibrosis through multiple mechanisms in rats
教材专著:

科研项目:
FXR调控EMT和肺成纤维细胞活化参与肺纤维化的机制研究

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法尼酯X受体FXR介导炎性微环境-肿瘤交互作用促进肺癌发生发展研究

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FXR抑制剂抗肺纤维化的作用与机

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FXR参与肺纤维化的机制研究

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胃食管反流病诱导肺纤维化发病的
获奖成果:
瘦素在支气管哮喘中的作用机制和

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脂联素对肥胖哮喘大鼠气道炎症和