叶新春
硕士生导师

职称：教授
***

学院：第一临床医学院
xinchunye@foxmail.com







个人简介
徐州医科大学附属医院卒中中心副主任，徐州市卒中防治重点实验室副主任，徐州市神经介入关键技术研究与示范平台负责人，主任医师，特聘青年教授，医学博士，留美博士后，神经病学后备学科带头人，硕导；
徐州医科大学附属医院科技处处长；第十四届徐州市青年联合会副主席，首届徐州医科大学青年人才联合会副主席；
江苏省卒中学会青委会副主任委员，江苏省医学会医学科研分会副主委；徐州市卒中学会副主任委员；中华医学会神经病学分会神经血管介入协作组成员，中国医师协会神经内科医师分会神经介入专委会委员，中国研究型医院协会介入神经病学分会委员，中国卒中学会青委会委员；
主持国自然课题3项，省自然课题2项等课题十余项，以第一或者通讯作者在Stroke等杂志发表SCI论文26篇；
获江苏省“333工程”中青年学术带头人；省卫生拔尖人才A类；省“六大人才高峰”高层次人才B类；省“青蓝工程”中青年学术带头人；省“科教强卫”青年医学重点人才；首届徐州市青年医师后备人才；首届徐州医科大学十大****；徐州医科大学附属医院优秀中青年等称号；
擅长急性脑梗死的介入取栓治疗，颅内外动脉狭窄的支架植入治疗。



成果奖励（近五年）
序
号
获奖项目名称
奖励名称
奖励等级
授奖单位
奖励年度
排序

1
骨髓基质干细胞在糖尿病脑梗死中的作用及机制
徐州市科技进步奖
三等奖
徐州市人民政府
2016
1

2
骨髓基质干细胞对1型糖尿病脑卒中预后的影响
江苏省教育科学研究成果奖
二等奖
江苏省教育厅
2016
2



科研项目（近五年）

序
号
项目名称
项目来源及类别
项目经费
起始年度
终止年度
排序

1
TET1蛋白介导的ELN羟甲基化修饰促进脑梗死后血管新生的机制研究
国家自然科学基金面上项目
55
2020
2023
1

2
HDAC6介导的Prx2乙酰化修饰在脑梗死后神经元凋亡中的作用
国家自然科学基金面上项目
57
2016
2019
1

3
TET1在脑梗死后血管新生中的作用及其作用机制
江苏省自然科学基金面上项目
10
2019
2021
1

4
骨髓基质干细胞加重糖尿病脑缺血损伤的新机制-RAGE介导的信号通路
国家自然科学基金青年基金
23
2013
2015
1

5
HMGB1在骨髓基质干细胞加重糖尿病脑缺血再灌注损伤中的作用及其作用机制
江苏省自然科学基金面上项目
10
2013
2016
1

6
慢性症状性颈内动脉闭塞血管内再通治疗的临床研究
徐州市医疗关键技术与应用示范项目
20
2019
2021
1

7
江苏省青蓝工程中青年学术带头人项目
江苏省教育厅
10
2019
2021
1

8
江苏省六个一工程卫生拔尖人才项目
江苏省卫健委
5
2019
2021
1

9
江苏省六大人才高峰高层次人才项目
江苏省人力资源和社会保障厅
10
2013
2015
1



论文情况（近五年）


[1] Ye XC, Hao Q, Ma WJ, Zhao QC, Wang WW, Yin HH, Zhang T, Wang M, Zan K, Yang XX, Zhang ZH, Shi HJ, Zu J, Raza HK, Zhang XL, Geng DQ, Hu JX, Cui GY. Dectin-1/Syk signaling triggers neuroinflammation after ischemic stroke in mice. J Neuroinflammation 2020; 17: 17.
[2] Hu J, Wang W, Hao Q, Zhang T, Yin H, Wang M, Zhang C, Zhang C, Zhang L, Zhang X, Wang W, Cao X, Xiang J, Ye X. Suppressors of cytokine signalling (SOCS)-1 inhibits neuroinflammation by regulating ROS and TLR4 in BV2 cells. Inflammation research 2020; 69: 27-39.
[3] Ye XC, Hu JX, Li L, Li Q, Tang FL, Lin S, Sun D, Sun XD, Cui GY, Mei L, Xiong WC. Astrocytic Lrp4 (Low-Density Lipoprotein Receptor-Related Protein 4) Contributes to Ischemia-Induced Brain Injury by Regulating ATP Release and Adenosine-A2AR (Adenosine A2A Receptor) Signaling. Stroke 2018; 49: 165-174.
[4] Ye X, Shen T, Hu J, Zhang L, Zhang Y, Bao L, Cui C, Jin G, Zan K, Zhang Z, Yang X, Shi H, Zu J, Yu M, Song C, Wang Y, Qi S, Cui G. Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse. Exp Neurol 2017; 292: 46-55.
[5] Ye X, Zuo D, Yu L, Zhang L, Tang J, Cui C, Bao L, Zan K, Zhang Z, Yang X, Chen H, Tang H, Zu J, Shi H, Cui G. ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia. Biochemical and biophysical research communications 2017; 485: 499-505.
[6] Xiang J, Hu J, Shen T, Liu B, Hua F, Zan K, Zu J, Cui G, Ye X. Bone marrow mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke in type 2 diabetic rats. Neurosci Lett 2017; 644: 62-66.
[7] Ye X, Yu L, Zuo D, Zhang L, Zu J, Hu J, Tang J, Bao L, Cui C, Zhang R, Jin G, Zan K, Zhang Z, Yang X, Shi H, Zhang Z, Xiao Q, Liu Y, Xiang J, Zhang X, Cui G. Activated mGluR5 protects BV2 cells against OGD/R induced cytotoxicity by modulating BDNF-TrkB pathway. Neurosci Lett 2017; 654: 70-79.
[8] Ye X, Hu J, Cui G. Therapy Effects of Bone Marrow Stromal Cells on Ischemic Stroke. Oxidative medicine and cellular longevity 2016; 2016: **.
[9] Ye X, Kong D, Wang J, Ishrat T, Shi H, Ding X, Cui G, Hua F. MyD88 contributes to neuroinflammatory responses induced by cerebral ischemia/reperfusion in mice. Biochemical and biophysical research communications 2016; 480: 69-74.
[10] Cui C, Ye X, Chopp M, Venkat P, Zacharek A, Yan T, Ning R, Yu P, Cui G, Chen J. miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats. Stem cells translational medicine 2016; 5: 1656-1667.
[11] Hu J, Liu B, Zhao Q, Jin P, Hua F, Zhang Z, Liu Y, Zan K, Cui G, Ye X. Bone marrow stromal cells inhibits HMGB1-mediated inflammation after stroke in type 2 diabetic rats. Neuroscience 2016; 324: 11-19.
[12] Ye X, Chopp M, Cui X, Zacharek A, Cui Y, Yan T, Shehadah A, Roberts C, Liu X, Lu M, Chen J. Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats. Exp Neurol 2011; 232: 299-308.
[13] Ye X, Chopp M, Liu X, Zacharek A, Cui X, Yan T, Roberts C, Chen J. Niaspan reduces high-mobility group box 1/receptor for advanced glycation endproducts after stroke in type-1 diabetic rats. Neuroscience 2011; 190: 339-345.
[14] Ye X, Yan T, Chopp M, Zacharek A, Ning R, Venkat P, Roberts C, Chen J. Combination BMSC and Niaspan treatment of stroke enhances white matter remodeling and synaptic protein expression in diabetic rats. International journal of molecular sciences 2013; 14: 22221-22232.
[15] Yan T, Ye X, Chopp M, Zacharek A, Ning R, Venkat P, Roberts C, Lu M, Chen J. Niaspan attenuates the adverse effects of bone marrow stromal cell treatment of stroke in type one diabetic rats. PLoS One 2013; 8: e81199.
[16] Cui G, Ye X, Zuo T, Zhao H, Zhao Q, Chen W, Hua F. Chloroquine pretreatment inhibits toll-like receptor 3 signaling after stroke. Neurosci Lett 2013; 548: 101-104.
[17] Cui G, Zuo T, Zhao Q, Hu J, Jin P, Zhao H, Jing J, Zhu J, Chen H, Liu B, Hua F, Ye X. ROCK mediates the inflammatory response in thrombin induced microglia. Neurosci Lett 2013; 554: 82-87.
[18] Zhao Q, Hu J, Xiang J, Gu Y, Jin P, Hua F, Zhang Z, Liu Y, Zan K, Zhang Z, Zu J, Yang X, Shi H, Zhu J, Xu Y, Cui G, Ye X. Intranasal administration of human umbilical cord mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke. Brain Res 2015; 1624: 489-496.
[19] Bao L, Zhou S, Zhao H, Zu J, He Q, Ye X, Cui G. Neuroprotective Effects of 17beta-Estradiol against Thrombin-Induced Apoptosis in Primary Cultured Cortical Neurons. Pharmacology 2015; 96: 284-289.
[20] He Q, Bao L, Zimering J, Zan K, Zhang Z, Shi H, Zu J, Yang X, Hua F, Ye X, Cui G. The protective role of (-)-epigallocatechin-3-gallate in thrombin-induced neuronal cell apoptosis and JNK-MAPK activation. Neuroreport 2015; 26: 416-423.





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