花放
博士生导师

职称：教授
***

学院：第一临床医学院
huafang@xzhmu.edu.cn







个人简介
医学博士，主任医师，江苏****，博士生导师。徐州医科大学神经系统疾病研究所副所长、徐州医科大学附属医院脑科医院副院长、神经科副主任。扬州大学医学院临床医学专业毕业，中国医科大学临床神经病学专业研究生毕业获硕士学位，曾任徐州医科大学神经精神病学专业讲师、副教授，徐医附院神经科主治医师、副主任医师。2001年获中国医科大学博士学位。2002年至2008年在美国东田纳西州大学医学院从事博士后研究工作。2008至2012年任美国埃默里（EMORY）大学医学院助理教授。2012年至今，任徐州医科大学教授、徐医附院神经科主任医师。主持和参与多项美国心脏与卒中协会、美国国立卫生研究院、埃默里大学、中国国家自然科学基金、江苏省教育厅、“六大人才高峰”等资助的科研项目。从事神经损伤与神经保护方面的研究，发表SCI文章三十余篇。擅长脑血管病及神经科疑难危重疾病的诊断与治疗。



论文情况（近五年）


Selected publications (first and corresponding author):
Hu Y. Sun X, Wang S, Zhou C, Lin L, Ding X, Han J, Zhou Y, Jin G, Wang Y, Zhang W, Shi H, Zhang Z, Yang X, Hua F^*. Toll-like receptor-2 gene knockout results in neurobehavioral dysfunctions and multiple brain structural and functional abnormalities in mice. Brain Behavior and Immunity. Accepted for publication on Oct. 06, 2020. ^*corresponding author
Zhou C, Sun X, Hu Y, Song J, Dong S, Kong D, Wang Y, Hua X, Han J, Zhou Y, Jin G, Yang X, Shi H, Zhang Z, Hua F^*. Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease. Aging (Albany NY). 2019; 11(17):7257-7273. ^*corresponding author
Shi H, Hua X, Kong D, Stein D, Hua F^*. Role of Toll-like receptor mediated signaling in traumatic brain injury. Neuropharmacology. 2019; 145: 259-267. ^*corresponding author
Dong S, Zhang Q, Kong D, Zhou C, Zhou J, Han J, Zhou Y, Jin G, Hua X, Wang J, Hua F^*. Gender difference in the effect of progesterone on neonatal hypoxic/ischemic brain injury in mouse. Exp Neurol. 2018; 306:190-198. ^*corresponding author
Ye X, Kong D, Wang J, Ishrat T, Shi H, Ding X, Cui G, Hua F^*. MyD88 contributes to neuroinflammatory responses induced by cerebral ischemia/reperfusion in mice. Biochem Biophys Res Commun. 2016; 480(1):69-74. ^*corresponding author
Hua F^*, Tang H, Wang J, Prunty MC, Hua X, Sayeed I, Stein DG. TAK-242, an antagonist for Toll-like receptor 4, protects against acute cerebral ischemia/reperfusion injury in mice. J Cereb Blood Flow Metab. 2015; 35(4): 536-542. ^*corresponding author






发表论文:
Toll-like receptor-2 gene knockout results in neurobehavioral dysfunctions and multiple brain structural and functional abnormalities in mice

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Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer’s disease

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Role of Toll-like receptor mediated signaling in traumatic brain injury

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Gender difference in the effect of progesterone on neonatal hypoxic/ ischemic brain injury in mouse

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MyD88 contributes to neuroinfl

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Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone

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Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases

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The TRIF-dependent signaling pathway is not required for acute cerebral ischemia/reperfusion injury in mice

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Chloroquine pretreatment inhibits toll-like receptor 3 signaling after stroke

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Progesterone and low-dose vitamin D hormone treatment enhances sparing of memory following traumatic brain injury
教材专著:

科研项目:
黄体酮受体信号通路在新生儿缺血缺氧性脑病中的作用和机制

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Therapeutic effects of TAK-242

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PROG attenuates acute seizure

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Progesterone and low-dose vita

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Genomic profile of Toll-like r

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The TRIF-dependent signaling p

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Differential roles of TLR2 and

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Preconditioning with a TLR2 sp

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Activation of Toll-like recept

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Protection against myocardial
获奖成果:
骨髓基质干细胞对1型糖尿病脑梗