汤道权
硕士生导师

职称：教授

学院：药学院
tangdq@xzhmu.edu.cn







个人简介
中共党员，教授，药学博士。江苏高校青蓝工程优秀青年骨干教师，徐州医学院中青年学术带头人、优秀青年骨干教师。全国高等教育医学会药学分会委员，江苏省药理学会理事，江苏省高等学校医药教育研究会理事，徐州药学会理事，淮海科技奖专家库成员，徐州市应急管理专家组成员。

成果奖励（近五年）

江苏省高校科学技术研究类自然科学奖三等奖：体内外复杂体系中几类成分分析方法的建立及应用. 无证书编号。授予单位：江苏省教育厅。获奖时间：2018.7。本人排名：第一。
淮海科学技术奖一等奖：中药色谱指纹图谱结合多组分定量质量控制模式的建立及其应用. 证书编号：2016-HJC-1-8-1。授予单位：淮海科学技术奖委员会。获奖时间：2016.9。本人排名：第一。
江苏省高校科学技术研究类自然科学奖三等奖：8种中药质控模式的建立及其在银杏叶提取物活性成分发现中应用. 无证书编号。授予单位：江苏省教育厅。获奖时间：2016.7。本人排名：第一。


科研项目（近五年）

江苏省自然科学基金社会发展项目：癫痫类药物治疗药物监测技术的构建及其在个体化治疗中的应用。项目编号：BE**。项目起止时间：2019.7~2022.6。项目经费：50万元。本人角色：项目主持人。
江苏省自然科学基金面上项目：抗癫痫药物HS-SPE/GC-MS分析方法的构建及其在临床血药浓度监测中的应用。项目编号：BK**。项目起止时间：2018.7~2021.6。项目经费：10万元。本人角色：项目主持人。
徐州市自然科学基金：石墨烯量子点/分子印迹聚合物复合膜的构建及其在卡马西平/奥卡西平精准药物治疗中的应用。项目编号：KC17187。项目起止时间：2017.9~2020.8。项目经费：5万元。本人角色：项目主持人。
江苏省高校自然科学基金重大项目：细胞动态代谢组学探寻糖尿病肾病形成过程的生物标志物。项目编号：16KJA350001。项目起止时间：2016.9~2019.8。项目经费：30万元。本人角色：项目主持人。


论文情况（近五年）

Ji S*, Wang YJ, Shao X, Zhu CC, Lin Y, Gao SK, Tang DQ*. Extraction and purification of triterpenoid saponins from licorice by ionic liquid based extraction combined with in situ alkaline aqueous biphasic systems. Sep Purif Technol. 2020; 247:116953.
Zhang L, Wang CX, Wu J, Wang TY, Zhong QQ, Du Y, Ji S, Wang L, Guo MZ, Xu SQ, Tang DQ*. Metabolic profiling of mice plasma, bile, urine and feces after oral administration of two licorice flavonones. J Ethnopharmacol. 2020; 257:112892.
Guo M, Du W, Lyu N, Chen X, Du Y, Wang H, Yang D, Wu S, Liang J, Pan Y, Tang D*. Ultra-Early Diagnosis of Acute Myocardial Infarction in Rats Using Ultrasound Imaging of Hollow Double-Layer Silica Nanospheres. Adv Healthc Mater. 2020 Feb; 9(3):e**.
Ji S#, Wang YJ#, Gao SK, Shao X, Cui W, Du Y, Guo MZ, Tang DQ*. Highly efficient and selective extraction of minor bioactive natural products using pure ionic liquids: Application to prenylated flavonoids in licorice. J Ind Eng Chem. 2019; 80:352-360.
Wang L#, Du Y#, Xu BJ#, Deng X, Liu QH, Zhong QQ, Wang CX, Ji S, Guo MZ, Tang DQ*. Metabolomics study of metabolic changes in renal cells in response to high-glucose exposure based on liquid or gas chromatography coupled with mass spectrometry. Front Pharmacol. 2019 Aug 20; 10:928.
Wang L#, Liu Q#, Tan X, Wang Z, Wang M, Wise MJ, Li C, Ma C, Li E, Deng B, Du Y, Tang D*, Gilbert RG*. Molecular Structure of Glycogen in Escherichia coli. Biomacromolecules. 2019 Jul 8; 20(7):2821-2829.
Ji S#, Shao X#, Su ZY, Ji L, Wang YJ, Ma YS, Zhao L, Du Y, Guo MZ, Tang DQ*. Segmented scan modes and polarity-based LC-MS for pharmacokinetic interaction study between Fufang Danshen Dripping Pill and Clopidogrel Bisulfate Tablet. J Pharm Biomed Anal. 2019 May 30; 174:367-375.
Guo MZ, Shao L, Chen X, Li HJ, Wang L, Pan YJ, Tang DQ*. Assay of dried blood spot from finger prick for sodium valproate via ink auxiliary headspace gas chromatography mass spectrometry. J Chromatogr A. 2019 Sep 13; 1601:335-339.
Yao Y, Zhao D, Li N, Shen F, Machuki JO, Yang D, Li J, Tang D*, Yu Y, Tian J, Dong H, Gao F*. Multifunctional Fe₃O₄@Polydopamine@DNA-Fueled Molecular Machine for Magnetically Targeted Intracellular Zn²⁺ Imaging and Fluorescence/MRI Guided Photodynamic-Photothermal Therapy. Anal Chem. 2019 Jun 18; 91(12):7850-7857.
Qiu J#, Chen W#, Zhang Y, Zhou Q, Chen J, Yang L, Gao J*, Gu X*, Tang D*. Assessment of quinazolinone derivatives as novel non-nucleoside hepatitis B virus inhibitors. Eur J Med Chem. 2019 Aug 15; 176:41-49.
Guo M, Shao L, Du Y, Qian Z, Huang T, Tang D*. Microporous polymer based on the new compound "bi-(4-vinyl phenylquinoline) amide" for enrichment and quantitative determination of lamotrigine in rat and human serum. Anal Bioanal Chem. 2019 Jun; 411(15):3353-3360.
Yao Y, Li N, Zhang X, Ong'achwa Machuki J, Yang D, Yu Y, Li J, Tang D*, Tian J, Gao F*. DNA-Templated Silver Nanocluster/Porphyrin/MnO₂ Platform for Label-Free Intracellular Zn²⁺ Imaging and Fluorescence-/Magnetic Resonance Imaging-Guided Photodynamic Therapy. ACS Appl Mater Interfaces. 2019 Apr 17; 11(15):13991-14003.
Yu Y#, Yin T#, Peng Q, Kong L, Li C, Tang D*, Yin X*. Simultaneous Monitoring of Amyloid-β (Aβ) Oligomers and Fibrils for Effectively Evaluating the Dynamic Process of Aβ Aggregation. ACS Sens. 2019; 4(2):471-478.
Ji S #, He DD #, Su ZY, Du Y, Wang YJ, Gao SK, Guo MZ, Tang DQ*. P450 enzymes-based metabolic interactions between monarch drugs and the other constituent herbs: A strategy to explore compatibility mechanism of Sangju-Yin. Phytomedicine. 2019; 58:152866.
Guo MZ, Wang TY, Yang J, Chang H, Ji S, Tang DQ*. Interaction of clopidogrel and fufang danshen dripping pills assay in coronary heart disease based on non-target metabolomics. J Ethnopharmacol. 2019; 234:189-196.
Zheng XX #, Du Y #, Xu BJ #, Wang TY, Zhong QQ, Li Z, Ji S, Guo MZ, Yang DZ, Tang DQ*. Off-line two-dimensional liquid chromatography coupled with diode array detection and quadrupole-time of flight mass spectrometry for the biotransformation kinetics of Ginkgo biloba leaves extract by diabetic rat liver microsomes. J Chromatogr B. 2019; 1109:1-9.
Du Y^#, Xu BJ^#, Deng X, Wu XW, Li YJ, Wang SR, Wang YN, Ji S, Guo MZ, Yang DZ, Tang DQ*. Predictive metabolic signatures for the occurrence and development of diabetic nephropathy and the intervention of Ginkgo biloba leaves extract based on gas or liquid chromatography with mass spectrometry. J Pharm Biomed Anal. 2019, 166:30-39.
Asenso J#, Wang L#, Du Y, Liu QH, Xu BJ, Guo MZ, Tang DQ*. Advances in detection and quantification of methylcytosine and its derivatives. J Sep Sci. 2019 Mar; 42(5):1105-1116.
Guo M, Liu D, Sha Q, Geng H, Liang J*, Tang D*. Succinic acid enhanced quantitative determination of blood modified nucleosides in the development of diabetic nephropathy based on hydrophilic interaction liquid chromatography mass spectrometry. J Pharm Biomed Anal. 2019; 164:309-316.
Wu J, Li N, Yao Y, Tang D*, Yang D, Ong'achwa Machuki J, Li J, Yu Y, Gao F*. DNA-Stabilized Silver Nanoclusters for Label-Free Fluorescence Imaging of Cell Surface Glycans and Fluorescence Guided Photothermal Therapy. Anal Chem. 2018; 90(24):14368-14375.
Yu Y, Yang Y, Wang F, Ding J, Meng S, Li C, Tang D*, Yin X**. Functional and biocompatible polymeric ionic liquid (PIL) - Decorated immunomagnetic nanospheres for the efficient capture of rare number CTCs. Anal Chim Acta. 2018; 1044:162-173.
Ji S, Wang YJ, Su ZY, He DD, Du Y, Guo MZ, Yang DZ, Tang DQ*. Ionic liquids-ultrasound based efficient extraction of flavonoid glycosides and triterpenoid saponins from licorice. RSC Adv. 2018; 8(25): 13989-13996.
Ji S, Liu ZZ, Wu J, Du Y, Su ZY, Wang TY, Han J, Yang DZ, Guo MZ, Tang DQ*. Chemical profiling and comparison of Sangju Ganmao tablet and its component herbs using two-dimensional liquid chromatography to explore compatibility mechanism of herbs. Front Pharmacol. 2018; 9:1167.
Gao F, Yao Y , Wu J , Cui L , Zhang Y , Geng D , Tang D*, Yu Y . A robust fluorescent probe for detection of telomerase activity in vitro and imaging in living cells via telomerase-triggering primer extension to desorb DNA from graphene oxide. Analyst. 2018; 143(15):3651-3660.
Gao FL, Wu J, Yao Y, Zhang Y, Liao XJ, Geng DQ, Tang DQ*. Proximity hybridization triggered strand displacement and DNAzyme assisted strand recycling for ATP fluorescence detection in vitro and imaging in living cells. RSC Adv. 2018; 8(49):28161-28171.
Guo MZ, Zhang LY, Du Y, Du WC, Liu DT, Guo C, Pan YJ, Tang DQ*. Enrichment and quantitative determination of 5-(hydroxymethyl)-2'-deoxycytidine, 5-(formyl)-2'-deoxycytidine, and 5-(carboxyl)-2'-deoxycytidine in human urine of breast cancer by magnetic high-cross-linked microporous polymers based on poly-ionic liquid. Anal Chem. 2018; 90(6):3906-3913.
Qiu J, Gong Q, Gao J, Chen W, Zhang Y, Gu X, Tang D*. Design, synthesis and evaluation of novel phenyl propionamide derivatives as non-nucleoside hepatitis B virus inhibitors. Eur J Med Chem. 2018; 144:424-434.
Ji S, He DD, Wang TY, Han J, Li Z, Du Y, Zou JH, Guo MZ, Tang DQ*. Separation and characterization of chemical constituents in Ginkgo biloba extract by off-line hydrophilic interaction×reversed-phase two-dimensional liquid chromatography coupled with quadrupole-time of flight mass spectrometry. J Pharm Biomed Anal. 2017; 146:68-78.
Guo M, Li X, Zhang L, Liu D, Du W, Yin D, Lyu N, Zhao G, Guo C, Tang D*. Accurate quantification of 5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine in genomic DNA from breast cancer by chemical derivatization coupled with ultra performance liquid chromatography- electrospray quadrupole time of flight mass spectrometry analysis. Oncotarget. 2017; 8(53):91248-91257.
Shen WW, Zhang HX, Qiu SB, Wei YJ, Zhu FX, Wang J, Wang DD, Jia XB, Tang DQ*, Chen B**. Biotransformation of ginsenosides F4 and Rg6 in zebrafish. J Asian Nat Prod Res. 2018; 20(7):686-696.
Guo MZ, Han J, He DD, Zou JH, Li Z, Du Y, Tang DQ*. Optimization and assessment of three different high performance liquid chromatographic systems for the combinative fingerprint analysis and multi-ingredients quantification of Sangju Ganmao tablet. J Chromatogr Sci. 2017; 55(3):334-345.
Guo M, Yin D, Han J, Guo C, Li X, Zhang L, Du Y, Wang H, Tang D*. Investigation of the formation of [2(iohexol) + Mg]²⁺ complex and its fragmentation in ESI tandem mass spectrometry. Rapid Commun Mass Spectrom. 2017; 31(1):9-15.
Du Y, Li YJ, Hu XX, Deng X, Qian ZT, Li Z, Guo MZ, Tang DQ*. Development and evaluation of a HILIC-MS/MS method to quantify 19 nucleobases and nucleosides in rat plasma. Biomed Chromatogr. 2017; 31(4):e3860.
Yu Y, Yu C, Yin T, Ou S, Sun X, Wen X, Zhang L, Tang D*, Yin X**. Functionalized poly (ionic liquid) as the support to construct a ratiometric electrochemical biosensor for the selective determination of copper ions in AD rats. Biosens Bioelectron. 2017; 87:278-284.
Guo M, Yin D, Han J, Zhang L, Li X, He D, Du Y, Tang D*. Phenylboronic acid modified solid-phase extraction column: Preparation, characterization and application to the analysis of amino acids in sepia capsule by removing the maltose. J Sep Sci. 2016; 39(17):3428-3435.
Gao F^#, Du L^#, Zhang Y^#, Zhou F, Tang D*. A sensitive sandwich-type electrochemical aptasensor for thrombin detection based on platinum nanoparticles decorated carbon nanocages as signal labels. Biosens Bioelectron. 2016; 86:185-193.
Li Z¹, Han J¹, Sun SA, Chen K, Tang DQ*. Hydrophilic interaction liquid chromatography/mass spectrometry: An attractive and prospective method for the quantitative bioanalysis in drug metabolism. Curr Drug Metab. 2016; 17(4):386-400.
Li Z, Chen K, Guo MZ*, Tang DQ**. Two-dimensional liquid chromatography and its application in traditional Chinese medicine analysis and metabonomic investigation. J Sep Sci. 2016, 39(1):21-37.
Tang DQ*, Zou L, Yin XX, Ong CN. HILIC-MS for metabolomics: an attractive and complementary approach to RPLC-MS. Mass Spectrometry Reviews. 2016; 35(5):574-600.
Guo MZ, Weng GF, Yin DY, Hu XX, Han J, Du Y, Liu YQ, Tang DQ*, Pan YJ**. Identification of the over alkylation sites of a protein by IAM in MALDI-TOF/TOF tandem mass spectrometry. RSC Adv. 2015; 5(125):103662-103668.
Du LL^#, Zhang Y^#, Du Y, Yang DZ, Gao FL*, Tang DQ*. A novel label-free aptasensor based on target-induced structure switching of aptamer-functionalized mesoporous silica nanoparticles. RSC Adv. 2015; 5(122): 100960-100967.
Chen H¹, Li Z¹, Li YJ, Wu XW, Wang SR, Chen K, Zheng XX, Du Q, Tang DQ*. Simultaneous determination of baicalin, oroxylin A-7-O-glucuronide and wogonoside in rat plasma by UPLC-DAD and its application in pharmacokinetics of pure baicalin, Radix Scutellariae and Yinhuang granule. Biomed Chromatogr. 2015; 29(12):1819-1825.
Li Y^#, Li YJ^#, Li Z, Qiu JY, Zheng XX, Bian TT, Gao FL, Yu YY, Yang DZ, Tang DQ*. Screening for Potential Bioactive Components in Ginkgo Biloba Extract by the Rat Renal Tubular Epithelial Cell Extraction and LC-MS/MS. Comb Chem High Throughput Screen. 2015; 18(5):514-523.
Li YJ^#, Li Z^#, Zheng XX^#, Wu XW, Wang SR, Guo H, Yu YY, Guo MZ, Yan DZ, Tang DQ*. Evaluation of sample preparation and chromatographic separation for the parallel determination of taurine and edaravone in rat tissues using HILIC-MS/MS. Anal Bioanal Chem. 2015; 407(14): 4143-4153.
Qiu JY¹, Chen X¹, Li Z, Wang SR, Wu XW, Li YJ, Yang DZ, Yu YY, Yin XX, Tang DQ*. LC-MS/MS method for the simultaneous quantification of 11 compounds of Ginkgo Biloba extract in lysates of mesangial cell cultured by high glucose. J Chromatogr B. 2015; 997:122-128.
Guo M, Zhai Y, Guo C, Liu Y, Tang D*, Pan Y*. A new strategy to determine the protein mutation site using matrix-assisted laser desorption ionization in-source decay: Derivatization by ionic liquid. Anal Chim Acta. 2015; 865:31-38.
Tang DQ*, Li YJ, Li Z, Bian TT, Chen K, Zheng XX, Yu YY, Jiang SS. Study on the interaction of plasma protein binding rate between edaravone and taurine in human plasma based on HPLC analysis coupled with ultrafiltration technique. Biomed Chromatogr. 2015; 29(8):1137-1145.
Yang DZ, Li Y, Yang FX, Du Y, Li YJ, Zheng XX, Tang DQ*. High performance liquid chromatographic columns packing with different particle size: chromatographic behavior for quality analysis of Huanglian Shangqing pill. J Sep Sci. 2015; 38(3):381-389.
Qiu JY^#, Chen X^#, Zheng XX, Jiang XL, Yang DZ, Yu YY, Du Q, Tang DQ *, Yin XX. Target cell extraction coupled with LC-MS/MS analysis for screening potential bioactive components in Ginkgo biloba extract with preventive effects against diabetic nephropathy. Biomed Chromatogr. 2015; 29(2):226-232.


指导研究生情况(近五年)
近5年累计指导全日制研究生42人，其中毕业32人，在读10人。

主讲课程（近五年）
近5年，主讲的研究生课程有：药学概论、药物色谱分析、中药分析选论、天然产物分离技术等

知识产权（近五年）
[1] 一种从厚朴中提取、分离纯化和厚朴酚及厚朴酚的方法。汤道权、孙世安、纪海侠、杨方秀、董露露、栗政。专利号：ZL2.4
[2] 一种治疗心脑血管疾病的中药复方及其制备方法。汤道权、江相兰、郑笑笑。专利号：ZL8.5

著作教材（近五年）
1. 《药物分析》，编委，2016年，科学出版社。
2. 《药物分析》，编委，2017年，高等医药出版社。




发表论文:
Molecular Structure of Glycogen in Escherichia coli.

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Segmented scan modes and polarity-based LC-MS for pharmacokinetic interaction study between Fufang Danshen Dripping Pill and Clopidogrel Bisulfate Tablet.

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Development and evaluation of a HILIC-MS/MS method to quantify 19 nucleobases and nucleosides in rat plasma

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Functionalized poly (ionic liquid) as the support to construct a ratiometric electrochemical biosensor for the selective determination of copper ions in AD rats

---

HILIC-MS for metabolomics: an attractive and complementary approach to RPLC-MS.

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Optimization and assessment of three different high performance liquid chromatographic systems for the combinative fingerprint analysis and multi-ingredients quantification of Sangju Ganmao tablet

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Investigation of the formation of [2(iohexol) + Mg]2+ complex and its fragmentation in ESI tandem mass spectrometry

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Phenylboronic acid modified solid-phase extraction column: Preparation, characterization and application to the analysis of amino acids in sepia capsule by removing the maltose

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A sensitive sandwich-type electrochemical aptasensor for thrombin detection based on platinum nanoparticles decorated carbon nanocages as signal labels

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Hydrophilic interaction liquid chromatography/mass spectrometry: An attractive and prospective method for the quantitative bioanalysis in drug metabolism.
教材专著:
药物分析

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药物分析

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治疗药物监测与个体化给药

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药物分析
科研项目:
基于体内动态过程的银杏叶提取物

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银杏叶提取物防治糖尿病肾病的药

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基于体内动态过程的银杏叶提取物

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抗癫痫药物HS-SPE/GC-MS分析方法

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细胞动态代谢组学探寻糖尿病肾病

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癫痫类药物治疗监测技术的构建及

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石墨烯量子点/分子印迹聚合物复
获奖成果:
体内外复杂体系中几类成分分析方

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中药色谱指纹图谱结合多组分定量

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8种中成药质控模式的建立及其在

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基于HPLC-DAD-MS/MS的银黄制剂质

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基于体内动态过程的银杏叶提取物

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银杏叶提取物防治糖尿病肾病的药

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基于指纹图谱结合多组分定量的双

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医药兼备的临床药学人才培养模式

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HPLC-DAD法化学指纹图谱结合多组

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银杏叶提取物防治糖尿病肾病物质