郭梦喆
硕士生导师

职称：副教授
**

学院：药学院
guomengzhe@xzhmu.edu.cn







个人简介
郭梦喆，理学博士，徐州医学院副教授。2009年6月于浙江大学生命科学学院本科毕业后，保送进入浙江大学生命科学学院吴世华副教授课题组从事天然药物色谱分析技术开发等相关研究工作。并于2012年进入浙江大学化学系潘远江教授课题组攻读博士学位（硕博连读）。研究课题为多肽、蛋白质等生物大分子的质谱行为研究。尤其擅长运用电喷雾、基质辅助激光解吸质谱技术研究生物大分子的裂解反应机理以及利用衍生化等手段开发其高效质谱分析方法。
参加工作后主要从事疾病生物标志物探寻以及相关机制研究。利用液质联用等手段，并自主开发富集、分析材料对糖尿病肾病、肿瘤等疾病中核苷类小分子进行富集分析，并通过分子生物学手段进一步探索核苷小分子作为潜在生物标志物在疾病发生、发展中起到的机制。参加工作以来以第一作者或通讯作者发表SCI论文17篇，其中影响因子大于5，4篇；影响因子大于3，11篇。获得国家自然科学基金一项，江苏省自然科学基金一项，徐州市科技项目两项，中国博士后特别资助、面上项目各一项。省教育厅科学技术研究三等奖一项，排名第三；淮海科技一等奖一项，排名第二。培养硕士研究生8名。






发表论文:
Enrichment and Quantitative Determination of Free 3,5- Diiodothyronine, 3',5'-Diiodothyronine, and 3,5-Diiodothyronamine in Human Serum of Thyroid Cancer by Covalent Organic Hyper Cross-linked Poly-ionic Liquid

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Multi-Omics Analysis of Diabetic Nephropathy Reveals Potential New Mechanisms and Drug Targets

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A Risk Prediction Model for Evaluating the Disease Progression of COVID-19 Pneumonia

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Ultra-Early Diagnosis of Acute Myocardial Infarction in Rats using Ultrasound Imaging of Hollow Double-Layer Silica Nanospheres

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Interaction of Clopidogrel and Fufang Danshen Dripping Pills Assay in Coronary Heart Disease based on Non-target Metabolomics

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Assay of dried blood spot from finger prick for sodium valproate via ink auxiliary headspace gas chromatography mass spectrometry

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Microporous Polymer Based on New Compound “bi-(4-vinyl phenylquinoline) amide” for Enrichment and Quantitative Determination of Lamotrigine in Rat and Human Serum

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Succinic acid enhanced quantitative determination of blood modified nucleosides in the development of diabetic nephropathy based on hydrophilic interaction liquid chromatography mass spectrometry

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Enrichment and Quantitative Determination of 5-(Formyl)-2’-deoxycytidine, 5-(Hydroxymethyl)-2’-deoxycytidine, 5-(Carboxyl)-2’-deoxycytidine in Human Urine of Breast Cancer Patients by Magnetic Hype

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Accurate Quantification of 5-Methylcytosine, 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxylcytosine in Genomic DNA from Breast Cancer by Chemical Derivatization Coupled with Ultra Performan
教材专著:

科研项目:
咪唑类离子液衍生化DNA的质谱碎

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基于液质联用技术的糖尿病肾病中

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基于碳纳米材料的靶向性超声造影

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糖尿病肾病发病中α-KG调控DNA甲
获奖成果:
淮海科技一等奖

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江苏省高校自然科学三等奖