姓名：韩京
系所：制药工程
职称：副教授（硕士生导师）
学科专业：药学
E-mail: hj**@jsnu.edu.cn
个人简介：
韩京，副教授，理学博士（药物化学）。近年来主要从事小分子和多肽类药物的设计、合成及生物活性研究，抗糖尿病及肥胖领域的新药筛选，以及药用新材料的设计等。近几年主持和完成国家自然科学基金、江苏省自然科学基金等各类纵向科研项目9项，主持校企合作产学研项目2项，在药学及化学领域顶尖期刊Chem. Sci.,J. Med. Chem.,Euro. J. Med. Chem.,Chem. Commun.,Brit. J. Pharmacol., Biochem. Pharmacol.等发表SCI论文40余篇，其中以第一作者及/或通讯作者身份发表论文27篇，授权发明专利2项。现为J. Med. Chem., Euro. J. Med. Chem., Chem. Commun., Biochem. Pharmacol.等权威刊物特约审稿人，聊城大学学报青年编委。
研究领域：
1. 新药分子的设计与合成
2. 多肽类药物的设计、合成及生物活性研究
3. 抗糖尿病、肥胖及非酒精性脂肪肝病/炎多肽类新药研发
教育背景：
2004.09-2008.06 中国药科大学药学院制药工程专业学士
2008.09-2013.06 中国药科大学药学院药物化学专业博士（硕博连读）
社会兼职
江苏省双创计划“科技副总”（江苏万邦医药科技有限公司）
科研项目：
1. 国家自然科学基金，具有降糖和减肥双重作用的新型多肽的设计、合成及生物活性研究，编号：**，批准经费：23万，2017.01-2019.12，项目负责人
2. 江苏省自然科学基金，新型降糖多肽及其纳米缓释制剂的设计、合成生物活性研究，编号：BK**，批准经费：20万，2015.07-2018.06，项目负责人
3. 产学研合作项目，GLP-1/GIP受体双重激动剂开发，编号：HX**，批准经费：64万，2021.01-2022.07，项目负责人
4. 江苏省高校自然科学研究面上项目，长效化胰高血糖素样肽-1衍生物的合成及生物活性研究，编号：14KJB350003，批准经费：5万，2014.08-2016.12，项目负责人
5. 徐州市重点研发计划（社会发展项目），具有GLP-1和CCK-1受体双重激动活性的新型多肽的构建及其在2型糖尿病和肥胖治疗中的应用，编号：KC19154，批准经费：5万，2019.08-2021.07，项目负责人
6. 广西重点实验室运行补助项目计划，新型荜茇酰胺衍生物的设计、合成和抗肿瘤活性研究，编号：GKE-KF202006，批准经费：7万，2020.10-2022.09，项目负责人
7. 中央引导地方科技发展专项（自由探索类基础研究）项目，壮药天等指椒活性成分结构修饰-多靶点活性-成药性的系统性研究，编号：GKE-KF202006，批准经费：9万，2020.09-2023.09，项目子课题负责人
8. 产学研合作项目，多肽的固相合成及化学修饰，编号：HX**，批准经费：6.8万，2020.10-2021.04，项目负责人
9. 江苏师范大学博士教师科研启动经费，长效化胰高血糖素样肽-1衍生物的合成及生物活性研究，编号：14XLR001，批准经费：20万，2015.01-2017.01，项目负责人
10.江苏省新药与临床药学重点实验室，新型降糖多肽GLP-1类似物的设计、合成及生物活性研究，批准经费：5万，2015.01-2016.12，项目负责人
11. 糖化学与生物技术教育部重点实验室，具有GLP-1和CCK-1受体双重激动活性的新型糖基化改构多肽的构建及其生物活性研究，批准经费：3万，2020.06-2022.06，项目负责人
代表性论文：
1. Neng Jiang¹, Lin Jing¹, Qing Li¹, Sibiao Su, Qimeng Yang, Feng Zhou, Xinyu Chen, Jing Han^*, Chunli Tang^***, Weizhong Tang^**. Design of novel Xenopus GLP-1-based dual glucagon-like peptide 1 (GLP-1)/glucagon receptor agonists. European Journal of Medicinal Chemistry, 2021, 212, 113118.
2. Xinyu Chen^#Junjie Fu^#Feng Zhou^#Qimeng Yang, Jialing Wang, Hui Feng, Wen Jiang, Luofan Jin, Xuelin Tang, Neng Jiang,^*Jian Yin,^*Jing Han^*.Journal of Medicinal Chemistry, 2020, 63, 12595-12613.
3. Jing Han¹, Junjie Fu¹, Qimeng Yang, Feng Zhou, Xinyu Chen, Chenglin Li, Jian Yin^*. Rational design and biological evaluation of gemfibrozil modified Xenopus GLP-1 derivatives as long-acting hypoglycemic agents. European Journal of Medicinal Chemistry, 2020, 198, 112389.
4. Tingting Meng¹, Jing Han¹, Pengfei Zhang, Jing Hu, Junjie Fu^*, Jian Yin^*. Introduction of the a-ketoamide structure: en route to develop hydrogen peroxide responsive Prodrugs. Chemical Science, 2019, 10, 7156.
5. Junjie Fu¹,Jing Han¹,Tingting Meng,Jing Hu,Jian Yin^*. Novel α-ketoamide based diazeniumdiolates as hydrogen peroxide responsive nitric oxide donors with anti-lung cancer activity. Chemical Communications,2019,55, 12904-12907.
6. Jing Han, Tingting Meng, Xinyu Chen, Yue Han, Junjie Fu,^*Feng Zhou, Yingying Fei, Chenglin Li^*. The chronic administration of two novel long-acting Xenopus glucagon-like peptide-1 analogues xGLP159 and xGLP296 potently improved systemic metabolism and glycemic control in rodent models. FASEB Journal, 2019, 33, 7113-7125.
7. Jing Han^*, Yue Huang, Xinyu Chen, Feng Zhou, Yingying Fei, Junjie Fu. Rational design of dimeric lipidated Xenopus glucagon-like peptide 1analogues as long-acting antihyperglycaemic agents. European Journal of Medicinal Chemistry, 2018, 157, 177-187.
8. Jing Han^*, Yingying Fei, Feng Zhou, Xinyu Chen, Ying Zhang, Lin Liu, Junjie Fu^*. Xenopus GLP-1 derived and PEGylated GLP-1 receptor agonists: long-acting hypoglycemic and insulinotropic activities with potential therapeutic utilities. British Journal of Pharmacology, 2018, 175, 544-557.
9. Jing Han^*, Feng Zhou, Yingying Fei, Xinyu Chen, Junjie Fu^*, Hai Qian^*. Preparation and pharmaceutical characterizations of lipidated dimeric Xenopus glucagon-like peptide-1 conjugates. Bioconjugate Chemistry, 2018, 29, 390-402.
10. Jing Han^*, Xinyu Chen, Liming Zhao, Junjie Fu^*, Lidan Sun^*, Ying Zhang, Feng Zhou, Yingying Fei. Lithocholic acid-based peptide delivery system for an enhanced pharmacological and pharmacokinetic profile of Xenopus GLP-1 analogs. Molecular Pharmaceutics, 2018, 15, 2840-2856.
11. Jing Han^*, Yue Huang, Xinyu Chen, Feng Zhou, Yingying Fei, Junjie Fu. Lipidation and conformational constraining for prolonging the effects of peptides: Xenopus glucagon-like peptide 1 analogues with potent and long-acting hypoglycemic activity. European Journal of Pharmaceutical Sciences, 2018, 123, 111-123.
12. Jing Han^*, Yiyun Wang, Qinghua Meng, Guangchao Li, Fangmin Huang, Su Wu, Yingying Fei, Feng Zhou, Junjie Fu^*. Design, synthesis and biological evaluation of PEGylated Xenopus glucagon-like peptide-1 derivatives as long-acting hypoglycemic agents. European Journal of Medicinal Chemistry, 2017, 132, 81-89.
13. Jing Han^*, Xinyu Chen, Yiyun Wang, Yingying Fei, Feng Zhou, Ying Zhang, Lin Liu, Pengbin Si, Junjie Fu^*. Xenopus GLP-1-inspired discovery of novel GLP-1 receptor agonists as long-acting hypoglycemic and insulinotropic agents with significant therapeutic potential. Biochemical Pharmacology, 2017, 142, 155-167.
14. Jing Han^*, Yingying Fei, Feng Zhou, Xinyu Chen, Weiwei Zheng, Junjie Fu^*. Micellar nanomedicine of novel fatty acid modified Xenopus glucagon-like peptide-1: improved physicochemical characteristics and therapeutic utilities for type 2 diabetes. Molecular Pharmaceutics, 2017, 14, 3954-3967.
15. Jing Han¹, Lidan Sun¹, Yingying Chu, Zheng Li, Dandan Huang, Xiaoyun Zhu, Hai Qian^*, Wenlong Huang^*. Design, Synthesis, and Biological Activity of Novel Dicoumarol Glucagon-like Peptide-1 Conjugates. Journal of Medicinal Chemistry, 2013, 56, 9955-9968.
16. Jing Han¹, Lidan Sun¹, Xun Huang¹, Zheng Li, Chenyu Zhang, Hai Qian^*, Wenlong Huang^*. Novel coumarin modified GLP-1 derivatives with enhanced plasma stability and prolonged in vivo glucose-lowering ability. British Journal of Pharmacology, 2014, 171, 5252-5264.
授权发明专利：
1. 韩京，傅俊杰，崔旭，费颖颖，周凤，张莹，司鹏斌，胡月，卫婷，一种新型非洲爪蟾胰高血糖素样肽-1（GLP-1）缀合肽及其应用，发明专利，授权时间：2019.12.03，专利号：ZL6.0
2. 黄文龙，钱海，韩京，倪帅健，陈巍，赵鑫鑫，杨宝卫，朱孝云，胰高血糖素样肽-1(GLP-1)类似物及其应用，发明专利，授权时间：2014.06，专利号：ZL0.5