胡磊，湖南津市人，博士，教授，硕士研究生导师。
研究方向
以动态组合化学为指导的酶抑制剂研发
酶催化生物活性分子不对称合成
动态乳化剂研发

招收药物化学研究方向的学术型研究生以及生物与医药（制药工程）专业学位研究生，欢迎具有制药工程、药学、化学、生物等相关学习背景的同学报考。

联系方式
办公室：药学楼2413室
实验室：药学楼2404室
微信：**
Email：leihu@ujs.edu.cn

教育背景：
2010.10至2014.10 瑞典皇家工学院 (KTH-Royal Institute of Technology) 有机化学博士
2007.09至2010.06 暨南大学药学院 药物化学专业硕士
2003.09至2007.06 湖南师范大学 制药工程专业学士

工作经历：
2017.04至今 江苏大学药学院 教授
2014.12至2016.08 美国俄亥俄州立大学化学系 博士后研究员
代表性科研成果：
Zhang, S., Li, Y., Han, M., Wu, Y., Hu, L.*, Comparative Study of Surface-active and Biological Properties of Lactose-derived Acylhydrazones. J. Mol. Liq., DOI: 10.1016/j.molliq.2020.114989
Zhao, S., Xu, J., Zhang, S., Han, M., Wu, Y., Li, Y., Hu, L.*, Multivalent Butyrylcholinesterase Inhibitor Discovered by Exploiting Dynamic Combinatorial Chemistry. Bioorg. Chem., accepted.
Zhao, S., Zhang, S., Xu, J., Hu, L.*, Synthesis and comparative study of emulsifying and biological properties of triazolated glucolipids. Tetrahedron, 2020, 76, 131517.
Xu, J.¹, Zhao, S.¹, Zhang, S., Hu, L.*, Development of a multivalent acetylcholinesterase inhibitor via dynamic combinatorial chemistry. Int. J. Biol. Macromol., 2020, 150, 1184.
Xu, J., Zhao, S., Zhang, S., Hu, L.*, Identification and synthesis of an efficient multivalent E. coli heat labile toxin inhibitor - A dynamic combinatorial chemistry approach. Bioorgan. Med. Chem., 2020, 28, 115436.
Xu, J., Hu, L.*, Asymmetric One-pot Synthesis of Five- and Six-membered Lactones viaDynamic Covalent Kinetic Resolution: Exploring the Regio- and Stereoselectivities of Lipase. Tetrahedron Lett., 2019, 60, 868.
Ren, Y., Hu, L., Ramstr?m, O.*, Multienzymatic Cascade Synthesis of an Enantiopure (2R,5R)-1,3-Oxathiolane anti-HIV Agent Precursor. Mol. Catal., 2019, 468, 52.
Pratumyot, Y.; Chen, S.; Hu, L.; Polen, M. S.; Hadad, M. C.; Badjic?, D. B. Assembly and folding of twisted baskets in organic solvents, Org. Lett., 2016, 18, 4238.

Hu, L.; Polen, S.; Hardin, A.; Pratumyot, Y.; Hadad, C.; Badji?, J. On the Transfer of Chirality, Thermodynamic Stability, and Folding Characteristics of Stereoisomeric Gated Baskets. Eur. J. Org. Chem., 2015, 31, 6832.


Hu, L.; Zhang, Y.; Ramstr?m, O. Gelation-driven Dynamic Systemic Resolution: in situ Generation and Self-Selection of an Organogelator. Sci. Rep., 2015, 5, 11065.
Hu, L.; Ren, Y., Ramstr?m, O. Chirality Control in Enzyme-Catalyzed Dynamic Kinetic Resolution of 1,3-Oxathiolanes. J. Org. Chem., 2015, 80, 8478.
Schaufelberger, F.; Hu, L.; Ramstr?m, O. trans-Symmetric Dynamic Covalent Systems: Connected Transamination and Transimination Reactions. Chem. Eur. J., 2015, 21, 9776.

Hu, L.; Ramstr?m, O. Silver-catalyzed dynamic systemic resolution of α-iminonitriles in a 1,3-dipolar cycloaddition process. Chem. Commun., 2014, 50, 3792.
Hu, L.; Zhang, Y.; Ramstr?m, O. Lipase-catalyzed asymmetric synthesis of oxathiazinanones through dynamic covalent kinetic resolution. Org. Biomol. Chem., 2014, 12, 3572.
Hu, L.; Schaufelberger, F.; Timmer, B. J. J.; Abellán Flos, M.; Ramstr?m, O. Dynamic constitutional chemistry. In: Kirk-Othmer Encyclopedia of Chemical Technology., John Wiley & Sons, Inc., 2014. DOI: 10.1002/.consrams.a01
Zhang, Y.; Hu, L.; Ramstr?m, O. Constitutional dynamic chemistry for Bioactive Compounds. In: Supramolecular systems in biomedical fields. (Ed.: H.-J. Schneider) RSC, UK, 2013. （书籍章节）
Hu, L.; Schaufelberger, F.; Zhang, Y.; Ramstr?m, O. Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution. Chem. Comm. 2013, 49, 10376.
Zhang, Y.; Hu, L.; Ramstr?m, O. Double Parallel Dynamic resolution through lipase-catalyzed asymmetric transformation. Chem. Comm. 2013, 49, 1805.
Hu, L; Lan, P; Song, Q; Huang, Z; Sun, P; Zhuo, C; Wang, Y; Xiao, S; Chen, WM. Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides. Eur. J. Med. Chem., 2010, 45, 5943.
Wang, Y-T? ; Hu, L? ; Chen W-M; Hu A-X; Song, Q-L; Guan D. Synthesis and antibacterial activities of (9S)-3-O-descladinose-6-O-methyl-3-oxo-12-(Δ2- pyrazolinyl)-12-dehydroxy-21-demethyl-9-dihydro-erythromycin A. Lett. Org. Chem., 2009，6, 306. ? 共同第一作者



主持项目：
江苏省自然科学基金青年项目 在研
中国博士后面上基金 在研
江苏省日常资助博士后项目 在研
江苏省双创博士项目 在研
江苏省六大人才高峰项目 在研
江苏大学高级人才启动基金 在研



主讲课程
药物化学
波谱解析（留学生）
健康科学导论（留学生）
天然药物化学（留学生）





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