研究专业:药物化学,放射药物化学,新能源材料化学,有机金属化学。
电话:**
邮箱:@ujs.edu.cn or organicboron@ujs.edu.cn
欢迎药物化学,纳米材料,高分子纳米药物,有机化学,有机金属化学,硼化学(BNCT),能源材料,有机发光OLED材料,超水溶性靶向荧光探针及生物医药方向感兴趣的同学加盟。
教育与工作简历:
2017.4-至今, 江苏大学, 药学院, 教授
2014.6-2017.2, 韩国圆光大学, 自然科技学院, 研究教授
2011.10-2016.12, 韩国高丽大学, 博士后(研究教授)
2010.7–2016.10,韩国 Carbotech(株)研究所,技术总监(兼职)
2009.7–2011.10,韩国 OCT(株)医药研究所,科研组长
2006.7–2009.7, 韩国圆光大学, 药物化学, 理学博士
2004.7–2006.6, 韩国圆光大学, 药物化学, 理学硕士
2000.9–2004.6, 延边大学, 药学, 药学学士
研究方向:
1. 治疗癌症及肿瘤药物的合成设计研究:主要包括1)BNCT新型抗癌药物的设计,2)ODS治疗骨质疏松症新型药物研发,3)HIF-1新型抑制抗癌药物的研发.
2. 有机发光材料(Orgainc Light Emitting Diodides, OLED)设计合成与研发:(ETL, HTL, EML and R, G, B dopant materials).
3. BODIPY荧光靶向探针研究:1)构建水溶性动态自主装纳米靶向荧光探针设计,2)表达蛋白靶向探针设计。
4. 石墨烯锂电池分子构建设计及高效太阳能分子设计研究。
代表性论文:
1. Tingyu Shao, Yulin Wang, Fuyan Xiao, Guofan Jin* Strategies of porous network quinolone polymers: A comprehensive evaluation of their biological activity. Dyes and Pigments. 2020. 12. 26.
2. Yulin Wang, Fuyan Xiao, Guofan Jin*. Structural basis of quinolone derivatives, inhibition of type I and II topoisomerases and inquiry into the relevance of bioactivity in odd or even branches with molecular docking study. Journal of Molecular Structure. 2020.12. 11.
3. Jianpeng Hu, Fuyan Xiao, Fan, Jin Guo. Amorphous chalconylurea polymer-doped zirconium metal enhancement of the fluorescence effect applied to cell imaging. Dyes and Pigments. 2020. 12. 16.
4. Jianpeng Hu, Fuyan Xiao, Guofan Jin*. Zirconium doping level modulation combined with chalconylthiourea organic frameworks induced enhancement of luminescence applied to cell imaging. New Journal of Chemistry. 2020. 44. 10689-10696.
5. Fuyan Xiao, Yuling Wang, Tingyu Shao, Guofan Jin*. Acetonitrilated Unsymmetric BODIPYs having glycine fluorescence responsive quenching: Design, synthesis and spectroscopic properties. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2020. 233. 118211.
6. Yuling Wang, Fuyan Xiao, Tingyu Shao, Guofan Jin*. A near-infrared azadipyrromethene dye: Photophysical properties under different acidity conditions. Inorganic Chemistry Communications. 2020. 116. 107942.
7. Guofan Jin,* Fuyan Xiao, Zhenwang Li, Xueyong Qi, Lei Zhao, and Xianyu Sun. Design, Synthesis, and Dual Evaluation of Quinoline and Quinolinium Iodide Salt Derivatives as Potential Anticancer and Antibacterial Agents. ChemMedChem. 2020. 15. 600–609.
8. Guofan Jin*, Zhenwang Li, Fuyan Xiao, Xueyong Qi, Xianyu Sun. Optimization of activity localization of quinoline derivatives: Design, synthesis, and dual evaluation of biological activity for potential antitumor and antibacterial agents. Bioorganic Chemistry. 2020. 99. 103837.
9. Zhixiang Lv, Zhou Wang, Fuyan Xiao and Guofan Jin*. Synthesis and Evaluation of Fenofibric Acid Ester Derivatives: Studies of Different Formulation with Their Bioavailability and Absorption Conditions. J. Braz. Chem. Soc. 2020. 2. 280-287.
10. Zhixiang Lv, Zhou Wang, Fuyan Xiao and Guofan Jin*. Well Defined Rich Electronic Structure: Facile Approach for Nido-Carborane Fused Azaspirodecaniums in Water Solution. J. Braz. Chem. Soc. 2020. 1. 170-174.
11. Dawei He, Fuyan Xiao, Zhou Wang, Aolin He, Ruijiang Liu and Guofan Jin*. Dynamic Hierarchical Self-Assemble Small Molecule Structure Hexabenzocoronene for the High-Performance Anodes Lithium Ion Storage. Nanoscale Research Letters. 2019. 14.6 5.
12. ZhouWang, Ruijiang Liu and Guofan Jin*. Multinitrogen doped small honeycomb structure: investigation of their on SEM and TEM microscopy dynamic hierarchal selfassembles for high performance anodes lithium ion storage. Mater. Res. Express. 2019. 6. 085084.
13. Shasha Li, Zhou Wang, and Guofan Jin*. Well defined double nitrogen doped small molecular nano-graphene structure: Observed their dynamic hierarchical self-assemble unique patterns. Mater. Res. Express. 2019. 9. 1-11.
14. Guofan Jin*, Hyun Seung Ban, Hiroyuki Nakamura and Jong-Dae Lee. o-Carboranylalkoxy-1,3,5-Triazine Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Activity. Molecules. 2018. 23. 2194.
15. Guofan Jin*, Fuyan Xiao and Ruijiang Liu. Synthesis and biological evaluation of a new series of ortho-carboranyl biphenyloxime derivatives. Chemistry Central Journal. 2018. 12. 76.
授权国内外专利
1. Guofan Jin; Yoon, Ji Ho; Park, HyeonGyu; Jung, YeongJu; Kim, SeonHui; Kang, Sang Uk; Yoo, Ho Seong; Lee, Jong Dae; Lee, Chae Ho. Synthesis of 1,3,5-triazin-4-yl-dicarba-closo-dodecaborane derivative for use in anticancer agent for boron-neutron capture radiotherapy. KRXXA7 KR A **.
2. Guofan Jin; Yoon, Ji Ho; Jung, YeongJu; Kang, Sang Uk; Lee, Jong Dae; Lee, Chae Ho. 1,3,5-triazinylthiocarborane derivatives, their isomers and pharmaceutically acceptable salts, pharmaceutical composition containing the same and preparation method thereof.KRXXA7 KR A **.
3. 金国范; 金峰; 郑兵; 王凯,一种邻碳硼烷苯酚衍生物及其制备方法和应用.中国, 1 .5.
4. 金国范; 金峰; 王凯; 张艳; 张慧; 李柳斌,一种利用邻苯二甲酰亚胺制备双氟磺酰亚胺锂盐的方法,中国, 2 .4.
5. 金国范; 金峰; 王凯; 张艳; 张慧; 李柳斌. 一种利用芳香甲基叠氮制备双氟磺酰亚胺锂盐的方法,中国, 2 .4.
6. 金峰; 王凯; 金国范; 金英兰,邻碳硼烷衍生物、其制备方法和应用及制备该邻碳硼烷衍生物的中间体,中国, 7 .9.
7. 金国范; 金峰; 王凯, 一种双氟磺酰亚胺锂盐的制备方法.中国,8 .5.
8. 金国范;金峰;王凯;张艳;张慧;李柳斌,一种利用联氨制备双氟磺酰亚胺锂盐的方法,4.7.
9. 金国范;金峰;王凯;张艳;张慧;李柳斌,一种利用羟基氨制备双氟磺酰亚胺锂盐的方法,0.4.