姓名侯永忠
联系方式Email:houyz@ujs.edu.cn
教育背景　
2002-2005.博士，天津大学
1998-2000.硕士，贵州大学
1992-1995.大学，重庆三峡学院研究经历：
2012/9-现在教授.江苏大学生命科学研究院
2007/11-2012/7博士后.UniversityofCalgary,Canada.
2006/4-2007/11.博士后.KinkiUniversity,Japan.
2005/6-2006/2博士后.UniversityofFlorida,USA.奖励（Award）
TheCanadianAssociationofGastroenterology(CAG)fellowshipaward.研究兴趣
蛋白质泛素化修饰与癌症发生机制
泛素蛋白酶体系统在DNA复制、DNA修复、转录、蛋白合成、细胞分化、凋亡等生命活动中具有重要调节作用。蛋白泛素化过程中包含E1泛素化激活酶，E2泛素化连接酶，E3泛素化蛋白连接酶的参与。泛素蛋白自身含有76个氨基酸残基，分子量为8.5kDa.其重要特点是其含有7个Lysine残基。许多RINGFINGER蛋白功能上作为E3连接酶，诱导底物泛素化和蛋白水解酶体依赖的降解。目前我们主要集中下面三个方面的研究：1）PPARγE3ligase功能机制；2）PPARs（PPARα、PPARγ、PPARδ）调节肿瘤发生分子机制；3）新的PPARs配体合成、筛选及其临床运用。
Theubiquitin-proteasomesystemfunctionsinawidevarietyofcellularprocesses,includingDNAreplication,DNArepair,transcription,proteinsynthesis,celldifferentiationandapoptosis.UbiquitinationiscarriedoutbyanenzymaticcascadecomposedoftheE1ubiquitin-activatingenzyme,theE2ubiquitin-conjugatingenzymeandtheE3ubiquitin-proteinligase.LotsofstudiesshowthatLys-63-linkedchainsisassociatedwithsignaltransduction,membrane-proteintrafficking,endocytosisandDNArepair,incontrast,K6,K11,K27,K29,K33,K48linkedubiquitinchainstargetproteinsforproteasome-mediateddegradation.Atpresent,wefocusthreeareasasfollows:
1)ThefunctionalmechanismofPPARγE3ubiquitinligase.
2)ThemolecularmechanismofPPARs(PPARα,PPARγ,PPARδ)regulatestumorigenesis.
3)synthesisandscannovelPPARsligandstotreatdiseases.
主要发表论文
YHou*,JGao,HXu,YXu,ZZhang,QXu,CZhang.PPARγE3ubiquitinligaseregulatesMUC1-Concoproteinstability.Oncogene(Inpress)(*通讯作者)YongzhongHou*,ZhiZhang,QinggangXu,HongWang,YingXu,KepingChen.Inhibitorofgrowth4inducesNFκB/p65ubiquitin-dependentdegradation.Oncogene.2013(Inpress).(*通讯作者).
YongzhongHou,FranceMoreauandKrisChadee.PPARγisanE3ligasethatinducesthedegradationofNFκB/p65.NatureCommunications.2012.3:1300.
YongzhongHou,LeanneMortimer,andKrisChadee.E.histolyticacysteineproteinase-5bindsintegrinoncoloniccellsandstimulatesNF?B-mediatedpro-inflammatoryresponse.J.Biol.Chem.2010.285:35497-504.
YongZhongHou*,KiyotakaOkada,ChikakoOkamoto,ShigesaUeshima,andOsamuMatsu.Alpha2-AntiplasminIsaCriticalRegulatorofAngiotensinII-MediatedVascularRemodeling.ArteriosclerThrombVascBiol.2008,28:1257-62(*通讯作者).
YongZhongHou,ChikakoOkamoto,KiyotakaOkada,NaoyakiKawao,ShuheiKawata,ShigesaUeshima,andOsamuMatsu.c-Mycisessentialforurokinaseplasminogenactivatorexpressiononhypoxiainducedvascularsmoothmusclecells.Cardiovas.Res.2007,75:186-94.
YongzhongHou,FengqinGao,QinhongWang,JinfengZhao,TammyFlagg,YangdeZhang,andXingmingDeng.Bcl2impedesDNAmismatchrepairbydirectlyregulatingthehMSH2-hMSH6heterodimericcomplex.J.Biol.Chem.2007,282:9279-87.