辛瑜
职称：副教授、硕士生导师
学历/学位：研究生、博士
电话：+86**
电子邮箱：yuxin@jiangnan.edu.cn


简介
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长期从事生物转化、生物大分子相互作用的研究，主要承担蛋白质纯化技术、生物技术基础（双语）课程的讲授工作。近年来共发表国际权威期刊论文30余篇，参与出版专著（或教材）2部；申请发明专利10余项，授权发明专利5项；主持包括国家自然科学基金青年基金、江苏省自然科学基金优秀青年基金、江苏省自然科学基金青年基金、江苏省产学研项目等在内的省部级以上科研项目4项；获得江西省科技进步三等奖1项，南昌市科技进步二等奖1项，指导学生获得2014年校级本科优秀毕业论文。现为中国整形美容协会新技术与新材料分会委员，Molecular Catalysis、Journal of Chromatography B、Journal of Separation Science等杂志审稿人及特刊编辑。



学习工作经历
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2000-2004 上海交通大学，生命科学技术学院 生物技术本科
2004-2009 上海交通大学，生命科学技术学院 生物医学工程（生物工程）博士
2009-2020 江南大学，生物工程学院 副教授
2014-2015 美国明尼苏达大学（双城校区） 生物技术中西 访问****
2020-至今 粮食发酵工艺与技术国家工程实验室 副教授



主要成果
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一、论文（论著）发表情况
部分代表性论文如下：
1. Guangming Fan, Yu Gu, Jiaojiao Zhang, Yu Xin*, Jun Shao*, Francesca Giampieri, Maurizio Battino*, Transthyretin Upregulates Long Non-Coding RNA MEG3 by Affecting PABPC1 in Diabetic Retinopathy. International Journal of Molecular Sciences, 2019, 20, 6313. (IF 4.183)
2. Jun Shao, Yunbin Zhang, Guangming Fan, Yu Xin*, Yong Yao*, Transcriptome analysis identified a novel 3-LncRNA regulatory network of transthyretin attenuating glucose induced hRECs dysfunction in diabetic retinopathy. BMC Medical Genomics, 2019, 12: 134. (IF 2.568)
3. Jun Shao, Guangming Fan, Xiaowen Yin, Yu Gu, Xiaolu Wang, Yu Xin*, Yong Yao*, A novel transthyretin/STAT4/miR-223-3p/FBXW7 signaling pathway affects neovascularization in diabetic retinopathy. Molecular and Cellular Endocrinology, 2019, 498，110541. (IF 3.693)
4. Jun Shao, Xubin Pan, Xiaowen Yin, Guangming Fan, Chengye Tan, Yong Yao*, Yu Xin*, Chao Sun*, KCNQ1OT1 affects the progression of diabetic retinopathy by regulating miR-1470 and epidermal growth factor receptor. Journal of Cellular Physiology, 2019, 234, 17269-17279 (IF 4.522).
5. Yu Xin*, Mengyao Hao, Guangming Fan, Yao Zhang, Liang Zhang*，Soluble expression of Thermomicrobium roseum sarcosine oxidase and characterization of N-demethylation activity. Molecular Catalysis, 2019, 464, 48-56 (IF 4.211).
6. Mengyao Hao, Guangming Fan, Yao Zhang, Yu Xin*, Liang Zhang*，Preparation and characterization of copper-Brevibacterium cholesterol oxidase hybrid nanoflowers, International Journal of Biological Macromolecules, 2019, 126, 539-548 (IF 4.784).
7. Mengling Zheng, Mengyao Hao, Guangming Fan, Yao Zhang, Yu Xin*, Liang Zhang*, Preparation, reconstruction, and characterization of a predicted Thermomicrobium roseum sarcosine oxidase. Molecular Catalysis, 2018, 455, 132-142 (IF 4.211).
8. Yu Xin*, Mengyao Hao, Guangming Fan, Yao Zhang, Mengling Zheng, Liang Zhang*, Affinity adsorption of bovine hyaluronidase with ligands targeting to active site. Journal of Chromatography B, 2018, 1092,422-431 (IF 2.813).
9. Jun Shao, Ying Yin, Xiaowen Yina, Li Jia, Yu Xin*, Jian Zouc*, Yong Yao*, Transthyretin exerts pro-apoptotic effects in human retinal microvascular endothelial cells through a GRP78-dependent pathway in diabetic retinopathy. Cellular Physiology and Biochemistry， 2017, 43, 788-800. (IF 5.50)
10. Yu Xin，Mengling Zheng，Qing Wang，Liushen Lu，Ling Zhang，Yanjun Tong，Wu Wang，Structural and catalytic alteration of sarcosine oxidase through reconstruction with coenzyme-like ligands，Journal of Molecular Catalysis B: Enzymatic，2016，133: S250–S258. (IF 2.269)
11. Yu Xin，Liushen Lu，Qing Wang，Ling Zhang，Yanjun Tong，Wu Wang，Coenzyme-like ligands for affinity isolation of cholesterol oxidase, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences，2016, 1021, 169-174. (IF 2.813)
12. Xin Y., Liu L.H., Chen B.Z., Zhang L., Tong Y.J., Affinity purification of aprotinin from bovine lung. Journal of Separation Science, 2015, 38, 1441-1448. (IF 2.516)
13. Xin Y., Yang H.L., Xia X.L., Zhang L., Cheng C., Mou G.C., Shi J.B., Han Y.F., Wang W., Affinity purification of a cholesterol oxidase expressed in Escherichia coli. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2011, 879, 853-858. (IF 2.813)
14. Xin Y., Yang H.L., Xia X.L., Zhang L., Zhang Y.R., Tong Y.J., Wang W., Preparation and characterization of affinity sorbents based on isoalloxazine-like ligands for separation of flavoenzymes. Journal of Separation Science, 2011, 34, 2940-2949. (IF 2.516)
15. Xin Y., Yang H.L., Xia X.L., Zhang L., Zhang Y.R., Cheng C., Wang W., Expression, purification and partial characterization of a xanthine oxidase (XOD) in Arthrobacter sp.. Process Biochemistry, 2012, 47, 1539-1544. (IF 2.883)
16. Xin Y., Yang H.L., Xia X.L., Zhang L., Zhang Y.R., Tong Y.J., Chen Y., Wang W.,
Expression and comparison of recombinant cholesterol oxidases (COD) in Escherichia coli with native cholesterol oxidase expressed in Brevibacterium sp.. Afr J Biotechnol, 2011, 10(66), 14968-14976.
17. Xin Y., Yang H.L., Xia X.L., Zhang L., Zhang Y.R., Tong Y.J., Chen Y., Wang W.,
Affinity purification of urinary trypsin inhibitor from human urine. Journal of Separation Science, 2012, 35, 1–6. (IF 2.516)
18. Tong Y.J., Xin Y., Yang H.L., Zhang L., Zhang Y.R., Chen Y., Xia X.L., Wang W.,
Preparation and Performance Research on Glutathione Molecularly Imprinted Polymers. Chromatographia, 2011, 74, 443–450. (IF 1.552)
19. Xin Y., Tong Y.J., Yang H.L., Zhang L., Zhang Y.R., Chen Y., Wang W., Study on the Glutathione Molecularly Imprinted Polymers with different functional monomers. Acta Chimica Sinica, 2012, 70 (6), 803-811. (IF 2.463)
20. Shao J.^#, Xin Y.^#, Li R.X., Fan Y., Vitreous and serum levels of transthyretin (TTR) in high myopia patients are correlated with ocular pathologies. Clinical Biochemistry, 2011 44, 681-685. (并列第一) (IF 2.43)
21. Shao J.^#, Xin Y.^#, Yao Y., Correlation of misfolded transthyretin in abnormal vitreous and high myopia related ocular pathologies. Clinica Chimica Acta, 2011, 412, 2117-2121. (并列第一) (IF 2.735)
22. Xin Y., Dong D.X., Wang T., Li R.X., Affinity purification of serine proteinase from Deinagkistrodon acutus venom. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2007, 859 (1), 111-118. (IF 2.813)
23. Xin Y., Dong D.X., Chen D.Z., Li R.X., Structural and biological characterization of a novel acutobinlike enzyme isolated from the venom of the sharp-nosed pit viper (Deinagkistrodon acutus). Biotechnology and Applied Biochemistry, 2009, 53, 123-131. (IF 1.559)
24. Shao J.^#, Xin Y.^#, Yao Y., Zhu J., Functional analysis of misfolded transthyretin extracted from abnormal vitreous with high myopia related ocular pathologies. Clinica Chimica Acta, 2012, 415, 20-24. (并列第一) (IF 2.735)
25. Yanjun Tong, Yu Xin, Hailin Yang, Ling Zhang, Xiumei Tao, Hui Xu, Wu Wang, Novel affinity purification of monomeric sarcosine oxidase expressed in Escherichia coli. Journal of Separation Science, 2013, 36, 3086–3092. (IF 2.516)
26. Yuran Zhang, Yu Xin, Hailin Yang, Ling Zhang, Xiaole Xia, Yanjun Tong, Yi Chen, Wu Wang, Thermal inactivation of xanthine oxidase from Arthrobacter M3: mechanism and the corresponding thermostabilization strategy. Bioprocess and Biosystems Engineering, 2014, 37 (4): 719-725 (IF 2.371).
27. Yi Chen,Yu Xin, Hailin Yang, Ling Zhang, Yuran Zhang, Xiaole Xia, Yanjun Tong, Wu Wang, Immobilization and stabilization of cholesterol oxidase on modified sepharose particles. International Journal of Biological Macromolecules, 2013, 56, 6-13. (IF 4.784)
28.辛瑜，张玲，张玉然，陈亦，仝艳军，王武. 纯化大肠杆菌表达胆固醇氧化酶的两种亲和分离介质的研究. 食品与生物技术学报 2012, 31 (6), 599-605.
二、专利情况
1. 辛瑜; 张梁; 一种重组枯草芽孢杆菌细胞在酶法生物降解N-甲基有机氮农药中的应用, 2020-01-09, 中国, CN1.1.
2. 辛瑜; 张梁; 张瑶; 高秋月; 一种酶法拆分制备N-甲基-D-天冬氨酸的方法，申请; 2019-01-14, 中国, CN3.5.
3. 辛瑜; 张梁; 牛来源透明质酸酶亲和介质及其吸附方法; 2018-02-27, 中国, CN8.2.
4. 辛瑜; 陈备战; 熊晓云; 熊蔚; 一种牛肺抑肽酶异性制备层析介质的合成和应用; 2014-04-15, 中国, ZL9.4.
5. 杨海麟; 辛瑜; 仝艳军; 王武; 张玲; 肌氨酸氧化酶亲和介质及其合成和纯化肌氨酸氧化酶的方法, 2014-06-25, 中国, ZL7.X.
6. 辛瑜; 杨海麟; 张玲; 张玉然; 陈亦; 仝艳军; 一种黄素酶亲和介质及其合成和应用, 2014-05-07, 中国, ZL8.2.
7. 辛瑜; 杨海麟; 张玲; 夏小乐; 张玉然; 仝艳军; 王武; 一种胆固醇氧化酶亲和介质及其合成和大规模纯化胆固醇氧化酶方法, 2014-01-29, 中国, ZL9.1.
三、承担教学科研项目情况
1. 江苏省优秀青年基金项目“针对关键微结构域的黄素酶构效改造研究” 项目编号 BK** (2016-2019)
2. 国家自然科学基金青年基金项目“基于类辅酶配体的黄素酶构效优化机制研究” 项目编号**（2014-2016）
3. 江苏省自然科学基金青年基金项目“类辅酶配体在黄素酶稳态平衡与亲和分离中机理的研究” 项目编号BK**（2012-2015）
4. 江苏省产学研项目“高效制备高浓度凝结芽孢杆菌菌粉的产业化关键技术研究” 项目编号BY**-36 （2015-2018）
5. 获奖情况（含指导学生获奖）
（1）. 2018年江西省科技进步三等奖-基于高特异性靶向分离技术的抑肽酶制备工艺-1/8
（2）. 2016年南昌市科技进步二等奖-基于高特异性靶向分离技术的抑肽酶制备工艺-1/8
（3）. 2017年江南大学教学成果二等奖—双语精品课程《生物技术基础》“三元一体”改革与建设
（4）. 2014年江南大学本科优秀毕业论文（薛慧慧）
（5）. 2011年江南大学教学成果一等奖—《生物技术基础本科双语课程》-3/5
以上资料更新时间截止：2020年4月